Nitrogen trifluoride
RTECS #
QX1925000
CAS #
Updated
December 2018
Molecular Weight
71.01
Molecular Formula
F3N
Synonyms
Nitrogen fluoride (NF3)
Nitrogen trifluoride (ACGIH:OSHA)
Perfluoroammonia
Trifluoroammonia
Nitrogen trifluoride (ACGIH:OSHA)
Perfluoroammonia
Trifluoroammonia
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lethal concentration (50 percent kill): 9600 ppm/1H | Lung, Thorax, or Respiration: Cyanosis Blood: Methemoglobinemia- Carboxhemoglobinemia | AMRL** TR-69-84,1969 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 200 mg/m3 | Blood: Other changes Blood: Changes in erythrocyte (RBC) count | TOVEFN (2),37,2001 |
| inhalation/monkey | lethal concentration (50 percent kill): 7500 ppm/1H | Lung, Thorax, or Respiration: Cyanosis Blood: Methemoglobinemia- Carboxhemoglobinemia | AMRL** TR-69-84,1969 |
| inhalation/mouse | lethal concentration (50 percent kill): 2000 ppm/4H | 34ZIAG -,427,1969 | |
| inhalation/rat | lethal concentration (50 percent kill): 6700 ppm/1H | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis Lung, Thorax, or Respiration: Respiratory stimulation | TXAPA9 26,1,1973 |
| inhalation/rat | lethal concentration (50 percent kill): 7900 mg/m3 | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Cyanosis Lung, Thorax, or Respiration: Respiratory depression | TOVEFN (2),37,2001 |
| inhalation/rat | lethal concentration (16 percent kill): 4250 mg/m3 | Vascular: Other changes Lung, Thorax, or Respiration: Other changes Liver: Other changes | TOVEFN (2),37,2001 |
| inhalation/rat | lethal concentration (16 percent kill): 4250 mg/m3 | Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney Kidney, Ureter, and Bladder: Urine volume increased Kidney, Ureter, and Bladder: Other changes in urine composition | TOVEFN (2),37,2001 |
| inhalation/rat | lethal concentration (16 percent kill): 4250 mg/m3 | Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in spleen Biochemical: Metabolism (intermediary): Other | TOVEFN (2),37,2001 |
| intraperitoneal/rat | lethal dose (50 percent kill): 26 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | TXAPA9 17,585,1970 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 98.7 mg/m3/122D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Liver: Other changes | TOVEFN (2),37,2001 |
| inhalation/rat | lowest published toxic concentration: 98.7 mg/m3/122D- intermittent | Kidney, Ureter, and Bladder: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Other changes | TOVEFN (2),37,2001 |
| inhalation/rat | lowest published toxic concentration: 98.7 mg/m3/122D- intermittent | Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TOVEFN (2),37,2001 |
| inhalation/rat | lowest published toxic concentration: 10.2 mg/m3/182D- intermittent | Cardiac: Other changes Liver: Other changes Blood: Other changes | TOVEFN (2),37,2001 |
| inhalation/rat | lowest published toxic concentration: 10.2 mg/m3/182D- intermittent | Blood: Changes in erythrocyte (RBC) count | TOVEFN (2),37,2001 |
| inhalation/rat | lowest published toxic concentration: 1.18 mg/m3/182D- intermittent | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes Liver: Other changes | TOVEFN (2),37,2001 |
| inhalation/rat | lowest published toxic concentration: 1.18 mg/m3/182D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | TOVEFN (2),37,2001 |
| inhalation/rat | lowest published toxic dose: 100 ppm/7H/19W- intermittent | Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Interstitial nephritis Blood: Changes in spleen | TXAPA9 4,770,1962 |
| inhalation/rat | lowest published toxic concentration: 100 ppm/6H/2W- intermittent | Blood: Normocytic anemia | NTIS** OTS0559285 |
| intraperitoneal/rabbit | lowest published toxic dose: 85 gm/kg/29D- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen | TXAPA9 4,770,1962 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 ppm | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 ppm (29 mg/m3) | DTLVS* 3,187,1971 |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (29 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 2.5 mg(F)/m3, JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 ppm (29 mg/m3), MAR2002 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 2.5 mg(F)/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 10 ppm (29 mg/m3), MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 2.5 mg(F)/m3, JUN2000 | |
| Occupational Exposure Limit-FINLAND | short term exposure limit 10 ppm (29 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 2.5 mg(F)/m3, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 ppm (30 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 1 mg(F)/m3, inhal, 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 10 ppm (29 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 ppm (30 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 ppm (30 mg/m3);short term exposure limit 15 ppm (45 mg/m3), 2004 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 2.5 mg(F)/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 ppm (29 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2.5 mg(F)/m3, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 ppm (29 mg/m3), JUL2005 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 30 mg/m3, short term exposure limit 10 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 ppm (30 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 29 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 2.5 mg(F)/m3, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 10 ppm (29 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 10 ppm (29 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 10 ppm (29 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 10 ppm (29 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROGEN TRIFLUORIDE-air | 10H time-weighted average 10 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 50885; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1096; Total Number of Female Employees Exposed 140 | |
| National Occupational Hazard Survey 1974 | Hazard Code 50885; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health