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Nitrogen dioxide

RTECS #: QW9800000

CAS #: 10102-44-0


UPDATE: May 2009 MW: 46.01 MF: NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Azote (French)
  2. Azoto (Italian)
  3. Nitrito
  4. Nitrogen dioxide (ACGIH:OSHA)
  1. Nitrogen peroxide
  2. RCRA waste number P078
  3. Stickstoffdioxid (German)
  4. Stikstofdioxyde (Dutch)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster fibroblast 10 ppm/10 minute- continuous MUREAV 89,303,1981
cytogenetic analysis inhalation
rat
27 ppm/3 hour- continuous MUREAV 136,119,1984
DNA adduct inhalation
rat
108 mg/kg/300 day- intermittent CALEDQ 139,189,1999
DNA damage hamster lung 10 ppm CRNGDP 11,37,1990
unscheduled DNA synthesis inhalation
rat
30 ppm/1 hour ENVRAL 27,352,1982
mutation in microorganisms Escherichia coli 198 g/L (-enzymatic activation step) MUREAV 162,1,1986
mutation in microorganisms Salmonella typhimurium 6 ppm (+enzymatic activation step) MUREAV 136,119,1984
mutation in microorganisms Salmonella typhimurium 5 ppm (-enzymatic activation step) EMMUEG 11,65,1988
mutation in mammalian somatic cells inhalation
rat
15 ppm/3 hour- continuous MUREAV 136,119,1984
other mutation test systems Escherichia coli 297 g/L MUREAV 162,1,1986
other mutation test systems Salmonella typhimurium 50 ppm MUREAV 192,239,1987
sister chromatid exchange hamster lung 5 ppm/10 minute- continuous MUREAV 89,303,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic dose: 22 ppm (7-18 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NRTXDN 9,545,1988
inhalation
rat
lowest published toxic concentration: 10 mg/m3/6 hour (1-22 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTOTDY 7,785,1985
inhalation
rat
lowest published toxic concentration: 85 g/m3/24 hour (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 42(12),22,1977
inhalation
rat
lowest published toxic concentration: 800 g/m3/24 hour (1-22 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) GISAAA 42(12),22,1977
inhalation
rat
lowest published toxic concentration: 2,360 g/m3/12 hour (12 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HYSAAV 36(7-9),178,1971
inhalation
rat
lowest published toxic concentration: 100 g/m3/6 hour (1-22 day pregnant) Reproductive: Effects on newborn: Behavioral NTOTDY 7,785,1985
inhalation
rat
lowest published toxic concentration: 40 pph (8-10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
VCVN5* -,37,1989
inhalation
rat
lowest published toxic concentration: 40 pph (12-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
VCVN5* -,37,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 108 mg/kg/300 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Facilitates action of known carcinogens

Lung, Thorax, or Respiration: Tumors
CALEDQ 139,189,1999


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published lethal concentration: 123 mg/m3/8 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 9,160,1966
inhalation
dog
lowest published lethal concentration: 110 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
VCVN5* -,35,1993
inhalation
dog
lowest published toxic concentration: 19 mg/m3/6 hour Blood: Methemoglobinemia- Carboxhemoglobinemia VCVN5* -,35,1993
inhalation
dog
lowest published toxic concentration: 37.2 ppm/4 hour Lung, Thorax, or Respiration: Acute pulmonary edema EXMPA6 33,90,1980
inhalation
guinea pig
lethal concentration (50 percent kill): 30 ppm/1 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Methemoglobinemia- Carboxhemoglobinemia
AEHLAU 10,220,1965
inhalation
guinea pig
lethal concentration (50 percent kill): 900 mg/m3/30 minute N/R VCVN5* -,28,1993
inhalation
human
lowest published lethal concentration: 200 ppm/1 minute N/R AOHYA3 17,159,1974
inhalation
human
lowest published toxic concentration: 200 mg/m3 Lung, Thorax, or Respiration: Cough VCVN5* -,28,1993
inhalation
human
lowest published toxic concentration: 90 mg/m3/15 minute Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands
VCVN5* -,28,1993
inhalation
human
lowest published toxic concentration: 0.2 mg/m3 Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Cough
VCVN5* -,36,1993
inhalation
human
lowest published toxic concentration: 0.14 mg/m3/5 hour Eye: Other eye effects VCVN5* -,36,1993
inhalation
human
lowest published toxic concentration: 0.59 mg/m3/5 minute Brain and Coverings: Changes in surface EEG VCVN5* -,36,1993
inhalation
human
lowest published toxic concentration: 14 mg/m3 Eye: Conjunctiva irritation VCVN5* -,36,1993
inhalation
human
lowest published toxic concentration: 120 mg/m3 Lung, Thorax, or Respiration: Dyspnea VCVN5* -,36,1993
inhalation
human
lowest published toxic concentration: 70 mg/m3 Behavioral: Muscle weakness VCVN5* -,36,1993
inhalation
human
lowest published toxic concentration: 38 mg/m3/2 hour Blood: Methemoglobinemia- Carboxhemoglobinemia VCVN5* -,36,1993
inhalation
human
lowest published toxic concentration: 510 mg/m3/5 minute Lung, Thorax, or Respiration: Other changes VCVN5* -,36,1993
inhalation
human
lowest published toxic concentration: 950 mg/m3/5 minute Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,36,1993
inhalation
human
lowest published toxic concentration: 0.5 ppm/2 hour Eye: Conjunctiva irritation

Behavioral: Headache

Lung, Thorax, or Respiration: Dyspnea
TOXID9 44,301,2005
inhalation
man
lowest published toxic concentration: 2 ppm/4 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
INHTE5 11,89,1999
inhalation
man
lowest published toxic concentration: 6,200 ppb/10 minute Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance KEKHA7 17,337,1968
inhalation
man
lowest published toxic concentration: 90 ppm/40 minute Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
JOCMA7 8,301,1966
inhalation
man
lowest published toxic concentration: 30 ppm/70 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
TOXID9 44,301,2005
inhalation
man
lowest published toxic concentration: 30 ppm/70 minute Lung, Thorax, or Respiration: Sputum TOXID9 44,301,2005
inhalation
monkey
lowest published lethal concentration: 123 mg/m3/8 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 9,160,1966
inhalation
monkey
lowest published lethal concentration: 95 mg/m3/2 hour N/R VCVN5* -,36,1993
inhalation
monkey
lowest published toxic concentration: 50 ppm/2 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
TOXID9 44,301,2005
inhalation
mouse
lethal concentration (50 percent kill): 1,000 ppm/10 minute Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
JCTODH 4,246,1977
inhalation
mouse
lethal concentration (50 percent kill): 800 mg/m3/25 minute N/R VCVN5* -,28,1993
inhalation
mouse
lethal concentration (50 percent kill): 900 mg/m3/2 hour N/R VCVN5* -,35,1993
inhalation
mouse
lowest published toxic concentration: 9.5 mg/m3/1 hour Blood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVN5* -,35,1993
inhalation
rat
lethal concentration (50 percent kill): 220 mg/m3/1 hour Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,35,1993
inhalation
rat
lethal concentration (50 percent kill): 310 mg/m3/30 minute Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,35,1993
inhalation
rat
lethal concentration (50 percent kill): 790 mg/m3/5 minute Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,35,1993
inhalation
rat
lowest published toxic concentration: 4 mg/m3/17 hour Lung, Thorax, or Respiration: Other changes VCVN5* -,35,1993
inhalation
rat
lowest published toxic concentration: 32 mg/m3/2 hour Lung, Thorax, or Respiration: Ciliary function changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
VCVN5* -,35,1993
inhalation
rat
lowest published toxic concentration: 25 mg/m3/2 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,35,1993
inhalation
rat
lowest published toxic concentration: 22.7 mg/m3/4 hour Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Endocrine: Other changes
VCVN5* -,35,1993
inhalation
rat
lowest published toxic concentration: 1.9 mg/m3/4 hour Lung, Thorax, or Respiration: Other changes VCVN5* -,35,1993
inhalation
rat
lowest published toxic concentration: 20 ppm/20 hour Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 6,149,1980
inhalation
rat
lowest published toxic concentration: 200 ppm/15 minute Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 184,1,2002
inhalation
rat
lethal concentration (50 percent kill): 200 ppm/30 minute N/R ENTOX* -,639,2005
inhalation
rat
lethal concentration (50 percent kill): 88 ppm/4 hour N/R ENTOX* -,244,2005
inhalation
rat
lowest published toxic concentration: 58 mg/m3/4 hour Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Changes in adrenal weight
TPKVAL 15,53,1979
inhalation
rat
lowest published toxic concentration: 20 mg/m3/4 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects TPKVAL 15,53,1979
inhalation
rat
lowest published toxic concentration: 0.475 gm/m3/4 hour Behavioral: Alteration of classical conditioning TPKVAL 9,37,1967
inhalation
rabbit
lethal concentration (50 percent kill): 315 ppm/15 minute Lung, Thorax, or Respiration: Respiratory depression

Eye: Conjunctiva irritation
AIHAAP 23,457,1962
inhalation
rabbit
lethal concentration (50 percent kill): 60 mg/m3/15 minute N/R VCVN5* -,35,1993
inhalation
rabbit
lethal concentration (50 percent kill): 12 mg/m3/15 minute Eye: Conjunctiva irritation VCVN5* -,35,1993
inhalation
rabbit
lowest published toxic concentration: 28 mg/m3/3 hour Immunological Including Allergic: Decrease in cellular immune response VCVN5* -,35,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 15 ppm/24 hour/10 week- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
AEHLAU 10,220,1965
inhalation
guinea pig
lowest published toxic concentration: 3,284 g/m3/8 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
BCTKAG 8,241,1975
inhalation
guinea pig
lowest published toxic concentration: 68 mg/m3/8 hour/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
guinea pig
lowest published toxic concentration: 17 mg/m3/24 hour/4 week- continuous Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Effect on specific coenzyme: Proportion of isoenzymes
VCVN5* -,37,1989
inhalation
guinea pig
lowest published toxic concentration: 22 mg/m3/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
guinea pig
lowest published toxic concentration: 0.9 mg/m3/6 hour/13 week- intermittent Immunological Including Allergic: Decreased immune response VCVN5* -,38,1989
inhalation
guinea pig
lowest published toxic concentration: 5 ppm/2 hour/35 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Lipids including transport
JPFCD2 B27,53,1992
inhalation
guinea pig
lowest published toxic concentration: 5,800 g/m3/4 hour/17 week- intermittent Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
TPKVAL 15,53,1979
inhalation
guinea pig
lowest published toxic concentration: 5,800 g/m3/4 hour/91 day- intermittent Olfaction: Change in sensation of smell

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 15,53,1979
inhalation
guinea pig
lowest published toxic concentration: 5,800 g/m3/4 hour/8 day- intermittent Lung, Thorax, or Respiration: Other changes TPKVAL 15,53,1979
inhalation
hamster
lowest published toxic concentration: 30 ppm/22 hour/36 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi EXLRDA 11,179,1986
inhalation
human
lowest published toxic concentration: 1.9 mg/m3/2 hour/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
VCVN5* -,36,1989
inhalation
human
lowest published toxic concentration: 0.8 mg/m3/3 year- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Blood: Change in clotting factors
VCVN5* -,38,1989
inhalation
mammal (species unspecified)
lowest published toxic concentration: 10 ppm/4 hour/15 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes
TOLED5 73,241,1994
inhalation
monkey
lowest published toxic concentration: 9.5 mg/m3/24 hour/8 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,36,1989
inhalation
monkey
lowest published toxic concentration: 68 mg/m3/8 hour/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
monkey
lowest published toxic concentration: 22 mg/m3/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
mouse
lowest published toxic concentration: 250 ppb/7 hour/7 week- intermittent Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
JTEHD6 25,247,1988
inhalation
mouse
lowest published toxic concentration: 20 ppm/24 hour/4 day- continuous Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
ENVRAL 42,446,1987
inhalation
mouse
lowest published toxic concentration: 10 ppm/2 hour/30 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Blood: Pigmented or nucleated red blood cells
ENVRAL 19,154,1979
inhalation
mouse
lowest published toxic concentration: 500 ppb/30 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi NKYZA2 10,16,1972
inhalation
mouse
lowest published toxic concentration: 5.7 mg/m3/2 hour/15 week- intermittent Blood: Normocytic anemia

Immunological Including Allergic: Decrease in cellular immune response
VCVN5* -,37,1989
inhalation
mouse
lowest published toxic concentration: 5.7 mg/m3/2 hour/1 year- intermittent Lung, Thorax, or Respiration: Other changes VCVN5* -,37,1989
inhalation
mouse
lowest published toxic concentration: 9.5 mg/m3/6 hour/1 year- intermittent Lung, Thorax, or Respiration: Tumors VCVN5* -,37,1989
inhalation
mouse
lowest published toxic concentration: 0.9 mg/m3/6 hour/13 week- intermittent Immunological Including Allergic: Decreased immune response VCVN5* -,38,1989
inhalation
mouse
lowest published toxic concentration: 0.7 ppm/2 hour/3 day- intermittent Lung, Thorax, or Respiration: Other changes JTEHD6 65,1999,2002
inhalation
mouse
lowest published toxic concentration: 0.7 ppm/3 day- intermittent Biochemical: Metabolism (intermediary): Other

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 1,71,2001
inhalation
mouse
lowest published toxic concentration: 5 ppm/4 hour/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,295,2008
inhalation
mouse
lowest published toxic concentration: 25 ppm/4 hour/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,295,2008
inhalation
rat
lowest published toxic concentration: 2 ppm/24 hour/14 day- continuous Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
JTEHD6 15,23,1985
inhalation
rat
lowest published toxic concentration: 16 ppm/23 hour/74 week- continuous Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Changes in lung weight
ARDSBL 121,541,1980
inhalation
rat
lowest published toxic concentration: 5,700 g/m3/6 hour/26 week- intermittent Endocrine: Other changes GISAAA 26(12),79,1961
inhalation
rat
lowest published toxic concentration: 3 ppm/24 hour/39 week- continuous Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Lipids including transport
AEHLAU 26,156,1973
inhalation
rat
lowest published toxic concentration: 2 ppm/24 hour/1 year- continuous Lung, Thorax, or Respiration: Changes in lung weight AEHLAU 17,181,1968
inhalation
rat
lowest published toxic concentration: 4 ppm/24 hour/14 week- continuous Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
ENVRAL 41,184,1986
inhalation
rat
lowest published toxic concentration: 8 ppm/24 hour/7 day- continuous Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
AECTCV 15,733,1986
inhalation
rat
lowest published toxic concentration: 5 ppm/24 hour/4 week- continuous Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
BECTA6 40,139,1988
inhalation
rat
lowest published toxic concentration: 10 ppm/3 day- continuous Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in cellular immune response
TOLED5 121,135,2001
inhalation
rat
lowest published toxic concentration: 68 mg/m3/8 hour/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
rat
lowest published toxic concentration: 50 mg/m3/24 hour/2 week- continuous Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema
VCVN5* -,37,1989
inhalation
rat
lowest published toxic concentration: 17 mg/m3/4 hour/10 day- intermittent Lung, Thorax, or Respiration: Other changes VCVN5* -,37,1989
inhalation
rat
lowest published toxic concentration: 22 mg/m3/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
rat
lowest published toxic concentration: 5 mg/m3/5 day/39 week- continuous Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVN5* -,38,1989
inhalation
rat
lowest published toxic concentration: 5 mg/m3/5 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVN5* -,38,1989
inhalation
rat
lowest published toxic concentration: 3.8 mg/m3/24 hour/2 year- continuous Lung, Thorax, or Respiration: Ciliary function changes VCVN5* -,38,1989
inhalation
rat
lowest published toxic concentration: 2.4 mg/m3/12 hour/13 week- intermittent Endocrine: Effect on menstrual cycle VCVN5* -,38,1989
inhalation
rat
lowest published toxic concentration: 0.9 mg/m3/6 hour/13 week- intermittent Immunological Including Allergic: Decreased immune response VCVN5* -,38,1989
inhalation
rat
lowest published toxic concentration: 0.6 mg/m3/24 hour/13 week- continuous Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)
VCVN5* -,38,1989
inhalation
rat
lowest published toxic concentration: 5,800 g/m3/4 hour/17 week- intermittent Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
TPKVAL 15,53,1979
inhalation
rat
lowest published toxic concentration: 5,800 g/m3/4 hour/91 day- intermittent Olfaction: Change in sensation of smell

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 15,53,1979
inhalation
rat
lowest published toxic concentration: 5,800 g/m3/4 hour/8 day- intermittent Lung, Thorax, or Respiration: Other changes TPKVAL 15,53,1979
inhalation
rabbit
lowest published toxic concentration: 68 mg/m3/8 hour/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
rabbit
lowest published toxic concentration: 22 mg/m3/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 3 ppm;short term exposure limit 5 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 558,7,2004
TOXICOLOGY REVIEW
FEPRA7 35,89,1976
TOXICOLOGY REVIEW
NTIS** PB228-002
TOXICOLOGY REVIEW
CTOXAO 7,145,1974
TOXICOLOGY REVIEW
AEHLAU 16,903,1968
TOXICOLOGY REVIEW
NTIS** CONF-691001
TOXICOLOGY REVIEW
AEHLAU 12,522,1966
TOXICOLOGY REVIEW
XPHBAO 272,1,1941
TOXICOLOGY REVIEW
DIMON* 46,551,2000
TOXICOLOGY REVIEW
ENTOX* -,639,2005
TOXICOLOGY REVIEW
ENTOX* -,244,2005
TOXICOLOGY REVIEW
HUTOX* -,661,1996
TOXICOLOGY REVIEW
MUREAV 543,195,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 5 ppm (9 mg/m3) DTLVS* 3,185,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 ppm (9 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 ppm (9 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 ppm (9 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 ppm (9 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 3 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 ppm (5.6 mg/m3), short term exposure limit 5 ppm (9.4 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 3 ppm (5.7 mg/m3), short term exposure limit 5 ppm (9.5 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 2 ppm (4 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 3 ppm (6 mg/m3), short term exposure limit 6 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VLE 3 ppm (6 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 9 mg/m3, short term exposure limit 9 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit Pending, APR2007
Occupational Exposure Limit - KOREA time-weighted average 3 ppm (6 mg/m3), short term exposure limit 5 ppm (10 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 3 ppm (6 mg/m3);
short term exposure limit 5 ppm (10 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 3 ppm (5.6 mg/m3), short term exposure limit 5 ppm (9.4 mg/m3), JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (9 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 2 ppm (4 mg/m3), ceiling concentration 5 ppm (10 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 3 ppm (6 mg/m3),KZG- week 3 ppm (6 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 5 ppm (9 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (9 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROGEN DIOXIDE-air short term exposure limit 1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50870;
Number of Industries 16;
Total Number of Facilities 424;
Number of Occupations 19;
Total Number of Employees Exposed 11,419
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50870;
Number of Industries 5;
Total Number of Facilities 94;
Number of Occupations 24;
Total Number of Employees Exposed 18,737;
Total Number of Female Employees Exposed 1,773


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical and chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitric oxide and nitrogen dioxide, 6014
OSHA ANALYTICAL METHOD #ID-109
OSHA ANALYTICAL METHOD #ID-182


REFERENCES:

CODEN
REFERENCE

AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EXLRDA Experimental Lung Research. (Hemisphere Publishing, c/o Taylor & Francis 1900 Frost Road, Suite 101, Bristol, PA 19007) V.1- 1980-
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JCTODH Journal of Combustion Toxicology. (Westport, CT) V.3-9, 1976-82.
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67. For publisher information, see:JJOMDZ
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KEKHA7 Koshu Eiseiin Kenkyu Hokoku. Bulletin of the Institute of Public Health. (Kokuritsu Koshu Eiseiin, 4-6-1 Shirokanedai Minato-ku, Tokyo 108, Japan) V.1- 1951-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NKYZA2 Japanaese Journal of Thoracic Diseases. (Nihon Kyobu Shikkan Gakkai Zasshi, c/o Toyo Bunko, No. 28-21, 2-Chome, Kamagome, Bunkyo-ku, Tokyo 112 Japan) V.10- 1972-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used as an industrial chemical and chemical intermediate

NIOSH PROFILE (DIESEL EMISSIONS), SRI, 2/77

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

NIOSH PROFILE (INCINERATION), FIRL, 4/78

NIOSH PROFILE (WELDING AND BRAZING), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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