Phosphoric acid, triphenyl ester

RTECS #

TC8400000

CAS #

115-86-6
See: NMAM or OSHA Methods

Updated

June 2018

Molecular Weight

326.30

Molecular Formula

C₁₈H₁₅O₄P

Synonyms

Celluflex TPP
Disflamoll TP
Phosflex TPP
Reolube TPP
Reomol TPP
TPP
Trifenylfosfat (Czech)
Triphenyl phosphate
Triphenyl phosphate (ACGIH:OSHA)

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/gtd	Inhibitor Concentration Low: 1 µmol/L	In Vitro Toxicity Studies: Membrane currents	TOLED5 213,266,2012
In Vitro/gtd	Inhibitor Concentration (50 percent kill): 7.9 µmol/L	In Vitro Toxicity Studies: Membrane currents	TOLED5 213,266,2012
In Vitro/Hamster, ovary	Inhibitor Concentration (50 percent kill): 37 µmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)	TOLED5 227,93,2014
In Vitro/Hamster, ovary	Inhibitor Concentration (20 percent kill): 4.9 µmol/L/24H	Endocrine: Estrogenic	TXCYAC 314,76,2013
In Vitro/Hamster, ovary	Inhibitor Concentration (20 percent kill): 15 µmol/L/24H	Endocrine: Other changes	TXCYAC 314,76,2013
In Vitro/Human, liver	Inhibitor Concentration Low: 100 µmol/L/24H	Biochemical: Metabolism (intermediary): Other proteins	TOLED5 232,533,2015
In Vitro/Human, liver tumor	Inhibitor Concentration (10 percent kill): 44.3 µmol/L/72H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 29,2045,2015
In Vitro/Human, liver tumor	Inhibitor Concentration Low: 44.3 µmol/L/72H	In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.	TIVIEQ 29,2045,2015
In Vitro/jrd	Inhibitor Concentration Low: 1000 µmol/L/24H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 33,153,2016
In Vitro/jrd	Inhibitor Concentration (20 percent kill): 88.0 µmol/L/24H	Endocrine: Estrogenic	TIVIEQ 33,153,2016
In Vitro/jvx	Inhibitor Concentration Low: 30 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TOLED5 227,93,2014
In Vitro/Mouse, fibroblast	Inhibitor Concentration Low: >50 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay	TIVIEQ 40,280,2017
In Vitro/Mouse, fibroblast	Inhibitor Concentration Low: 0.1 µmol/L/48H	Endocrine: Other changes	TIVIEQ 40,280,2017
In Vitro/Mouse, fibroblast	Inhibitor Concentration Low: 0.01 µmol/L/48H	Biochemical: Metabolism (intermediary): Lipids including transport	TIVIEQ 40,280,2017
In Vitro/Mouse, fibroblast	Inhibitor Concentration Low: 10 µmol/L/8D	In Vitro Toxicity Studies: Cell differentiation	TIVIEQ 40,280,2017
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 4200 mg/m³	Olfaction: Other olfaction effects Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay)	GISAAA 39(8),98,1974
intramuscular/rabbit	Lethal dose: >1 gm/kg		NIHBAZ 160,1,1932
intraperitoneal/cat	Lethal dose: >400 mg/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity) Behavioral: Muscle weakness	AEHLAU 1,33,1960
intraperitoneal/mouse	lethal dose (50 percent kill): 1273 mg/kg		ABCHA6 31,1288,1967
intraperitoneal/rat	Lethal dose: >5 gm/kg	Gastrointestinal: Other changes Skin and Appendages: Other: Hair	NTIS** OTS0535042
oral/cat	lowest published lethal dose: 2 gm/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Tremor Behavioral: Muscle weakness	ARZNAD 7,585,1957
oral/chicken	lowest published lethal dose: 5 gm/kg	Spinal Cord: Other degenerative changes	NTIS** OTS0539872
oral/guinea pig	Lethal dose: >4 gm/kg		AEHLAU 1,33,1960
oral/mouse	lethal dose (50 percent kill): 1320 mg/kg	Olfaction: Other olfaction effects Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay)	GISAAA 39(8),98,1974
oral/rabbit	lowest published lethal dose: 3 gm/kg		AEHLAU 1,33,1960
oral/rat	lethal dose (50 percent kill): 3500 mg/kg	Behavioral: Tremor Behavioral: Ataxia Gastrointestinal: Hypermotility, diarrhea	ARZNAD 7,585,1957
skin/guinea pig	lethal dose (50 percent kill): >4 gm/kg		KODAK* 21MAY1971
skin/rabbit	lethal dose (50 percent kill): >7900 mg/kg		TXAPA9 41,291,1977
subcutaneous/cat	lowest published lethal dose: 300 mg/kg	Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Tremor Behavioral: Muscle weakness	NIHBAZ 160,1,1932
subcutaneous/guinea pig	Lethal dose: >3 gm/kg		AEHLAU 1,33,1960
subcutaneous/monkey	lowest published lethal dose: 500 mg/kg		DTLVS* 4,420,1980
subcutaneous/mouse	Lethal dose: >3 gm/kg		AEHLAU 1,33,1960
subcutaneous/rabbit	lowest published lethal dose: 1 gm/kg		AEHLAU 1,33,1960
subcutaneous/rat	Lethal dose: >3 gm/kg		AEHLAU 1,33,1960

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/cat	lowest published toxic dose: 600 mg/kg/10D- intermittent	Behavioral: Tremor Nutritional and Gross Metabolic: Other changes	ARZNAD 7,585,1957
oral/chicken	lowest published toxic dose: 25 gm/kg/5D- intermittent	Spinal Cord: Other degenerative changes Behavioral: Ataxia	NTIS** OTS0539873
oral/rat	lowest published toxic dose: 65 gm/kg/65D- continuous	Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Sensory syndrome diagnostic of central lesion Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ARZNAD 7,585,1957
oral/rat	lowest published toxic dose: 59353 mg/kg/35D- continuous	Liver: Changes in liver weight	AEHLAU 1,33,1960
skin/domestic bird	lowest published toxic dose: 1200 mg/kg/3D- intermittent	Spinal Cord: Other degenerative changes Behavioral: Ataxia	NEZAAQ 52,281,1997

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 3 mg/m³	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		CRTXB2 3,289,1975
TOXICOLOGY REVIEW		TXCYAC 313,94,2013
TOXICOLOGY REVIEW		NETEEC 52,248,2015

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 3 mg/m³	DTLVS* 3,272,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 3 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 3 mg/m³;KZW 6 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 3 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 3 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 3 mg/m³, short term exposure limit 6 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 3 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 3 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 3 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 3 mg/m³;short term exposure limit 6 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 3 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 3 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 3 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 3 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 3 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 3 mg/m³;short term exposure limit 6 mg/m³, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 3 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 3 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 3 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 3 mg/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIPHENYL PHOSPHATE-air	10H time-weighted average 3 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 74635; Number of Industries 51; Total Number of Facilities 2869; Number of Occupations 54; Total Number of Employees Exposed 91754; Total Number of Female Employees Exposed 22800
National Occupational Hazard Survey 1974	Hazard Code 74635; Number of Industries 11; Total Number of Facilities 341; Number of Occupations 30; Total Number of Employees Exposed 7631

Status in Federal Agencies

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9169;8EHQ-0892-8839
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9290
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Triphenyl phosphate, 5038

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health