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Nitroglycerin

RTECS #: QX2100000

CAS #: 55-63-0


UPDATE: May 2009 MW: 227.11 MF: C3H5N3O9


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2,3 - Propanetriol, trinitrate (9CI)
  2. 1,2,3 - Propanetriyl nitrate
  3. Angibid
  4. Anginine
  5. Angiolingual
  6. Angorin
  7. Blasting gelatin
  8. Blasting oil
  9. Cardamist
  10. GTN
  11. Gilucor nitro
  12. Glonoin
  13. Glycerintrinitrate (Czech)
  14. Glycerol, nitric acid triester
  15. Glyceroltrinitraat (Dutch)
  16. Glycerol trinitrate
  17. Glycerol (trinitrate de) (French)
  18. Glyceryl nitrate
  19. Glyceryl trinitrate
  20. Klavikordal
  21. Lenitral
  22. Myocon
  23. Myoglycerin
  24. NG
  25. NK - 843
  26. NTG
  27. Niglin
  28. Niglycon
  29. Niong
  30. Nitora
  31. Nitric acid triester of glycerol
  32. Nitrin
  33. Nitrine
  34. Nitrine - TDC
  35. Nitro - dur
  36. Nitro - lent
  37. Nitro - span
  38. Nitroglicerina (Italian)
  1. Nitrogliceryna (Polish)
  2. Nitroglycerin (ACGIH:OSHA)
  3. Nitroglycerin - ACC
  4. Nitroglycerine
  5. Nitroglycerin, spirits of
  6. Nitroglycerol
  7. Nitroglyn
  8. Nitrolan
  9. Nitroletten
  10. Nitrolingual
  11. Nitrolowe
  12. Nitromel
  13. Nitronet
  14. Nitrong
  15. Nitrorectal
  16. Nitrostabilin
  17. Nitrostat
  18. Nitrozell retard
  19. Nysconitrine
  20. Perglottal
  21. Propanetriol trinitrate
  22. RCRA waste number P081
  23. S.N.G
  24. SK - 106N
  25. Solution glyceryl trinitrate
  26. Soup
  27. Spirit of glonoin
  28. Spirit of glyceryl trinitrate
  29. Spirit of trinitroglycerin
  30. TNG
  31. Temponitrin
  32. Trinalgon
  33. Trinitrin
  34. Trinitroglycerin
  35. Trinitroglycerol
  36. Trinitrol
  37. Vasoglyn


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour mild NTIS** AD-B011-150


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition cattle mammary gland 30 mol/L/24 hour MOCAE8 59,1044,2001
mutation in microorganisms Salmonella typhimurium 2,500 nmol/plate (+enzymatic activation step) MUREAV 298,187,1993
mutation in microorganisms Salmonella typhimurium 50 g/well (-enzymatic activation step) CBINA8 19,77,1977
mutation in mammalian somatic cells human other cell types 800 mol/L/24 hour EMMUEG 38,261,2001
mutation in mammalian somatic cells intraperitoneal
mouse
5 mg/kg JJIND8 92,1429,2000
specific locus test human other cell types 800 mol/L/24 hour EMMUEG 38,261,2001
specific locus test intraperitoneal
mouse
5 mg/kg JJIND8 92,1429,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 11 mg/kg (7-17 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death
YACHDS 13,3807,1985
intraperitoneal
rat
lowest published toxic dose: 220 mg/kg (7-17 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
YACHDS 13,3807,1985
intraperitoneal
rat
lowest published toxic dose: 2,580 mg/kg (91 day male/2 week prior to copulation-7 day pregnant) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Other effects to embryo or fetus
YACHDS 13,3783,1985
intraperitoneal
rat
lowest published toxic dose: 520 mg/kg (17 day pregnant-20 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) YACHDS 13,3843,1985
skin
rat
lowest published toxic dose: 3,640 mg/kg (17-21 day pregnant/21 day after birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
KSRNAM 18,3564,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 36,500 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
ATSUDG 4,88,1980
oral
rat
toxic dose : 438 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
ATSUDG 4,88,1980


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraarterial
dog
lowest published toxic dose: 1,000 ng/kg Vascular: Measurement of regional blood flow

Blood: Changes in spleen
CEXPB9 33,81,2006
intraperitoneal
mouse
lethal dose (50 percent kill): 104 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
IYKEDH 13,90,1982
intraperitoneal
rat
lethal dose (50 percent kill): 102 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
IYKEDH 13,90,1982
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg Behavioral: Analgesia EJPHAZ 464,159,2003
intraperitoneal
rabbit
lethal dose (50 percent kill): 189 mg/kg N/R NIIRDN -,786,1990
intravenous
cat
lowest published toxic dose: 1 mg/kg Cardiac: Other changes

Vascular: BP lowering not characterized in autonomic section

Vascular: Measurement of regional blood flow
FATOAO 47,55,1984
intravenous
cat
lowest published lethal dose: 5 mg/kg Cardiac: Change in conduction velocity

Vascular: BP lowering not characterized in autonomic section
FATOAO 47,55,1984
intravenous
cat
lowest published toxic dose: 0.5 mg/kg Cardiac: Change in force of contraction

Cardiac: Pulse rate increased without fall in BP

Vascular: BP lowering not characterized in autonomic section
FATOAO 44,174,1981
intravenous
dog
lethal dose (50 percent kill): 19 mg/kg Eye: Hemorrhage

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
OYYAA2 22,629,1981
intravenous
man
lowest published toxic dose: 51,429 g/kg/2 day- intermittent Brain and Coverings: Encephalitis

Eye: Miosis (pupilliary constriction)

Eye: Corneal damage
AIMEAS 101,500,1984
intravenous
man
lowest published toxic dose: 7.14 ng/kg Vascular: Regional or general arteriolar or venous dilation CLPTAT 67,22,2000
intravenous
mouse
lethal dose (50 percent kill): 10,600 g/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
IYKEDH 13,90,1982
intravenous
mouse
lethal dose (50 percent kill): 30 mg/kg N/R FATOAO 47,55,1984
intravenous
rat
lethal dose (50 percent kill): 23,200 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia
JJATDK 3,161,1983
intravenous
rat
lowest published toxic dose: 8 g/kg Vascular: BP lowering not characterized in autonomic section BIPBU* 24,1370,2001
intravenous
rat
lowest published toxic dose: 1,714.3 g/kg/1 hour Behavioral: Tolerance AAPSP* 4,10,2002
intravenous
rabbit
lethal dose (50 percent kill): 45 mg/kg N/R NIIRDN 6,547,1982
intravenous
rabbit
lowest published toxic dose: 340 g/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section
CEXPB9 30,812,2003
intravenous
woman
lowest published toxic dose: 48 g/kg Behavioral: Headache

Vascular: BP lowering not characterized in autonomic section

Reproductive: Maternal effects: Uterus, cervix, vagina
FCLPH* 18,207,2004
oral
guinea pig
lethal dose (50 percent kill): 1,450 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia
STGNBT -,180,1999
oral
human
lowest published toxic dose: 0.83 mg/kg Cardiac: Change in rate

Vascular: Measurement of regional blood flow
FATOAO 49,84,1986
oral
mammal (species unspecified)
lethal dose (50 percent kill): 105 mg/kg N/R TOVEFN (1),14,2001
oral
mouse
lethal dose (50 percent kill): 115 mg/kg Behavioral: Somnolence (general depressed activity) YACHDS 13,3649,1985
oral
rat
lethal dose (50 percent kill): 105 mg/kg Behavioral: Somnolence (general depressed activity) YACHDS 13,3649,1985
oral
rat
lowest published toxic dose: 1,360 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Tetany

Cardiac: Cardiomyopathy including infarction
FATOAO 48,76,1985
oral
rabbit
lethal dose (50 percent kill): 1,607 mg/kg N/R NIIRDN -,786,1990
oral
woman
lowest published toxic dose: 8 g/kg Behavioral: Headache

Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Nausea or vomiting
AJEMEN 11,253,1993
oral
woman
lowest published toxic dose: 8 g/kg Cardiac: Pulse rate decreased with fall in BP

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes
AEMED3 23,31,1994
oral
woman
lowest published toxic dose: 5 mg/kg Behavioral: General anesthetic

Cardiac: Other changes

Kidney, Ureter, and Bladder: Incontinence
NAYXEW 8,181,1988
subcutaneous
cat
lowest published lethal dose: 150 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Normocytic anemia
AEPPAE 200,271,1942
subcutaneous
mouse
lethal dose (50 percent kill): 110 mg/kg Behavioral: Somnolence (general depressed activity) YACHDS 13,3649,1985
subcutaneous
mouse
lowest published toxic dose: 6,359 g/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation EJPHAZ 501,209,2004
subcutaneous
rat
lethal dose (50 percent kill): 94 mg/kg Behavioral: Somnolence (general depressed activity) YACHDS 13,3649,1985
subcutaneous
rabbit
lowest published lethal dose: 400 mg/kg N/R AEPPAE 200,271,1942
skin
mouse
lethal dose (50 percent kill): >35,200 g/kg N/R NIIRDN -,786,1990
skin
rat
lethal dose (50 percent kill): >29,200 g/kg N/R NIIRDN -,786,1990
skin
rabbit
lethal dose (50 percent kill): >280 mg/kg N/R NIIRDN -,786,1990
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 230 mg/kg N/R FRXXBL #2454807
unreported route
rat
lowest published toxic dose: 9,504 g/kg Vascular: BP lowering not characterized in autonomic section NSAPCC 375(Suppl 1),64,2007


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 86 g/m3/17 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Fatty liver degeneration

Cardiac: EKG changes not diagnostic of above
STGNBT -,180,1999
implant
mouse
lowest published toxic dose: 54,506.4 ng/kg/4 day- continuous Cardiac: Other changes

Vascular: Relaxation (isolated tissue)

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
NSAPCC 375(Suppl 1),107,2007
implant
rat
lowest published toxic dose: 64 mg/kg/48 hour- continuous Vascular: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
JPETAB 317,188,2006
intraperitoneal
rat
lowest published toxic dose: 825 mg/kg/33 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
YACHDS 13,3689,1985
intraperitoneal
rat
lowest published toxic dose: 1,575 mg/kg/13 week- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Changes in: K

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
YACHDS 13,3753,1985
intraperitoneal
rat
: 15 mg/kg/15 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
EJPHAZ 541,191,2006
intravenous
dog
lowest published toxic dose: 300 mg/kg/30 day- intermittent Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Changes in thymus weight

Blood: Changes in platelet count
YACHDS 13,3753,1985
multiple
rat
lowest published toxic dose: 64.3 mg/kg/48 hour- intermittent Vascular: BP lowering not characterized in autonomic section

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
JPETAB 317,188,2006
oral
human
lowest published toxic dose: 0.6 mg/kg/14 day- intermittent Cardiac: Change in force of contraction

Cardiac: Change in rate

Vascular: Measurement of regional blood flow
FATOAO 49,84,1986
oral
rat
lowest published toxic dose: 22.75 mg/kg/26 week- continuous Cardiac: Cardiomyopathy including infarction

Cardiac: EKG changes not diagnostic of above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FATOAO 48,76,1985
oral
rat
lowest published toxic dose: 4,080 mg/kg/30 day- intermittent Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FATOAO 48,76,1985
oral
rabbit
lowest published toxic dose: 30 mg/kg/26 week- continuous Cardiac: Cardiomyopathy including infarction

Cardiac: EKG changes not diagnostic of above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FATOAO 48,76,1985
oral
rabbit
lowest published toxic dose: 4,080 mg/kg/30 day- intermittent Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP
FATOAO 48,76,1985
skin
rat
lowest published toxic dose: 1,500 mg/kg/30 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
YACHDS 9,1477,1981
skin
rat
lowest published toxic dose: 25,480 mg/kg/26 week- intermittent Liver: Other changes

Blood: Pigmented or nucleated red blood cells

Blood: Changes in platelet count
KSRNAM 18,2817,1984
skin
rabbit
lowest published toxic dose: 4,900 mg/kg/5 week- intermittent Endocrine: Changes in thymus weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count
KSRNAM 18,2794,1984
skin
woman
lowest published toxic dose: 32 mg/kg/20 day- intermittent Skin: After topical application: Dermatitis, allergic CODEDG 45,299,2001
unreported route
rat
lowest published toxic dose: 28,512 g/kg/3 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases NSAPCC 375(Suppl 1),64,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
NTIS** AD778-725
TOXICOLOGY REVIEW
ARPTDI 43,97,2003
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TPHSDY 23,401,2002
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
MUREAV 612,115,2006
TOXICOLOGY REVIEW
BJPCBM 146,479,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
TOPADD 33,517,2005
TOXICOLOGY REVIEW
HUTOX* -,395,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.2 ppm (2 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.2 ppm (2 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.2 ppm (2 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.2 ppm (2 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.02 ppm (0.2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.46 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.47 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.02 ppm (0.2 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.9 mg/m3), short term exposure limit 0.3 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (1 mg/m3), Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.5 mg/m3, short term exposure limit 2 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 0.05 ppm (0.46 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.05 ppm (0.5 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.05 ppm (0.5 mg/m3);
short term exposure limit 0.1 ppm (1 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 ppm (0.46 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.03 ppm (0.27 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 ppm (2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.02 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.03 ppm (0.3 mg/m3);
short term exposure limit 0.1 ppm (0.9 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.5 mg/m3),KZG- week 0.05 ppm (0.5 mg/m3), Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.2 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.2 ppm (2 mg/m3), Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROGLYCERIN-air short term exposure limit 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50890;
Number of Industries 4;
Total Number of Facilities 413;
Number of Occupations 10;
Total Number of Employees Exposed 4,331
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50890;
Number of Industries 3;
Total Number of Facilities 384;
Number of Occupations 9;
Total Number of Employees Exposed 38,471;
Total Number of Female Employees Exposed 29,144


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a high exploxive and as a vasodilator
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitroglycerin, 2507
OSHA ANALYTICAL METHOD #43


REFERENCES:

CODEN
REFERENCE

AAPSP* AAPS pharmSci (electronic resource) (Alexandria, Va. : American Association of Pharmaceutical Scientists) V.1- 1999-
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BIPBU* Biological & pharmaceutical bulletin. (Pharmaceutical Society of Japan, 2-12-15, Shibuya, Shibuya-ku, Tokyo 150-0002, Japan) V.1- 1993-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
HUTOX*
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MOCAE8 Molecular Carcinogenesis. (John Wiley & Sons, 605 Third Avenue, New York, NY 10158) V.1- 1988-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NAYXEW Nanjing Yixueyuan Xuebao. Journal of Nanjing Medical College. (Nanjing Yixueyuan, 140 Hanzhonglu, Nanjing, Peop. Rep. China) V.1- 1981(?)-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
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Used as a high exploxive and as a vasodilator

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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