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2 - Heptanone

RTECS #: MJ5075000

CAS #: 110-43-0


UPDATE: May 2009 MW: 114.21 MF: C7H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Amyl - methyl - cetone (French)
  2. Ketone, methyl pentyl
  3. Methyl n - amyl ketone
  4. Methyl n - amyl ketone (ACGIH:OSHA)
  1. Methyl pentyl ketone
  2. Methyl - amyl - cetone (French)
  3. n - Amyl methyl ketone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
14 mg/24 hour open irritation test mild AIHAAP 23,95,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 7,000 mg/m3/4 hour Lung, Thorax, or Respiration: Cough VCVGK* -,429,1994
inhalation
guinea pig
lowest published toxic concentration: 9,300 mg/m3/4 hour Behavioral: General anesthetic VCVGK* -,429,1994
inhalation
guinea pig
lowest published lethal concentration: 22,400 mg/m3/4 hour N/R VCVGK* -,429,1994
inhalation
rat
lowest published lethal concentration: 4,000 ppm/4 hour N/R AIHAAP 23,95,1962
intraperitoneal
mouse
lethal dose (50 percent kill): 400 mg/kg N/R 38MKAJ 2C,4757,1982
intraperitoneal
rat
lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4757,1982
oral
mouse
lethal dose (50 percent kill): 730 mg/kg N/R ENTOX* -,506,2005
oral
rat
lethal dose (50 percent kill): 1,670 mg/kg N/R UCDS** 8/11/1958
skin
rabbit
lethal dose (50 percent kill): 12,600 ÁL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 45,500 mg/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight
FCTXAV 10,625,1972


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,506,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (465 mg/m3) DTLVS* 3,157,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (465 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (465 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (465 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (465 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (233 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (238 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 100 ppm (475 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (238 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 50 ppm (238 mg/m3);
short term exposure limit 100 ppm (skin), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (345 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (238 mg/m3), VLE 100 ppm (475 mg/m3), Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 238 mg/m3, short term exposure limit 476 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 50 ppm (235 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (235 mg/m3);
short term exposure limit 100 ppm (465 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 233 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (233 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (120 mg/m3);
short term exposure limit 50 ppm (250 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (235 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (237 mg/m3);
short term exposure limit 100 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL AMYL KETONE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 36340;
Number of Industries 10;
Total Number of Facilities 489;
Number of Occupations 8;
Total Number of Employees Exposed 3,345
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 36340;
Number of Industries 62;
Total Number of Facilities 5,080;
Number of Occupations 47;
Total Number of Employees Exposed 78,196;
Total Number of Female Employees Exposed 17,866


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent in metal roll coatings and in synthetic resin finishes
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent in metal roll coatings and in synthetic resin finishes

RTECS Compound Description:
   Primary Irritant

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