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1,3,4 - Metheno - 2H - cyclobuta (cd) pentalen - 2 - one, 1,1a,3,3a,4,5,5,5a,5b,6 - decachloroctahydro -

RTECS #: PC8575000

CAS #: 143-50-0


UPDATE: May 2009 MW: 490.60 MF: C10Cl10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1a,3,3a,4,5,5,5a,5b,6 - Decachlorooctahydro - 1,3,4 - metheno - 2H - cyclobuta (cd) pentalen - 2 - one
  2. 1,2,3,5,6,7,8,9,10,10 - Decachloro (5.2.1.0 (sup 2,6) .0 (sup 3,9) .0 (sup 5,8) ) decano - 4 - one
  3. Chlordecone
  4. Ciba 8514
  5. Clordecone
  6. Compound 1189
  7. Decachloroketone
  8. Decachloro - 1,3,4 - metheno - 2H - cyclobuta (cd) pentalen - 2 - one
  9. Decachlorooctahydro - 1,3,4 - metheno - 2H - cyclobuta (cd) pentalen - 2 - one
  10. Decachloropentacyclo (5.2.1.0 (sup 2,6) .0 (sup 3,9) .0 (sup 5,8) ) decan - 4 - one
  1. Decachloropentacyclo (5.3.0.0 (sup 2,6) .0 (sup 4,10) .0 (sup 5,9) ) decan - 3 - one
  2. Decachlorotetracyclodecanone
  3. Decachlorotetrahydro - 4,7 - methanoindeneone
  4. ENT 16,391
  5. GC 1189
  6. General chemicals 1189
  7. Kepone
  8. NCI - C00191
  9. RCRA waste number U142


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
other mutation test systems rat liver 100 mol/L TIVIEQ 4,179,1990
sister chromatid exchange hamster ovary 1,700 g/L EMMUEG 10(Suppl 10),1,1987
specific locus test intraperitoneal
mouse
71.3 mol/L MUREAV 608,29,2006
sperm morphology oral
quail
200 ppm/42 day- continuous TXAPA9 43,535,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 25 mg/kg (1 day prior to copulation) Reproductive: Other effects on female REPTED 5,65,1991
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
NTOTDY 8,121,1986
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) REPTED 1,105,1987/1988
intraperitoneal
rat
lowest published toxic dose: 75 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 5,65,1991
intraperitoneal
rat
lowest published toxic dose: 60 mg/kg (18-22 day pregnant/7 day after birth) Reproductive: Effects on newborn: Physical HBPTO* 1,733,2001
intraperitoneal
rat
lowest published toxic dose: 5 mg/kg (16 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
NETEEC 29,255,2007
oral
mouse
lowest published toxic dose: 16,500 g/kg (4 week male/4 week prior to copulation) Reproductive: Effects on fertility: Other measures of fertility JEENAI 58,754,1965
oral
mouse
lowest published toxic dose: 120 mg/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 38,189,1976
oral
mouse
lowest published toxic dose: 100 mg/kg (8-12 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JTEHD6 10,541,1982
oral
mouse
lowest published toxic dose: 120 mg/kg (8-12 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 6,361,1986
oral
mouse
lowest published toxic dose: 72 mg/kg (30 day male/30 day prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) HBPTO* 1,732,2001
oral
mouse
lowest published toxic dose: 60 mg/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death VCVGK* -,484,1994
oral
rat
lowest published toxic dose: 63 mg/kg (2-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOLED5 4,247,1979
oral
rat
lowest published toxic dose: 42 mg/kg (2-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects TXAPA9 41,142,1977
oral
rat
lowest published toxic dose: 100 mg/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Homeostasis
TXAPA9 38,189,1976
oral
rat
lowest published toxic dose: 60 mg/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 38,189,1976
oral
rat
lowest published toxic dose: 17 mg/kg (1-22 day pregnant/12 day after birth) Reproductive: Effects on newborn: Behavioral FEPRA7 40,667,1981
oral
rat
lowest published toxic dose: 18 mg/kg (5 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TOLED5 30,237,1986
oral
rat
lowest published toxic dose: 105 mg/kg (14-20 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
ENVRAL 18,437,1979
oral
rat
lowest published toxic dose: 40 mg/kg (1 day prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) VCVGK* -,483,1994
oral
rat
lowest published toxic dose: 25 mg/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death VCVGK* -,484,1994
oral
rat
lowest published toxic dose: 47 mg/kg (60 day prior to copulation-12 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
NRTXDN 3,131,1982
oral
rat
lowest published toxic dose: 30.9 mg/kg (60 day prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Delayed effects
NRTXDN 3,119,1982
oral
rat
lowest published toxic dose: 88.2 mg/kg (7 week male) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) FEPRA7 37,501,1978
subcutaneous
rat
lowest published toxic dose: 2 mg/kg (2 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina ENVRAL 16,131,1978
subcutaneous
rat
lowest published toxic dose: 10 mg/kg (2 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes ENVRAL 16,131,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 1,200 mg/kg/80 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-b,1976
oral
mouse
toxic dose : 1,340 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
AIHAAP 37,680,1976
oral
mouse
toxic dose : 1,550 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
AIHAAP 37,680,1976
oral
mouse
toxic dose : 1,344 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JTEHD6 4,895,1978
oral
rat
lowest published toxic dose: 200 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NEOLA4 26,231,1979
oral
rat
toxic dose : 670 mg/kg/80 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-b,1976
oral
rat
toxic dose : 504 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
JTEHD6 4,895,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 5 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 -,167,2008
intraperitoneal
rat
lowest published toxic dose: 500 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HBPTO* 1,733,2001
intraperitoneal
rat
lowest published toxic dose: 80 mg/kg Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes
VCVGK* -,483,1994
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NRTXDN 8,15,1987
intraperitoneal
rat
lowest published toxic dose: 75 mg/kg Endocrine: Changes in adrenal weight NRTXDN 8,15,1987
intraperitoneal
rat
lowest published toxic dose: 40 mg/kg Behavioral: Tremor PSEBAA 195,44,1990
intraperitoneal
rat
lowest published toxic dose: 60 mg/kg Endocrine: Other changes

Blood: Other changes
PSEBAA 195,44,1990
oral
chicken
lethal dose (50 percent kill): 480 mg/kg N/R ENTOX* -,542,2005
oral
dog
lethal dose (50 percent kill): 250 mg/kg Behavioral: Tremor VCVGK* -,483,1994
oral
dog
lethal dose (50 percent kill): 250 mg/kg N/R ENTOX* -,542,2005
oral
quail
lethal dose (50 percent kill): 237 mg/kg N/R JRPFA4 48,371,1976
oral
rat
lethal dose (50 percent kill): 91,300 g/kg N/R NTOTDY 5,91,1983
oral
rat
lethal dose (50 percent kill): 96 mg/kg Behavioral: Tremor VCVGK* -,483,1994
oral
rat
lowest published toxic dose: 40 mg/kg Endocrine: Effect on menstrual cycle VCVGK* -,483,1994
oral
rabbit
lethal dose (50 percent kill): 65 mg/kg N/R PCOC** -,642,1966
oral
rabbit
lethal dose (50 percent kill): 65 mg/kg Behavioral: Tremor VCVGK* -,483,1994
subcutaneous
rat
lowest published toxic dose: 100 mg/kg Behavioral: Tremor NRTXDN 3,111,1982
subcutaneous
rat
lowest published toxic dose: 100 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Tremor

Endocrine: Other changes
NRTXDN 3,111,1982
subcutaneous
rat
lowest published toxic dose: 75 mg/kg Endocrine: Other changes TXAPA9 100,506,1989
subcutaneous
rat
lowest published toxic dose: 100 mg/kg Endocrine: Adrenal cortex hypoplasia

Endocrine: Other changes
NTOTDY 7,33,1985
skin
rat
lethal dose (50 percent kill): 2,000 mg/kg N/R VCVGK* -,483,1994
skin
rabbit
lethal dose (50 percent kill): 345 mg/kg N/R GUCHAZ 6,96,1973
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 126 mg/kg N/R 30ZDA9 -,65,1971
unreported route
mammal (species unspecified)
lowest published toxic dose: 25 mg/kg Brain and Coverings: Other degenerative changes VCVGK* -,483,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
implant
mouse
lowest published toxic dose: 400 mg/kg/14 week- continuous Kidney, Ureter, and Bladder: Renal function tests depressed TXCYAC 218,81,2006
implant
mouse
lowest published toxic dose: 40 mg/kg/60 day- continuous Immunological Including Allergic: Autoimmune (multiple organ involvement) TXCYAC 218,81,2006
implant
mouse
lowest published toxic dose: 120 mg/kg/22 week- continuous Kidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes
TXCYAC 218,81,2006
intraperitoneal
mouse
lowest published toxic dose: 83 mg/kg/10 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TXAPA9 49,151,1979
intraperitoneal
mouse
lowest published toxic dose: 199.8 mg/kg/6 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TXAPA9 49,151,1979
intraperitoneal
mouse
lowest published toxic dose: 277.6 mg/kg/4 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TXAPA9 49,151,1979
intraperitoneal
mouse
lowest published toxic dose: 160 mg/kg/20 day- intermittent Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes
TOSCF2 68,473,2002
intraperitoneal
mouse
lowest published toxic dose: 80 mg/kg/2 week- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 60,383,2001
intraperitoneal
rat
lowest published toxic dose: 12,500 g/kg/5 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) PCBPBS 18,113,1982
oral
dog
lowest published toxic dose: 560 mg/kg/2.5 year- continuous Cardiac: Changes in heart weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
TXAPA9 48,29,1979
oral
hamster
lowest published toxic dose: 12 mg/kg/2 day- intermittent Endocrine: Estrogenic HBPTO* 1,732,2001
oral
mouse
lowest published toxic dose: 180 mg/kg/18 day- intermittent Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NRTXDN 2,113,1981
oral
mouse
lowest published toxic dose: 150 mg/kg/3 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Tremor

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TOLED5 6,275,1980
oral
mouse
lowest published toxic dose: 320 mg/kg/10 week- intermittent Liver: Changes in liver weight BECTA6 39,615,1987
oral
mouse
lowest published toxic dose: 240 mg/kg/30 day- intermittent Endocrine: Estrogenic

Endocrine: Effect on menstrual cycle
HBPTO* 1,732,2001
oral
mouse
lowest published toxic dose: 14 mg/kg/14 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) VCVGK* -,483,1994
oral
mouse
lowest published toxic dose: 224 mg/kg/4 week- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes VCVGK* -,484,1994
oral
mouse
lowest published toxic dose: 60 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,484,1994
oral
quail
lowest published toxic dose: 1,470 mg/kg/42 day- continuous Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in testicular weight
TXAPA9 43,535,1978
oral
rat
lowest published toxic dose: 307 mg/kg/15 week- intermittent Behavioral: Alteration of operant conditioning

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature increase
NTOTDY 5,91,1983
oral
rat
lowest published toxic dose: 912 mg/kg/2 year- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 48,29,1979
oral
rat
lowest published toxic dose: 100 mg/kg/10 day- intermittent Endocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Immunological Including Allergic: Decreased immune response
JTEHD6 15,561,1985
oral
rat
lowest published toxic dose: 162 mg/kg/90 day- continuous Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum TXAPA9 59,262,1981
oral
rat
lowest published toxic dose: 287 mg/kg/35 day- continuous Liver: Other changes

Liver: Changes in liver weight
TXAPA9 58,132,1981
oral
rat
lowest published toxic dose: 75 mg/kg/3 day- intermittent Behavioral: Tremor

Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
BECTA6 25,262,1980
oral
rat
lowest published toxic dose: 126 mg/kg/12 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct HBPTO* 1,732,2001
oral
rat
lowest published toxic dose: 81 mg/kg/90 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) HBPTO* 1,733,2001
oral
rat
lowest published toxic dose: 9 mg/kg/15 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 1,880,2001
oral
rat
lowest published toxic dose: 31.5 mg/kg/105 day- continuous Brain and Coverings: Other degenerative changes NRTXDN 3,119,1982
oral
rat
lowest published toxic dose: 50.4 mg/kg/4 week- continuous Endocrine: Androgenic FEPRA7 37,501,1978
oral
rat
lowest published toxic dose: 84 mg/kg/8 week- continuous Endocrine: Effect on menstrual cycle FEPRA7 37,501,1978
oral
rat
lowest published toxic dose: 105 mg/kg/10 week- continuous Endocrine: Estrogenic

Endocrine: Change in LH

Related to Chronic Data: Changes in uterine weight
FEPRA7 37,501,1978
oral
rat
lowest published toxic dose: 1,600 mg/kg/8 day- continuous Liver: Other changes

Endocrine: Other changes
VCVGK* -,484,1994
oral
rat
lowest published toxic dose: 140 mg/kg/14 day- continuous Liver: Other changes

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,484,1994
oral
rat
lowest published toxic dose: 140 mg/kg/14 day- continuous Liver: Other changes

Endocrine: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVGK* -,484,1994
oral
rat
lowest published toxic dose: 25 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,484,1994
oral
rat
lowest published toxic dose: 96.12 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Blood: Other changes
JESEDU A22,639,1987
oral
rat
lowest published toxic dose: 49.06 mg/kg/10 day- intermittent Liver: Changes in liver weight JESEDU A22,639,1987
oral
rat
lowest published toxic dose: 1.68 mg/kg/28 day- continuous Liver: Fatty liver degeneration

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JTEHD6 6,421,1980
subcutaneous
mouse
lowest published toxic dose: 3 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight

Endocrine: Estrogenic
EVHPAZ 104,1296,1996
skin
rat
lowest published toxic dose: 75 mg/kg/15 day- intermittent Related to Chronic Data: Changes in testicular weight VCVGK* -,484,1994
unreported route
mouse
lowest published toxic dose: 6 mg/kg/10 day- continuous Reproductive: Maternal effects: Uterus, cervix, vagina HBPTO* 1,732,2001
unreported route
mouse
lowest published toxic dose: 840 mg/kg/4 week- intermittent Liver: Other changes

Liver: Tumors
VCVGK* -,484,1994
unreported route
rat
lowest published toxic dose: 700 mg/kg/4 week- intermittent Behavioral: Tremor VCVGK* -,484,1994
unreported route
rat
lowest published toxic dose: 2,250 mg/kg/90 day- intermittent Liver: Changes in liver weight VCVGK* -,484,1994
unreported route
rat
lowest published toxic dose: 730 mg/kg/2 year- intermittent Liver: Tumors VCVGK* -,484,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 20,67,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 20,67,1979
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
STEVA8 9,1,1978
TOXICOLOGY REVIEW
JTEHD6 4,895,1978
TOXICOLOGY REVIEW
CTOXAO 13,231,1978
TOXICOLOGY REVIEW
JEPTDQ 2(3),671,1979
TOXICOLOGY REVIEW
ENTOX* -,542,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HETOEA 25,413,2006
TOXICOLOGY REVIEW
REPTED 26,1,2008
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KEPONE-air Carcinogen;
10 hour time-weighted average 0.001 mg/m3
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2969;
Number of Industries 1;
Total Number of Facilities 280;
Number of Occupations 2;
Total Number of Employees Exposed 12,600


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264354)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human
Used as an insecticide
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8899
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Kepone, 5508
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HTOPA*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JESEDU Journal of Environmental Science and Health, Part A: Environmental Science and Engineering. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.A11- 1976-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
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TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
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VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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