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Phenothiazine

RTECS #: SN5075000

CAS #: 92-84-2


UPDATE: May 2009 MW: 199.28 MF: C12H9NS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. AFI - Tiazin
  2. Agrazine
  3. Antiverm
  4. Biverm
  5. Contaverm
  6. Dibenzothiazine
  7. Dibenzo - 1,4 - thiazine
  8. ENT 38
  9. Feeno
  10. Fenothiazine (Dutch)
  11. Fenotiazina (Italian)
  12. Fenoverm
  13. Fentiazin
  14. Helmetina
  15. Lethelmin
  16. Nemazene
  17. Orimon
  1. Padophene
  2. Penthazine
  3. Phenegic
  4. Phenosan
  5. Phenothiazine (ACGIH)
  6. Phenoverm
  7. Phenovis
  8. Phenoxur
  9. Phenthiazine
  10. Reconox
  11. Souframine
  12. Thiodifenylamine (Dutch)
  13. Thiodiphenylamin (German)
  14. Thiodiphenylamine
  15. Tiodifenilamina (Italian)
  16. Wurm - thional
  17. XL - 50


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,250 mg/kg (1-22 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) AJANA2 110,29,1962


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
mouse
lethal dose (50 percent kill): 178 mg/kg N/R CSLNX* NX#00586
oral
child
lowest published lethal dose: 425 mg/kg/5 day Behavioral: Headache

Liver: Jaundice, other or unclassified

Blood: Normocytic anemia
LANCAO 242,86,1942
oral
cattle
lethal dose (50 percent kill): 500 mg/kg N/R 85JCAE -,1104,1986
oral
mouse
lethal dose (50 percent kill): 5 gm/kg Behavioral: Antipsychotic DNEUD5 7,45,1980
oral
rabbit
lethal dose (50 percent kill): 4 gm/kg N/R 85JCAE -,1104,1986
unreported route
wild bird
lowest published lethal dose: 500 mg/kg N/R JACSAT 66,888,1944


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
PLMJAP 6,160,1975
TOXICOLOGY REVIEW
CLCHAU 19,361,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,198,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 (skin) DTLVS* 3,204,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3 (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENOTHIAZINE-air 10 hour time-weighted average 5 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84116;
Number of Industries 5;
Total Number of Facilities 175;
Number of Occupations 15;
Total Number of Employees Exposed 5,639
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84116;
Number of Industries 54;
Total Number of Facilities 5,473;
Number of Occupations 68;
Total Number of Employees Exposed 88,048;
Total Number of Female Employees Exposed 8,791


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pesticide and as a base for the manufacture of tranquilizers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91.
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as a pesticide and as a base for the manufacture of tranquilizers

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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