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Phosphorothioic acid, O,O - dimethyl O - (p - nitrophenyl) ester

RTECS #: TG0175000

CAS #: 298-00-0


UPDATE: May 2009 MW: 263.22 MF: C8H10NO5PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 8056HC
  2. Azofos
  3. Azophos
  4. BAY 11405
  5. BAY E - 601
  6. Bladan - M
  7. Cekumethion
  8. Dalf
  9. Demethylfenitrothion
  10. Devithion
  11. Dimethyl 4 - nitrophenyl phosphorothionate
  12. Dimethyl p - nitrophenyl monothiophosphate
  13. Dimethyl p - nitrophenyl thiophosphate
  14. Dimethyl parathion
  15. Dimethyl - p - nitrophenyl thionphosphate
  16. Drexel methyl parathion 4E
  17. ENT 17,292
  18. Folidol M
  19. Folidol - 80
  20. Fosferno M 50
  21. Kilex parathion
  22. M - Parathion
  23. Mepaton
  24. Meptox
  25. Metacid
  26. Metacid 50
  27. Metafos
  28. Metaphos
  29. Methyl fosferno
  30. Methyl niran
  31. Methyl parathion
  32. Methyl parathion (ACGIH)
  33. Methyl - E 605
  34. Metilparation (Hungarian)
  35. Metron (pesticide)
  36. Metyloparation (Polish)
  1. Metylparation (Czech)
  2. NCI - C02971
  3. Nitrox
  4. Nitrox 80
  5. O,O - Dimethyl O - (p - nitrophenyl) phosphorothioate
  6. O,O - Dimethyl O - (p - nitrophenyl) thionophosphate
  7. O,O - Dimethyl O - 4 - nitrophenyl phosphorothioate
  8. O,O - Dimethyl O - p - nitrophenyl thiophosphate
  9. O,O - Dimethyl - O - (4 - nitro - fenyl) - monothiofosfaat (Dutch)
  10. O,O - Dimethyl - O - (4 - nitro - phenyl) - monothiophosphat (German)
  11. O,O - Dimethyl - O - (4 - nitrophenyl) phosphorothioate
  12. O,O - Dimethyl - O - (4 - nitrophenyl) - thionophosphat (German)
  13. O,O - Dimethyl - O - (p - nitrophenyl) - thionophosphat (German)
  14. O,O - Dimethyl - O - p - nitrofenylester kyseliny thiofosforecne (Czech)
  15. O,O - Dimethyl - O - p - nitrofenylthiofosfat (Czech)
  16. O,O - Dimetil - O - (4 - nitro - fenil) - monotiofosfato (Italian)
  17. Oleovofotox
  18. Parapest M - 50
  19. Parataf
  20. Parathion methyl
  21. Parathion - metile (Italian)
  22. Penncap - M
  23. Phenol, p - nitro - , O - ester with O,O - dimethylphosphorothioate
  24. Phosphorothioic acid, O,O - dimethyl O - (4 - nitrophenyl) ester
  25. Quinophos
  26. RCRA waste number P071
  27. Sinafid M - 48
  28. Tekwaisa
  29. Thiophenit
  30. Thiophosphate de O,O - dimethyle et de O - (4 - nitrophenyle) (French)
  31. Thylpar M - 50
  32. Vofatox
  33. Wofatox
  34. Yphos
  35. p - Nitrophenyldimethylthionophosphate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
mouse
10 mg/kg SOGEBZ 11,1534,1975
cytogenetic analysis intraperitoneal
rat
3 mg/kg MUREAV 321,103,1994
dominant lethal test oral
Drosophila melanogaster
4,500 ng/L FCTOD7 33,309,1995
DNA damage Escherichia coli 100 mg/L MUREAV 52,161,1978
DNA damage intraperitoneal
mouse
6 mg/kg TXAPA9 216,216,2006
DNA repair other microorganisms 50 L/plate BIZNAT 95,463,1976
DNA repair Salmonella typhimurium 250 g/disc JPFCD2 19,565,1984
mutation in microorganisms Escherichia coli 10 mmol/L (-enzymatic activation step) MUREAV 20,7,1973
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) CYGEDX 15(3),64,1981
mutation in microorganisms Salmonella typhimurium 667 g/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 0.5 mmol/L/3 day (+enzymatic activation step) MUREAV 536,103,2003
micronucleus test intraperitoneal
mouse
1 mg/kg MUREAV 155,131,1985
micronucleus test oral
mouse
9,375 g/kg MUTAEX 5,147,1990
micronucleus test intraperitoneal
rat
2,500 g/kg/5 day- continuous MUREAV 188,45,1987
gene conversion and mitotic recombination Saccharomyes cerevisiae 114 mmol/L IARCCD 10,161,1974
mutation in mammalian somatic cells mouse lymphocyte 100 mg/L NTIS** PB84-138973
sister chromatid exchange hamster lung 10 mg/L MUREAV 88,307,1981
sister chromatid exchange human lymphocyte 20 mg/L MUREAV 88,307,1981
specific locus test multiple
Drosophila melanogaster
31,500 ppb ARTODN 61,53,1987
specific locus test oral
Drosophila melanogaster
6 g/L FCTOD7 33,309,1995
sperm morphology oral
mouse
9,375 g/kg MUREAV 280,169,1992
sperm morphology intraperitoneal
rat
6 mg/kg/12 day- intermittent MUREAV 588,28,2005
sperm morphology intraperitoneal
rat
18.75 mg/kg/25 day- intermittent MUREAV 588,28,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 60 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
AEHLAU 15,609,1967
intraperitoneal
rat
lowest published toxic dose: 15 mg/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) AEHLAU 15,609,1967
intraperitoneal
rat
lowest published toxic dose: 45 mg/kg (15 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
IJEBA6 37,176,1999
intraperitoneal
rat
lowest published toxic dose: 12 mg/kg (12 day male) Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) MUREAV 588,28,2005
intraperitoneal
rat
lowest published toxic dose: 18.75 mg/kg (25 day male) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
MUREAV 588,28,2005
intraperitoneal
rat
lowest published toxic dose: 37.5 mg/kg (25 day male) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) MUREAV 588,28,2005
oral
rat
lowest published toxic dose: 9 mg/kg (7-15 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Behavioral
JPFCD2 15,365,1980
oral
rat
lowest published toxic dose: 15 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
JEBIDP 17,51,1996
oral
rat
lowest published toxic dose: 600 g/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) AXVMAW 30,343,1976
oral
rat
lowest published toxic dose: 2,200 g/kg (1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) GISAAA 38(8),21,1973
oral
rat
lowest published toxic dose: 900 mg/kg (30 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) ETOPFR 14,91,2003
oral
rat
lowest published toxic dose: 20 mg/kg (1-20 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
ETPAEK 55,489,2004
skin
rat
lowest published toxic dose: 10 mg/kg (18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
JTEHD6 63,173,2001
unreported route
rat
lowest published toxic dose: 44 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Behavioral AMSHAR 28,210,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
mouse
lethal dose (50 percent kill): 47 mg/kg N/R PCBPBS 8,302,1978
inhalation
mouse
lethal concentration (50 percent kill): 120 mg/m3/4 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** PB241-840
inhalation
rat
lethal concentration (50 percent kill): 34 mg/m3/4 hour Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
EGESAQ 24,173,1980
intraperitoneal
mouse
lethal dose (50 percent kill): 5,400 g/kg N/R PCBPBS 8,302,1978
intraperitoneal
rat
lethal dose (50 percent kill): 2,800 g/kg N/R APCRAW 4,117,1961
intravenous
guinea pig
lethal dose (50 percent kill): 50 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** PB241-840
intravenous
mouse
lethal dose (50 percent kill): 9,800 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** PB241-840
intravenous
rat
lethal dose (50 percent kill): 9 mg/kg N/R NTIS** PB277-077
oral
wild bird
lethal dose (50 percent kill): 5 mg/kg N/R JTCEEM 6(3),175,1986
oral
duck
lethal dose (50 percent kill): 10 mg/kg N/R DOEAAH 35,25,1979
oral
dog
lethal dose (50 percent kill): 90 mg/kg Gastrointestinal: Nausea or vomiting PESTD5 16,273,1975
oral
guinea pig
lethal dose (50 percent kill): 1,270 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** PB241-840
oral
mammal (species unspecified)
lethal dose (50 percent kill): 57 mg/kg Behavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
NTIS** PB288-416
oral
mouse
lethal dose (50 percent kill): 17,800 g/kg N/R HETOEA 11,11,1992
oral
rat
lethal dose (50 percent kill): 6,010 g/kg N/R 85JCAE -,1155,1986
oral
rat
lowest published toxic dose: 1.75 mg/kg Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,309,2003
oral
rat
lowest published toxic dose: 0.6 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
TOSCF2 76,400,2003
oral
rabbit
lethal dose (50 percent kill): 420 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** PB241-840
subcutaneous
mouse
lethal dose (50 percent kill): 18 mg/kg N/R BLLIAX 38,151,1958
subcutaneous
rat
lethal dose (50 percent kill): 6 mg/kg N/R JEENAI 50,356,1957
subcutaneous
rabbit
lowest published toxic dose: 37.05 mg/kg Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 191,33,2003
skin
duck
lethal dose (50 percent kill): 54 mg/kg N/R TXAPA9 47,451,1979
skin
mouse
lethal dose (50 percent kill): 1,200 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JTEHD6 9,491,1982
skin
rat
lethal dose (50 percent kill): 67 mg/kg N/R WRPCA2 4,36,1965
skin
rat
lowest published toxic dose: 10 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Changes in leukocyte (WBC) count

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JTEHD6 63,173,2001
skin
rabbit
lethal dose (50 percent kill): 300 mg/kg N/R AFDOAQ 16,3,1952
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 25 mg/kg N/R 30ZDA9 -,327,1971
unreported route
mouse
lethal dose (50 percent kill): 23 mg/kg N/R BWHOA6 44,31,1971
unreported route
rat
lethal dose (50 percent kill): 10 mg/kg N/R NYKZAU 74,41P,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 24 g/m3/24 hour/93 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(10),10,1968
intraperitoneal
rat
lowest published toxic dose: 7 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
IJTHEZ 1,95,1991
intraperitoneal
rat
lowest published toxic dose: 7 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes
HBPTO* 2,1027,2001
intraperitoneal
rat
lowest published toxic dose: 12 mg/kg/12 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
MUREAV 588,28,2005
intraperitoneal
rat
lowest published toxic dose: 18.75 mg/kg/25 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
MUREAV 588,28,2005
intraperitoneal
rat
: 17.5 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
ETOPFR 22,315,2006
intraperitoneal
rat
: 6 mg/kg/12 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ETOPFR 22,315,2006
intraperitoneal
rat
: 18.75 mg/kg/25 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in prostate weight
ETOPFR 22,315,2006
intraperitoneal
rat
: 8.75 mg/kg/5 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct ETOPFR 22,315,2006
intraperitoneal
rat
lowest published toxic dose: 6 mg/kg/4 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 31,177,2006
intraperitoneal
rat
lowest published toxic dose: 12 mg/kg/16 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 31,177,2006
intraperitoneal
rat
lowest published toxic dose: 18.75 mg/kg/25 day- intermittent Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
JTSCDR 31,177,2006
intraperitoneal
rat
lowest published toxic dose: 17.5 mg/kg/5 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct JTSCDR 31,177,2006
intraperitoneal
rat
lowest published toxic dose: 6 mg/kg/12 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct JTSCDR 31,177,2006
oral
domestic bird
lowest published toxic dose: 20,500 g/kg/5 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AECTCV 11,617,1982
oral
cat
lowest published toxic dose: 91 mg/kg/26 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FATOAO 20(3),78,1957
oral
dog
lowest published toxic dose: 42 mg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 1,1,1959
oral
human
lowest published toxic dose: 2.4 mg/kg/24 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,59,2001
oral
mammal (species unspecified)
lowest published toxic dose: 202 mg/kg/12 day- continuous Behavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AECTCV 16,357,1987
oral
mammal (species unspecified)
lowest published toxic dose: 4,450 mg/kg/30 day- continuous Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** PB288-416
oral
rat
lowest published toxic dose: 13,200 g/kg/6 week- intermittent Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Decreased motility or constipation

Kidney, Ureter, and Bladder: Incontinence
NETEEC 12,125,1990
oral
rat
lowest published toxic dose: 182 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 23(12),19,1958
oral
rat
lowest published toxic dose: 1,400 g/kg/15 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 75,13,1992
oral
rat
lowest published toxic dose: 25 mg/kg/21 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Nutritional and Gross Metabolic: Body temperature decrease
TXCYAC 75,13,1992
oral
rat
lowest published toxic dose: 35 mg/kg/4 week- continuous Liver: Other changes

Liver: Other changes
FATOAO 39,470,1976
oral
rat
lowest published toxic dose: 1.8 mg/kg/6 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOSCF2 76,400,2003
oral
rat
lowest published toxic dose: 900 mg/kg/30 day- intermittent Blood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight
ETOPFR 14,91,2003
oral
rat
lowest published toxic dose: 4.2 mg/kg/21 day- intermittent Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 44,198,2005
oral
rat
lowest published toxic dose: 9,900 gm/m3/11 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other
TOXID9 44,199,2005
oral
rat
lowest published toxic dose: 13.5 mg/kg/21 day- intermittent Biochemical: Metabolism (intermediary): Other TOXID9 44,199,2005
oral
rat
lowest published toxic dose: 4.2 mg/kg/21 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 78,378,2004
oral
rat
lowest published toxic dose: 12 mg/kg/20 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 90,295,2006
oral
rat
lowest published toxic dose: 2.18 mg/kg/2 week- intermittent Behavioral: Alteration of classical conditioning EESADV 57,270,2004
oral
rat
: 87.5 mg/kg/25 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in prostate weight
ETOPFR 22,315,2006
oral
rat
lowest published toxic dose: 45.5 mg/kg/13 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 31,177,2006
oral
rat
lowest published toxic dose: 87.5 mg/kg/25 day- intermittent Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
JTSCDR 31,177,2006
oral
rabbit
lowest published toxic dose: 48 mg/kg/28 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
BECTA6 54,258,1995
oral
rabbit
lowest published toxic dose: 9.2 mg/kg/57 day- continuous Endocrine: Change in gonadotropins

Endocrine: Changes in spleen weight

Immunological Including Allergic: Decreased immune response
TXAPA9 32,587,1975
oral
rabbit
lowest published toxic dose: 29.6 mg/kg/57 day- continuous Endocrine: Other changes

Blood: Changes in spleen
TXAPA9 32,587,1975
subcutaneous
rat
lowest published toxic dose: 20 mg/kg/10 day- intermittent Behavioral: Alteration of operant conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 24,797,2002
subcutaneous
rat
lowest published toxic dose: 21 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,304,2003
subcutaneous
rat
lowest published toxic dose: 20 mg/kg/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 24,797,2002
subcutaneous
rat
lowest published toxic dose: 9 mg/kg/3 day- intermittent Behavioral: Tremor

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JTSCDR 28,427,2003
subcutaneous
rat
lowest published toxic dose: 21 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes JTSCDR 28,427,2003
skin
rat
lowest published toxic dose: 60 mg/kg/30 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
IJEBA6 29,149,1991
skin
rat
lowest published toxic dose: 65 mg/kg/13 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 72,89,2003
skin
rat
lowest published toxic dose: 9.5 mg/kg/95 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,304,2003
skin
rat
lowest published toxic dose: 16 mg/kg/16 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,128,2003
skin
rat
lowest published toxic dose: 32 mg/kg/16 day- intermittent Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,128,2003
skin
rat
lowest published toxic dose: 90 mg/kg/90 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other
TOXID9 60,244,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal NO EVIDENCE IMSUDL 7,392,1987
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,131,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
ECMAAI 14,141,1973
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
TOLED5 128,45,2002
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
MUTAEX 20,389,2005
TOXICOLOGY REVIEW
CCATAR 366,1,2006
TOXICOLOGY REVIEW
ENTOX* -,588,2005
TOXICOLOGY REVIEW
ENTOX* -,85,2005
TOXICOLOGY REVIEW
MUTAEX 20,389,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTEHD6 6,185,2003
TOXICOLOGY REVIEW
FEREAC 73,31788,2008
TOXICOLOGY REVIEW
FEREAC 73,31788,2008
TOXICOLOGY REVIEW
MUREAV 543,251,2003
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,132,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 (skin) DTLVS* 3,168,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.2 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg/m3;
short term exposure limit 0.6 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3, Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL PARATHION-air 10 hour time-weighted average 0.2 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109105/AS)
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
used as a broad spectrum insecticide in a wide variety of agricultural applications
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-157,1979


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74.
AMSHAR Acta Morphologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-30, 1951-82.
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881-
BLLIAX Bratislavske Lekarske Listy. (PNS-Ustredna Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava, Czechoslovakia) V.1- 1921-
BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49 Sheridan Ave., Albany, NY 12210)
CCATAR Clinica Chimica Acta. (Elsevier Science B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1956-
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
ECMAAI Economie et Medecine Animales. (Paris, France) V.1-17, 1960-76. Discontinued.
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EGESAQ Egeszsegtudomany. (Kultura, POB 149, H-1389 Budapest, Hungary) V.1- 1957-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HTOPA*
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO.
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IJTHEZ International Journal of Toxicology, Occupational and Environmental Health. (Wiley Eastern, 4835/24 Ansari Road, Daryaganj New Delhi 110002, India) V.1- 1991-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JEBIDP Journal of Environmental Biology. (Academy of Environmental Biology, India, 657/5, Civil Lines (South), Muzaffarnagar, 251001, India) V.1- 1980-
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.5- 1985-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam, Netherlands) V.16-18, 1975-77. Discontinued.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

used as a broad spectrum insecticide in a wide variety of agricultural applications

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 37359-35-6
Click Here for Additional Information about RTECS

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