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Methanol

RTECS #: PC1400000

CAS #: 67-56-1


UPDATE: May 2009 MW: 32.05 MF: CH4O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Alcool methylique (French)
  2. Alcool metilico (Italian)
  3. Bieleski's solution
  4. Carbinol
  5. Colonial Spirit
  6. Columbian Spirit
  7. Metanolo (Italian)
  8. Methanol (ACGIH)
  9. Methyl alcohol
  10. Methyl alcohol (DOT:OSHA)
  11. Methyl hydrate
  1. Methyl hydroxide
  2. Methylalkohol (German)
  3. Methylol
  4. Metylowy alkohol (Polish)
  5. Monohydroxymethane
  6. Pyroxylic Spirit
  7. RCRA waste number U154
  8. Wood Spirit
  9. Wood alcohol
  10. Wood naphtha


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
40 mg moderate UCDS** 3/24/1970
eye
rabbit
100 mg/24 hour moderate 85JCAE -,187,1986
skin
rabbit
20 mg/24 hour moderate 85JCAE -,187,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis parenteral
grasshopper
3,000 ppm IJEBA6 12,72,1974
cytogenetic analysis oral
mouse
1 gm/kg ENMUDM 4,317,1982
cytogenetic analysis intraperitoneal
mouse
75 mg/kg ENMUDM 5,381,1983
DNA damage oral
rat
10 mol/kg ENMUDM 4,317,1982
DNA inhibition human lymphocyte 300 mmol/L PNASA6 79,1171,1982
DNA repair Escherichia coli 20 mg/well MUREAV 133,161,1984
mutation in microorganisms mouse lymphocyte 7,900 mg/L (+enzymatic activation step) ENMUDM 7(Suppl 3),10,1985
mutation in microorganisms Saccharomyes cerevisiae 12 pph (-enzymatic activation step) GENRA8 37,173,1981
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sex chromosome loss and nondisjunction Aspergillus nidulans 56,000 ppm MUREAV 215,187,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1,500 ppm/6 hour (7-9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 12,101,1992
inhalation
mouse
lowest published toxic concentration: 5,000 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TJADAB 47,175,1993
inhalation
mouse
lowest published toxic concentration: 7,500 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 47,175,1993
inhalation
mouse
lowest published toxic concentration: 2,000 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 47,175,1993
inhalation
mouse
lowest published toxic concentration: 15,000 ppm (7-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 21,508,1993
inhalation
rat
lowest published toxic concentration: 20,000 ppm/7 hour (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 29(2),48A,1984
inhalation
rat
lowest published toxic concentration: 20,000 ppm/7 hour (7-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Endocrine system
FAATDF 5,727,1985
inhalation
rat
lowest published toxic concentration: 10,000 ppm/7 hour (7-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 5,727,1985
inhalation
rat
lowest published toxic concentration: 15,000 ppm/7 hour (7-19 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 11,118,1991
inhalation
rat
lowest published toxic concentration: 2.6 mg/m3 (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) VCVGK* -,89,1994
intraperitoneal
mouse
lowest published toxic dose: 5 gm/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 130,417,1984
intraperitoneal
mouse
lowest published toxic dose: 2.3 gm/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system BDERE* 70,172,2004
intraperitoneal
mouse
lowest published toxic dose: 4,900 mg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BDERB* 71,80,2004
intraperitoneal
mouse
lowest published toxic dose: 3,400 mg/kg (7 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
BDERB* 71,80,2004
intraperitoneal
mouse
lowest published toxic dose: 3,400 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system BDERB* 71,80,2004
oral
mouse
lowest published toxic dose: 40 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TJADAB 47,175,1993
oral
mouse
lowest published toxic dose: 4 gm/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 55,138,1997
oral
rat
lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
ONGZAC 22(1),71,1991
oral
rat
lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Biochemical and metabolic
ONGZAC 22(1),71,1991
oral
rat
lowest published toxic dose: 20 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TJADAB 49,399,1994
oral
rat
lowest published toxic dose: 200 ppm/20 hour (78 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 14,75,1994
oral
rat
lowest published toxic dose: 5,200 L/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 11,503,1997
oral
rat
lowest published toxic dose: 6,000 mg/kg (15-17 day pregnant) Reproductive: Effects on newborn: Behavioral VCVGK* -,89,1994
oral
rat
lowest published toxic dose: 6,000 mg/kg (17-19 day pregnant) Reproductive: Effects on newborn: Behavioral VCVGK* -,89,1994
oral
rat
lowest published toxic dose: 42 mL/kg (21 day after birth) Reproductive: Effects on newborn: Behavioral NETEEC 24,519,2002
oral
rat
lowest published toxic dose: 82 mL/kg (21 day after birth) Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NETEEC 24,519,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 44 gm/m3/6 hour Behavioral: Food intake (animal)

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands
AGGHAR 5,1,1933
inhalation
cat
lowest published lethal concentration: 4,400 mg/m3/6 hour N/R VCVGK* -,87,1984
inhalation
human
lowest published toxic concentration: 86,000 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
AGGHAR 5,1,1933
inhalation
human
lowest published toxic concentration: 300 ppm Eye: Visual field changes

Behavioral: Headache

Lung, Thorax, or Respiration: Other changes
NPIRI* 1,74,1974
inhalation
monkey
lowest published lethal concentration: 1,000 ppm N/R IECHAD 23,931,1931
inhalation
monkey
lowest published lethal concentration: 1,300 mg/m3 N/R VCVGK* -,88,1984
inhalation
mouse
lowest published lethal concentration: 50 gm/m3/2 hour N/R 85GMAT -,80,1982
inhalation
mouse
lowest published toxic concentration: 120,000 mg/m3/2 hour Behavioral: Alteration of classical conditioning VCVGK* -,87,1984
inhalation
mouse
lowest published toxic concentration: 40,000 mg/m3/4 hour Behavioral: Alteration of classical conditioning VCVGK* -,87,1984
inhalation
rat
lethal concentration (50 percent kill): 64,000 ppm/4 hour N/R NPIRI* 1,74,1974
inhalation
rat
lowest published toxic concentration: 5,000 ppm/6 hour Endocrine: Change in LH TXCYAC 71,69,1992
inhalation
rabbit
lethal concentration (50 percent kill): 81,000 mg/m3/14 hour N/R VCVGK* -,87,1984
intraperitoneal
guinea pig
lethal dose (50 percent kill): 3,556 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
hamster
lethal dose (50 percent kill): 8,555 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
mouse
lethal dose (50 percent kill): 10,765 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
rat
lethal dose (50 percent kill): 7,529 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
rat
lowest published toxic dose: 3,490 mg/kg Behavioral: Ataxia VCVGK* -,87,1984
intraperitoneal
rat
lowest published toxic dose: 3,000 mg/kg Brain and Coverings: Other degenerative changes

Eye: Retinal changes pigmentary deposition, retinitis, other)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 165,265,2006
intraperitoneal
rabbit
lethal dose (50 percent kill): 1,826 mg/kg N/R EVHPAZ 61,321,1985
intravenous
cat
lowest published lethal dose: 4,641 mg/kg N/R JPETAB 16,1,1920
intravenous
mouse
lethal dose (50 percent kill): 4,710 mg/kg N/R EVHPAZ 61,321,1985
intravenous
rat
lethal dose (50 percent kill): 2,131 mg/kg N/R EVHPAZ 61,321,1985
intravenous
rabbit
lethal dose (50 percent kill): 8,907 mg/kg N/R EVHPAZ 61,321,1985
oral
dog
lowest published lethal dose: 7,500 mg/kg N/R HBAMAK 4,1365,1935
oral
human
lowest published lethal dose: 428 mg/kg Behavioral: Headache

Lung, Thorax, or Respiration: Other changes
NPIRI* 1,74,1974
oral
human
lowest published lethal dose: 143 mg/kg Eye: Optic nerve neuropathy

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting
34ZIAG -,382,1969
oral
man
lowest published toxic dose: 3,571 L/kg Eye: Visual field changes

Lung, Thorax, or Respiration: Dyspnea

Blood: Other changes
YAKUD5 35,2095,1993
oral
man
lowest published toxic dose: 9,450 L/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: General anesthetic

Nutritional and Gross Metabolic: Body temperature decrease
AJEMEN 16,538,1998
oral
man
lowest published lethal dose: 6,422 mg/kg Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting
CMAJAX 128,14,1983
oral
man
lowest published toxic dose: 3,429 mg/kg Eye: Visual field changes AMSVAZ 212,5,1982
oral
monkey
lethal dose (50 percent kill): 7 gm/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Behavioral: Coma
TXAPA9 3,202,1961
oral
monkey
lowest published lethal dose: 5,000 mg/kg Eye: Mydriasis (pupilliary dilation)

Eye: Other eye effects
VCVGK* -,88,1984
oral
mouse
lethal dose (50 percent kill): 7,300 mg/kg N/R TXCYAC 25,271,1982
oral
mouse
lowest published lethal dose: 420 mg/kg N/R VCVGK* -,87,1984
oral
rat
lowest published toxic dose: 8 gm/kg Endocrine: Change in LH TOXID9 13,14,1993
oral
rat
lethal dose (50 percent kill): 5,600 mg/kg N/R VCVGK* -,87,1984
oral
rat
lowest published toxic dose: 3,500 mg/kg Liver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FAATDF 28,264,1995
oral
rat
lowest published toxic dose: 3 gm/kg Liver: Other changes TOXID9 72,315,2003
oral
rat
lowest published toxic dose: 3 gm/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
JTEHF8 67,583,2004
oral
rabbit
lethal dose (50 percent kill): 14,200 mg/kg N/R FAONAU 48A,105,1970
oral
rabbit
lowest published lethal dose: 7,500 mg/kg N/R VCVGK* -,87,1984
oral
woman
lowest published toxic dose: 4 gm/kg Eye: Visual field changes

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting
AMSVAZ 212,5,1982
oral
woman
lowest published lethal dose: 10 mL/kg Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Gastrointestinal: Changes in structure or function of exocrine pancreas
JTCTDW 38,297,2000
parenteral
frog
lowest published lethal dose: 59 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)
AIPTAK 50,296,1935
subcutaneous
mouse
lethal dose (50 percent kill): 9,800 mg/kg N/R VCVGK* -,87,1984
skin
monkey
lowest published lethal dose: 393 mg/kg N/R IECHAD 23,931,1931
skin
rabbit
lethal dose (50 percent kill): 15,800 mg/kg N/R NPIRI* 1,74,1974
unreported route
man
lowest published lethal dose: 868 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
monkey
lowest published toxic concentration: 6.5 mg/m3/6 hour/4 week- intermittent Eye: Conjunctiva irritation

Endocrine: Changes in adrenal weight

Endocrine: Changes in spleen weight
VCVGK* -,88,1994
inhalation
rat
lowest published toxic concentration: 50 mg/m3/12 hour/13 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Muscle contraction or spasticity
GISAAA 24(10),7,1959
inhalation
rat
lowest published toxic concentration: 2,610 ppm/6 hour/4 week- intermittent Endocrine: Changes in spleen weight TIHEEC 11,343,1995
inhalation
rat
lowest published toxic concentration: 6.5 mg/m3/6 hour/4 week- intermittent Eye: Conjunctiva irritation VCVGK* -,88,1994
inhalation
rat
lowest published toxic concentration: 50 mg/m3/12 hour/120 day- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
VCVGK* -,89,1994
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/213 day- intermittent Eye: Other eye effects VCVGK* -,89,1994
intraperitoneal
rat
lowest published toxic dose: 3,846 g/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TIHEEC 9,479,1993
intraperitoneal
rat
lowest published toxic dose: 10 gm/kg/3 day- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other) NRTXDN 24,255,2003
multiple
non-mammalian species
lowest published toxic dose: 22,300 gm/m3/4 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 22,263,2006
oral
monkey
lowest published toxic dose: 63,000 mg/kg/3 week- intermittent Liver: Other changes VCVGK* -,89,1994
oral
rat
lowest published toxic dose: 2,885 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition IJTOFN 19,179,2000
oral
rat
lowest published toxic dose: 12 gm/kg/8 week- intermittent Behavioral: Ataxia

Behavioral: Alteration of operant conditioning
NETEEC 15,223,1993
oral
rat
lowest published toxic dose: 7 mL/kg/7 day- intermittent Liver: Other changes

Biochemical: Effect on specific coenzyme: B vitamins including folate
JDGRAX 10(1-2),25,1978
oral
rat
lowest published toxic dose: 268.8 gm/kg/21 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 13,14,1993
oral
rat
lowest published toxic dose: 625 mg/kg/200 day- continuous Liver: Other changes VCVGK* -,89,1994
skin
monkey
lowest published toxic dose: 2 mL/kg/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,88,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm;short term exposure limit 250 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
REPTED 17,349,2003
TOXICOLOGY REVIEW
FNSCA6 2,67,1973
TOXICOLOGY REVIEW
JTEHD6 1,153,1975
TOXICOLOGY REVIEW
MJAUAJ 2,483,1978
TOXICOLOGY REVIEW
TOLED5 140-141,239,2003
TOXICOLOGY REVIEW
CRTXB2 33,137,2003
TOXICOLOGY REVIEW
JEMME* 1,51,1983
TOXICOLOGY REVIEW
AINCM* 7,63,2006
TOXICOLOGY REVIEW
CHHSA* 9,6,2002
TOXICOLOGY REVIEW
ENTOX* -,54,2005
TOXICOLOGY REVIEW
AJEMEN 22,404,2004
TOXICOLOGY REVIEW
FSINDR 179,206,2008
TOXICOLOGY REVIEW
HUTOX* -,577,1996
TOXICOLOGY REVIEW
HUTOX* -,623,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,290,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (260 mg/m3) (skin) DTLVS* 3,155,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (260 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (260 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (260 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (260 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 200 ppm (260 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (262 mg/m3), short term exposure limit 250 ppm (328 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (266 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 250 ppm (333 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (260 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 260 mg/m3 (200 mL/m3), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (260 mg/m3), short term exposure limit 250 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (260 mg/m3), VLE 1000 ppm (1300 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 270 mg/m3 (200 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 260 mg/m3, short term exposure limit 1040 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (260 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 200 ppm (260 mg/m3), short term exposure limit 250 ppm (310 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 200 ppm (260 mg/m3);
short term exposure limit 310 mg/m3 (250 ppm), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 260 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 200 ppm (262 mg/m3);
short term exposure limit 250 ppm (328 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (130 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (260 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 5 mg/m3, short term exposure limit 15 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 200 ppm (250 mg/m3);
short term exposure limit 250 ppm (350 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (260 mg/m3),KZG- week 800 ppm (1040 mg/m3), Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 200 ppm (260 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (260 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (266 mg/m3);
short term exposure limit 250 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm;
short term exposure limit 250 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm;
short term exposure limit 250 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHANOL-air 10 hour time-weighted average 200 ppm (Sk);
short term exposure limit 250 ppm (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 45930;
Number of Industries 344;
Total Number of Facilities 78,840;
Number of Occupations 203;
Total Number of Employees Exposed 737,242
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 45930;
Number of Industries 373;
Total Number of Facilities 101,075;
Number of Occupations 225;
Total Number of Employees Exposed 1,620,617;
Total Number of Female Employees Exposed 388,352


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8989
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methanol, 2000
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
OSHA ANALYTICAL METHOD #91


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
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BDERB*
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HUTOX*
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Top 50 chemical production: 8.73 billions lbs in 1992, 8.71 billions in 1991

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SOLDER, MANUFACTURE AND USE), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 54841-71-3
Click Here for Additional Information about RTECS

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