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2 - Pentanol, 4 - methyl -

RTECS #: SA7350000

CAS #: 108-11-2


UPDATE: May 2009 MW: 102.20 MF: C6H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 4 - pentanol
  2. 3 - Mic
  3. 4 - Methyl - 2 - pentanol
  4. 4 - Methylpentanol - 2
  5. 4 - Metilpentan - 2 - olo (Italian)
  6. 4 - Pentanol, 2 - methyl -
  7. Alcool methyl amylique (French)
  8. Isobutylmethylcarbinol
  9. Isobutylmethylmethanol
  1. MAOH
  2. MIBC
  3. MIC
  4. Methyl amyl alcohol (OSHA)
  5. Methyl isobutyl carbinol
  6. Methyl isobutyl carbinol (ACGIH:OSHA)
  7. Methyl - isobutylkarbinol (Czech)
  8. Methylisobutyl carbinol
  9. Metilamil alcohol (Italian)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 4.32 mg/m3 Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
GISAAA 5,8,1994
inhalation
rat
lowest published lethal concentration: 2,000 ppm/4 hour N/R JIHTAB 31,343,1949
intraperitoneal
mouse
lethal dose (50 percent kill): 812 mg/kg N/R SCCUR* -,7,1961
oral
mouse
lowest published lethal dose: 1 gm/kg Gastrointestinal: Other changes UCPHAQ 2,217,1949
oral
rat
lethal dose (50 percent kill): 2,590 mg/kg N/R AMIHBC 4,119,1951
oral
rat
lowest published toxic dose: 510 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 136,199,2003
skin
rabbit
lethal dose (50 percent kill): 3,560 ÁL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm;short term exposure limit 40 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (100 mg/m3) DTLVS* 3,166,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (104 mg/m3), short term exposure limit 40 ppm (167 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (106 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 40 ppm (169 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (100 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (100 mg/m3), short term exposure limit 40 ppm (170 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (100 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 85 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 25 ppm (100 mg/m3), short term exposure limit 40 ppm (165 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 25 ppm (100 mg/m3);
short term exposure limit 40 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 100 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 25 ppm (104 mg/m3);
short term exposure limit 40 ppm (167 mg/m3), skin, JAN2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 160 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.07 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (110 mg/m3);
short term exposure limit 40 ppm (170 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (85 mg/m3),KZG- week 20 ppm (85 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (106 mg/m3);
short term exposure limit 40 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm;
short term exposure limit 40 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm;
short term exposure limit 40 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 25 ppm (Sk);
short term exposure limit 40 ppm (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3241;
Number of Industries 31;
Total Number of Facilities 2,585;
Number of Occupations 33;
Total Number of Employees Exposed 26,405;
Total Number of Female Employees Exposed 2,882


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402


REFERENCES:

CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
UCPHAQ University of California, Berkeley, Publications in Pharmacology. (Berkeley, CA) V.1-3, 1938-57. Discontinued.

Used as a solvent

RTECS Compound Description:
   Human Data

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