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Phosphorothioic acid, O,O - diethyl O - (2 - isopropyl - 6 - methyl - 4 - pyrimidinyl) ester

RTECS #: TF3325000

CAS #: 333-41-5

UPDATE: May 2009 MW: 304.38 MF: C12H21N2O3PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 4 - Pyrimidinol, 2 - isopropyl - 6 - methyl - , O - ester with O,O - diethyl phosphorothioate
  2. Antigal
  3. Bassadinon
  4. Basudin S
  5. Compass
  6. Dacutox
  7. Dassitox
  8. Dazzel
  9. Delzinon
  10. Diazinon
  11. Diazinon (ACGIH)
  12. Diazinone
  13. Dicid
  14. Diethyl 4 - (2 - isopropyl - 6 - methylpyrimidinyl) phosphorothionate
  15. Dimpylate
  16. Dizictol
  17. Drawizon
  18. Dyzol
  19. ENT 19,507
  20. Exodin
  21. Flytrol
  22. G 301
  23. G - 24480
  24. Galesan
  25. Garden Tox
  26. Geigy 24480
  27. Isopropylmethylpyrimidyl diethyl thiophosphate
  1. Knox Out 2FM
  2. Knox Out Yellow Jacket Contorl
  3. NCI - C08673
  4. Neocidol
  5. Neodinon
  6. Nipsan
  7. Nucidol
  8. O,O - Diaethyl - O - (2 - isopropyl - 4 - methyl) - 6 - pyrimidyl - thionophosphat (German)
  9. O,O - Diaethyl - O - (2 - isopropyl - 4 - methyl - pyrimidin - 6 - yl) - monothiophosphat (German)
  10. O,O - Diethyl O - (2 - isopropyl - 4 - methyl - 6 - pyrimidyl) thionophosphate
  11. O,O - Diethyl O - (2 - isopropyl - 6 - methyl - 4 - pyrimidinyl) phosphorothioate
  12. O,O - Diethyl O - 6 - methyl - 2 - isopropyl - 4 - pyrimidinyl phosphorothioate
  13. O,O - Diethyl - O - (2 - isopropyl - 4 - methyl - 6 - pyrimidinyl) - phosphorothioate
  14. O,O - Diethyl - O - (2 - isopropyl - 4 - methyl - 6 - pyrimidyl) phosphorothioate
  15. O,O - Diethyl - O - (2 - isopropyl - 4 - methyl - pyrimidin - 6 - yl) - monothiofosfaat (Dutch)
  16. O,O - Dietil - O - (2 - isopropil - 4 - metil - pirimidin - 6 - il) - monotiofosfato (Italian)
  17. O - 2 - Isopropyl - 4 - methylpyrimidyl - O,O - diethyl phosphorothioate
  18. OMS 469
  19. Oleodiazinon
  20. Optimizer
  21. PT 265
  22. Phosphorothioate, O,O - diethyl O - 6 - (2 - isopropyl - 4 - methylpyrimidyl)
  23. Sarolex
  24. Srolex
  25. Terminator
  26. Thiophosphate de O,O - diethyle et de O - 2 - isopropyl - 4 - methyl - 6 - pyrimidyle (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe CIGET* -,-,1977
skin
rabbit 		500 mg open irritation test moderate CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 100 mg/L/27 hour MUREAV 66,277,1979
cytogenetic analysis human lymphocyte 500 µg/L TSITAQ 18,1490,1976
DNA damage intraperitoneal
mouse 		8.12 mg/kg/1 day TOXID9 78,426,2004
DNA inhibition multiple
other fish 		640 µg/L STEVA8 76,63,1988
micronucleus test hamster ovary 52.7 mg/L/24 hour (-enzymatic activation step) MUREAV 582,116,2005
micronucleus test hamster ovary 94 mg/L/3 hour (+enzymatic activation step) MUREAV 582,116,2005
micronucleus test human lymphocyte 4 mg/L MUREAV 388,27,1997
mutation in mammalian somatic cells mouse lymphocyte 60 mg/L EMMUEG 12,85,1988
morphological transform rat embryo 11 µg/plate JJATDK 1,190,1981
other mutation test systems human lymphocyte 500 µg/L BIHAA2 38(Pt1),344,1971
other mutation test systems multiple
other fish 		1,060 µg/L STEVA8 76,63,1988
sister chromatid exchange multiple
other fish 		540 pmol/L MUREAV 118,61,1983
sister chromatid exchange rat lymphocyte 20 mg/L/2 hour MUREAV 472,85,2000
sperm morphology human sperm 50 µmol/L/1 hour REPTED 22,508,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 8.12 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male 		TOXID9 78,426,2004
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system AEHLAU 16,805,1968
intraperitoneal
rat 		lowest published toxic dose: 150 mg/kg (11 day pregnant) Reproductive: Other effects on female

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		AEHLAU 16,805,1968
intraperitoneal
rat 		lowest published toxic dose: 200 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		AEHLAU 16,805,1968
oral
mouse 		lowest published toxic dose: 3,960 µg/kg (1-22 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects 		JTEHD6 3,989,1977
oral
mouse 		lowest published toxic dose: 189 mg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system JEPTDQ 2(2),357,1978
oral
mouse 		lowest published toxic dose: 3,780 µg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic JEPTDQ 2(2),357,1978
oral
mouse 		lowest published toxic dose: 210 µg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Delayed effects 		JEPTDQ 4(5-6),53,1980
oral
mouse 		lowest published toxic dose: 189 mg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) JEPTDQ 4(5-6),53,1980
oral
pig 		lowest published toxic dose: 570 mg/kg (1-16 week pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		32OAAP -,253,1973
oral
rat 		lowest published toxic dose: 26,400 µg/kg (12-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JFMAAQ 54,452,1967
oral
rat 		lowest published toxic dose: 45 mg/kg (8-12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JFMAAQ 54,452,1967
oral
rat 		lowest published toxic dose: 63,500 µg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JFMAAQ 54,452,1967
oral
rabbit 		lowest published toxic dose: 130 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NNGADV 14,113,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 5,500 mg/m3/4 hour N/R PSDTAP 15,239,1974
inhalation
mouse 		lethal concentration (50 percent kill): 1,600 mg/m3/4 hour N/R PSDTAP 15,239,1974
inhalation
rat 		lethal concentration (50 percent kill): 3.5 gm/m3/4 hour N/R ENTOX* -,785,2005
intramuscular
monkey 		lowest published toxic dose: 10 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JOPSEQ 19,455,2005
intramuscular
monkey 		lowest published toxic dose: 90 mg/kg Behavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JOPSEQ 19,455,2005
intramuscular
monkey 		lowest published toxic dose: 130 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JOPSEQ 19,455,2005
intraperitoneal
mouse 		lethal dose (50 percent kill): 33 mg/kg N/R TXAPA9 2,495,1960
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg Brain and Coverings: Other degenerative changes TOLED5 135,89,2002
intraperitoneal
mouse 		lowest published toxic dose: 8.12 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 202,189,2005
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases 		TXAPA9 205,149,2005
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases 		TXAPA9 224,98,2007
intraperitoneal
rat 		lethal dose (50 percent kill): 65 mg/kg N/R ARZNAD 5,436,1955
intraperitoneal
rat 		lowest published toxic dose: 6.5 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOLED5 170,229,2007
intraperitoneal
rat 		lowest published toxic dose: 65 mg/kg Brain and Coverings: Other degenerative changes TOLED5 170,229,2007
intratracheal
rat 		lethal dose (50 percent kill): 210 mg/kg N/R JJATDK 19,133,1999
intravenous
mouse 		lethal dose (50 percent kill): 180 mg/kg N/R CSLNX* NX#00023
oral
domestic bird 		lowest published toxic dose: 0.5 mg/kg Behavioral: Analgesia TOXID9 90,322,2006
oral
wild bird 		lethal dose (50 percent kill): 2 mg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 8,400 µg/kg N/R 85DPAN -,-,1971/1976
oral
duck 		lethal dose (50 percent kill): 3,500 µg/kg N/R DOEAAH 35,25,1979
oral
guinea pig 		lethal dose (50 percent kill): 250 mg/kg N/R 85DPAN -,-,1971/1976
oral
human 		lowest published toxic dose: 214 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness

Skin and Appendages: Other: Sweating 		CTOXAO 12,435,1978
oral
mouse 		lethal dose (50 percent kill): 17 mg/kg N/R SKEZAP 24,268,1983
oral
pigeon 		lethal dose (50 percent kill): 3,160 µg/kg N/R ASTTA8 (680),157,1979
oral
pig 		lethal dose (50 percent kill): 320 mg/kg N/R YKYUA6 31,459,1980
oral
quail 		lethal dose (50 percent kill): 4,210 µg/kg N/R ASTTA8 (680),157,1979
oral
rat 		lethal dose (50 percent kill): 66 mg/kg N/R DOEAAH 35,25,1979
oral
rat 		lowest published toxic dose: 1 mg/kg Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,306,2003
oral
rat 		lowest published toxic dose: 100 mg/kg Eye: Lacrimation

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Changes in structure or function of salivary glands 		TOXID9 1,112,2001
oral
rat 		lowest published toxic dose: 15 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 205,31,2005
oral
rat 		lowest published toxic dose: 30 mg/kg Brain and Coverings: Other degenerative changes TXAPA9 205,31,2005
oral
rat 		lowest published toxic dose: 6 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOSCF2 92,235,2006
oral
rat 		lowest published toxic dose: 60 mg/kg Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOSCF2 92,235,2006
oral
rabbit 		lethal dose (50 percent kill): 143 mg/kg N/R YKYUA6 31,459,1980
subcutaneous
mouse 		lethal dose (50 percent kill): 58 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase OIZAAV 71,6099,1959
skin
mouse 		lethal dose (50 percent kill): 2,750 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JTEHD6 9,491,1982
skin
pig 		lethal dose (50 percent kill): 633 mg/kg N/R YKYUA6 31,459,1980
skin
rat 		lethal dose (50 percent kill): 180 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase PMJMAQ -,155,1957
skin
rabbit 		lethal dose (50 percent kill): 3.6 gm/kg N/R ENTOX* -,785,2005
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 76 mg/kg N/R 30ZDA9 -,338,1971
unreported route
rat 		lethal dose (50 percent kill): 250 mg/kg N/R RISHDJ 23,101,1983
unreported route
rat 		lowest published toxic dose: 75 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 66,312,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 201 µg/m3/24 hour/13 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 42(1),6,1977
intraperitoneal
mouse 		lowest published toxic dose: 40 mg/kg/28 day- intermittent Blood: Other changes

Immunological Including Allergic: Decreased immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		TXCYAC 196,173,2004
intraperitoneal
mouse 		lowest published toxic dose: 500 mg/kg/28 day- intermittent Blood: Changes in spleen

Immunological Including Allergic: Decreased immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		TXCYAC 196,173,2004
oral
dog 		lowest published toxic dose: 4,900 mg/kg/35 week- intermittent Gastrointestinal: Other changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXAPA9 18,285,1971
oral
dog 		lowest published toxic dose: 1,200 mg/kg/46 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JAFCAU 3,1017,1955
oral
dog 		lowest published toxic dose: 157 mg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 1,1,1959
oral
dog 		lowest published toxic dose: 3,395 mg/kg/1 year- continuous Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NNGADV 14,113,1989
oral
domestic animal 		lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VHTODE 41,287,1999
oral
mouse 		lowest published toxic dose: 26,280 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NNGADV 14,113,1989
oral
mouse 		lowest published toxic dose: 1,620 mg/kg/45 day- continuous Blood: Changes in spleen

Blood: Other changes

Immunological Including Allergic: Uncharacterized (multiple organ involvement) 		TXCYAC 172,13,2002
oral
mouse 		lowest published toxic dose: 1.62 gm/kg/45 day- intermittent Blood: Hemorrhage

Blood: Changes in spleen

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXCYAC 172,13,2002
oral
mouse 		lowest published toxic dose: 750 mg/kg/15 day- intermittent Immunological Including Allergic: Decrease in cellular immune response TXCYAC 236,123,2007
oral
pig 		lowest published toxic dose: 2,450 mg/kg/35 week- intermittent Gastrointestinal: Other changes

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 18,285,1971
oral
rat 		lowest published toxic dose: 46 mg/kg/92 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		AECTCV 9,637,1980
oral
rat 		lowest published toxic dose: 86 mg/kg/30 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 54,359,1980
oral
rat 		lowest published toxic dose: 91 mg/kg/26 week- continuous Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JPFCD2 16,1,1981
oral
rat 		lowest published toxic dose: 371 mg/kg/14 day- continuous Blood: Change in clotting factors JEPOEC 7(3),67,1987
oral
rat 		lowest published toxic dose: 28 mg/kg/28 week- intermittent Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		BECTA6 37,501,1986
oral
rat 		lowest published toxic dose: 1,095 mg/kg/2 year- continuous Endocrine: Changes in thyroid weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NNGADV 14,113,1989
oral
rat 		lowest published toxic dose: 98 mg/kg/28 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		DCTODJ 9,117,1986
oral
rat 		lowest published toxic dose: 70 mg/kg/1 week- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		TXCYAC 211,197,2005
oral
rat 		lowest published toxic dose: 280 mg/kg/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain ETOPFR 22,46,2006
oral
rat 		lowest published toxic dose: 70 mg/kg/1 week- intermittent Blood: Thrombocytopenia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		ETOPFR 22,46,2006
oral
rat 		lowest published toxic dose: 70 mg/kg/1 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases ETOPFR 22,46,2006
oral
rat 		lowest published toxic dose: 50 mg/kg/5 day- intermittent Gastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		TOLED5 161,200,2006
skin
rabbit 		lowest published toxic dose: 210 mg/kg/21 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NNGADV 14,113,1989
unreported route
rat 		lowest published toxic dose: 2 mg/kg/4 day- intermittent Cardiac: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOXID9 -,271,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
TOLED5 127,29,2002
TOXICOLOGY REVIEW
TOLED5 142,207,2003
TOXICOLOGY REVIEW
MUREAV 589,208,2005
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
NETOX* 26,531,2005
TOXICOLOGY REVIEW
NETOX* 26,573,2005
TOXICOLOGY REVIEW
CCATAR 366,1,2006
TOXICOLOGY REVIEW
ENTOX* -,588,2005
TOXICOLOGY REVIEW
ENTOX* -,785,2005
TOXICOLOGY REVIEW
ENTOX* -,306,2005
TOXICOLOGY REVIEW
ENTOX* -,308,2005
TOXICOLOGY REVIEW
JTCTDW 42,579,2004
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTEHD6 7,267,2004
TOXICOLOGY REVIEW
REPTED 23,260,2007
TOXICOLOGY REVIEW
FEREAC 73,29456,2008
TOXICOLOGY REVIEW
REPTED 26,1,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,109,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 (skin) DTLVS* 3,780,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3, short term exposure limit 0.4 mg/m3, Skin, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg/m3, skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3,KZG- week 0.2 mg/m3, Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIAZINON-air 10 hour time-weighted average 0.1 mg/m3 (Sk) NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 23360;
Number of Industries 9;
Total Number of Facilities 1,268;
Number of Occupations 9;
Total Number of Employees Exposed 26,581
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 23360;
Number of Industries 10;
Total Number of Facilities 3,168;
Number of Occupations 18;
Total Number of Employees Exposed 39,342;
Total Number of Female Employees Exposed 3,216


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121107/AS)
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agricultural chemical and pesticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-137,1979
OSHA ANALYTICAL METHOD #ID-62


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
32OAAP "Pesticide and the Environment: a Continuing Controversy, Selected Papers Presented and Papers Reviewed at the 8th Inter-American Conference on Toxicology and Occupational Medicine, Miami, FL, 1973," Deichmann, W.B., ed., New York, Stratton Intercontinental Medical Book Corp., 1973
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
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CCATAR Clinica Chimica Acta. (Elsevier Science B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1956-
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
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FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
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Used as an agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 65863-03-8
 Click Here for Additional Information about RTECS

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