CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Mineral oil

RTECS #: PY8030000

CAS #: 8012-95-1


UPDATE: May 2009 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Adepsine oil
  2. Alboline
  3. Bayol 55
  4. Bayol F
  5. Blandlube
  6. Crystol 325
  7. Crystosol
  8. Glymol
  9. Kondremul
  10. Liquid paraffin
  11. Neo - cultol
  1. Nujol
  2. Oil mist, mineral
  3. Oil mist, mineral (ACGIH:OSHA)
  4. Paraffin oil
  5. Paroleine
  6. Petrogalar
  7. Primol 355
  8. Primol D
  9. Saxol
  10. USP mineral oil


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg moderate AJOPAA 29,1363,1946
skin
guinea pig
100 mg/24 hour mild CTOIDG 94(8),41,1979
skin
rabbit
100 mg/24 hour mild CTOIDG 94(8),41,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
man
lowest published toxic concentration: 5 mg/m3/5 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
JJOMDZ 23,333,1981
intraperitoneal
mouse
lowest published toxic dose: 14 gm/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Lung, Thorax, or Respiration: Bronchogenic carcinoma
NATUAS 193,1086,1962
intraperitoneal
mouse
toxic dose : 60 gm/kg/17 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Tumors
CNREA8 38,703,1978
intraperitoneal
mouse
toxic dose : 60 gm/kg/17 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
IMMUAM 17,481,1969
intraperitoneal
mouse
toxic dose : 50 gm/kg/9 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Tumors

Immunological Including Allergic: Decreased immune response
IJCNAW 6,422,1970
intraperitoneal
mouse
toxic dose : 72 gm/kg/26 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Tumors
JOIMA3 92,747,1962
skin
mouse
lowest published toxic dose: 332 gm/kg/20 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
ANYAA9 132,439,1965


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 4 gm/m3/4 hour Behavioral: Somnolence (general depressed activity)

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 -,221,2008
intraperitoneal
mouse
lowest published toxic dose: 20 mL/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Autoimmune (multiple organ involvement)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BIPHEX 58,325,2004
oral
mouse
lethal dose (50 percent kill): 22 gm/kg N/R ATXKA8 30,243,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 70 mg/m3/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Lung, Thorax, or Respiration: Other changes
VCVPS* -,91,1998
oral
rat
lowest published toxic dose: 900 mg/kg/90 day- continuous Immunological Including Allergic: Decrease in humoral immune response TOXID9 60,30,2001
skin
mouse
lowest published toxic dose: 20,800 ÁL/kg/13 week- intermittent Liver: Changes in liver weight NTPTR* NIH-92-3340
skin
rat
lowest published toxic dose: 5,200 ÁL/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-92-3340


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3;short term exposure limit 10 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
PAASAH 54,171,1959
TOXICOLOGY REVIEW
BIPHEX 58,325,2004
TOXICOLOGY REVIEW
BIPHEX 58,325,2004
TOXICOLOGY REVIEW
BIPHEX 58,325,2004
TOXICOLOGY REVIEW
BIPHEX 58,325,2004
TOXICOLOGY REVIEW
DIMON* 39,678,1993


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,225,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 (particulate) DTLWS* 3,25,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3 (particulate), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - HUNGARY ceiling concentration 5 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 3 mg/m3, group 1 carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, short term exposure limit 10 ppm, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg/m3;
short term exposure limit 3 mg/m3, JUN2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T1542;
Number of Industries 3;
Total Number of Facilities 22;
Number of Occupations 7;
Total Number of Employees Exposed 698
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1542;
Number of Industries 275;
Total Number of Facilities 49,328;
Number of Occupations 178;
Total Number of Employees Exposed 1,100,229;
Total Number of Female Employees Exposed 433,405


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in cosmetics, pharmaceutical bases, food and fiber production, as carriers and bases
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Oil mist, mineral, 5026
NTP 9th Report on Carcinogens, 2000:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BIPHEX Biomedicine & Pharmacotherapy (Editions Scientifiques et Medicales Elsevier, Journals Fulfilment Department, 23 rue Linois, F -75724 Paris Cedex 15, France OR Editions Scientifiques et Medicales Elsevier, P.O.BOX 7247-7576, Philadelphia, PA 19170-7576,USA) V. 36- Jan.1982-)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IMMUAM Immunology. (Blackwell Scientific Pub., 52 Beacon St., Boston, MA 02108) V.1- 1958-
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
JOIMA3 Journal of Immunology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1916-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PAASAH Publication of the American Association for the Advancement of Science. (Washington, DC) No.1-94, 1934-73. Discontinued.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used in cosmetics, pharmaceutical bases, food and fiber production, as carriers and bases

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Human Data
   Primary Irritant

ALT CAS #: 39355-35-6
ALT CAS #: 79956-36-8
ALT CAS #: 83046-05-3
Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us