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Octane

RTECS #: RG8400000

CAS #: 111-65-9


UPDATE: May 2009 MW: 114.26 MF: C8H18


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Octane (ACGIH:OSHA)
  2. Oktan (Polish)
  3. Oktanen (Dutch)
  1. Ottani (Italian)
  2. n - Octane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published lethal concentration: 80,000 mg/m3/2 hour N/R VCVGH* -,37,1990
inhalation
rat
lethal concentration (50 percent kill): 118 gm/m3/4 hour N/R GTPZAB 32(10),23,1988
inhalation
rat
lethal concentration (50 percent kill): 25,260 ppm/4 hour N/R ENTOX* -,291,2005
intravenous
mouse
lowest published lethal dose: 428 mg/kg Behavioral: Altered sleep time (including change in righting reflex) APTOA6 37,56,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 5 mg/kg/7 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
ENVRAL 22,271,1980


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 300 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,291,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 400 ppm (1900 mg/m3) DTLVS* 3,191,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (2350 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 400 ppm (1900 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 400 ppm (1900 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (2350 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 300 ppm (1400 mg/m3), short term exposure limit 375 ppm (1750 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 300 ppm (1420 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 375 ppm (1775 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (935 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 300 ppm (1400 mg/m3), short term exposure limit 375 ppm (1750 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 300 ppm (1450 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 2400 mg/m3 (500 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2350 mg/m3, short term exposure limit 9400 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 300 ppm (1400 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 300 ppm (1450 mg/m3), short term exposure limit 375 ppm (1800 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 300 ppm (1450 mg/m3);
short term exposure limit 375 ppm (1800 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1450 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 300 ppm (1400 mg/m3), short term exposure limit 375 ppm (1750 mg/m3),JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 150 ppm (725 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 500 ppm (2350 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 1800 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 300 ppm, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 200 ppm (900 mg/m3);
short term exposure limit 300 ppm (1400 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 300 ppm (1400 mg/m3),KZG- week 600 ppm (2800 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 400 ppm (1900 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 300 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 300 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OCTANE-air 10 hour time-weighted average 75 ppm;
ceiling concentration 385 ppm/15 minute
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 51705;
Number of Industries 5;
Total Number of Facilities 95;
Number of Occupations 8;
Total Number of Employees Exposed 940
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 51705;
Number of Industries 22;
Total Number of Facilities 1,172;
Number of Occupations 18;
Total Number of Employees Exposed 9,186;
Total Number of Female Employees Exposed 612


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent, in organic synthesis, and in azeotropic distillations
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a solvent, in organic synthesis, and in azeotropic distillations

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