Phosphorothioic acid, O,O-dimethyl O-(p-nitrophenyl) ester
RTECS #
TG0175000
CAS #
Updated
December 2017
Molecular Weight
263.22
Molecular Formula
C8H10NO5PS
Synonyms
8056HC
Azofos
Azophos
BAY 11405
BAY E-601
Bladan-M
Cekumethion
Dalf
Demethylfenitrothion
Devithion
Dimethyl 4-nitrophenyl phosphorothionate
Dimethyl parathion
Dimethyl p-nitrophenyl monothiophosphate
Dimethyl p-nitrophenyl thiophosphate
Dimethyl-p-nitrophenyl thionphosphate
Drexel methyl parathion 4E
ENT 17,292
Folidol M
Folidol-80
Fosferno M 50
Kilex parathion
Mepaton
Meptox
Metacid
Metacid 50
Metafos
Metaphos
Methyl fosferno
Methyl niran
Methyl parathion
Methyl parathion (ACGIH)
Methyl-E 605
Metilparation (Hungarian)
Metron (pesticide)
Metyloparation (Polish)
Metylparation (Czech)
M-Parathion
NCI-C02971
Nitrox
Nitrox 80
O,O-Dimethyl O-(p-nitrophenyl) phosphorothioate
O,O-Dimethyl O-(p-nitrophenyl) thionophosphate
O,O-Dimethyl O-4-nitrophenyl phosphorothioate
O,O-Dimethyl O-p-nitrophenyl thiophosphate
O,O-Dimethyl-O-(4-nitro-fenyl)-monothiofosfaat (Dutch)
O,O-Dimethyl-O-(4-nitrophenyl) phosphorothioate
O,O-Dimethyl-O-(4-nitro-phenyl)-monothiophosphat (German)
O,O-Dimethyl-O-(4-nitrophenyl)-thionophosphat (German)
O,O-Dimethyl-O-(p-nitrophenyl)-thionophosphat (German)
O,O-Dimethyl-O-p-nitrofenylester kyseliny thiofosforecne (Czech)
O,O-Dimethyl-O-p-nitrofenylthiofosfat (Czech)
O,O-Dimetil-O-(4-nitro-fenil)-monotiofosfato (Italian)
Oleovofotox
Parapest M-50
Parataf
Parathion methyl
Parathion-metile (Italian)
Penncap-M
Phenol, p-nitro-, O-ester with O,O-dimethylphosphorothioate
Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester
p-Nitrophenyldimethylthionophosphate
Quinophos
RCRA waste number P071
Sinafid M-48
Tekwaisa
Thiophenit
Thiophosphate de O,O-dimethyle et de O-(4-nitrophenyle) (French)
Thylpar M-50
Vofatox
Wofatox
Yphos
Azofos
Azophos
BAY 11405
BAY E-601
Bladan-M
Cekumethion
Dalf
Demethylfenitrothion
Devithion
Dimethyl 4-nitrophenyl phosphorothionate
Dimethyl parathion
Dimethyl p-nitrophenyl monothiophosphate
Dimethyl p-nitrophenyl thiophosphate
Dimethyl-p-nitrophenyl thionphosphate
Drexel methyl parathion 4E
ENT 17,292
Folidol M
Folidol-80
Fosferno M 50
Kilex parathion
Mepaton
Meptox
Metacid
Metacid 50
Metafos
Metaphos
Methyl fosferno
Methyl niran
Methyl parathion
Methyl parathion (ACGIH)
Methyl-E 605
Metilparation (Hungarian)
Metron (pesticide)
Metyloparation (Polish)
Metylparation (Czech)
M-Parathion
NCI-C02971
Nitrox
Nitrox 80
O,O-Dimethyl O-(p-nitrophenyl) phosphorothioate
O,O-Dimethyl O-(p-nitrophenyl) thionophosphate
O,O-Dimethyl O-4-nitrophenyl phosphorothioate
O,O-Dimethyl O-p-nitrophenyl thiophosphate
O,O-Dimethyl-O-(4-nitro-fenyl)-monothiofosfaat (Dutch)
O,O-Dimethyl-O-(4-nitrophenyl) phosphorothioate
O,O-Dimethyl-O-(4-nitro-phenyl)-monothiophosphat (German)
O,O-Dimethyl-O-(4-nitrophenyl)-thionophosphat (German)
O,O-Dimethyl-O-(p-nitrophenyl)-thionophosphat (German)
O,O-Dimethyl-O-p-nitrofenylester kyseliny thiofosforecne (Czech)
O,O-Dimethyl-O-p-nitrofenylthiofosfat (Czech)
O,O-Dimetil-O-(4-nitro-fenil)-monotiofosfato (Italian)
Oleovofotox
Parapest M-50
Parataf
Parathion methyl
Parathion-metile (Italian)
Penncap-M
Phenol, p-nitro-, O-ester with O,O-dimethylphosphorothioate
Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester
p-Nitrophenyldimethylthionophosphate
Quinophos
RCRA waste number P071
Sinafid M-48
Tekwaisa
Thiophenit
Thiophosphate de O,O-dimethyle et de O-(4-nitrophenyle) (French)
Thylpar M-50
Vofatox
Wofatox
Yphos
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | intraperitoneal/rat | 3 mg/kg | MUREAV 321,103,1994 |
| Cytogenetic Analysis | oral/mouse | 10 mg/kg | SOGEBZ 11,1534,1975 |
| Cytogenetic Analysis | sperm/human | 300 µmol/L/1H | REPTED 25,455,2008 |
| DNA Damage | sperm/human | 3.435 mmol/L/1H | REPTED 25,455,2008 |
| DNA Damage | intraperitoneal/mouse | 6 mg/kg | TXAPA9 216,216,2006 |
| DNA Damage | other cell types/human | 1 mg/L/24H | EMMUEG 49,360,2008 |
| DNA Damage | other cell types/human | 100 mg/L/4H | EMMUEG 49,360,2008 |
| DNA Damage | lymphocyte/rat | 0.00675 mg/L/2H | MUREAV 761,10,2014 |
| DNA Damage | lymphocyte/rat | 0.00675 mg/L/4H | MUREAV 761,10,2014 |
| DNA Damage | /Escherichia coli | 100 mg/L | MUREAV 52,161,1978 |
| DNA repair | /Salmonella typhimurium | 250 µg/disc | JPFCD2 19,565,1984 |
| DNA repair | /Other microorganisms | 50 µL/plate | BIZNAT 95,463,1976 |
| Dominant Lethal Test | oral/Drosophila melanogaster | 4500 ng/L | FCTOD7 33,309,1995 |
| gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 114 mmol/L | IARCCD 10,161,1974 |
| micronucleus test | intraperitoneal/mouse | 1 mg/kg | MUREAV 155,131,1985 |
| micronucleus test | oral/mouse | 9375 µg/kg | MUTAEX 5,147,1990 |
| micronucleus test | intraperitoneal/rat | 2500 µg/kg/5D-continuous | MUREAV 188,45,1987 |
| micronucleus test | other cell types/human | 0.1 mg/L/4H | MUREAV 671,84,2009 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 100 mg/L | NTIS** PB84-138973 |
| mutation in microorganisms | /Salmonella typhimurium | 0.5 mmol/L/3D (+enzymatic activation step) | MUREAV 536,103,2003 |
| mutation in microorganisms | /Salmonella typhimurium | 667 µg/plate (+enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
| mutation in microorganisms | /Escherichia coli | 10 mmol/L (-enzymatic activation step) | MUREAV 20,7,1973 |
| mutation in microorganisms | /Other microorganisms | 100 mg/L (-enzymatic activation step) | CYGEDX 15(3),64,1981 |
| mutation in microorganisms | /Salmonella typhimurium | 0.5 mmol/L/72H (+enzymatic activation step) | MUREAV 536,103,2003 |
| sister chromatid exchange | lung/hamster | 10 mg/L | MUREAV 88,307,1981 |
| sister chromatid exchange | lymphocyte/human | 20 mg/L | MUREAV 88,307,1981 |
| specific locus test | multiple/Drosophila melanogaster | 31500 ppb | ARTODN 61,53,1987 |
| specific locus test | oral/Drosophila melanogaster | 6 µg/L | FCTOD7 33,309,1995 |
| sperm morphology | intraperitoneal/rat | 6 mg/kg/12D- intermittent | MUREAV 588,28,2005 |
| sperm morphology | intraperitoneal/rat | 18.75 mg/kg/25D- intermittent | MUREAV 588,28,2005 |
| sperm morphology | oral/mouse | 9375 µg/kg | MUREAV 280,169,1992 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 15 mg/kg (13D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | AEHLAU 15,609,1967 |
| intraperitoneal/rat | 45 mg/kg (15D prior to copulation) | Reproductive: Maternal effects: Menstrual cycle changes or disorders Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | IJEBA6 37,176,1999 |
| intraperitoneal/mouse | 60 mg/kg (11D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | AEHLAU 15,609,1967 |
| intraperitoneal/rat | 12 mg/kg (12D male) | Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) | MUREAV 588,28,2005 |
| intraperitoneal/rat | 18.75 mg/kg (25D male) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | MUREAV 588,28,2005 |
| intraperitoneal/rat | 37.5 mg/kg (25D male) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | MUREAV 588,28,2005 |
| oral/rat | 20 mg/kg (1-20D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | ETPAEK 55,489,2004 |
| oral/rat | 20 mg/kg (1-20D pregnant) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) | HETOEA 27,241,2008 |
| oral/mouse | 5 mg/kg (1D prior to copulation) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TXAPA9 279,338,2014 |
| oral/mouse | 20 mg/kg (1D prior to copulation) | Reproductive: Effects on newborn: Other postnatal measures or effects | TXAPA9 279,338,2014 |
| oral/rat | 900 mg/kg (30D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | ETOPFR 14,91,2003 |
| oral/rat | 9 mg/kg (7-15D pregnant) | Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Behavioral | JPFCD2 15,365,1980 |
| oral/rat | 15 mg/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) | JEBIDP 17,51,1996 |
| oral/rat | 600 µg/kg (5-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | AXVMAW 30,343,1976 |
| oral/rat | 2200 µg/kg (1-22D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | GISAAA 38(8),21,1973 |
| skin/rat | 10 mg/kg (18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system | JTEHD6 63,173,2001 |
| unreported route/rat | 44 mg/kg (1-22D pregnant) | Reproductive: Effects on newborn: Behavioral | AMSHAR 28,210,1980 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 6 µmol/L/72H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 25,2074,2011 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 2 µmol/L/48H | In Vitro Toxicity Studies: Other assays | TIVIEQ 25,2074,2011 |
| In Vitro/Non-mammalian species, liver | Inhibitor Concentration Low: 13 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 29,204,2015 |
| In Vitro/Non-mammalian species, liver | Inhibitor Concentration Low: 0.13 µmol/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,204,2015 |
| inhalation/mouse | lethal concentration (50 percent kill): 120 mg/m3/4H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NTIS** PB241-840 |
| inhalation/rat | lethal concentration (50 percent kill): 34 mg/m3/4H | Behavioral: Tremor Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea | EGESAQ 24,173,1980 |
| intracerebral/mouse | lethal dose (50 percent kill): 47 mg/kg | PCBPBS 8,302,1978 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 5400 µg/kg | PCBPBS 8,302,1978 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 2800 µg/kg | APCRAW 4,117,1961 | |
| intravenous/guinea pig | lethal dose (50 percent kill): 50 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NTIS** PB241-840 |
| intravenous/mouse | lethal dose (50 percent kill): 9800 µg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NTIS** PB241-840 |
| intravenous/rat | lethal dose (50 percent kill): 9 mg/kg | NTIS** PB277-077 | |
| oral/Dog | lethal dose (50 percent kill): 90 mg/kg | Gastrointestinal: Nausea or vomiting | PESTD5 16,273,1975 |
| oral/duck | lethal dose (50 percent kill): 10 mg/kg | DOEAAH 35,25,1979 | |
| oral/guinea pig | lethal dose (50 percent kill): 1270 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NTIS** PB241-840 |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 57 mg/kg | Behavioral: Tremor Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | NTIS** PB288-416 |
| oral/man | lowest published toxic dose: 0.17 gm/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | JTCTDW 45,956,2007 |
| oral/man | lowest published lethal dose: 0.286 gm/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | JTCTDW 45,956,2007 |
| oral/mouse | lowest published toxic dose: 5 mg/kg | Reproductive: Maternal effects: Oogenesis | TXAPA9 279,338,2014 |
| oral/mouse | lethal dose (50 percent kill): 17800 µg/kg | HETOEA 11,11,1992 | |
| oral/rabbit | lethal dose (50 percent kill): 420 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NTIS** PB241-840 |
| oral/rat | lowest published toxic dose: 0.6 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold | TOSCF2 76,400,2003 |
| oral/rat | lethal dose (50 percent kill): 6 mg/kg | JTCTDW 45,956,2007 | |
| oral/rat | lowest published toxic dose: 1.75 mg/kg | Brain and Coverings: Other degenerative changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,309,2003 |
| oral/wild bird | lethal dose (50 percent kill): 5 mg/kg | JTCEEM 6(3),175,1986 | |
| skin/duck | lethal dose (50 percent kill): 54 mg/kg | TXAPA9 47,451,1979 | |
| skin/mouse | lethal dose (50 percent kill): 1200 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JTEHD6 9,491,1982 |
| skin/rabbit | lethal dose (50 percent kill): 300 mg/kg | AFDOAQ 16,3,1952 | |
| skin/rat | lethal dose (50 percent kill): 67 mg/kg | WRPCA2 4,36,1965 | |
| skin/rat | lowest published toxic dose: 10 mg/kg | Lung, Thorax, or Respiration: Respiratory stimulation Blood: Changes in leukocyte (WBC) count Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JTEHD6 63,173,2001 |
| subcutaneous/mouse | lethal dose (50 percent kill): 18 mg/kg | BLLIAX 38,151,1958 | |
| subcutaneous/rabbit | lowest published toxic dose: 37.05 mg/kg | Musculoskeletal: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 191,33,2003 |
| subcutaneous/rat | lethal dose (50 percent kill): 25.3 mg/kg | Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | TOVEFN -,7,2009 |
| subcutaneous/rat | lethal dose (50 percent kill): 6 mg/kg | JEENAI 50,356,1957 | |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 25 mg/kg | 30ZDA9 -,327,1971 | |
| unreported route/mouse | lethal dose (50 percent kill): 23 mg/kg | BWHOA6 44,31,1971 | |
| unreported route/rat | lethal dose (50 percent kill): 10 mg/kg | NYKZAU 74,41P,1978 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 24 µg/m3/24H/93D- continuous | Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 33(10),10,1968 |
| intraperitoneal/mouse | lowest published toxic dose: 45 mg/kg/5D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | TOLED5 196S,S188,2010 |
| intraperitoneal/rat | lowest published toxic dose: 18.75 mg/kg/25D- intermittent | Endocrine: Androgenic Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight | JTSCDR 31,177,2006 |
| intraperitoneal/rat | lowest published toxic dose: 17.5 mg/kg/5D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | JTSCDR 31,177,2006 |
| intraperitoneal/rat | lowest published toxic dose: 6 mg/kg/12D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | JTSCDR 31,177,2006 |
| intraperitoneal/rat | lowest published toxic dose: 17.5 mg/kg/5D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | ETOPFR 22,315,2006 |
| intraperitoneal/rat | lowest published toxic dose: 6 mg/kg/12D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | ETOPFR 22,315,2006 |
| intraperitoneal/rat | lowest published toxic dose: 18.75 mg/kg/25D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in prostate weight | ETOPFR 22,315,2006 |
| intraperitoneal/rat | lowest published toxic dose: 8.75 mg/kg/5D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | ETOPFR 22,315,2006 |
| intraperitoneal/rat | lowest published toxic dose: 6 mg/kg/4D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 31,177,2006 |
| intraperitoneal/rat | lowest published toxic dose: 12 mg/kg/16D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 31,177,2006 |
| intraperitoneal/rat | lowest published toxic dose: 7 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | IJTHEZ 1,95,1991 |
| intraperitoneal/rat | lowest published toxic dose: 7 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes | HBPTO* 2,1027,2001 |
| intraperitoneal/rat | lowest published toxic dose: 12 mg/kg/12D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | MUREAV 588,28,2005 |
| intraperitoneal/rat | lowest published toxic dose: 18.75 mg/kg/25D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | MUREAV 588,28,2005 |
| oral/cat | lowest published toxic dose: 91 mg/kg/26W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FATOAO 20(3),78,1957 |
| oral/Dog | lowest published toxic dose: 42 mg/kg/12W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 1,1,1959 |
| oral/domestic bird | lowest published toxic dose: 20500 µg/kg/5D- continuous | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AECTCV 11,617,1982 |
| oral/human | lowest published toxic dose: 2.4 mg/kg/24D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
| oral/mammal (species unspecified) | lowest published toxic dose: 202 mg/kg/12D- continuous | Behavioral: Food intake (animal) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AECTCV 16,357,1987 |
| oral/mammal (species unspecified) | lowest published toxic dose: 4450 mg/kg/30D- continuous | Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** PB288-416 |
| oral/rabbit | lowest published toxic dose: 48 mg/kg/28D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | BECTA6 54,258,1995 |
| oral/rabbit | lowest published toxic dose: 9.2 mg/kg/57D- continuous | Endocrine: Change in gonadotropins Endocrine: Changes in spleen weight Immunological Including Allergic: Decreased immune response | TXAPA9 32,587,1975 |
| oral/rabbit | lowest published toxic dose: 29.6 mg/kg/57D- continuous | Endocrine: Other changes Blood: Changes in spleen | TXAPA9 32,587,1975 |
| oral/rat | lowest published toxic dose: 35 mg/kg/4W- continuous | Liver: Other changes Liver: Other changes | FATOAO 39,470,1976 |
| oral/rat | lowest published toxic dose: 13200 µg/kg/6W- intermittent | Behavioral: Change in motor activity (specific assay) Gastrointestinal: Decreased motility or constipation Kidney, Ureter, and Bladder: Incontinence | NETEEC 12,125,1990 |
| oral/rat | lowest published toxic dose: 182 mg/kg/26W- intermittent | Behavioral: Alteration of classical conditioning | GISAAA 23(12),19,1958 |
| oral/rat | lowest published toxic dose: 1400 µg/kg/15D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 75,13,1992 |
| oral/rat | lowest published toxic dose: 25 mg/kg/21W- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Nutritional and Gross Metabolic: Body temperature decrease | TXCYAC 75,13,1992 |
| oral/rat | lowest published toxic dose: 1.8 mg/kg/6D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 76,400,2003 |
| oral/rat | lowest published toxic dose: 900 mg/kg/30D- intermittent | Blood: Normocytic anemia Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Changes in testicular weight | ETOPFR 14,91,2003 |
| oral/rat | lowest published toxic dose: 4.2 mg/kg/21D- intermittent | Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 44,198,2005 |
| oral/rat | lowest published toxic dose: 9.9 mg/kg/11D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Other | TOXID9 44,199,2005 |
| oral/rat | lowest published toxic dose: 13.5 mg/kg/21D- intermittent | Biochemical: Metabolism (intermediary): Other | TOXID9 44,199,2005 |
| oral/rat | lowest published toxic dose: 4.2 mg/kg/21D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 78,378,2004 |
| oral/rat | lowest published toxic dose: 12 mg/kg/20D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | TOXID9 90,295,2006 |
| oral/rat | lowest published toxic dose: 2.18 mg/kg/2W- intermittent | Behavioral: Alteration of classical conditioning | EESADV 57,270,2004 |
| oral/rat | lowest published toxic dose: 45.5 mg/kg/13D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 31,177,2006 |
| oral/rat | lowest published toxic dose: 87.5 mg/kg/25D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in prostate weight | ETOPFR 22,315,2006 |
| oral/rat | lowest published toxic dose: 7.84 mg/kg/4W- intermittent | Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | PCBPBS 88,213,2007 |
| oral/rat | lowest published toxic dose: 22405 mg/kg/28D- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 46,2796,2008 |
| oral/rat | lowest published toxic dose: 12.6 mg/kg/21D- intermittent | Brain and Coverings: Other degenerative changes | NETEEC 31,98,2009 |
| oral/rat | lowest published toxic dose: 87.5 mg/kg/25D- intermittent | Endocrine: Androgenic Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight | JTSCDR 31,177,2006 |
| skin/rat | lowest published toxic dose: 16 mg/kg/16D- intermittent | Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,128,2003 |
| skin/rat | lowest published toxic dose: 32 mg/kg/16D- intermittent | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,128,2003 |
| skin/rat | lowest published toxic dose: 90 mg/kg/90D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other | TOXID9 60,244,2001 |
| skin/rat | lowest published toxic dose: 65 mg/kg/13D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TOXID9 72,89,2003 |
| skin/rat | lowest published toxic dose: 9.5 mg/kg/95D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,304,2003 |
| skin/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | IJEBA6 29,149,1991 |
| subcutaneous/rat | lowest published toxic dose: 20 mg/kg/10D- intermittent | Behavioral: Alteration of operant conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 24,797,2002 |
| subcutaneous/rat | lowest published toxic dose: 21 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,304,2003 |
| subcutaneous/rat | lowest published toxic dose: 20 mg/kg/10D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 24,797,2002 |
| subcutaneous/rat | lowest published toxic dose: 9 mg/kg/3D- intermittent | Behavioral: Tremor Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JTSCDR 28,427,2003 |
| subcutaneous/rat | lowest published toxic dose: 21 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes | JTSCDR 28,427,2003 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.02 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal NO EVIDENCE | IMSUDL 7,392,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 30,131,1983 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
| TOXICOLOGY REVIEW | AQMOAC #73-19,1973 | |
| TOXICOLOGY REVIEW | RREVAH 46,1,1973 | |
| TOXICOLOGY REVIEW | ECMAAI 14,141,1973 | |
| TOXICOLOGY REVIEW | DTTIAF 80,485,1973 | |
| TOXICOLOGY REVIEW | RREVAH 63,1,1976 | |
| TOXICOLOGY REVIEW | MUREAV 557,109,2004 | |
| TOXICOLOGY REVIEW | TOLED5 128,45,2002 | |
| TOXICOLOGY REVIEW | MUREAV 567,109,2004 | |
| TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | MUTAEX 20,389,2005 | |
| TOXICOLOGY REVIEW | CCATAR 366,1,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,588,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,85,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | JTEHD6 6,185,2003 | |
| TOXICOLOGY REVIEW | FEREAC 73,31788,2008 | |
| TOXICOLOGY REVIEW | MUREAV 543,251,2003 | |
| TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
| TOXICOLOGY REVIEW | FEREAC 73,54954,2008 | |
| TOXICOLOGY REVIEW | HETOEA 26,321,2007 | |
| TOXICOLOGY REVIEW | FCTOD7 47,2906,2009 | |
| TOXICOLOGY REVIEW | NEUCL* 23,321,2005 | |
| TOXICOLOGY REVIEW | NBREV* 9,479,1985 | |
| TOXICOLOGY REVIEW | TOLED5 190,107,2009 | |
| TOXICOLOGY REVIEW | TXAPA9 258,309,2012 | |
| TOXICOLOGY REVIEW | TOLED5 201,152,2011 | |
| TOXICOLOGY REVIEW | TOLED5 209,86,2012 | |
| TOXICOLOGY REVIEW | TOLED5 230,146,2014 | |
| TOXICOLOGY REVIEW | TXAPA9 268,157,2013 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
| TOXICOLOGY REVIEW | NETEEC 52,25,2015 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,132,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.2 mg/m3 (skin) | DTLVS* 3,168,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.2 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.2 mg/m3;KZW 0.4 mg/m3, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.2 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.2 mg/m3, skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.2 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 0.2 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.2 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.2 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.2 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.2 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,2 mg/m3, JUL2005 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.2 mg/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.2 mg/m3, Skin, 2003 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL PARATHION-air | 10H time-weighted average 0.2 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109105/AS) | |
| EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9 | |
| EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test | |
| EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; In vitro UDS-human fibroblast | |
| EPA GENETOX PROGRAM 1988, Negative: TRP reversion | |
| EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat | NCITR* NCI-TR-157,1979 |
| NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health