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Phosphorodithioic acid, S,S' - p - dioxane - 2,3 - diyl O,O,O',O' - tetraethyl ester

RTECS #: TE3350000

CAS #: 78-34-2


UPDATE: May 2009 MW: 456.56 MF: C12H26O6P2S4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,4 - Diossan - 2,3 - diyl - bis (O,O - dietil - ditiofosfato) (Italian)
  2. 1,4 - Dioxaan - 2,3 - diyl - bis (O,O - diethyl - dithiofosfaat) (Dutch)
  3. 1,4 - Dioxan - 2,3 - diyl - bis (O,O - diaethyl - dithiophosphat) (German)
  4. 1,4 - Dioxan - 2,3 - diyl bis (O,O - diethylphosphorothiolothionate)
  5. 1,4 - Dioxan - 2,3 - diyl O,O,O',O' - tetraethyl di (phosphoromithioate)
  6. 2,3 - P - Dioxan - S,S' - bis (O,O - diaethyldithiophosphat) (German)
  7. 2,3 - p - Dioxane S,S - bis (O,O - diethylphosphorodithioate)
  8. 2,3 - p - Dioxandithiol S,S - bis (O,O - diethyl phosphorodithioate)
  9. AC 528
  10. Bis (dithiophosphate de O,O - diethyle) de S,S' - (1,4 - dioxanne - 2,3 - diyle) (French)
  11. Delnatex
  12. Delnav
  13. Deltic
  14. Dioxane phosphate
  1. Dioxathion
  2. Dioxathion (ACGIH)
  3. Dioxation
  4. Dioxothion
  5. ENT 22,897
  6. Hercules 528
  7. Hercules AC528
  8. Kavadel
  9. NCI - C00395
  10. Navadel
  11. Phosphorodithioic acid, S,S' - 1,4 - dioxane - 2,3 - diyl O,O,O',O' - tetraethyl ester (9CI)
  12. Ruphos
  13. p - Dioxane - 2,3 - dithiol, S,S - diester with O,O - diethyl phosphorodithioate
  14. p - Dioxane - 2,3 - diyl ethyl phosphorodithioate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 6,667 g/plate (+enzymatic activation step) ENMUDM 8(Suppl 7),1,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 340 mg/m3/1 hour Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 5,605,1963
inhalation
rat
lethal concentration (50 percent kill): 1,398 mg/m3/1 hour Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 5,605,1963
intraperitoneal
mouse
lethal dose (50 percent kill): 33 mg/kg N/R PSEBAA 129,699,1968
intraperitoneal
rat
lethal dose (50 percent kill): 30 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 5,605,1963
oral
chicken
lethal dose (50 percent kill): >316 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
TXAPA9 5,605,1963
oral
dog
lethal dose (50 percent kill): 10 mg/kg N/R PCOC** -,427,1966
oral
human
lowest published toxic dose: 9 mg/kg/60 day Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 34ZIAG -,200,1969
oral
mouse
lethal dose (50 percent kill): 176 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 5,605,1963
oral
rat
lethal dose (50 percent kill): 20 mg/kg N/R WRPCA2 9,119,1970
subcutaneous
chicken
lethal dose (50 percent kill): >200 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 5,605,1963
subcutaneous
rat
lethal dose (50 percent kill): 95 mg/kg N/R JEENAI 52,20,1959
skin
rat
lethal dose (50 percent kill): 63 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 5,605,1963
skin
rabbit
lethal dose (50 percent kill): 85 mg/kg N/R PCOC** -,427,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 9,600 g/kg/12 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 5,605,1963
oral
human
lowest published toxic dose: 4.2 mg/kg/28 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,59,2001
oral
rat
lowest published toxic dose: 70,980 g/kg/13 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 5,605,1963


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,114,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 mg/m3, skin, JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3, Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIOXATHION-air 10 hour time-weighted average 0.2 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
Used for control of insects and mites on grapes, citrus, etc.
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-125,1978


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used for control of insects and mites on grapes, citrus, etc.

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

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