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Pentaborane (9)

RTECS #: RY8925000

CAS #: 19624-22-7


UPDATE: May 2009 MW: 63.14 MF: B5H9


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Nonahydropentaborane
  2. Pentaborane
  1. Pentaborane (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lethal concentration (50 percent kill): 92 mg/m3/15 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
JPETAB 145,382,1964
inhalation
monkey
lethal concentration (50 percent kill): 640 mg/m3/2 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
JPETAB 145,382,1964
inhalation
mouse
lethal concentration (50 percent kill): 3,400 ppb/4 hour N/R AIHAAP 19,46,1958
inhalation
mouse
lethal concentration (50 percent kill): 0.17 gm/m3/2 hour N/R TPKVAL 9,7,1967
inhalation
mouse
lethal concentration (50 percent kill): 6.8 ppm/2 hour N/R TPKVAL 9,7,1967
inhalation
rat
lethal concentration (50 percent kill): 6 ppm/4 hour N/R AIHAAP 19,46,1958
inhalation
rat
lethal concentration (50 percent kill): 18 mg/m3/4 hour N/R VCVN1* -,199,1988
inhalation
rat
lowest published toxic concentration: 18 mg/m3/30 minute Brain and Coverings: Other degenerative changes VCVN1* -,199,1988
intraperitoneal
dog
lowest published lethal dose: 15,800 g/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Behavioral: Coma
STGNBT -,191,1999
intraperitoneal
rat
lethal dose (50 percent kill): 11,100 g/kg N/R 14KTAK -,693,1964


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 3,700 ppb/1 hour/3 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 6,121,1964
inhalation
dog
lowest published toxic concentration: 2.6 mg/m3/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988
inhalation
hamster
lowest published toxic concentration: 2.6 mg/m3/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988
inhalation
mouse
lowest published toxic concentration: 3,700 ppb/1 hour/4 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 6,121,1964
inhalation
rat
lowest published toxic concentration: 67 mg/m3/5 minute/5 day- intermittent Behavioral: Tetany

Eye: Miosis (pupilliary constriction)

Eye: Conjunctiva irritation
VCVN1* -,199,1988
inhalation
rat
lowest published toxic concentration: 30 mg/m3/5 day- intermittent Behavioral: Tetany

Eye: Miosis (pupilliary constriction)

Eye: Conjunctiva irritation
VCVN1* -,199,1988
inhalation
rat
lowest published toxic concentration: 7.8 mg/m3/60 minute/5 day- intermittent Behavioral: Tetany

Eye: Miosis (pupilliary constriction)

Eye: Conjunctiva irritation
VCVN1* -,199,1988
inhalation
rat
lowest published toxic concentration: 2.6 mg/m3/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988
inhalation
rabbit
lowest published toxic concentration: 2.6 mg/m3/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm;short term exposure limit 0.015 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.005 ppm (0.01 mg/m3) DTLVS* 3,197,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.005 ppm (0.01 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.005 ppm (0.01 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.005 ppm (0.01 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.005 ppm (0.01 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.005 ppm (0.013 mg/m3), short term exposure limit 0.015 ppm (0.039 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.005 ppm (0.013 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.015 ppm (0.04 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.01 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.005 ppm (0.01 mg/m3), short term exposure limit 0.015 ppm, JAN1999
Occupational Exposure Limit - FRANCE VME 0.005 ppm (0.01 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.013 mg/m3 (0.005 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.005 ppm (0.01 mg/m3), short term exposure limit 0.015 ppm (0.03 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.005 ppm (0.01 mg/m3);
short term exposure limit 0.015 ppm, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.01 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.005 ppm (0.013 mg/m3), JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.005 ppm (0.01 mg/m3), JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 ppm (0.01 mg/m3),KZG- week 0.01 ppm (0.02 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.01 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.005 ppm;
short term exposure limit 0.015 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.005 ppm;
short term exposure limit 0.015 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTABORANE-air 10 hour time-weighted average 0.005 ppm;
short term exposure limit 0.015 ppm
NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

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