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Heptane

RTECS #: MI7700000

CAS #: 142-82-5


UPDATE: May 2009 MW: 100.23 MF: C7H16


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Dipropyl methane
  2. Eptani (Italian)
  3. Gettysolve - C
  4. Heptan (Polish)
  5. Heptane (ACGIH:OSHA)
  1. Heptanen (Dutch)
  2. Heptyl hydride
  3. n - Heptane (OSHA)
  4. n - Heptane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lethal concentration : >17,937 ppm/4 hour N/R NTIS** OTS0556754
inhalation
human
lowest published toxic concentration: 1,000 ppm/6 minute Behavioral: Hallucinations, distorted perceptions BMRII* 2979,-,1929
inhalation
mouse
lowest published lethal concentration: 59 gm/m3/41 minute Behavioral: Convulsions or effect on seizure threshold BIZEA2 115,235,1921
inhalation
mouse
lowest published lethal concentration: 75,000 mg/m3/2 hour N/R VCVGH* -,35,1990
inhalation
rat
lethal concentration (50 percent kill): 103 gm/m3/4 hour N/R GTPZAB 32(10),23,1988
inhalation
rat
lowest published lethal concentration: 65,000 mg/m3 N/R VCVGH* -,35,1990
intravenous
mouse
lethal dose (50 percent kill): 222 mg/kg N/R JPMSAE 67,566,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 4,000 ppm/6 hour/28 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Ear: Change in cochlear structure or function

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
PHTOEH 76,41,1995
inhalation
rat
lowest published toxic concentration: 420 mg/m3/12 hour/2 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
VCVGH* -,35,1990
intraperitoneal
rat
lowest published toxic dose: 9,625 mg/kg/7 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 14,169,1982
intraperitoneal
rat
lowest published toxic dose: 8,840 mg/kg/45 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
JJATDK 8,81,1988
oral
rat
lowest published toxic dose: 60 gm/kg/3 week- intermittent Liver: Changes in liver weight NTIS** OTS0571116
oral
rat
lowest published toxic dose: 260 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0571116


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 400 ppm;short term exposure limit 500 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,504,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (2000 mg/m3) DTLVS* 3,124,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 400 ppm (1640 mg/m3), short term exposure limit 500 ppm (2050 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 400 ppm (1664 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 500 ppm (2085 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (820 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 2085 mg/m3 (500 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 300 ppm (1200 mg/m3), short term exposure limit 500 ppm (2000 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 500 ppm (2085 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 2100 mg/m3 (500 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2000 mg/m3, short term exposure limit 8000 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (820 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 400 ppm (1600 mg/m3), short term exposure limit 500 ppm (2000 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 400 ppm (1600 mg/m3);
short term exposure limit 500 ppm (skin), 2004
Occupational Exposure Limit - MEXICO Simple asphyxiant, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1200 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 400 ppm (1640 mg/m3);
short term exposure limit 500 ppm (2050 mg/m3),JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 200 ppm (800 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1200 mg/m3, MAC(short term exposure limit) 2000 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 200 ppm, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 200 ppm (800 mg/m3);
short term exposure limit 300 ppm (1200 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 400 ppm (1600 mg/m3),KZG- week 400 ppm (1600 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 500 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 400 ppm;
short term exposure limit 500 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 400 ppm;
short term exposure limit 500 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEPTANE-air 10 hour time-weighted average 85 ppm;
ceiling concentration 440 ppm/15 minute
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 36060;
Number of Industries 153;
Total Number of Facilities 20,154;
Number of Occupations 110;
Total Number of Employees Exposed 221,101
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 36060;
Number of Industries 191;
Total Number of Facilities 37,852;
Number of Occupations 134;
Total Number of Employees Exposed 449,487;
Total Number of Female Employees Exposed 44,550


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in graphics, textiles, adhesives and coatings
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE

BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For publisher information, see EJBCAI.
BMRII* "U.S. Bureau of Mines Report of Investigation No. 2979," Patty, F.A., and W.P. Yant, 1929
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in graphics, textiles, adhesives and coatings

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   Human Data

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