Phosphoramidic acid, isopropyl-, 4-(methylthio)-m-tolyl ethyl ester

RTECS #

TB3675000

CAS #

22224-92-6
See: NMAM or OSHA Methods

Updated

December 2017

Molecular Weight

303.39

Molecular Formula

C₁₃H₂₂NO₃PS

Synonyms

1-(Methylethyl)-ethyl 3-methyl-4-(methylthio)phenyl phosphoramidate
BAY 68138
BAY sra 3886
ENT 27572
Ethyl 3-methyl-4-(methylthio)phenyl(1-methylethyl)phosphoramidate
Ethyl 4-(methylthio)-m-tolyl isopropylphosphoramidate
Fenamiphos
Fenamiphos (ACGIH)
Isopropylamino-O-ethyl-(4-methylmercapto-3-methylphenyl)phosphate
Nemacur
Nemacur P
NSC 195106
O-Aethyl-O-(3-methyl-4-methylthiophenyl)-isopropylamido-phosphorsaeureester (German)
Phenamiphos
Phosphoramidic acid, (1-methylethyl)-, ethyl (3-methyl-4-(methylthio)phenyl) ester
SRA 3886

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	30 mg/kg (6-15D pregnant)	Reproductive: Other effects on female	TIHEEC 14,869,1998

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, neuroblastoma	Inhibitor Concentration (50 percent kill): 19.9 µmol/L/24H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	TIVIEQ 29,1079,2015
In Vitro/Human, neuroblastoma	Inhibitor Concentration (50 percent kill): 4.40 µmol/L/24H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TIVIEQ 29,1079,2015
In Vitro/Human, neuroblastoma	Inhibitor Concentration Low: 1 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays	TIVIEQ 29,1079,2015
In Vitro/Human, neuroblastoma	Inhibitor Concentration Low: 1 mmol/L/48H	In Vitro Toxicity Studies: Cell differentiation	TIVIEQ 29,1079,2015
inhalation/rat	lethal concentration (50 percent kill): 91 mg/m³/4H		85DPAN -,-,1971/1976
oral/cat	lethal dose (50 percent kill): 10 mg/kg		85DPAN -,-,1971/1976
oral/chicken	lethal dose (50 percent kill): 12 mg/kg		PEMNDP 9,361,1991
oral/Dog	lethal dose (50 percent kill): 10 mg/kg		28ZEAL 5,112,1976
oral/domestic bird	lethal dose (50 percent kill): 2400 µg/kg		85KYAH 11,621,1989
oral/duck	lethal dose (50 percent kill): 1680 µg/kg		TXAPA9 47,451,1979
oral/mouse	lethal dose (50 percent kill): 22700 µg/kg		85DPAN -,-,1971/1976
oral/quail	lethal dose (50 percent kill): 1 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	EESADV 8,551,1984
oral/rabbit	lethal dose (50 percent kill): 10 mg/kg		DTLWS* 4,191,1982
oral/rat	lethal dose (50 percent kill): 8 mg/kg		BESAAT 15,116,1969
oral/rat	lowest published toxic dose: 3.5 mg/kg	Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NETEEC 26,407,2004
oral/rat	lowest published toxic dose: 7 mg/kg	Eye: Lacrimation Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning	NETEEC 26,407,2004
skin/duck	lethal dose (50 percent kill): 24 mg/kg		TXAPA9 47,451,1979
skin/rabbit	lethal dose (50 percent kill): 178 mg/kg		DTLWS* 4,191,1982
skin/rat	lethal dose (50 percent kill): 80 mg/kg		FMCHA2 -,C216,1991

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.05 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		RREVAH 63,1,1976
TOXICOLOGY REVIEW		MUREAV 562,77,2004
TOXICOLOGY REVIEW		FEREAC 73,6867,2008
TOXICOLOGY REVIEW		FEREAC 73,53732,2008
TOXICOLOGY REVIEW		TOLED5 190,107,2009

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,119,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 mg/m³;KZW 0.2 mg/m³, inhal, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 mg/m³, skin, MAY2011
Occupational Exposure Limit-FRANCE	VME 0.1 mg/m³, Skin, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 mg/m³, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.1 mg/m³, skin, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 mg/m³, skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,1 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 mg/m³, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.1 mg/m³, Skin, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FENAMIPHOS-air	10H time-weighted average 0.1 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health