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Ketene

RTECS #: OA7700000

CAS #: 463-51-4


UPDATE: May 2009 MW: 42.04 MF: C2H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Carbomethene
  2. Ethenone (9CI)
  1. Ketene (ACGIH:OSHA)
  2. Keto - ethylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 750 ppm/10 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of salivary glands
JIHTAB 31,209,1949
inhalation
guinea pig
lowest published lethal concentration: 53 ppm/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
JIHTAB 31,209,1949
inhalation
monkey
lowest published lethal concentration: 200 ppm/10 minute Eye: Ptosis

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
JIHTAB 31,209,1949
inhalation
mouse
lowest published lethal concentration: 23 ppm/30 minute Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JIHTAB 31,209,1949
inhalation
rabbit
lowest published lethal concentration: 53 ppm/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
JIHTAB 31,209,1949


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm;short term exposure limit 1.5 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 ppm (0.9 mg/m3) DTLVS* 3,143,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 ppm (0.9 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 ppm (0.9 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 ppm (0.9 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 ppm (0.9 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.5 ppm (0.9 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (0.86 mg/m3), short term exposure limit 1.5 ppm (2.6 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (0.87 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 1.5 ppm (2.6 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (0.9 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.5 ppm (0.9 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 ppm (0.9 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.5 ppm (0.9 mg/m3), short term exposure limit 1.5 ppm (3 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 ppm (0.9 mg/m3);
short term exposure limit 1.5 ppm (3 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.9 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 ppm (0.86 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.5 ppm, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 ppm (0.9 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (0.9 mg/m3),KZG- week 0.5 ppm (0.9 mg/m3),DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.5 ppm (0.9 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 ppm (0.87 mg/m3);
short term exposure limit 1.5 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 ppm;
short term exposure limit 1.5 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 ppm;
short term exposure limit 1.5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KETENE-air 10 hour time-weighted average 0.5 ppm;
short term exposure limit 1.5 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 41840;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 66


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for synthesis of various organic compounds
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used for synthesis of various organic compounds

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

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