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Molybdenum

RTECS #: QA4680000

CAS #: 7439-98-7


UPDATE: May 2009 MW: 95.94 MF: Mo


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Molybdate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis inhalation
rat
19,500 g/m3 GTPZAB 24(9),33,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 448 mg/kg (multigenerations) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
AEHLAU 23,102,1971
oral
rat
lowest published toxic dose: 6,050 g/kg (35 week prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
GISAAA 42(8),30,1977
oral
rat
lowest published toxic dose: 5,800 g/kg (30 week prior to copulation/1-20 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FATOAO 41,620,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratracheal
rabbit
lowest published lethal dose: 70 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) NTIS** PB249-458


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 7 mg/kg/2 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
VCVN5* -,317,1989
oral
rabbit
lowest published toxic dose: 66.5 mg/kg/19 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,317,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 3 mg/m3 (resp);time-weighted average 10 mg/m3 (inhal) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
JAVMA4 164,277,1974
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
ENTOX* -,145,2005
TOXICOLOGY REVIEW
HBTME* ,731,2007
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg(Mo)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 mg/m3 (total dust);
time-weighted average 5 mg/m3 (resp. dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 48625;
Number of Industries 17;
Total Number of Facilities 935;
Number of Occupations 29;
Total Number of Employees Exposed 6,097
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5919;
Number of Industries 2;
Total Number of Facilities 29;
Number of Occupations 6;
Total Number of Employees Exposed 2,426;
Total Number of Female Employees Exposed 1,114
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5984;
Number of Industries 5;
Total Number of Facilities 187;
Number of Occupations 11;
Total Number of Employees Exposed 4,474;
Total Number of Female Employees Exposed 2,432
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 48625;
Number of Industries 173;
Total Number of Facilities 15,780;
Number of Occupations 88;
Total Number of Employees Exposed 238,124;
Total Number of Female Employees Exposed 4,166


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as alloying element
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Metals in urine, 8310
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
OSHA ANALYTICAL METHOD #ID121
OSHA ANALYTICAL METHOD #ID125G


REFERENCES:

CODEN
REFERENCE

AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBTME*
HTOPA*
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as alloying element

NIOSH PROFILE (MOLYBDENUM AND ITS COMPOUNDS), SRC, 12/79

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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