Pentaerythritol

RTECS #

RZ2490000

CAS #

115-77-5
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

136.17

Molecular Formula

C₅H₁₂O₄

Synonyms

1,3-Propanediol, 2,2-bis(hydroxymethyl)-
2,2-Bis(hydroxymethyl)-1,3-propanediol
Auxinutril
Hercules P6
Maxinutril
Methane tetramethylol
Monopentek
PE
Pentaerythrite
Pentaerythritol (ACGIH:OSHA)
Pentek
Tetrahydroxymethylmetane
Tetrakis(hydroxymethyl)methane
Tetramethylolmethane

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	Lethal concentration: >11 gm/m³/6H		TXAPA9 6,351,1964
oral/guinea pig	lethal dose (50 percent kill): 11300 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Tremor Behavioral: Ataxia	TXAPA9 6,351,1964
oral/mouse	lethal dose (50 percent kill): 18500 mg/kg		VCVGK* -,158,1984
oral/mouse	lethal dose (50 percent kill): 25500 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Tremor Behavioral: Ataxia	TXAPA9 6,351,1964
oral/rabbit	lethal dose (50 percent kill): 18500 mg/kg	Behavioral: General anesthetic Gastrointestinal: Ulceration or bleeding from stomach Liver: Other changes	GISAAA 36(2),25,1971
oral/rabbit	lethal dose (50 percent kill): 18500 mg/kg		VCVGK* -,158,1984
oral/rat	lethal dose (50 percent kill): 19500 mg/kg	Behavioral: General anesthetic Gastrointestinal: Ulceration or bleeding from stomach Liver: Other changes	GISAAA 36(2),25,1971
oral/rat	lethal dose (50 percent kill): 18500 mg/kg		VCVGK* -,158,1984

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rabbit	lowest published toxic dose: 10605 mg/kg/30W- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin)	GISAAA 36(2),25,1971
oral/rat	lowest published toxic dose: 10600 µg/kg/30W- intermittent	Behavioral: Alteration of classical conditioning	GISAAA 36(2),25,1971

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 mg/m³	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD	NUISANCE PARTICULATES	DTLVS* 3,199,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUM	time-weighted average 10 mg/m³, MAR2002
Occupational Exposure Limit-FINLAND	time-weighted average 10 mg/m³, short term exposure limit 20 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 mg/m³, FEB2006
Occupational Exposure Limit-KOREA	time-weighted average 10 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 10 mg/m³ (inhal), 4 mg/m³ (resp), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 4 mg/m³, JUN2003
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³ (respirable dust), 2003
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³ (total dust), 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³ (inhal. dust), OCT2007
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 4 mg/m³ (resp. dust), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTAERYTHRITOL, resp. fraction-air	10H time-weighted average 5 mg/m³	NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTAERYTHRITOL, total dust-air	10H time-weighted average 10 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code X6984; Number of Industries 1; Total Number of Facilities 18; Number of Occupations 2; Total Number of Employees Exposed 201
National Occupational Exposure Survey 1983	Hazard Code 54185; Number of Industries 122; Total Number of Facilities 15717; Number of Occupations 97; Total Number of Employees Exposed 271094; Total Number of Female Employees Exposed 60232
National Occupational Hazard Survey 1974	Hazard Code 54185; Number of Industries 93; Total Number of Facilities 6400; Number of Occupations 81; Total Number of Employees Exposed 89325

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health