3-Heptanone

RTECS #

MJ5250000

CAS #

106-35-4
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

114.21

Molecular Formula

C₇H₁₄O

Synonyms

3-Heptanone (OSHA)
Aethylbutylketon (German)
Butyl ethyl ketone
Eptan-3-one (Italian)
Ethyl butyl ketone
Ethyl butyl ketone (ACGIH:OSHA)
Ethylbutylcetone (French)
Ethylbutylketon (Dutch)
Etilbutilchetone (Italian)
Heptan-3-on (Dutch, German)
Heptan-3-one
n-Butyl ethyl ketone

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg	mild	FCTXAV 16,731,1978
eye /rabbit	500 mg/24H	mild	85JCAE -,286,1986
skin /rabbit	500 mg open irritation test	mild	UCDS** 3/12/1969
skin /rabbit	500 mg/24H	moderate	FCTXAV 16,731,1978

Acute Toxicity Data and References

Route/Organism	Dose	Reference
inhalation/rat	Lowest published lethal concentration: 2000 ppm/4H	JIHTAB 31,343,1949
oral/rat	lethal dose (50 percent kill): 2760 mg/kg	JIHTAB 31,60,1949
skin/rabbit	lethal dose (50 percent kill): >20 mL/kg	UCDS** 3/12/1969

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 2863 mg/m³/16H/4D- intermittent	Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath	VCVGK* -,430,1994
oral/rat	lowest published toxic dose: 140000 mg/kg/14W- intermittent	Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath	VCVGK* -,430,1994

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 50 ppm;short term exposure limit 75 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		RTOPDW 60,120,2011

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 50 ppm (230 mg/m³)	DTLVS* 3,105,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 50 ppm (234 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 20 ppm (95 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 20 ppm (95 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 20 ppm (95 mg/m³), MAY2011
Occupational Exposure Limit-EC	time-weighted average 95 mg/m³ (20 ppm), JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 20 ppm (95 mg/m³), short term exposure limit 75 ppm (360 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 20 ppm (95 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 10 ppm (47 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 95 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 20 ppm (95 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 50 ppm (230 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 50 ppm (230 mg/m³);short term exposure limit 75 ppm (345 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 50 ppm (234 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 25 ppm (115 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 50 ppm (234 mg/m³); short term exposure limit 75 ppm (350 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 25 ppm (120 mg/m³);short term exposure limit 50 ppm (250 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 ppm (47 mg/m³), KZG-week 20 ppm (94 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 163 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 35 ppm (166 mg/m³);short term exposure limit 100 ppm (475 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 50 ppm (230 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 50 ppm (230 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 50 ppm (230 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 50 ppm (230 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL BUTYL KETONE-air	10H time-weighted average 50 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 36330; Number of Industries 20; Total Number of Facilities 2103; Number of Occupations 9; Total Number of Employees Exposed 11318; Total Number of Female Employees Exposed 1164
National Occupational Hazard Survey 1974	Hazard Code 36330; Number of Industries 8; Total Number of Facilities 320; Number of Occupations 14; Total Number of Employees Exposed 1923

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health