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Phosphoryl chloride

RTECS #: TH4897000

CAS #: 10025-87-3


UPDATE: May 2009 MW: 153.32 MF: Cl3OP


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Fosforoxychlorid (Czech)
  2. Oxychlorid fosforecny (Czech)
  3. Phosphorus oxychloride
  4. Phosphorus oxychloride (ACGIH)
  1. Phosphorus oxytrichloride
  2. Phosphoryl trichloride
  3. Trichlorophosphine oxide
  4. Trichlorophosphorus oxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lethal concentration (50 percent kill): 53 ppm/4 hour Eye: Other eye effects

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 25,470,1964
inhalation
mammal (species unspecified)
lowest published toxic concentration: 0.48 mg/m3 Lung, Thorax, or Respiration: Cough VCVN5* -,72,1993
inhalation
mouse
lethal concentration (50 percent kill): 404 mg/m3/2 hour N/R WDZAEK 6,98,1992
inhalation
mouse
lowest published lethal concentration: 48 mg/m3/36 minute N/R VCVN5* -,72,1993
inhalation
mouse
lowest published lethal concentration: 5.7 mg/m3/4 hour N/R VCVN5* -,72,1993
inhalation
rat
lethal concentration (50 percent kill): 32 ppm/4 hour N/R 28ZPAK -,17,1972
inhalation
rat
lowest published lethal concentration: 48 mg/m3/36 minute N/R VCVN5* -,72,1993
inhalation
rat
lowest published lethal concentration: 5.7 mg/m3/4 hour N/R VCVN5* -,72,1993
inhalation
rat
lethal concentration : 0.56 gm/m3 Eye: Lacrimation

Eye: Corneal damage

Behavioral: Somnolence (general depressed activity)
TPKVAL 13,107,1973
inhalation
rat
lethal concentration (50 percent kill): 0.71 gm/m3 N/R TPKVAL 13,107,1973
inhalation
rat
lethal concentration : 0.89 gm/m3 N/R TPKVAL 13,107,1973
inhalation
rat
lowest published toxic concentration: 0.6 gm/m3 Lung, Thorax, or Respiration: Respiratory depression TPKVAL 13,107,1973
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3 Skin: After systemic exposure: Dermatitis, irritative TPKVAL 13,107,1973
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour Nutritional and Gross Metabolic: Changes in: Metabolic acidosis TPKVAL 14,112,1975
ocular
rabbit
lowest published toxic dose: 100 pph Behavioral: Excitement

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 13,107,1973
oral
mouse
lethal dose (50 percent kill): 327 mg/kg N/R WDZAEK 6,98,1992
oral
rat
lethal dose (50 percent kill): 36 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0534840
oral
rat
lethal dose (16 percent kill): 250 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
TPKVAL 13,107,1973
oral
rat
lethal dose (50 percent kill): 380 mg/kg N/R TPKVAL 13,107,1973
oral
rat
lethal dose : 580 mg/kg N/R TPKVAL 13,107,1973
skin
mouse
lowest published toxic dose: 100 pph/5 minute Skin: After systemic exposure: Dermatitis, irritative TPKVAL 13,107,1973
skin
mouse
lowest published toxic dose: 100 pph/1 minute N/R TPKVAL 13,107,1973
skin
rabbit
lowest published lethal dose: 1 gm/kg Behavioral: Muscle weakness

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0534840
skin
rabbit
lowest published toxic dose: 100 pph Behavioral: Excitement

Gastrointestinal: Ulceration or bleeding from stomach
TPKVAL 13,107,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 1 mg/m3/122 day- intermittent Musculoskeletal: Osteoporosis TPKVAL 14,112,1975
inhalation
mammal (species unspecified)
lowest published toxic concentration: 1,340 g/m3/17 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Musculoskeletal: Osteoporosis

Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)
JHEMA2 21,387,1977
inhalation
rat
lowest published toxic concentration: 4 mg/m3/50 day- intermittent Lung, Thorax, or Respiration: Other changes WDZAEK 6,98,1992
inhalation
rat
lowest published toxic concentration: 1 mg/m3/30 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TPKVAL 14,112,1975
inhalation
rat
lowest published toxic concentration: 1 mg/m3/122 day- intermittent Musculoskeletal: Osteoporosis TPKVAL 14,112,1975
inhalation
rat
lowest published toxic concentration: 1 mg/m3/91 day- intermittent Nutritional and Gross Metabolic: Changes in: Ca TPKVAL 14,112,1975
oral
mouse
lowest published toxic dose: 480 mg/kg/60 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
WDZAEK 6,98,1992
oral
rat
lowest published toxic dose: 480 mg/kg/60 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
WDZAEK 6,98,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.63 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.64 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.6 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.5 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.6 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 1.3 mg/m3 (0.2 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.6 mg/m3), short term exposure limit 0.5 ppm (3 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.6 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.63 mg/m3), JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 ppm (0.6 mg/m3);
short term exposure limit 0.2 ppm (1.2 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.6 mg/m3),KZG- week 0.1 ppm (0.6 mg/m3),DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.5 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 ppm (1.3 mg/m3);
short term exposure limit 0.6 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORUS OXYCHLORIDE-air 10 hour time-weighted average 0.1 ppm;
short term exposure limit 0.5 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81931;
Number of Industries 7;
Total Number of Facilities 155;
Number of Occupations 22;
Total Number of Employees Exposed 7,258
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81931;
Number of Industries 9;
Total Number of Facilities 165;
Number of Occupations 29;
Total Number of Employees Exposed 12,587;
Total Number of Female Employees Exposed 2,945


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of plasticizers, hydraulic fluids and gasoline additives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology. (Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1- 1957-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used in the manufacture of plasticizers, hydraulic fluids and gasoline additives

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