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Magnesium oxide

RTECS #: OM3850000

CAS #: 1309-48-4


UPDATE: May 2009 MW: 40.31 MF: MgO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Akro - mag
  2. Animag
  3. Calcined brucite
  4. Calcined magnesia
  5. Calcined magnesite
  6. Granmag
  7. Magcal
  8. Magchem 100
  9. Maglite
  10. Magnesia
  11. Magnesia USTA
  12. Magnesium oxide fume
  1. Magnesium oxide fume (ACGIH:OSHA)
  2. Magnezu tlenek (Polish)
  3. Magox
  4. Magox 85
  5. Magox 90
  6. Magox 95
  7. Magox 98
  8. Magox OP
  9. Marmag
  10. Oxymag
  11. Periclase
  12. Seawater magnesia


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratracheal
hamster
lowest published toxic dose: 480 mg/kg/30 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
CNREA8 33,2209,1973


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 400 mg/m3 N/R 38MKAJ 2A,1745,1981
inhalation
mammal (species unspecified)
lowest published toxic concentration: 4 mg/m3/12 minute Nutritional and Gross Metabolic: Body temperature increase VCVN1* -,104,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,120 g/m3/24 hour/29 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 49(11),82,1984
inhalation
rat
lowest published toxic concentration: 1,000 mg/m3/4 hour/50 day- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Other hemolysis with or without anemia
VCVN1* -,105,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 (inhalable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 (fume) DTLVS* 3,147,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total particulate CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 ppm, total particulate CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 ppm, total particulate CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 15 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3 (fume), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3 (fume), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 6 mg(Mg)/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 10 mg/m3 (fume), FEB2006
Occupational Exposure Limit - GERMANY MAK 4 mg/m3 (inhalable), 2005
Occupational Exposure Limit - GERMANY MAK 1.5 mg/m3 (respirable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 6 mg/m3 (resp), short term exposure limit 24 mg/m3 (resp), SEP2000
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg(Mg)/m3 (fume), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3 (fume), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) dust 10 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) fume 5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 4 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 3 mg/m3, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 4 mg(Mg)/m3;
short term exposure limit 10 mg/m3 (fume,resp), 2005
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg(Mg)/m3 (inhalable), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80298;
Number of Industries 201;
Total Number of Facilities 28,931;
Number of Occupations 134;
Total Number of Employees Exposed 354,380
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80298;
Number of Industries 258;
Total Number of Facilities 42,587;
Number of Occupations 177;
Total Number of Employees Exposed 765,812;
Total Number of Female Employees Exposed 149,523


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
OSHA ANALYTICAL METHOD #ID-125G


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

NIOSH PROFILE (PULP AND PAPER MILLS), SRI, 2/77

NIOSH PROFILE (TIRE MANUFACTURING), SRI, 2/77

NIOSH PROFILE (TIRE MANUFACTURING), FIRL, 4/78

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Human Data

Click Here for Additional Information about RTECS

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