Phosphorothioic acid, O,O-dimethyl O-(2,4,5-trichlorophenyl) ester
RTECS #
TG0525000
CAS #
Updated
December 2015
Molecular Weight
321.54
Molecular Formula
C8H8Cl3O3PS
Synonyms
Blitex
Dermafosu (Polish)
Dermaphos
Dimethyl trichlorophenyl thiophosphate
Dow ET 14
Dow ET 57
Ectoral
ENT 23,284
ET 14
Etrolene
Fenchloorfos (Dutch)
Fenchlorfos
Fenchlorfosu (Polish)
Fenchlorphos
Korlan
Korlane
Moorman's Medicated Rid-Ezy
Nanchor
Nankor
O-(2,4,5-Trichloor-fenyl)-O,O-dimethyl-monothiofosfaat (Dutch)
O-(2,4,5-Trichlor-phenyl)-O,O-dimethyl-monothiophosphat (German)
O-(2,4,5-Tricloro-fenil)-O,O-dimetil-monotiofosfato (Italian)
O,O-Dimethyl O-(2,4,5-trichlorophenyl)thiophosphate
O,O-Dimethyl O-2,4,5-trichlorophenyl phosphorothioate
O,O-Dimethyl-O-(2,4,5-trichlorphenyl)-thionophosphat (German)
OMS 123
Phenchlorfos
Phenol, 2,4,5-trichloro-, O-ester with O,O-dimethyl phosphorothioate
Remelt
Ronnel
Ronnel (ACGIH:OSHA)
Rovan
Thiophosphate de O,O-dimethyle et de O-(2,4,5-trichlorophenyle) (French)
Trichlorometafos
Trolen
Trolene
Viozene
Dermafosu (Polish)
Dermaphos
Dimethyl trichlorophenyl thiophosphate
Dow ET 14
Dow ET 57
Ectoral
ENT 23,284
ET 14
Etrolene
Fenchloorfos (Dutch)
Fenchlorfos
Fenchlorfosu (Polish)
Fenchlorphos
Korlan
Korlane
Moorman's Medicated Rid-Ezy
Nanchor
Nankor
O-(2,4,5-Trichloor-fenyl)-O,O-dimethyl-monothiofosfaat (Dutch)
O-(2,4,5-Trichlor-phenyl)-O,O-dimethyl-monothiophosphat (German)
O-(2,4,5-Tricloro-fenil)-O,O-dimetil-monotiofosfato (Italian)
O,O-Dimethyl O-(2,4,5-trichlorophenyl)thiophosphate
O,O-Dimethyl O-2,4,5-trichlorophenyl phosphorothioate
O,O-Dimethyl-O-(2,4,5-trichlorphenyl)-thionophosphat (German)
OMS 123
Phenchlorfos
Phenol, 2,4,5-trichloro-, O-ester with O,O-dimethyl phosphorothioate
Remelt
Ronnel
Ronnel (ACGIH:OSHA)
Rovan
Thiophosphate de O,O-dimethyle et de O-(2,4,5-trichlorophenyle) (French)
Trichlorometafos
Trolen
Trolene
Viozene
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| sister chromatid exchange | lymphocyte/human | 2 mg/L | MUREAV 102,89,1982 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 368 mg/kg (16-22D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | NUPOBT 17,577,1979 |
| oral/rat | 6 gm/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | JTEHD6 10,111,1982 |
| oral/rabbit | 650 mg/kg (6-18D pregnant) | Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | AVSCA7 24,295,1983 |
| oral/rabbit | 162 mg/kg (6-18D pregnant) | Reproductive: Other developmental abnormalities | AVSCA7 24,295,1983 |
| oral/mammal (species unspecified) | 2100 mg/kg (30-50D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | AVSCA7 24,99,1983 |
| oral/mammal (species unspecified) | 2100 mg/kg (30-50D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Sex ratio | AVSCA7 24,99,1983 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | lethal dose (50 percent kill): 118 mg/kg | PSEBAA 129,699,1968 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 2823 mg/kg | PSEBAA 129,699,1968 | |
| oral/chicken | lethal dose (50 percent kill): 6375 mg/kg | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BCTKAG 10,339,1977 |
| oral/Dog | lethal dose (50 percent kill): 500 mg/kg | 85GYAV -,26,1971 | |
| oral/domestic animal | lowest published lethal dose: 1 gm/kg | VETNAL 51(8),101,1974 | |
| oral/duck | lethal dose (50 percent kill): 3500 mg/kg | PCOC** -,965,1966 | |
| oral/guinea pig | lethal dose (50 percent kill): 1400 mg/kg | PCOC** -,965,1966 | |
| oral/mouse | lethal dose (50 percent kill): 2 gm/kg | PCOC** -,965,1966 | |
| oral/rabbit | lethal dose (50 percent kill): 420 mg/kg | PCOC** -,965,1966 | |
| oral/rat | lethal dose (50 percent kill): 625 mg/kg | GISAAA 45(6),14,1980 | |
| oral/turkey | lethal dose (50 percent kill): 500 mg/kg | JAFCAU 7,689,1959 | |
| oral/wild bird | lethal dose (50 percent kill): 80 mg/kg | TXAPA9 21,315,1972 | |
| skin/guinea pig | lethal dose (50 percent kill): 2 gm/kg | 85DPAN -,-,1971/1976 | |
| skin/rabbit | lethal dose (50 percent kill): 1 gm/kg | FMCHA2 -,C265,1991 | |
| skin/rat | lethal dose (50 percent kill): 2 gm/kg | WRPCA2 9,119,1970 | |
| subcutaneous/chicken | lethal dose (50 percent kill): >1600 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) | BCPCA6 12,1377,1963 |
| subcutaneous/rat | lethal dose (50 percent kill): 1380 mg/kg | GISAAA 52(11),24,1987 | |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 400 mg/kg | 30ZDA9 -,333,1971 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/Dog | lowest published toxic dose: 5940 mg/kg/2Y- continuous | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 23,1,1972 |
| oral/rat | lowest published toxic dose: 350 mg/kg/14D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | BCTKAG 10,351,1977 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 mg/m3 (inhal, vapor) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | AQMOAC #73-19,1973 | |
| TOXICOLOGY REVIEW | RREVAH 46,1,1973 | |
| TOXICOLOGY REVIEW | RREVAH 63,1,1976 | |
| TOXICOLOGY REVIEW | TOLED5 230,434,2014 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,206,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 mg/m3 | DTLVS* 3,222,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 mg/m3;KZW 10 mg/m3, inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 mg/m3, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 mg/m3, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 mg/m3, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 mg/m3, JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.3 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 mg/m3, inhal, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 10 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 10 mg/m3, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 10 mg/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 15 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 15 mg/m3 | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 10 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO RONNEL-air | 10H time-weighted average 10 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 67525; Number of Industries 2; Total Number of Facilities 333; Number of Occupations 2; Total Number of Employees Exposed 3824; Total Number of Female Employees Exposed 574 | |
| National Occupational Hazard Survey 1974 | Hazard Code 67525; Number of Industries 2; Total Number of Facilities 86; Number of Occupations 2; Total Number of Employees Exposed 383 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health