Isocyanic acid, methyl ester
RTECS #
NQ9450000
CAS #
Updated
March 2019
Molecular Weight
57.06
Molecular Formula
C2H3NO
Synonyms
Isocyanate de methyle (French)
Iso-cyanatomethane
Methyl isocyanat (German)
Methyl isocyanate
Methyl isocyanate (ACGIH:OSHA)
Methylisocyanaat (Dutch)
Methylisokyanat (Czech)
Metil isocianato (Italian)
RCRA waste number P064
TL 1450
Iso-cyanatomethane
Methyl isocyanat (German)
Methyl isocyanate
Methyl isocyanate (ACGIH:OSHA)
Methylisocyanaat (Dutch)
Methylisokyanat (Czech)
Metil isocianato (Italian)
RCRA waste number P064
TL 1450
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 5 µL/24H | severe | NTIS** OTS0529151 |
| skin /rabbit | 10 µL/24H | moderate | NTIS** OTS0529151 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | inhalation/mouse | 3 ppm/6H/4D-continuous | ENMUDM 9,37,1987 |
| Cytogenetic Analysis | ovary/hamster | 10100 µg/L | ENMUDM 9,19,1987 |
| micronucleus test | inhalation/mouse | 6 ppm/6H/4D-continuous | ENMUDM 9,37,1987 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 8 µmol/L | MUREAV 174,285,1986 |
| mutation in microorganisms | /Salmonella typhimurium | 50 µg/plate (+enzymatic activation step) | IJEBA6 25,548,1987 |
| mutation in microorganisms | /Salmonella typhimurium | 100 µg/plate (-enzymatic activation step) | MUREAV 204,123,1988 |
| other mutation test systems | /Escherichia coli | 1 µmol/plate | MUREAV 283,97,1992 |
| other mutation test systems | inhalation/mouse | 3 ppm/6H/4D-continuous | ENMUDM 9,29,1987 |
| sister chromatid exchange | ovary/hamster | 900 µg/L | ENMUDM 9,19,1987 |
| sister chromatid exchange | inhalation/mouse | 1 ppm/6H/4D-continuous | ENMUDM 9,29,1987 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 9 ppm/3H (10D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | JTEHD6 30,1,1990 |
| inhalation/mouse | 9 ppm/3H (8D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | JTEHD6 30,1,1990 |
| inhalation/mouse | 9 ppm/3H (8D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Specific developmental abnormalities: Musculoskeletal system | JTEHD6 21,265,1987 |
| inhalation/mouse | 9 ppm/3H (1D pregnant) | Reproductive: Other effects on male Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) | JTEHD6 21,265,1987 |
| inhalation/mouse | 1 ppm/6H (14-17D pregnant) | Reproductive: Effects on newborn: Stillbirth | EVHPAZ 72,149,1987 |
| inhalation/mouse | 3 ppm/6H (14-17D pregnant) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) | EVHPAZ 72,149,1987 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lethal concentration (50 percent kill): 5400 ppb/6H | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea | FAATDF 6,747,1986 |
| inhalation/human | lowest published toxic concentration: 2 ppm | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes | ATXKA8 20,235,1964 |
| inhalation/mouse | lethal concentration (50 percent kill): 12200 ppb/6H | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea | FAATDF 6,747,1986 |
| inhalation/rat | lethal concentration (50 percent kill): 6100 ppb/6H | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea | FAATDF 6,747,1986 |
| oral/mouse | lethal dose (50 percent kill): 120 mg/kg | TXAPA9 42,417,1977 | |
| oral/rat | lethal dose (50 percent kill): 71 mg/kg | TOXID9 -,170,2009 | |
| oral/rat | lethal dose (50 percent kill): 51500 µg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression | IJEBA6 25,531,1987 |
| skin/mouse | lethal dose (50 percent kill): 1820 mg/kg | YKYUA6 38,391,1987 | |
| skin/rabbit | lethal dose (50 percent kill): 220 µL/kg | Skin: After systemic exposure: Dermatitis, other | NTIS** OTS0529151 |
| skin/rat | lethal dose (50 percent kill): 2780 mg/kg | YKYUA6 38,391,1987 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 81900 µg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression | IJEBA6 25,531,1987 |
| subcutaneous/rabbit | lethal dose (50 percent kill): 126 mg/kg | TXCYAC 51,223,1988 | |
| subcutaneous/rat | lethal dose (50 percent kill): 261 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression | IJEBA6 25,531,1987 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 3 ppm/6H/4D- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FAATDF 9,480,1987 |
| inhalation/rat | lowest published toxic concentration: 3 ppm/6H/4D- intermittent | Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Endocrine: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 9,480,1987 |
| inhalation/rat | lowest published toxic concentration: 3 ppm/6H/8D- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain | EVHPAZ 72,117,1987 |
| inhalation/rat | lowest published toxic concentration: 3070 ppb/6H/8D- intermittent | Behavioral: Food intake (animal) Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0535177 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.02 ppm (skin) | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | DIMON* 46,551,2000 | |
| TOXICOLOGY REVIEW | ENTOX* -,81,2005 | |
| TOXICOLOGY REVIEW | TOPADD 33,517,2005 | |
| TOXICOLOGY REVIEW | HUTOX* -,661,1996 | |
| TOXICOLOGY REVIEW | HTCWA* 2,293, | |
| TOXICOLOGY REVIEW | CCACL* 21,691,2005 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | RTOPDW 54,247,2009 | |
| TOXICOLOGY REVIEW | RTOPDW 61,1,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.02 ppm (0.05 mg/m3) (skin) | DTLVS* 3,167,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.01 ppm (0.024 mg/m3);KZW 0.01 ppm (0.024 mg/m3), skin, sen, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.02 ppm (0.048 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 0.01 ppm (0.03 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | short term exposure limit 0.02 ppm (0.05 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.02 ppm (0.05 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 0.01 ppm (0.024 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 0.024 mg/m3, short term exposure limit 0.024 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 0.01 ppm (0.03 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.02 ppm (0.05 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.02 ppm (0.05 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.02 ppm (0.047 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.005 ppm (0.015 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,02 ppm (0,047 mg/m3), JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.05 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 0.01 ppm (0.024 mg/m3), ceiling concentration 0.02 ppm (0.047 mg/m3), JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 0.02 mg(NCO)/m3, sen, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.05 mg/m3, Skin, 2003 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.02 ppm (0.05 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.02 ppm (0.05 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.02 ppm (0.05 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.02 ppm (0.05 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ISOCYANATE-air | 10H time-weighted average 0.02 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 47625; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1822; Total Number of Female Employees Exposed 272 | |
| National Occupational Hazard Survey 1974 | Hazard Code 47625; Number of Industries 2; Total Number of Facilities 56; Number of Occupations 3; Total Number of Employees Exposed 2381 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health