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Fluorine

RTECS #: LM6475000

CAS #: 7782-41-4


UPDATE: May 2009 MW: 38.00 MF: F2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Bifluoriden (Dutch)
  2. Fluor (Dutch, French, German, Polish)
  3. Fluorine (ACGIH:OSHA)
  4. Fluoro (Italian)
  1. Fluorures acide (French)
  2. Fluoruri acidi (Italian)
  3. RCRA waste number P056
  4. Saeure fluoride (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
dog
68 ppm/1 hour N/R AIHAAP 29,10,1968
eye
human
25 ppm/5 minute mild AIHAAP 29,10,1968
eye
mouse
467 ppm/5 minute mild AIHAAP 29,10,1968
eye
rat
140 ppm/30 minute mild AIHAAP 29,10,1968


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lethal concentration (50 percent kill): 1,120 mg/m3/15 minute Brain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema
STGNBT -,234,1999
inhalation
dog
lethal concentration (50 percent kill): 1,250 mg/m3/5 minute N/R VCVN5* -,342,1993
inhalation
dog
lethal concentration (50 percent kill): 250 mg/m3/60 minute N/R VCVN5* -,342,1993
inhalation
dog
lethal concentration : 28 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1993
inhalation
guinea pig
lethal concentration (50 percent kill): 170 ppm/1 hour Eye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 29,10,1968
inhalation
guinea pig
lethal concentration (50 percent kill): 1,250 mg/m3/5 minute N/R VCVN5* -,342,1993
inhalation
guinea pig
lethal concentration (50 percent kill): 250 mg/m3/60 minute N/R VCVN5* -,342,1993
inhalation
guinea pig
lowest published lethal concentration: 320 mg/m3/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation
guinea pig
lethal concentration : 160 mg/m3/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation
human
lowest published toxic concentration: 77 mg/m3 Lung, Thorax, or Respiration: Cough VCVN5* -,342,1993
inhalation
mouse
lethal concentration (50 percent kill): 150 ppm/1 hour Eye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 29,10,1968
inhalation
mouse
lethal concentration (50 percent kill): 1,250 mg/m3/5 minute N/R VCVN5* -,342,1993
inhalation
mouse
lethal concentration (50 percent kill): 250 mg/m3/60 minute N/R VCVN5* -,342,1993
inhalation
mouse
lowest published lethal concentration: 320 mg/m3/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation
mouse
lethal concentration : 160 mg/m3/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation
mouse
lethal concentration (50 percent kill): 150 ppm/60 minute Lung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes
ENTOX* -,343,2005
inhalation
rat
lethal concentration (50 percent kill): 185 ppm/1 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 29,10,1968
inhalation
rat
lethal concentration (50 percent kill): 1,250 mg/m3/5 minute N/R VCVN5* -,342,1993
inhalation
rat
lethal concentration (50 percent kill): 250 mg/m3/60 minute N/R VCVN5* -,342,1993
inhalation
rat
lowest published lethal concentration: 320 mg/m3/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation
rat
lethal concentration : 160 mg/m3/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation
rabbit
lethal concentration (50 percent kill): 270 ppm/30 minute Eye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 29,10,1968
inhalation
rabbit
lethal concentration (50 percent kill): 1,250 mg/m3/5 minute N/R VCVN5* -,342,1993
inhalation
rabbit
lethal concentration (50 percent kill): 250 mg/m3/60 minute N/R VCVN5* -,342,1993
inhalation
rabbit
lowest published lethal concentration: 320 mg/m3/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation
rabbit
lethal concentration : 160 mg/m3/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,342,1993
inhalation
rabbit
lethal concentration (50 percent kill): 820 ppm/5 minute N/R ENTOX* -,343,2005
oral
rat
lethal dose (75 percent kill): 50 mg/kg N/R VCVN5* -,342,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 3 mg/m3/30 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
inhalation
guinea pig
lowest published toxic concentration: 3 mg/m3/30 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
inhalation
mouse
lowest published toxic concentration: 3 mg/m3/30 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
inhalation
rat
lowest published toxic concentration: 10 mg/m3/2 hour/10 day- intermittent Liver: Liver function tests impaired

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
STGNBT -,234,1999
inhalation
rat
lowest published toxic concentration: 3 mg/m3/24 hour/35 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
inhalation
rat
lowest published toxic concentration: 25 mg/m3/24 hour/35 day- continuous Musculoskeletal: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVN5* -,342,1989
inhalation
rat
lowest published toxic concentration: 3 mg/m3/24 hour/35 day- continuous Musculoskeletal: Changes in teeth and supporting structures VCVN5* -,342,1989
inhalation
rat
lowest published toxic concentration: 1 mg/m3/24 hour/30 day- continuous Musculoskeletal: Changes in teeth and supporting structures

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
VCVN5* -,343,1989
inhalation
rat
lowest published toxic concentration: 3 mg/m3/30 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
inhalation
rabbit
lowest published toxic concentration: 3 mg/m3/30 day- continuous Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Bronchiectasis

Lung, Thorax, or Respiration: Cough
VCVN5* -,342,1989
oral
rat
lowest published toxic dose: 75 mg/kg/30 day- continuous Musculoskeletal: Changes in teeth and supporting structures

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
VCVN5* -,343,1989
oral
rat
lowest published toxic dose: 630 mg/kg/6 week- continuous Musculoskeletal: Changes in teeth and supporting structures VCVN5* -,343,1989
oral
rat
lowest published toxic dose: 1,368.7 mg/kg/2 year- continuous Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed

Musculoskeletal: Other changes
VCVN5* -,343,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm;short term exposure limit 2 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
JAVMA4 164,277,1974
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
IECHAD 26,791,1934
TOXICOLOGY REVIEW
TOLED5 134,3,2002
TOXICOLOGY REVIEW
ENTOX* -,343,2005
TOXICOLOGY REVIEW
HUTOX* -,661,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (2 mg/m3) DTLVS* 3,117,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (1.6 mg/m3), short term exposure limit 2 ppm (3.1 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (1.58 mg/m3), short term exposure limit 2 ppm (3.16 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.2 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 1.58 mg/m3 (1 ppm);
short term exposure limit 3.16 mg/m3 (2 ppm), FEB 2006
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.26 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VLE 1 ppm (1.58 mg/m3), VLE 2 ppm (3.16 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 1.58 mg/m3, short term exposure limit 3.16 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.2 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (1.6 mg/m3);
short term exposure limit 2 ppm (3.1 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.4 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.03 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 ppm (0.2 mg/m3);
short term exposure limit 0.3 ppm (0.5 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.15 mg/m3),KZG- week 0.2 ppm (0.3 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm;
short term exposure limit 1 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm;
short term exposure limit 2 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm;
short term exposure limit 2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORINE-air 10 hour time-weighted average 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 33370;
Number of Industries 10;
Total Number of Facilities 396;
Number of Occupations 13;
Total Number of Employees Exposed 2,580
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 33370;
Number of Industries 19;
Total Number of Facilities 490;
Number of Occupations 25;
Total Number of Employees Exposed 12,854;
Total Number of Female Employees Exposed 2,059


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182566/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
HUTOX*
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL.
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

RTECS Compound Description:
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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