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Phosphoric acid, tri - o - tolyl ester

RTECS #: TD0350000

CAS #: 78-30-8


UPDATE: May 2009 MW: 368.39 MF: C21H21O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Phosflex 179C
  2. Phosphoric acid, tri - o - cresyl ester
  3. Phosphoric acid, tris (2 - methylphenyl) ester
  4. TOCP
  5. TOFK
  6. TOTP
  7. Tri 2 - methylphenyl phosphate
  8. Tri - 2 - tolyl phosphate
  9. Tri - o - cresyl phosphate
  10. Tri - o - cresyl - phosphate
  11. Tri - o - tolyl phosphate
  1. Tri - o - totyl phosphate
  2. Triorthocresyl phosphate
  3. Triorthocresyl phosphate (ACGIH:OSHA)
  4. Tris (o - cresyl) - phosphate
  5. Tris (o - methylphenyl) phosphate
  6. Tris (o - tolyl) - phosphate
  7. Trojkrezylu fosforan (Polish)
  8. o - Cresyl phosphate
  9. o - Tolyl phosphate
  10. o - Trikresylphosphate (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage oral
rat
500 mg/kg/10 day- continuous CRNGDP 14,2039,1993


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,500 mg/kg (10 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 89,64,1987
oral
rat
lowest published toxic dose: 2,100 mg/kg (14 day pregnant) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 107,35,1991
oral
rat
lowest published toxic dose: 450 mg/kg (3 day male) Reproductive: Other effects on male TXAPA9 89,64,1987
oral
rat
lowest published toxic dose: 3,150 mg/kg (21 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 89,64,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rabbit
lowest published lethal dose: 135 mg/kg N/R AEPPAE 171,439,1933
intraperitoneal
chicken
lethal dose (50 percent kill): 500 mg/kg N/R EQSFAP 3,173,1974
intraperitoneal
mouse
lethal dose (50 percent kill): 1,960 mg/kg N/R TXAPA9 2,495,1960
intraperitoneal
rat
lethal dose (50 percent kill): 2,500 mg/kg N/R APCRAW 4,117,1961
intraperitoneal
rat
lowest published toxic dose: 100 mg/kg Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 72,315,2003
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 179,119,2002
intraperitoneal
rat
lowest published toxic dose: 100 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Metabolism (intermediary): Lipids including transport
JTEHF8 67,583,2004
intraperitoneal
rabbit
lowest published lethal dose: 100 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes
AEPPAE 168,473,1932
intravenous
chicken
lowest published toxic dose: 40 mg/kg Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 143,65,2003
intravenous
rabbit
lowest published lethal dose: 100 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Kidney, Ureter, and Bladder: Other changes in urine composition
AEPPAE 168,473,1932
oral
domestic bird
lowest published toxic dose: 375 mg/kg Peripheral Nerve and Sensation: Structural change in nerve or sheath

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 191,25,2003
oral
chicken
lethal dose (50 percent kill): 500 mg/kg N/R EQSFAP 3,173,1974
oral
chicken
lowest published toxic dose: 360 mg/kg Spinal Cord: Demyelination

Spinal Cord: Other degenerative changes
HBPTO* 2,989,2001
oral
chicken
lowest published toxic dose: 200 mg/kg Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
NRTXDN 9,539,1988
oral
chicken
lowest published toxic dose: 10 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
NRTXDN 6,79,1985
oral
chicken
lowest published toxic dose: 200 mg/kg Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Muscle weakness

Biochemical: Metabolism (intermediary): Other
ENVRAL 60,290,1993
oral
chicken
lowest published toxic dose: 50 mg/kg Peripheral Nerve and Sensation: Structural change in nerve or sheath

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)
TAEHC* 110IV,122,1990
oral
chicken
lowest published toxic dose: 750 mg/kg Peripheral Nerve and Sensation: Structural change in nerve or sheath

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
JPETAB 239,597,1986
oral
chicken
lowest published toxic dose: 800 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 136,143,2002
oral
chicken
lowest published toxic dose: 1,600 mg/kg Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 136,143,2002
oral
chicken
lowest published toxic dose: 1,600 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Ataxia
TOLED5 136,143,2002
oral
chicken
lowest published toxic dose: 750 mg/kg Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia
TXCYAC 223,127,2006
oral
chicken
lowest published toxic dose: 750 mg/kg Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Behavioral: Ataxia
TXCYAC 239,45,2007
oral
mammal (species unspecified)
lethal dose (50 percent kill): 400 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse
lethal dose (50 percent kill): 900 mg/kg Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair

Behavioral: Muscle weakness
TXAPA9 7,227,1965
oral
rat
lethal dose (50 percent kill): 1,160 mg/kg N/R TOXID9 4,55,1984
oral
rat
lowest published toxic dose: 840 mg/kg Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Peripheral Nerve and Sensation: Structural change in nerve or sheath
TAEHC* 110IV,122,1990
oral
rabbit
lowest published lethal dose: 100 mg/kg Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Interstitial nephritis
AEPPAE 168,473,1932
subcutaneous
cat
lowest published lethal dose: 185 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes
JHHBAI 52,39,1933
subcutaneous
dog
lowest published lethal dose: 100 mg/kg Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Interstitial nephritis
AEPPAE 168,473,1932
subcutaneous
guinea pig
lowest published lethal dose: 300 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Musculoskeletal: Other changes
AEPPAE 168,473,1932
subcutaneous
monkey
lowest published lethal dose: 1 gm/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea
AEPPAE 165,84,1972
subcutaneous
mouse
lowest published lethal dose: 12,500 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
EDWU** -,-,1937
subcutaneous
rabbit
lowest published lethal dose: 100 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes in urine composition
AEPPAE 168,473,1932
skin
cat
lethal dose (50 percent kill): 1,500 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea
NTOTDY 5,431,1983
skin
rabbit
lethal dose (50 percent kill): >3,700 mg/kg N/R TXAPA9 41,291,1977
unreported route
chicken
lowest published toxic dose: 500 mg/kg Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Ataxia
TOXID9 78,227,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 7 gm/kg/7 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Proteases
JEPOEC 17,69,1998
intraperitoneal
rat
lowest published toxic dose: 2,800 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
DTESD7 11,495,1983
oral
chicken
lowest published toxic dose: 1,800 mg/kg/18 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
TOLED5 37,279,1987
oral
chicken
lowest published toxic dose: 1,050 mg/kg/14 day- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia
TOXID9 42,126,1998
oral
chicken
lowest published toxic dose: 450 mg/kg/90 day- continuous Spinal Cord: Other degenerative changes

Behavioral: Ataxia
NTIS** OTS0518529
oral
duck
lowest published toxic dose: 3 gm/kg/30 day- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Ataxia
JTEHD6 14,789,1984
oral
domestic animal
lowest published toxic dose: 900 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 69,417,1983
oral
mouse
lowest published toxic dose: 4,725 mg/kg/21 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 18(Suppl 1),4,1983
oral
mouse
lowest published toxic dose: 60,750 mg/kg/39 week- intermittent Spinal Cord: Other degenerative changes

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Ataxia
TXAPA9 79,83,1985
oral
rat
lowest published toxic dose: 18,900 mg/kg/9 week- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
TOLED5 13,29,1982
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Autonomic Nervous System: Other (direct) parasympathomimetic

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 89,49,1987
oral
rat
lowest published toxic dose: 1,575 mg/kg/63 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXAPA9 89,49,1987
oral
rat
lowest published toxic dose: 1,600 mg/kg/2 day- intermittent Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 89,49,1987
oral
rat
lowest published toxic dose: 600 mg/kg/3 day- intermittent Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 89,49,1987
oral
rat
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXAPA9 89,49,1987
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 89,49,1987
oral
rat
lowest published toxic dose: 3,150 mg/kg/63 day- intermittent Behavioral: Food intake (animal)

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TXAPA9 89,49,1987
oral
rat
lowest published toxic dose: 4,725 mg/kg/63 day- intermittent Related to Chronic Data: Changes in testicular weight TXAPA9 89,49,1987
oral
rat
lowest published toxic dose: 1,575 mg/kg/63 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 89,49,1987
oral
rat
lowest published toxic dose: 630 mg/kg/63 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases TXAPA9 89,49,1987
oral
rat
lowest published toxic dose: 4,200 mg/kg/63 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 72,305,2003
oral
rat
lowest published toxic dose: 1,050 mg/kg/2 week- intermittent Brain and Coverings: Other degenerative changes TOXID9 72,305,2003
oral
rat
lowest published toxic dose: 4,200 mg/kg/48 day- intermittent Blood: Other changes TOXID9 66,316,2002
oral
rat
lowest published toxic dose: 8,400 mg/kg/48 day- intermittent Liver: Liver function tests impaired TOXID9 66,316,2002
oral
rat
lowest published toxic dose: 2,100 mg/kg/48 day- intermittent Liver: Other changes TOXID9 66,316,2002
oral
rat
lowest published toxic dose: 2.1 gm/kg/63 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath TOXID9 90,300,2006
oral
rat
lowest published toxic dose: 1,050 mg/kg/49 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOPADD 33,378,2005
oral
rat
lowest published toxic dose: 1,050 mg/kg/14 day- intermittent Behavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration
TOPADD 33,378,2005
oral
rat
lowest published toxic dose: 2,100 mg/kg/49 day- intermittent Nutritional and Gross Metabolic: Dehydration

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOPADD 33,378,2005
oral
rat
lowest published toxic dose: 2,100 mg/kg/14 day- intermittent Spinal Cord: Other degenerative changes

Behavioral: Tremor

Nutritional and Gross Metabolic: Dehydration
TOPADD 33,378,2005
oral
rat
lowest published toxic dose: 4,200 mg/kg/49 day- intermittent Spinal Cord: Demyelination

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOPADD 33,378,2005
oral
rat
lowest published toxic dose: 300 mg/kg/5 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
JTEHF8 67,431,2004
oral
rat
lowest published toxic dose: 2,100 mg/kg/14 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHF8 67,431,2004
oral
rat
lowest published toxic dose: 1,050 mg/kg/63 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath
TOXID9 12,468,2008
oral
rabbit
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Autonomic Nervous System: Other (direct) parasympathomimetic
TXAPA9 41,291,1977
subcutaneous
domestic bird
lowest published toxic dose: 2,250 mg/kg/5 day- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Ataxia

Blood: Other changes
NEZAAQ 47,222,1992
subcutaneous
rat
lowest published toxic dose: 4,200 mg/kg/50 day- intermittent Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 78,276,2004
subcutaneous
rat
lowest published toxic dose: 2,100 mg/kg/50 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 78,276,2004
skin
domestic bird
lowest published toxic dose: 6 gm/kg/10 day- intermittent Spinal Cord: Other degenerative changes NEZAAQ 52,281,1997
skin
cat
lowest published toxic dose: 900 mg/kg/90 day- intermittent Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 83,126,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CRTXB2 3,289,1975
TOXICOLOGY REVIEW
IRXPAT 3,219,1964
TOXICOLOGY REVIEW
CRTXB2 2,365,1973
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
ARENAA 26,29,1981
TOXICOLOGY REVIEW
CCATAR 366,1,2006
TOXICOLOGY REVIEW
ENTOX* -,441,2005
TOXICOLOGY REVIEW
ENTOX* -,302,2005
TOXICOLOGY REVIEW
ENTOX* -,302,2005
TOXICOLOGY REVIEW
ENTOX* -,308,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 DTLVS* 3,271,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.3 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIORTHOCRESYL PHOSPHATE-air 10 hour time-weighted average 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 74600;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 14
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74600;
Number of Industries 1;
Total Number of Facilities 20;
Number of Occupations 1;
Total Number of Employees Exposed 20;
Total Number of Female Employees Exposed 20


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in hydraulic fluids and as plasticizer, pigment dispersant, flame retardant
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Triorthocresyl phosphate, 5037


REFERENCES:

CODEN
REFERENCE

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
ARENAA Annual Review of Entomology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1956-
CCATAR Clinica Chimica Acta. (Elsevier Science B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1956-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier Science, New York, NY) V.1-15, 1977-87. Discontinued
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EDWU** "Beitrag zur Toxikologie Technischer Weichmachungsmittel, Dissertation," Eller, H., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1937
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IRXPAT International Review of Experimental Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JHHBAI Bulletin of the Johns Hopkins Hospital. (Baltimore, MD) V.1-119, 1889-1966. For publisher information, see JHMJAX.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
TAEHC* Environmental Health Criteria (United Nations Environment Programme. Geneva, World Health Organization) 1- 1976-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used in hydraulic fluids and as plasticizer, pigment dispersant, flame retardant

NIOSH PROFILE (ARYL PHOSPHATES), SRC, 12/79

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector

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