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Methane, chloro -

RTECS #: PA6300000

CAS #: 74-87-3


UPDATE: May 2009 MW: 50.49 MF: CH3Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Artic
  2. Chloor - methaan (Dutch)
  3. Chlor - methan (German)
  4. Chloromethane
  5. Chlorure de methyle (French)
  6. Clorometano (Italian)
  7. Cloruro di metile (Italian)
  1. Methyl chloride
  2. Methyl chloride (ACGIH:OSHA)
  3. Methylchlorid (German)
  4. Metylu chlorek (Polish)
  5. Monochloromethane
  6. R 40
  7. RCRA waste number U045


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 4 pph/6 hour (-enzymatic activation step) MUREAV 652,122,2008
cytogenetic analysis hamster lung 6 pph/6 hour (+enzymatic activation step) MUREAV 652,122,2008
cytogenetic analysis hamster lung 2 pph/48 hour (-enzymatic activation step) MUREAV 652,122,2008
cytogenetic analysis hamster lung 3 pph/24 hour (-enzymatic activation step) MUREAV 652,122,2008
dominant lethal test inhalation
rat
3,000 ppm/6 hour/5 day- continuous TXAPA9 77,133,1985
unscheduled DNA synthesis rat sperm 30 ppm/3 hour- continuous ENMUDM 6,392,1984
unscheduled DNA synthesis rat liver 1 pph MUREAV 162,219,1986
mutation in microorganisms Salmonella typhimurium 25,000 ppm (+/-enzymatic activation step) DHEFDK FDA-78-1046,1978
mutation in mammalian somatic cells human lymphocyte 5 pph MUREAV 155,75,1985
morphological transform hamster embryo 6 mL EVSRBT 25,75,1982
other mutation test systems human lymphocyte 3 pph MUREAV 155,75,1985
phage inhibition capacity Escherichia coli 5 pph MUREAV 263,107,1991
sister chromatid exchange human lymphocyte 3 pph MUREAV 155,75,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 500 ppm/6 hour (6-17 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system TJADAB 27,197,1983
inhalation
mouse
lowest published toxic concentration: 750 ppm/6 hour (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TJADAB 27,197,1983
inhalation
mouse
lowest published toxic concentration: 500 ppm/6 hour (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
NTIS** OTS0540987
inhalation
mouse
lowest published toxic concentration: 500 ppm/6 hour (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system NTIS** OTS0535810
inhalation
rat
lowest published toxic concentration: 2,000 ppm/6 hour (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JACTDZ 4(1),224,1985
inhalation
rat
lowest published toxic concentration: 1,500 ppm/6 hour (50 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EPASR* 8EHQ-1182-0464
inhalation
rat
lowest published toxic concentration: 1,500 ppm/6 hour (7-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 27,181,1983
inhalation
rat
lowest published toxic concentration: 3,000 ppm/6 hour (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
TOXID9 4,82,1984
inhalation
rat
lowest published toxic concentration: 3,000 ppm/6 hour (5 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TXAPA9 86,124,1986
inhalation
rat
lowest published toxic concentration: 1,500 ppm/6 hour (7-20 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** OTS0535810


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 997 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** OTS0540987
inhalation
mouse
toxic concentration (other than lowest) : 1,000 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NTIS** OTS0545215
inhalation
rat
lowest published toxic concentration: 997 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Testicular tumors
NTIS** OTS0540987


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 129 mg/m3/4 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
AHBAAM 116,131,1936
inhalation
dog
lowest published lethal concentration: 14,661 ppm/6 hour Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature increase
NIHBAZ 191,1,1949
inhalation
guinea pig
lowest published lethal concentration: 20,000 ppm/2 hour N/R FLCRAP 1,197,1967
inhalation
human
lowest published lethal concentration: 20,000 ppm/2 hour Eye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
34ZIAG -,386,1969
inhalation
mouse
lethal concentration (50 percent kill): 2,200 ppm/6 hour N/R TXAPA9 86,93,1986
inhalation
rat
lethal concentration (50 percent kill): 5,300 mg/m3/4 hour N/R 85GMAT -,82,1982
inhalation
rat
lowest published toxic concentration: 3,500 ppm/1 hour Liver: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXAPA9 76,328,1984
inhalation
rat
lethal concentration (50 percent kill): 4,900 mg/m3 N/R VCVGH* -,312,1990
inhalation
rat
lethal concentration (16 percent kill): 4,400 mg/m3 N/R VCVGH* -,312,1990
inhalation
rat
lethal concentration (84 percent kill): 8,000 mg/m3 N/R VCVGH* -,312,1990
oral
rat
lethal dose (50 percent kill): 1,800 mg/kg N/R 85JCAE -,86,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 500 ppm/24 hour/3 day- continuous Brain and Coverings: Other degenerative changes

Behavioral: Tremor

Behavioral: Ataxia
NTIS** OTS0534633
inhalation
mouse
lowest published toxic concentration: 150 ppm/22 hour/11 day- continuous Behavioral: Change in motor activity (specific assay)

Endocrine: Changes in thymus weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 5,87,1985
inhalation
mouse
lowest published toxic concentration: 1,473 ppm/6 hour/90 day- intermittent Liver: Liver function tests impaired

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
NTIS** OTS0540987
inhalation
rat
lowest published toxic dose: 3,000 ppm/6 hour/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 77,144,1985
inhalation
rat
lowest published toxic concentration: 41 mg/m3/4 hour/26 week- intermittent Liver: Liver function tests impaired

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 10(10),20,1966
inhalation
rat
lowest published toxic concentration: 1,473 ppm/6 hour/90 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0540987
inhalation
rat
lowest published toxic concentration: 240 mg/m3/4 hour/24 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in other cell count (unspecified)
VCVGH* -,313,1990
inhalation
rat
lowest published toxic concentration: 1,000 mg/m3/2 hour/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes VCVGH* -,313,1990
inhalation
rat
lowest published toxic concentration: 40 mg/m3/24 week- continuous Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGH* -,313,1990
inhalation
rat
lowest published toxic concentration: 25 mg/m3/24 week- continuous Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
VCVGH* -,313,1990
inhalation
rat
lowest published toxic concentration: 3,500 ppm/6 hour/5 day- continuous Endocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TXAPA9 76,328,1984
inhalation
rabbit
lowest published toxic concentration: 240 mg/m3/61 day- intermittent Eye: Hemorrhage TPKVAL 9,182,1967
inhalation
rabbit
lowest published toxic concentration: 40 mg/m3/61 day- intermittent Eye: Optic nerve neuropathy

Eye: Retinal changes pigmentary deposition, retinitis, other)

Eye: Changes in circulation
TPKVAL 9,182,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm;short term exposure limit 100 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 41,161,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,737,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 41,161,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,737,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,737,1999
TOXICOLOGY REVIEW
TOLED5 134,3,2002
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUREAV 588,88,2005
TOXICOLOGY REVIEW
DIMON* 39,678,1993


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 100 ppm (210 mg/m3) DTLVS* 3,160,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm;
ceiling concentration 200;
peak concentration 300/5 minute/3 hour
CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (210 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (210 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 100 ppm (210 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 50 ppm (105 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (103 mg/m3), short term exposure limit 100 ppm (207 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (104 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 100 ppm (210 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (52 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (105 mg/m3), short term exposure limit 75 ppm (160 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (105 mg/m3), VLE 100 ppm (210 mg/m3), continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - GERMANY MAK 100 mg/m3 (50 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 105 mg/m3, short term exposure limit 420 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (100 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 50 ppm (105 mg/m3), short term exposure limit 100 ppm (205 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (105 mg/m3);
short term exposure limit 100 ppm (205 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 52 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (103 mg/m3);
short term exposure limit 100 ppm (207 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (50 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (210 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, short term exposure limit 160 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (20 mg/m3);
short term exposure limit 20 ppm (40 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (105 mg/m3);
KZG- week 100 ppm (210 mg/m3), dayEC2006
Occupational Exposure Limit - THAILAND time-weighted average 100 mg/m3, short term exposure limit 200 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (210 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (105 mg/m3);
short term exposure limit 100 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL CHLORIDE-air Carcinogen lowest feasible concentration NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0421;
Number of Industries 32;
Total Number of Facilities 1,937;
Number of Occupations 29;
Total Number of Employees Exposed 8,804
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0421;
Number of Industries 18;
Total Number of Facilities 596;
Number of Occupations 38;
Total Number of Employees Exposed 10,003;
Total Number of Female Employees Exposed 571


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/121964)
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in production of silicones and TETRAMETHYL LEAD
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 43, 1984
NIOSH Analytical Method, 1994: Methyl chloride, 1001


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DHEFDK HEW Publication (FDA. United States). (Washington, DC) ?-1979(?). For publisher information, see HPFSDS.
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FLCRAP Fluorine Chemistry Reviews. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1967-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in production of silicones and TETRAMETHYL LEAD

NIOSH PROFILE (METHYL CHLORIDE), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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