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Phosphorothioic acid, O,O - diethyl O - (p - nitrophenyl) ester

RTECS #: TF4550000

CAS #: 56-38-2


UPDATE: May 2009 MW: 291.28 MF: C10H14NO5PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. AATP
  2. Alkron
  3. Alleron
  4. American cyanamid 3422
  5. Aphamite
  6. Aralo
  7. B 404
  8. BAY E - 605
  9. Bay 1605
  10. Bayer E - 605
  11. Bladan F
  12. Compound 3422
  13. Diethyl 4 - nitrophenyl phosphorothionate
  14. Diethyl p - nitrophenyl phosphorothionate
  15. Diethyl p - nitrophenyl thionophosphate
  16. Diethyl p - nitrophenyl thiophosphate
  17. Diethyl para - nitrophenol thiophosphate
  18. Diethylparathion
  19. Dietil tiofosfato de p - nitrofenila (Portuguese)
  20. Drexel parathion 8E
  21. E 605
  22. E 605 F
  23. E 605 forte
  24. ENT 15,108
  25. Ekatin WF & WF ULV
  26. Ekatox
  27. Ethyl parathion
  28. Etilon
  29. Etylparation (Czech)
  30. Folidol
  31. Folidol E
  32. Folidol E605
  33. Folidol oil
  34. Fosferno
  35. Fosfex
  36. Fostern
  37. Gearphos
  38. Kolphos
  39. Lethalaire G - 54
  40. Lirothion
  41. Murfos
  42. NCI - C00226
  43. NIUIF - 100
  44. Niran
  45. Niran E - 4
  46. Nitrostigmin (German)
  47. Nitrostigmine
  48. Nourithion
  49. O,O - Diaethyl - O - (4 - nitro - phenyl) - monothiophosphat (German)
  50. O,O - Diethyl O - (p - nitrophenyl) phosphorothioate
  1. O,O - Diethyl O - 4 - nitrophenyl thiophosphate
  2. O,O - Diethyl O - p - nitrophenyl thiophosphate
  3. O,O - Diethyl - O - (4 - nitro - fenil) - monothiofosfaat (Dutch)
  4. O,O - Diethyl - O - (4 - nitrophenyl) phosphorothioate
  5. O,O - Diethyl - O - (p - nitrophenyl) thionophosphate
  6. O,O - Diethyl - O - p - nitrofenylester kyseliny thiofosforecne (Czech)
  7. O,O - Dietil - O - (4 - nitro - fenil) - monotiofosfato (Italian)
  8. O,O - Dietyl - O - p - nitrofenyltiofosfat (Czech)
  9. OMS 19
  10. Oleofos 20
  11. Oleoparaphene
  12. Oleoparathion
  13. Orthophos
  14. Pacol
  15. Panthion
  16. Paradust
  17. Paramar 50
  18. Paraphos
  19. Parathene
  20. Parathion
  21. Parathion (ACGIH:OSHA)
  22. Parathion - aethyl (German)
  23. Parathion - ethyl
  24. Parawet
  25. Penncap E
  26. Pestox plus
  27. Pethion
  28. Phenol, p - nitro - , O - ester with O,O - diethylphosphorothioate
  29. Phoskil
  30. Phosphemol
  31. Phosphenol
  32. Phosphorothioic acid, O,O - diethyl O - (4 - nitrophenyl) ester
  33. Phosphostigmine
  34. RB
  35. RCRA waste number P089
  36. Rhodiasol
  37. Rhodiatox
  38. SNP
  39. Selephos
  40. Soprathion
  41. Stabilized ethyl parathion
  42. Super Rodiatox
  43. T - 47
  44. Thiofos
  45. Thiomex
  46. Thiophos
  47. Thiophos 3422
  48. Thiophosphate de O,O - diethyle et de O - (4 - nitrophenyle) (French)
  49. Vitrex


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage oral
mouse
20 mg/kg/28 day- intermittent MUREAV 53,175,1978
DNA damage intraperitoneal
mouse
3 g/kg MUREAV 53,175,1978
DNA damage mouse lymphocyte 10 mol/L/16 hour JAPTO* 23,23,2003
DNA damage oral
rat
10 mg/kg/28 day- intermittent MUREAV 53,175,1978
DNA damage intraperitoneal
rat
3 g/kg MUREAV 53,175,1978
DNA damage rat lymphocyte 10 mol/L/16 hour JAPTO* 23,23,2003
unscheduled DNA synthesis human fibroblast 10 mol/L NTIS** PB268-647
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 500 g/plate (-enzymatic activation step) JTEHD6 16,403,1985
sister chromatid exchange hamster ovary 300 mol/L JTEHD6 8,939,1981
sister chromatid exchange human lymphocyte 200 g/L MUREAV 102,89,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 3 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) AEHLAU 16,805,1968
intraperitoneal
rat
lowest published toxic dose: 3 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Other effects on female

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AEHLAU 16,805,1968
intraperitoneal
rat
lowest published toxic dose: 3,500 g/kg (11 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) AEHLAU 16,805,1968
intraperitoneal
rat
lowest published toxic dose: 980 g/kg (9 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
AJOGAH 96,1148,1966
oral
rat
lowest published toxic dose: 360 g/kg (2-22 day pregnant/15 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TOLED5 3,11,1979
oral
rat
lowest published toxic dose: 2,304 g/kg (16 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina TOERD9 3,279,1981
oral
rat
lowest published toxic dose: 22 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic JJATDK 9,401,1989
subcutaneous
rat
lowest published toxic dose: 6 mg/kg (13-16 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) PWPSA8 16,141,1973
subcutaneous
rat
lowest published toxic dose: 9,800 g/kg (7-13 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death OYYAA2 6,667,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,260 mg/kg/80 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors
NCITR* NCI-TR-70,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lethal concentration : >37,130 g/m3/4 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** AD-A041-973
inhalation
guinea pig
lowest published lethal concentration: 14 mg/m3/2 hour N/R AMIHBC 5,44,1952
inhalation
mouse
lowest published lethal concentration: 15 mg/m3 N/R 85GMAT -,52,1982
inhalation
rat
lethal concentration (50 percent kill): 84 mg/m3/4 hour Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NTIS** AD-A041-973
inhalation
rabbit
lowest published lethal concentration: 50 mg/m3/2 hour N/R AMIHBC 5,44,1952
intramuscular
domestic animal
lowest published lethal dose: 20 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Behavioral: Rigidity (includes catalepsy)
MRLR** #269,1954
intramuscular
mouse
lethal dose (50 percent kill): 7,200 g/kg N/R AEPPAE 237,211,1959
intramuscular
rat
lethal dose (50 percent kill): 6 mg/kg N/R JCINAO 37,350,1958
intraperitoneal
cat
lethal dose (50 percent kill): 3 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 95,79,1949
intraperitoneal
chicken
lethal dose (50 percent kill): 2,500 g/kg N/R EQSFAP 3,173,1974
intraperitoneal
dog
lethal dose (50 percent kill): 12 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 95,79,1949
intraperitoneal
guinea pig
lethal dose (50 percent kill): 12 mg/kg N/R ARZNAD 5,626,1955
intraperitoneal
mouse
lethal dose (50 percent kill): 3 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAFCAU 11,91,1963
intraperitoneal
mouse
lowest published toxic dose: 10 mg/kg Behavioral: Tremor TXAPA9 227,42,2008
intraperitoneal
rat
lethal dose (50 percent kill): 2 mg/kg N/R APCRAW 4,117,1961
intraperitoneal
rat
lowest published toxic dose: 2 mg/kg Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,314,2002
intratracheal
human
lowest published lethal dose: 714 g/kg N/R SKEZAP 9,1,1968
intratracheal
rat
lethal dose (50 percent kill): 6,200 g/kg N/R JJATDK 19,133,1999
intravenous
cat
lethal dose (50 percent kill): 3 mg/kg Eye: Lacrimation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
JAMAAP 144,104,1950
intravenous
dog
lethal dose (50 percent kill): 12 mg/kg Eye: Lacrimation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
JAMAAP 144,104,1950
intravenous
mouse
lethal dose (50 percent kill): 13 mg/kg N/R ENTOX* ,706,2005
intravenous
rat
lethal dose (50 percent kill): 3,800 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases CJBPAZ 34,197,1956
oral
wild bird
lethal dose (50 percent kill): 1,330 g/kg N/R ASTTA8 (680),157,1979
oral
cat
lethal dose (50 percent kill): 0.93 mg/kg N/R ENTOX* -,331,2005
oral
chicken
lethal dose (50 percent kill): 10 mg/kg N/R EQSFAP 3,173,1974
oral
duck
lethal dose (50 percent kill): 2,100 g/kg N/R DOEAAH 35,25,1979
oral
dog
lethal dose (50 percent kill): 3 mg/kg N/R SPEADM 78-1,33,1978
oral
domestic animal
lowest published lethal dose: 100 mg/kg Behavioral: Excitement

Behavioral: Rigidity (includes catalepsy)

Lung, Thorax, or Respiration: Dyspnea
MRLR** #269,1954
oral
guinea pig
lethal dose (50 percent kill): 8 mg/kg N/R ARZNAD 5,626,1955
oral
human
lowest published lethal dose: 171 g/kg N/R CMEP** -,1,1956
oral
human
lethal dose (50 percent kill): 3 mg/kg N/R 85JFAN A311,1986
oral
horse, donkey
lethal dose (50 percent kill): 5 mg/kg N/R 85DPAN -,-,1971/1976
oral
mammal (species unspecified)
lethal dose (50 percent kill): 49 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
NTIS** PB288-416
oral
man
lowest published toxic dose: 2,143 mg/kg Behavioral: Coma

Cardiac: Pulse rate decreased with fall in BP

Vascular: Shock
NEURAI 31,603,1981
oral
man
lowest published toxic dose: 214 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma
JNNPAU 56,1135,1993
oral
man
lowest published toxic dose: 429 g/kg/4 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 14,603,1969
oral
mouse
lethal dose (50 percent kill): 5 mg/kg N/R ABCHA6 30,181,1966
oral
mouse
lowest published toxic dose: 4 mg/kg Immunological Including Allergic: Decreased immune response JTEHF8 68,2187,2005
oral
pigeon
lethal dose (50 percent kill): 1,330 g/kg N/R ASTTA8 (680),157,1979
oral
quail
lethal dose (50 percent kill): 4,040 g/kg N/R PCBPBS 7,28,1977
oral
quail
lowest published toxic dose: 5 mg/kg Endocrine: Change in LH CBCPAI 83C,451,1986
oral
quail
lowest published lethal dose: 10 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Eye: Lacrimation

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
CBCPAI 83C,451,1986
oral
rat
lethal dose (50 percent kill): 2 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 11,546,1967
oral
rat
lowest published lethal dose: 0.5 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,308,2003
oral
rat
lowest published toxic dose: 0.35 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 210,142,2006
oral
rat
lowest published lethal dose: 0.5 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 210,142,2006
oral
rat
lowest published toxic dose: 0.35 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 210,142,2006
oral
rat
lethal dose (50 percent kill): 9 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
oral
rabbit
lethal dose (50 percent kill): 10 mg/kg N/R ENTOX* -,331,2005
oral
woman
lowest published lethal dose: 2,350 L/kg Behavioral: Coma

Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Respiratory depression
HETOEA 17,587,1998
oral
woman
lowest published toxic dose: 2 mL/kg Eye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Behavioral: Coma
JTCTDW 31,497,1993
oral
woman
lowest published toxic dose: 5,670 g/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
ANYAA9 160,383,1969
parenteral
frog
lethal dose (50 percent kill): 967 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Other changes
AIPTAK 124,212,1960
subcutaneous
guinea pig
lethal dose (50 percent kill): 10 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous
guinea pig
lethal dose (50 percent kill): 10 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
subcutaneous
guinea pig
lowest published toxic dose: 2.5 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Urine volume decreased or anuria
TPKVAL 7,122,1965
subcutaneous
mouse
lethal dose (50 percent kill): 10 mg/kg N/R PHARAT 37,729,1982
subcutaneous
rat
lowest published toxic dose: 0.63 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NETEEC 25,599,2003
subcutaneous
rat
lowest published toxic dose: 2.1 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain NETEEC 25,599,2003
subcutaneous
rat
lowest published lethal dose: 12 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
ARTODN 76,650,2002
subcutaneous
rat
lowest published toxic dose: 6 mg/kg Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 210,135,2005
subcutaneous
rat
lowest published toxic dose: 1.8 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 239,167,2007
subcutaneous
rat
lowest published toxic dose: 18 mg/kg Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Fasciculations

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 219,106,2007
subcutaneous
rat
lethal dose (50 percent kill): 9 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous
rat
lethal dose (50 percent kill): 9 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
subcutaneous
rabbit
lethal dose (50 percent kill): 30 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous
rabbit
lethal dose (50 percent kill): 30 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
skin
wild bird
lethal dose (50 percent kill): 1,800 g/kg N/R TXAPA9 26,154,1973
skin
duck
lethal dose (50 percent kill): 28 mg/kg N/R TXAPA9 47,451,1979
skin
guinea pig
lethal dose (50 percent kill): 45 mg/kg N/R ENTOX* -,331,2005
skin
human
lowest published lethal dose: 7,143 g/kg N/R SKEZAP 9,1,1968
skin
mouse
lethal dose (50 percent kill): 19 mg/kg N/R ENTOX* -,331,2005
skin
rat
lethal dose (50 percent kill): 6,800 g/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
TXAPA9 2,88,1960
skin
rabbit
lethal dose (50 percent kill): 15 mg/kg N/R ENTOX* -,331,2005
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 6 mg/kg N/R 30ZDA9 -,323,1971
unreported route
man
lowest published lethal dose: 1,471 g/kg N/R 85DCAI 2,73,1970
unreported route
mouse
lethal dose (50 percent kill): 14,500 g/kg N/R GTPZAB 7(5),38,1963
unreported route
rat
lowest published toxic dose: 1 mg/kg Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,309,2003
unreported route
rat
lowest published toxic dose: 18 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 60,241,2001
unreported route
rat
lowest published toxic dose: 18 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other
TOXID9 60,241,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 200 g/m3/7 hour/6 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NTIS** AD-A041-973
inhalation
rat
lowest published toxic concentration: 740 g/m3/7 hour/6 week- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NTIS** AD-A041-973
oral
chicken
lowest published toxic dose: 1,800 g/kg/18 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 37,279,1987
oral
duck
lowest published toxic dose: 92,500 g/kg/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RREVAH 81,1,1981
oral
dog
lowest published toxic dose: 15 mg/kg/6 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NTIS** AD-A041-973
oral
dog
lowest published toxic dose: 145 mg/kg/26 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JJATDK 14,145,1994
oral
dog
lowest published toxic dose: 7.9 mg/kg/168 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,59,2001
oral
human
lowest published toxic dose: 4.2 mg/kg/42 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,59,2001
oral
mammal (species unspecified)
lowest published toxic dose: 1,394 mg/kg/30 day- continuous Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** PB288-416
oral
mouse
lowest published toxic dose: 5.6 mg/kg/14 day- continuous Brain and Coverings: Other degenerative changes HBPTO* 2,1026,2001
oral
pig
lowest published toxic dose: 196 mg/kg/49 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HBPTO* 1,59,2001
oral
rat
lowest published toxic dose: 10,500 mg/kg/28 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXAPA9 18,607,1971
oral
rat
lowest published toxic dose: 788 mg/kg/15 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 2,523,1960
oral
rat
lowest published toxic dose: 234 mg/kg/90 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ENVRAL 17,1,1978
oral
rat
lowest published toxic dose: 182 mg/kg/26 week- continuous Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JPFCD2 16,1,1981
oral
rat
lowest published toxic dose: 21.84 mg/kg/84 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HBPTO* 1,59,2001
oral
rat
lowest published toxic dose: 901.6 mg/kg/112 week- continuous Endocrine: Adrenal cortex tumors HBPTO* 1,814,2001
subcutaneous
guinea pig
lowest published toxic dose: 420 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous
mouse
lowest published toxic dose: 12 mg/kg/6 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 25,582,1973
subcutaneous
rat
lowest published toxic dose: 32,500 g/kg/21 day- intermittent Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 73,33,1994
subcutaneous
rat
lowest published toxic dose: 378 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous
rat
lowest published toxic dose: 22.5 mg/kg/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TPKVAL 7,122,1965
subcutaneous
rabbit
lowest published toxic dose: 1,260 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous
rabbit
lowest published toxic dose: 225 mg/kg/30 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 7,122,1965
unreported route
rat
lowest published toxic dose: 16 mg/kg/16 day- intermittent Brain and Coverings: Other degenerative changes

Reproductive: Specific developmental abnormalities: Central nervous system
HBPTO* 2,1029,2001
unreported route
rat
lowest published toxic dose: 0.4 mg/kg/4 day- intermittent Cardiac: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 -,271,2008
unreported route
rat
lowest published toxic dose: 0.8 mg/kg/4 day- intermittent Behavioral: Antianxiety TOXID9 12,469,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,153,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,153,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
ANAEA3 35,165,1975
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
MZUZA8 (8),90,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
ECMAAI 14,141,1973
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
CCATAR 366,1,2006
TOXICOLOGY REVIEW
ENTOX* -,588,2005
TOXICOLOGY REVIEW
ENTOX* -,331,2005
TOXICOLOGY REVIEW
ENTOX* -,306,2005
TOXICOLOGY REVIEW
ENTOX* -,308,2005
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
REPTED 23,260,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,118,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 (skin) DTLVS* 3,195,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg/m3, skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.11 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PARATHION-air 10 hour time-weighted average 0.05 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 53920;
Number of Industries 1;
Total Number of Facilities 43;
Number of Occupations 4;
Total Number of Employees Exposed 302


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used as a broad spectrum insecticide in agricultural applications
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
NCI Carcinogenesis Bioassay (feed);clear evidence:rat NCITR* NCI-TR-70,1979
NCI Carcinogenesis Bioassay (feed);no evidence:mouse NCITR* NCI-TR-70,1979
OSHA ANALYTICAL METHOD #ID-62


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8.
CCATAR Clinica Chimica Acta. (Elsevier Science B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1956-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CJBPAZ Canadian Journal of Biochemistry and Physiology. (Ottawa, Ont., Canada) V.32-41, 1954-63. For publisher information, see CJBIAE.
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
ECMAAI Economie et Medecine Animales. (Paris, France) V.1-17, 1960-76. Discontinued.
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JNNPAU Journal of Neurology, Neurosurgery and Psychiatry. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.7- 1944-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
MRLR** U.S. Army, Chemical Corps Medical Laboratories Research Reports. (Army Chemical Center, Edgewood Arsenal, MD)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951-
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
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Used as a broad spectrum insecticide in agricultural applications

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 8057-70-3
ALT CAS #: 11111-91-4
ALT CAS #: 110616-89-2
Click Here for Additional Information about RTECS

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