Methane, chlorodifluoro-

RTECS #

PA6390000

CAS #

75-45-6
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

86.47

Molecular Formula

CHClF₂

Synonyms

Algeon 22
Algofrene 22
Algofrene type 6
Arcton 22
Arcton 4
CFC 22
Chlorodifluoromethane (ACGIH)
Daiflon 22
Difluorochloromethane
Difluoromonochloromethane
Dymel 22
Electro-CF 22
Eskimon 22
F 22
Flugene 22
Fluorocarbon-22
Forane 22
Freon 22
Frigen 22
Genetron 22
Haltron 22
HFA-22
Isceon 22
Isotron 22
Khaladon 22
Monochlorodifluoromethane
Propellant 22
R 22 (refrigerant)
R-22
Racon 22
Refrigerant R 22
Ucon 22

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Salmonella typhimurium	33 pph/24H-continuous (+/-enzymatic activation step)	TOLED5 2,1,1978

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	50000 ppm/5H (56D male)	Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	FAATDF 1,266,1981
inhalation/rat	5 ppm (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear	NTIS** OTS0520838
inhalation/rat	50000 ppm/6H (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear	NTIS** OTS0545682

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	Lowest published lethal concentration: 70 pph	Lung, Thorax, or Respiration: Other changes	TXAPA9 2,363,1960
inhalation/guinea pig	Lowest published lethal concentration: 30 pph/2H	Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold	ZAARAM 21,149,1971
inhalation/guinea pig	lowest published toxic concentration: 584000 mg/m³/55M	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation	VCVGH* -,618,1990
inhalation/guinea pig	lowest published toxic concentration: 1380000 mg/m³/2H	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation	VCVGH* -,618,1990
inhalation/guinea pig	Lowest published lethal concentration: 1800000 mg/m³/18M		VCVGH* -,618,1990
inhalation/mouse	lethal concentration (50 percent kill): 1000000 mg/m³/2H		VCVGH* -,618,1990
inhalation/mouse	lethal concentration (50 percent kill): 1020000 mg/m³/30M		VCVGH* -,618,1990
inhalation/mouse	lethal concentration (50 percent kill): 1380 gm/m³/2H	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Cyanosis	TLSMA6 75,241,1963
inhalation/rabbit	Lowest published lethal concentration: 1100000 mg/m³/30M		VCVGH* -,618,1990
inhalation/rabbit	Lowest published lethal concentration: 1530000 mg/m³/20M		VCVGH* -,618,1990
inhalation/rat	lethal concentration (50 percent kill): 35 pph/15M	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression	HUTODJ 1,239,1982
oral/rat	Lethal dose: >43200 µg/kg		GISAAA 48(8),69,1983

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 50 gm/m³/6H/43W- intermittent	Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Behavioral: Alteration of classical conditioning	TLSMA6 75,231,1963
oral/rat	lowest published toxic dose: 2457 mg/kg/26W- intermittent	Brain and Coverings: Other degenerative changes Blood: Changes in other cell count (unspecified) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	GISAAA 48(8),69,1983

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1000 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 41,237,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 71,1339,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 41,237,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 71,1339,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 71,1339,1999
TOXICOLOGY REVIEW		FAZMAE 18,365,1974
TOXICOLOGY REVIEW		NYSJAM 74,1939,1974
TOXICOLOGY REVIEW		ENTOX* -,384,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		HUTOX* -,683,1996
TOXICOLOGY REVIEW		HUTOX* -,577,1996

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1000 ppm (3540 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 500 ppm (1800 mg/m³);KZW 1000 ppm (3600 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1000 ppm (3600 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 500 ppm (1770 mg/m³), MAY2011
Occupational Exposure Limit-EC	time-weighted average 3600 mg/m³ (1000 ppm), JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 1000 ppm (3600 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 1000 ppm (3600 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 500 ppm (1800 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 3600 mg/m³, short term exposure limit 14400 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 500 ppm (1770 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 1000 ppm (3500 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 1000 ppm (3500 mg/m³), short term exposure limit 1250 ppm (4375 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1000 ppm (3500 mg/m³);short term exposure limit 1250 ppm, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1000 ppm (3540 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 500 ppm (1750 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1000 ppm (3537 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 3000 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 500 ppm (1800 mg/m³);short term exposure limit 750 ppm (2500 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 500 ppm (1800 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 3600 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1000 ppm (3590 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORODIFLUOROMETHANE-air	time-weighted average 1000 ppm;short term exposure limit 1250 ppm	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code 80048; Number of Industries 78; Total Number of Facilities 12513; Number of Occupations 57; Total Number of Employees Exposed 157080; Total Number of Female Employees Exposed 12185
National Occupational Hazard Survey 1974	Hazard Code 80048; Number of Industries 76; Total Number of Facilities 7420; Number of Occupations 44; Total Number of Employees Exposed 56234

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9099;8EHQ-0892-9107
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9108;8EHQ-0892-9117
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9118
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Chlorodifluoromethane, 1018
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health