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Phosphorus (white)

RTECS #: TH3500000

CAS #: 7723-14-0


UPDATE: May 2009 MW: 123.88 MF: P4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Bonide blue death rat killer
  2. Common sense cockroach and rat preparations
  3. Fosforo bianco (Italian)
  4. Gelber phosphor (German)
  5. Phosphore blanc (French)
  6. Phosphorous (white)
  7. Phosphorous yellow
  8. Phosphorus (yellow)
  1. Phosphorus, yellow (ACGIH:OSHA)
  2. Rat - Nip
  3. Tetrafosfor (Dutch)
  4. Tetraphosphor (German)
  5. Weiss phosphor (German)
  6. White phosphorus
  7. Yellow phosphorus


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 11 g/kg (1-22 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
ZDKAA8 36(5),87,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
cat
lowest published lethal dose: 4 mg/kg N/R YKYUA6 28,329,1977
oral
duck
lowest published lethal dose: 3 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
JAPMA8 39,151,1950
oral
duck
lethal dose (50 percent kill): 6.55 mg/kg N/R HBPTO* 2,1400,2001
oral
dog
lowest published lethal dose: 10 mg/kg N/R YKYUA6 28,329,1977
oral
human
lowest published lethal dose: 0.7 mg/kg N/R HBPTO* 2,1402,2001
oral
human
lethal dose (90 percent kill): 26 mg/kg N/R HBPTO* 2,1402,2001
oral
infant
lowest published lethal dose: 0.4 mg/kg N/R HBPTO* 2,1402,2001
oral
mammal (species unspecified)
lowest published lethal dose: 200 mg/kg N/R 28ZEAL 4,321,1969
oral
mouse
lethal dose (50 percent kill): 4,820 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Other changes
NTIS** AD-B011-150
oral
pig
lowest published lethal dose: 160 mg/kg N/R 28ZEAL 4,321,1969
oral
rat
lethal dose (50 percent kill): 3,030 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Other changes
NTIS** AD-B011-150
oral
woman
lowest published lethal dose: 22 mg/kg Cardiac: Cardiomyopathy including infarction AHJOA2 84,139,1972
oral
woman
lowest published toxic dose: 11 mg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature increase
AJMSA9 209,223,1944
oral
woman
lowest published lethal dose: 4,600 g/kg Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Nausea or vomiting

Skin and Appendages: Other: Sweating
AIMDAP 83,164,1949
oral
woman
lowest published toxic dose: 2,600 g/kg Behavioral: Fluid intake

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
NEJMAG 232,247,1945
subcutaneous
dog
lowest published lethal dose: 2 mg/kg Behavioral: Food intake (animal)

Cardiac: Other changes

Liver: Fatty liver degeneration
AEXPBL 52,173,1905
subcutaneous
rabbit
lowest published lethal dose: 10 mg/kg Behavioral: Muscle weakness

Endocrine: Hypoglycemia
AEXPBL 64,274,1911


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rabbit
lowest published toxic concentration: 160 mg/m3/30 minute/60 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
FKIZA4 46,604,1955
oral
duck
lowest published toxic dose: 14 mg/kg/14 day- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes
JAPMA8 39,151,1950
oral
guinea pig
lowest published toxic dose: 105 mg/kg/35 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Change in gall bladder structure or function

Liver: Other changes
PSEBAA 67,351,1945
oral
rat
lowest published toxic dose: 18 mg/kg/4 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
WDZAEK 4,206,1990
oral
rat
lowest published toxic dose: 12 mg/kg/4 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
WDZAEK 4,4,1990
oral
rat
lowest published toxic dose: 20,800 g/kg/16 day- continuous Musculoskeletal: Other changes ANREAK 177,15,1973
oral
rat
lowest published toxic dose: 85 mg/m3/17 week- intermittent Liver: Fatty liver degeneration

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
GTPZAB 26(9),17,1982
oral
rat
lowest published toxic dose: 91 g/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 44(5),74,1979
oral
rat
lowest published toxic dose: 11,088 g/kg/22 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JPETAB 24,119,1925


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
NTIS** AD778-725
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
HUTOX* -,683,1996
TOXICOLOGY REVIEW
HUTOX* -,683,1996
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 DTLVS* 3,210,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.02 ppm (0.1 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, VLE 0.3 mg/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3, short term exposure limit 0.1 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg/m3, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 0.03 mg/m3, short term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg/m3,KZG- week 0.1 mg/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORUS (YELLOW)-air 10 hour time-weighted average 0.1 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0004;
Number of Industries 2;
Total Number of Facilities 38;
Number of Occupations 3;
Total Number of Employees Exposed 205
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0005;
Number of Industries 1;
Total Number of Facilities 41;
Number of Occupations 5;
Total Number of Employees Exposed 626
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81650;
Number of Industries 19;
Total Number of Facilities 1,187;
Number of Occupations 42;
Total Number of Employees Exposed 13,630
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81684;
Number of Industries 3;
Total Number of Facilities 47;
Number of Occupations 4;
Total Number of Employees Exposed 261
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0004;
Number of Industries 1;
Total Number of Facilities 75;
Number of Occupations 1;
Total Number of Employees Exposed 675;
Total Number of Female Employees Exposed 225
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0005;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 1;
Total Number of Employees Exposed 91;
Total Number of Female Employees Exposed 6
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81650;
Number of Industries 104;
Total Number of Facilities 12,775;
Number of Occupations 88;
Total Number of Employees Exposed 208,975;
Total Number of Female Employees Exposed 7,598
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81684;
Number of Industries 5;
Total Number of Facilities 139;
Number of Occupations 10;
Total Number of Employees Exposed 2,924;
Total Number of Female Employees Exposed 67


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101090/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in fertilizer, phosphor-bronze, tracer bullets, smokes, incendiaries manufacturing
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9187
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925-
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841-
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FKIZA4 Fukuoka Igaku Zasshi. (c/o Kyushu Daigaku Igakubu, Tatekasu, Fukuoka-shi, Fukuoka, Japan) V.33- 1940-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
HUTOX*
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-
ZDKAA8 Zdravookhranenie Kazakhstana. Public Health of Kazakhstan. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1941-

Used in fertilizer, phosphor-bronze, tracer bullets, smokes, incendiaries manufacturing

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector
   Human Data

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