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Manganese, tricarbonyl methylcyclopentadienyl

RTECS #: OP1450000

CAS #: 12108-13-3


UPDATE: May 2009 MW: 218.10 MF: C9H7MnO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Methylcyclopentadienyl manganese tricarbonyl
  2. 2 - Methylcyclopentadienyl manganese tricarbonyl (ACGIH)
  3. AK - 33X
  4. Antiknock - 33
  5. CI - 2
  6. Combustion improver - 2
  1. MMT
  2. Manganese, (methylcyclopentadienyl) tricarbonyl -
  3. Methylcyclopentadienyl manganese tricarbonyl
  4. Methylcyklopentadientrikarbonylmanganium (Czech)
  5. Tricarbonyl (methylcyclopentadienyl) manganese


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
100 mg/24 hour mild AEHLAU 30,168,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 223 mg/m3/7 hour N/R TMMT** -,-,1976
inhalation
dog
lowest published lethal concentration: 489 mg/m3/2 hour N/R TMMT** -,-,1976
inhalation
guinea pig
lowest published lethal concentration: 411 mg/m3/7 hour N/R TMMT** -,-,1976
inhalation
mouse
lethal concentration (50 percent kill): 58,600 g/m3/4 hour N/R SAIGBL 20,553,1978
inhalation
rat
lethal concentration (50 percent kill): 76 mg/m3/4 hour Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 40,164,1979
inhalation
rabbit
lowest published lethal concentration: 411 mg/m3/7 hour N/R TMMT** -,-,1976
intraperitoneal
mouse
lethal dose (50 percent kill): 152 mg/kg Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
SKIZAB 34,183,1978
intraperitoneal
rat
lethal dose (50 percent kill): 12 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage
TOLED5 39,1,1987
intravenous
dog
lowest published lethal dose: 10 mg/kg N/R TMMT** -,-,1976
intravenous
rabbit
lethal dose (50 percent kill): 6,600 g/kg N/R TMMT** -,-,1976
oral
dog
lowest published lethal dose: 620 mg/kg N/R TMMT** -,-,1976
oral
guinea pig
lethal dose (50 percent kill): 905 mg/kg N/R TMMT** -,-,1976
oral
mouse
lethal dose (50 percent kill): 34 mg/kg N/R NICHAS 44,173,1985
oral
rat
lethal dose (50 percent kill): 8 mg/kg N/R TMMT** -,-,1976
oral
rabbit
lethal dose (50 percent kill): 95 mg/kg N/R TMMT** -,-,1976
skin
rat
lethal dose (50 percent kill): 665 mg/kg N/R TMMT** -,-,1976
skin
rabbit
lethal dose (50 percent kill): 140 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis
AIHAAP 40,164,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 75,426 mg/kg/1 year- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AECTCV 23,473,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m3 (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AMRL** TR-73-125,1973
TOXICOLOGY REVIEW
85DHAX Mn,126,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.2 mg/m3) (skin) DTLVS* 3,164,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(Mn)/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.2 mg(Mn)/m3), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m3 (dust), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m3 (fume), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 0.2 mg(Mn)/m3, Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Mn)/m3 (inhalable), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(Mn)/m3;
short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit - MEXICO time-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 mg(Mn)/m3, skin, JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.2 mg(Mn)/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Mn)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Mn)/m3 (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Mn)/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 0.2 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84547;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 1;
Total Number of Employees Exposed 34
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84547;
Number of Industries 2;
Total Number of Facilities 65;
Number of Occupations 5;
Total Number of Employees Exposed 4,891


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an octane improver in unleaded gasoline
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
SKIZAB Shikoku Igaku Zasshi. Shikoku Medical Journal. (Tokushima Igakkai, Tokushima Daigaku Igakubu, Kuramoto-cho, Tokushima 770, Japan) V.1- 1950-
TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as an octane improver in unleaded gasoline

RTECS Compound Description:
   Organometallic
   Primary Irritant

Click Here for Additional Information about RTECS

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