CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Ozone

RTECS #: RS8225000

CAS #: 10028-15-6


UPDATE: May 2009 MW: 48.00 MF: O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Ozon (Polish)
  2. Ozone (ACGIH:OSHA)
  1. Triatomic oxygen


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
2 ppm/4 hour N/R JPCAAC 10,17,1960


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis chicken fibroblast 1 g/L/30 minute ZEKBAI 67,113,1965
cytogenetic analysis inhalation
hamster
200 ppb/5 hour ENVRAL 4,262,1971
cytogenetic analysis inhalation
hamster
0.38 g/L/5 hour VCVN5* -,166,1989
cytogenetic analysis inhalation
human
500 ppb/6 hour MEHYDY 4,165,1978
cytogenetic analysis human leukocyte 7,230 ppb/1 hour ENVRAL 12,188,1976
cytogenetic analysis human other cell types 8 ppm/5 minute- continuous NATUAS 194,793,1962
cytogenetic analysis inhalation
human
200 ppb/4 hour- intermittent EMMUEG 44,179,2004
cytogenetic analysis inhalation
rat
28 mg/m3/5 day- continuous GISAAA 44(9),12,1979
dominant lethal test inhalation
other insects
30 ppm/3 hour- continuous ENMUDM 4,657,1982
DNA adduct inhalation
guinea pig
0.4 ppm/2 hour INHTE5 9,811,1997
DNA adduct inhalation
human
0.4 ppm/2 hour INHTE5 9,811,1997
DNA damage cattle other cell types 50 mol/L/10 minute MUREAV 585,60,2005
DNA damage Escherichia coli 500 g/L AIPAAV 114,595,1968
DNA damage human other cell types 0.9 mmol/L/1 hour MUREAV 517,13,2002
DNA damage mouse fibroblast 25 mmol/L BIJOAK 247,69,1987
DNA damage inhalation
mouse
1 ppm/90 minute MUREAV 520,63,2002
DNA damage other microorganisms 70 pph JOHYAY 78,199,1977
DNA inhibition hamster lung 2 ppm/1 hour JTEHD6 17,119,1986
DNA repair Escherichia coli 50 ppm/30 minute BBRCA9 77,220,1977
mutation in microorganisms Escherichia coli 50 ppm (-enzymatic activation step) MGGEAE 197,472,1984
mutation in microorganisms Salmonella typhimurium 19 ppb/35 minute (+enzymatic activation step) EMMUEG 17(Suppl 19),22,1991
mutation in microorganisms Salmonella typhimurium 3 mg/L (-enzymatic activation step) OZSEDS 8,217,1986
micronucleus test inhalation
human
200 ppb/4 hour- intermittent EMMUEG 44,179,2004
micronucleus test inhalation
human
200 ppb/4 hour MUTAEX 21,131,2006
morphological transform hamster embryo 5 ppm CRNGDP 7,1611,1986
morphological transform mouse fibroblast 5 ppm CRNGDP 7,1611,1986
phage inhibition capacity Escherichia coli 50 ppm CNJGA8 26,706,1984
sister chromatid exchange human lung 250 ppb/1 hour- continuous ENVRAL 18,336,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 2 mg/m3 (9-12 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
VCVN5* -,166,1989
inhalation
mammal (species unspecified)
lowest published toxic concentration: 2 mg/m3 (17-20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
VCVN5* -,166,1989
inhalation
rat
lowest published toxic concentration: 1,040 ppb/24 hour (6-9 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 48,19,1979
inhalation
rat
lowest published toxic concentration: 1,500 ppb/24 hour (17-20 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical
TOLED5 5,3,1980
inhalation
rat
lowest published toxic concentration: 3 ppm (5 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 16,269,2002
inhalation
rat
lowest published toxic concentration: 3 ppm (10 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 16,269,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 5 ppm/2 hour/75 day- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AEHLAU 20,16,1970
inhalation
mouse
toxic concentration (other than lowest) : 608 g/m3/24 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JJIND8 75,771,1985
inhalation
mouse
toxic concentration (other than lowest) : 1 ppm/6 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-440,1994
inhalation
mouse
lowest published toxic concentration: 44.1 mg/kg/105 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB95-226999
inhalation
mouse
lowest published toxic concentration: 88.2 mg/kg/105 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB95-226999
inhalation
mouse
lowest published toxic concentration: 0.5 ppm/12 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Maternal effects: Ovaries, fallopian tubes
VHTODE 43,370,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lethal concentration (50 percent kill): 34,500 ppb/3 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
IMSUAI 25,301,1956
inhalation
cat
lethal concentration (50 percent kill): 7 mg/m3/3 hour N/R VCVN5* -,163,1993
inhalation
child
lowest published toxic concentration: 135 g/m3/1 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other
TXAPA9 206,185,2005
inhalation
dog
lowest published toxic concentration: 0.2 mg/m3/1 hour Endocrine: Other changes VCVN5* -,163,1993
inhalation
domestic animal
lowest published toxic concentration: 1 mg/m3/3 hour Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
VCVN5* -,163,1993
inhalation
guinea pig
lethal concentration (50 percent kill): 24,800 ppb/3 hour Lung, Thorax, or Respiration: Other changes IMSUAI 26,63,1957
inhalation
guinea pig
lethal concentration (50 percent kill): 7 mg/m3/3 hour N/R VCVN5* -,163,1993
inhalation
guinea pig
lowest published toxic concentration: 1 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,163,1993
inhalation
guinea pig
lowest published toxic concentration: 0.2 mg/m3/1 hour Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
VCVN5* -,163,1993
inhalation
hamster
lethal concentration (50 percent kill): 10,500 ppb/4 hour N/R AMIHAB 15,181,1957
inhalation
human
lowest published lethal concentration: 50 ppm/30 minute Behavioral: Headache

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Dyspnea
34ZIAG -,446,1969
inhalation
human
lowest published toxic concentration: 100 ppm/1 minute Lung, Thorax, or Respiration: Other changes

Skin: After systemic exposure: Dermatitis, other
NEACA9 19,686,1941
inhalation
human
lowest published toxic concentration: 1 ppm Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
AEHLAU 10,295,1965
inhalation
human
lowest published toxic concentration: 200 ppb/4 hour/4 day- intermittent Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes
AJCMED 161,1855,2000
inhalation
human
lowest published toxic concentration: 600 ppb/2 hour Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
ARDSBL 118,287,1978
inhalation
human
lowest published toxic concentration: 0.2 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Respiratory depression
VCVN5* -,163,1993
inhalation
human
lowest published toxic concentration: 0.6 mg/m3/3 hour Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
VCVN5* -,163,1993
inhalation
human
lowest published toxic concentration: 0.4 mg/m3 Olfaction: Change in sensation of smell VCVN5* -,163,1993
inhalation
human
lowest published toxic concentration: 0.4 mg/m3/1 hour Behavioral: Alteration of classical conditioning VCVN5* -,163,1993
inhalation
human
lowest published toxic concentration: 0.4 mg/m3/4 hour Eye: Changes in refraction

Eye: Visual field changes

Eye: Other eye effects
VCVN5* -,163,1993
inhalation
human
lowest published toxic concentration: 0.2 mg/m3/30 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,163,1993
inhalation
human
lowest published toxic concentration: 2 mg/m3/1 hour Lung, Thorax, or Respiration: Respiratory depression VCVN5* -,163,1993
inhalation
human
lowest published toxic concentration: 8 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,163,1993
inhalation
human
lowest published toxic concentration: 20 mg/m3 Behavioral: Rigidity (includes catalepsy)

Behavioral: Headache

Cardiac: Pulse rate increased without fall in BP
VCVN5* -,163,1993
inhalation
human
lowest published toxic concentration: 0.6 ppm/2 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
EVHPAZ 108,533,2000
inhalation
human
lowest published toxic concentration: 0.1 ppm/2 hour Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 134,219,2002
inhalation
man
lowest published toxic concentration: 80 ppb/6.6 hour Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
AEHLAU 46,145,1991
inhalation
man
lowest published toxic concentration: 1,860 ppb/75 minute Eye: Lacrimation

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Cough
AEHLAU 10,517,1965
inhalation
mouse
lethal concentration (50 percent kill): 12,600 ppb/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
FEPRA7 16,22,1957
inhalation
mouse
lethal concentration (50 percent kill): 40 mg/m3/3 hour N/R VCVN5* -,163,1993
inhalation
mouse
lethal concentration (50 percent kill): 7.6 mg/m3/4 hour N/R VCVN5* -,163,1993
inhalation
mouse
lethal concentration (50 percent kill): 4 mg/m3/24 hour N/R VCVN5* -,163,1993
inhalation
mouse
lowest published toxic concentration: 1.6 mg/m3/3 hour Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
VCVN5* -,163,1993
inhalation
mouse
lowest published toxic concentration: 0.1 mg/m3 Behavioral: Alteration of classical conditioning VCVN5* -,163,1993
inhalation
mouse
lowest published toxic concentration: 0.8 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
EVHPAZ 108,533,2000
inhalation
mouse
lowest published toxic concentration: 0.8 ppm/8 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
EVHPAZ 108,533,2000
inhalation
mouse
lowest published toxic concentration: 0.8 ppm/3 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,63,2003
inhalation
mouse
lowest published toxic concentration: 2 ppm/2 hour Cardiac: Pulse rate decreased with fall in BP

Nutritional and Gross Metabolic: Body temperature decrease
EVHPAZ 109(Suppl 4),539,2001
inhalation
mouse
lowest published toxic concentration: 1 ppm/1 hour Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Sputum

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 172,69,2002
inhalation
mouse
lowest published toxic concentration: 0.8 ppm/8 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 44,190,2005
inhalation
mouse
lowest published toxic concentration: 0.8 ppm/3 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,144,2004
inhalation
mouse
lowest published toxic concentration: 0.3 ppm/48 hour Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 44,379,2005
inhalation
mouse
lowest published toxic concentration: 0.8 ppm/3 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 60,180,2001
inhalation
mouse
lowest published toxic concentration: 0.5 ppm/3 hour Lung, Thorax, or Respiration: Other changes JPETAB 312,256,2005
inhalation
mouse
lowest published toxic dose: 1 ppm/8 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi TXAPA9 213,74,2006
inhalation
mouse
lowest published toxic concentration: 2 ppm/3 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 220,72,2007
inhalation
mouse
lethal concentration (50 percent kill): 0.3 gm/m3/2 hour N/R TPKVAL 9,7,1967
inhalation
mouse
lethal concentration (50 percent kill): 15.3 ppm/2 hour N/R TPKVAL 9,7,1967
inhalation
mouse
lowest published toxic concentration: 0.8 ppm/8 hour Lung, Thorax, or Respiration: Other changes CRNGDP 24,613,2003
inhalation
mouse
lowest published toxic concentration: 300 ppb/24 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 -,42,2008
inhalation
mouse
lowest published toxic concentration: 0.9 ppm/3 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 12,402,2008
inhalation
rat
lethal concentration (50 percent kill): 4,800 ppb/4 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
AMIHAB 15,181,1957
inhalation
rat
lowest published toxic concentration: 0.8 ppm/3 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
JTEHD6 46,329,1995
inhalation
rat
lowest published toxic concentration: 0.8 ppm/3 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JTEHD6 46,329,1995
inhalation
rat
lethal concentration (50 percent kill): 28 mg/m3/2 hour N/R VCVN5* -,163,1993
inhalation
rat
lethal concentration (50 percent kill): 4.5 mg/m3/3 hour N/R VCVN5* -,163,1993
inhalation
rat
lethal concentration (50 percent kill): 1 mg/m3/44 hour N/R VCVN5* -,163,1993
inhalation
rat
lethal concentration : 0.5 mg/m3/1 hour N/R VCVN5* -,163,1993
inhalation
rat
lowest published toxic concentration: 1.2 mg/m3/18 hour Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,163,1993
inhalation
rat
lowest published toxic concentration: 0.65 mg/m3/6 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
VCVN5* -,163,1993
inhalation
rat
lowest published toxic concentration: 6.5 mg/m3/3 hour Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Respiratory depression

Blood: Normocytic anemia
VCVN5* -,163,1993
inhalation
rat
lowest published toxic concentration: 2 mg/m3/24 hour Endocrine: Other changes VCVN5* -,163,1993
inhalation
rat
lowest published toxic concentration: 2 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
EXLRDA 14,477,1988
inhalation
rat
lowest published toxic concentration: 0.4 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Metabolism (intermediary): Lipids including transport
INHTE5 6,267,1994
inhalation
rat
lowest published toxic concentration: 0.5 ppm/6 hour Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
EVHPAZ 109(Suppl 4),539,2001
inhalation
rat
lowest published toxic concentration: 1,600 g/m3/8 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JTEHD6 65,1571,2002
inhalation
rat
lowest published toxic concentration: 2 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JTEHD6 65,1453,2002
inhalation
rat
lowest published toxic concentration: 1 ppm/24 hour Brain and Coverings: Changes in surface EEG

Behavioral: Sleep
TXCYAC 191,89,2003
inhalation
rat
lowest published toxic concentration: 2 ppm/3 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 44,191,2005
inhalation
rat
lowest published toxic dose: 1 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 225,119,2006
inhalation
rat
lethal concentration (50 percent kill): 4.8 ppm N/R ENTOX* -,325,2005
inhalation
rat
lowest published toxic concentration: 0.6 mg/m3/4 hour Lung, Thorax, or Respiration: Other changes TPKVAL 14,73,1975
inhalation
rat
lethal concentration : 0.5 gm/m3/1 hour Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Gastrointestinal: Other changes

Liver: Other changes
TPKVAL 6,116,1964
inhalation
rat
lethal concentration : 0.5 gm/m3/1 hour Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage
TPKVAL 6,116,1964
inhalation
rabbit
lethal concentration (50 percent kill): 36 ppm/3 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
IMSUAI 25,301,1956
inhalation
rabbit
lethal concentration (50 percent kill): 7.4 mg/m3/3 hour N/R VCVN5* -,163,1993
inhalation
woman
lowest published toxic concentration: 350 ppb/75 minute Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
INHTE5 12,151,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 0.75 ppm/2 day/24 hour- continuous Endocrine: Other changes EXPADD 28,105,1985
inhalation
domestic animal
lowest published toxic concentration: 9.5 mg/m3/4 hour/6 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi VCVN5* -,165,1989
inhalation
guinea pig
lowest published toxic concentration: 2 ppm/2 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHD6 3,521,1977
inhalation
guinea pig
lowest published toxic concentration: 800 g/m3/24 hour/3 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 116,209,1992
inhalation
guinea pig
lowest published toxic concentration: 0.6 mg/m3/24 hour/2 week- continuous Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVN5* -,165,1989
inhalation
guinea pig
lowest published toxic concentration: 0.7 mg/m3/24 hour/90 day- continuous Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,165,1989
inhalation
guinea pig
lowest published toxic concentration: 0.6 mg/m3/24 hour/2 week- continuous Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVN5* -,166,1989
inhalation
guinea pig
lowest published toxic concentration: 0.4 ppm/5 week- intermittent Olfaction: Other olfaction effects

Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Increase in humoral response
TXCYAC 199,73,2004
inhalation
human
lowest published toxic concentration: 0.5 mg/m3/7 year- intermittent Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Pulse rate decreased with fall in BP

Behavioral: Muscle weakness
VCVN5* -,167,1989
inhalation
mammal (species unspecified)
lowest published toxic concentration: 8 mg/m3/24 hour/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,166,1989
inhalation
monkey
lowest published toxic concentration: 1,500 pph/8 hour/21 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 29,207,1985
inhalation
monkey
lowest published toxic concentration: 400 ppb/8 hour/90 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)
EXLRDA 12,57,1987
inhalation
monkey
lowest published toxic concentration: 1.2 mg/m3/4 hour/4 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVN5* -,165,1989
inhalation
monkey
lowest published toxic concentration: 1.2 mg/m3/8 hour/1 year- intermittent Blood: Other changes VCVN5* -,165,1989
inhalation
monkey
lowest published toxic concentration: 0.3 mg/m3/8 hour/90 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
VCVN5* -,165,1989
inhalation
monkey
lowest published toxic concentration: 0.7 mg/m3/24 hour/90 day- continuous Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,165,1989
inhalation
monkey
lowest published toxic concentration: 0.15 ppm/8 hour/90 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 24,125,1985
inhalation
monkey
lowest published toxic concentration: 0.3 ppm/8 hour/90 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 24,125,1985
inhalation
monkey
lowest published toxic concentration: 0.64 ppm/8 hour/1 year- intermittent Blood: Other changes ENVRAL 32,445,1983
inhalation
monkey
lowest published toxic concentration: 0.5 ppm/154 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 194,211,2004
inhalation
mouse
lowest published toxic concentration: 400 ppb/24 hour/14 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
ENVRAL 35,490,1984
inhalation
mouse
lowest published toxic concentration: 1 ppm/24 hour/4 week- continuous Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JEPOEC 9,243,1989
inhalation
mouse
lowest published toxic concentration: 608 g/m3/26 week- intermittent Endocrine: Changes in spleen weight TOLED5 26,139,1985
inhalation
mouse
lowest published toxic concentration: 300 ppb/3 day- continuous Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
EXLRDA 20,579,1994
inhalation
mouse
lowest published toxic concentration: 2 mg/m3/24 hour/3 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVN5* -,164,1989
inhalation
mouse
lowest published toxic concentration: 0.2 mg/m3/5 hour/100 day- intermittent Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decreased immune response
VCVN5* -,165,1989
inhalation
mouse
lowest published toxic concentration: 0.7 mg/m3/8 hour/1 year- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in erythrocyte (RBC) count
VCVN5* -,165,1989
inhalation
mouse
lowest published toxic concentration: 0.5 ppm/5 day/4 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 43,370,2001
inhalation
mouse
lowest published toxic concentration: 0.5 ppm/5 day/7 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 43,370,2001
inhalation
mouse
lowest published toxic concentration: 0.5 ppm/5 day/12 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight
VHTODE 43,370,2001
inhalation
mouse
lowest published toxic concentration: 0.5 ppm/5 day/12 week- continuous Related to Chronic Data: Changes in testicular weight VHTODE 43,370,2001
inhalation
mouse
lowest published toxic concentration: 0.5 ppm/5 day/12 week- continuous Cardiac: Changes in heart weight

Related to Chronic Data: Changes in ovarian weight
VHTODE 43,370,2001
inhalation
mouse
lowest published toxic concentration: 1 ppm/5 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosing alveolitis

Blood: Other changes
TXCYAC 204,75,2004
inhalation
mouse
lowest published toxic concentration: 1 ppm/3 day- intermittent Lung, Thorax, or Respiration: Sputum

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 208,117,2005
inhalation
mouse
lowest published toxic concentration: 0.5 ppm/9 day- intermittent Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 160,127,2006
inhalation
mouse
lowest published toxic concentration: 1 ppm/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 208,117,2005
inhalation
mouse
lowest published toxic concentration: 1 ppm/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 215,250,2006
inhalation
mouse
lowest published toxic concentration: 0.5 ppm/10 day- intermittent Biochemical: Metabolism (intermediary): Other TOLED5 160,127,2006
inhalation
mouse
lowest published toxic concentration: 0.25 ppm/4 day- intermittent Lung, Thorax, or Respiration: Other changes TXAPA9 222,227,2007
inhalation
mouse
lowest published toxic concentration: 0.25 ppm/4 day- intermittent Biochemical: Metabolism (intermediary): Other TOLED5 173,73,2007
inhalation
mouse
lowest published toxic concentration: 0.6 ppm/15 day- intermittent Blood: Changes in spleen

Immunological Including Allergic: Decreased immune response
JTEHF8 69,1511,2006
inhalation
mouse
lowest published toxic dose: 300 ppb/72 hour- continuous Cardiac: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 -,42,2008
inhalation
mouse
lowest published toxic dose: 300 ppb/72 hour- continuous Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 -,42,2008
inhalation
quail
lowest published toxic concentration: 3 mg/m3/24 hour/7 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
ENVRAL 54,39,1991
inhalation
rat
lowest published toxic concentration: 950 ppb/8 hour/90 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
TXAPA9 106,384,1990
inhalation
rat
lowest published toxic concentration: 1,600 g/m3/24 hour/7 day- continuous Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JTEHD6 24,515,1988
inhalation
rat
lowest published toxic concentration: 800 g/m3/24 hour/3 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 116,209,1992
inhalation
rat
lowest published toxic concentration: 700 ppb/2 hour/28 day- intermittent Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHD6 17,143,1986
inhalation
rat
lowest published toxic concentration: 200 ppb/24 hour/12 week- continuous Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
ENVRAL 42,425,1987
inhalation
rat
lowest published toxic concentration: 750 ppb/24 hour/14 day- continuous Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JEPTDQ 3(5-6),247,1980
inhalation
rat
lowest published toxic concentration: 2 mg/m3/24 hour/3 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVN5* -,164,1989
inhalation
rat
lowest published toxic concentration: 1.96 mg/m3/5 hour/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVN5* -,164,1989
inhalation
rat
lowest published toxic concentration: 1.4 mg/m3/24 hour/7 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Dyspnea
VCVN5* -,165,1989
inhalation
rat
lowest published toxic concentration: 0.4 mg/m3/24 hour/3 day- continuous Gastrointestinal: Other changes

Blood: Normocytic anemia
VCVN5* -,165,1989
inhalation
rat
lowest published toxic concentration: 0.25 mg/m3/24 hour/13 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,165,1989
inhalation
rat
lowest published toxic concentration: 9 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Endocrine: Changes in thyroid weight

Related to Chronic Data: Changes in testicular weight
VCVN5* -,165,1989
inhalation
rat
lowest published toxic concentration: 0.7 mg/m3/24 hour/90 day- continuous Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,165,1989
inhalation
rat
lowest published toxic concentration: 3.9 mg/m3/24 hour/13 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVN5* -,166,1989
inhalation
rat
lowest published toxic concentration: 2.4 mg/m3/6 hour/4 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,166,1989
inhalation
rat
lowest published toxic concentration: 0.48 ppm/4 hour/4 week- intermittent Lung, Thorax, or Respiration: Emphysema

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NEZAAQ 39,757,1984
inhalation
rat
lowest published toxic concentration: 0.5 ppm/23 hour/5 day- continuous Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
EVHPAZ 109(Suppl 4),539,2001
inhalation
rat
lowest published toxic concentration: 0.5 ppm/6 hour/5 day- intermittent Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
EVHPAZ 109(Suppl 4),539,2001
inhalation
rat
lowest published toxic concentration: 0.25 ppm/4 hour/14 day- intermittent Blood: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
ETOPFR 17,1,2004
inhalation
rat
lowest published toxic concentration: 1 ppm/3 day- continuous Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 197,37,2004
inhalation
rat
lowest published toxic concentration: 0.8 ppm/90 day- intermittent Olfaction: Other olfaction effects TOXID9 44,187,2005
inhalation
rat
lowest published toxic concentration: 0.3 ppm/3 day- continuous Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increased immune response
TOXID9 66,193,2002
inhalation
rat
lowest published toxic concentration: 0.1 ppm/1 week- intermittent Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increase in cellular immune response
TOXID9 60,30,2001
inhalation
rat
lowest published toxic concentration: 0.5 ppm/90 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 60,125,2001
inhalation
rat
lowest published toxic concentration: 0.5 ppm/16 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,220,2008
inhalation
rabbit
lowest published toxic concentration: 100 ppb/2 hour/13 day- intermittent Lung, Thorax, or Respiration: Other changes JTEHD6 21,27,1987
oral
rat
lowest published toxic dose: 4 mg/kg/40 day- continuous Immunological Including Allergic: Decreased immune response VCVN5* -,165,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (heavy work) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.08 ppm (moderate work) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (light work) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 ppm (< 2 hours) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 558,7,2004
TOXICOLOGY REVIEW
NTIS** PB228-002
TOXICOLOGY REVIEW
AEHLAU 16,903,1968
TOXICOLOGY REVIEW
NTIS** CONF-691001
TOXICOLOGY REVIEW
TOLED5 140-141,195,2003
TOXICOLOGY REVIEW
TOLED5 140-141,281,2003
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
ENTOX* -,325,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTEHD6 6,521,2003
TOXICOLOGY REVIEW
MUREAV 659,93,2008
TOXICOLOGY REVIEW
HUTOX* -,661,1996
TOXICOLOGY REVIEW
MUREAV 681,93,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.2 mg/m3) DTLVS* 3,194,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.02 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA ceiling concentration 0.1 ppm (0.2 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.2 mg/m3 (0.1 mL/m3), JAN 2006
Occupational Exposure Limit - BELGIUM short term exposure limit 0.1 ppm (0.2 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.1 ppm (0.2 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.2 mg/m3), short term exposure limit 0.3 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.2 mg/m3), VLE 0.2 ppm (0.4 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.2 mg/m3, short term exposure limit 0.2 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.2 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.2 mg/m3), short term exposure limit 0.3 ppm (0.6 mg/m3), 2006
Occupational Exposure Limit - MEXICO peak 0.1 ppm (0.2 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 0.1 ppm (0.20 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.6 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 ppm (0.2 mg/m3), ceiling concentration 0.3 ppm (0.6 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.2 mg/m3),KZG- week 0.1 ppm (0.2 mg/m3),DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.2 ppm (0.4 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OZONE-air ceiling concentration 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81651;
Number of Industries 54;
Total Number of Facilities 6,329;
Number of Occupations 53;
Total Number of Employees Exposed 32,552
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81651;
Number of Industries 70;
Total Number of Facilities 5,347;
Number of Occupations 67;
Total Number of Employees Exposed 72,134;
Total Number of Female Employees Exposed 32,361


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Negative: In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-nonhuman lymphocyte
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Inconclusive: Cytogenetics-male germ cell
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in purification of drinking water and preservation of goods in cold storage
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (inhalation);some evidence:mouse NTPTR* NTP-TR-440,1994
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse
NCI Carcinogenesis Studies (inhal);no evidence:rat
OSHA ANALYTICAL METHOD # ID214


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIPAAV Annales de l'Institut Pasteur (Paris). (Paris, France) V.1-123, 1887-1972. For publisher information, see ANMBCM.
AJCMED American Journal of Respiratory and Critical Care Medicine. (American Lung Association, 1740 Broadway, New Youk, NY 10019) V. 149- 1994-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EXLRDA Experimental Lung Research. (Hemisphere Publishing, c/o Taylor & Francis 1900 Frost Road, Suite 101, Bristol, PA 19007) V.1- 1980-
EXPADD Experimental Pathology (1981). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.19- 1981-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1901-
JPCAAC Journal of the Air Pollution Control Association. (Air Pollution Control Assoc., POB 2861, Pittsburgh, PA 15230) V.5- 1955-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
MEHYDY Medical Hypotheses. (Churchill Livingstone Inc., 1560 Broadway, New York, NY 10036) V.1- 1975-
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NEACA9 News Edition, American Chemical Society. (Easton, PA) V.18-19, 1940-41. For publisher information, see CENEAR.
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
OZSEDS Ozone: Science & Engineering. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1979-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7.

Used in purification of drinking water and preservation of goods in cold storage

NIOSH PROFILE (OZONE), SRC, 10/77

NIOSH PROFILE (SEWAGE TREATMENT), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us