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Ethylene, tetrachloro -

RTECS #: KX3850000

CAS #: 127-18-4


UPDATE: May 2009 MW: 165.82 MF: C2Cl4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,1,2,2 - Tetrachloroethylene
  2. Ankilostin
  3. Antisol 1
  4. Carbon bichloride
  5. Carbon dichloride
  6. Czterochloroetylen (Polish)
  7. Didakene
  8. Dilatin PT
  9. Dow - per
  10. ENT 1,860
  11. Ethene, tetrachloro -
  12. Ethylene tetrachloride
  13. Ethylenetetrachloride
  14. Fedal - UN
  15. NCI - C04580
  16. PER
  17. PERK
  18. Per
  19. Perawin
  20. Perc
  21. Perchloorethyleen, per (Dutch)
  22. Perchlor
  23. Perchloraethylen, per (German)
  24. Perchlorethylene
  25. Perchloroethylene
  1. Perchloroethylene (ACGIH:OSHA)
  2. Perclene
  3. Perclene D
  4. Percloroetilene (Italian)
  5. Percosolve
  6. Perk
  7. Perklone
  8. Persec
  9. RCRA waste number U210
  10. Tetlen
  11. Tetracap
  12. Tetrachlooretheen (Dutch)
  13. Tetrachloraethen (German)
  14. Tetrachlorethylene
  15. Tetrachloroethene
  16. Tetrachloroethylene
  17. Tetrachloroethylene (DOT:OSHA)
  18. Tetrachloroethylene (IUPAC)
  19. Tetracloroetene (Italian)
  20. Tetraleno
  21. Tetralex
  22. Tetravec
  23. Tetroguer
  24. Tetropil


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
162 mg mild EJTXAZ 9,171,1976
eye
rabbit
500 mg/24 hour mild 85JCAE -,108,1986
skin
rabbit
810 mg/24 hour severe EJTXAZ 9,171,1976
skin
rabbit
500 mg/24 hour mild 85JCAE -,108,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis inhalation
rat
500 ppm NTIS** PB82-185075
DNA damage unreported route
human
2.4 ppm/1 year MUREAV 539,9,2003
DNA damage intraperitoneal
mouse
4 mmol/kg TOLED5 31,31,1986
unscheduled DNA synthesis human lung 100 mg/L NTIS** PB82-185075
host-mediated assay mouse
Salmonella typhimurium
100 ppm NTIS** PB82-185075
mutation in microorganisms Salmonella typhimurium 50 ÁL/plate (+enzymatic activation step) NIOSH* 5AUG1977
morphological transform rat embryo 97 Ámol/L ITCSAF 14,290,1978
other mutation test systems oral
mouse
1 gm/kg MUREAV 343,157,1995
sex chromosome loss and nondisjunction hamster lung 190 Ámol/L MUREAV 182,135,1987
sperm morphology inhalation
mouse
500 ppm NTIS** PB82-185075


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 300 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis
TXAPA9 32,84,1975
inhalation
mouse
lowest published toxic concentration: 500 ppm/7 hour (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** PB82-185075
inhalation
rat
lowest published toxic concentration: 1,000 ppm/24 hour (14 day prior to copulation/1-22 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system APTOD9 19,A21,1980
inhalation
rat
lowest published toxic concentration: 1,000 ppm/24 hour (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) APTOD9 19,A21,1980
inhalation
rat
lowest published toxic concentration: 900 ppm/7 hour (7-13 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
TJADAB 19,41A,1979
inhalation
rat
lowest published toxic concentration: 300 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 32,84,1975
inhalation
rat
lowest published toxic concentration: 1,000 ppm/6 hour (multigeneration) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** OTS0557702
inhalation
rat
lowest published toxic concentration: 250 ppm (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
BDERB* 77,405,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 100 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-311,1986
inhalation
mouse
toxic concentration (other than lowest) : 100 ppm/6 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
TOLED5 31(Suppl),16,1986
inhalation
mouse
lowest published toxic concentration: 6,180 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB87-147054/AS
inhalation
mouse
lowest published toxic concentration: 2,100 mg/m3/6 hour/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria VCVGH* -,459,1990
inhalation
rat
lowest published toxic concentration: 200 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Reproductive: Tumorigenic effects: Testicular tumors
NTPTR* NTP-TR-311,1986
inhalation
rat
toxic concentration (other than lowest) : 200 ppm/6 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Blood: Leukemia
TOLED5 31(Suppl),16,1986
inhalation
rat
lowest published toxic concentration: 6,180 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB87-147054/AS
inhalation
rat
lowest published toxic concentration: 5,150 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB87-147054/AS
oral
mouse
lowest published toxic dose: 195 gm/kg/50 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-13,1977
oral
mouse
toxic dose : 240 gm/kg/62 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-13,1977


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 36,000 mg/m3/270 minute Behavioral: General anesthetic VCVGH* -,457,1990
inhalation
human
lowest published toxic concentration: 96 ppm/7 hour Peripheral Nerve and Sensation: Local anesthetic

Eye: Conjunctiva irritation

Behavioral: Hallucinations, distorted perceptions
NTIS** PB257-185
inhalation
human
lowest published toxic concentration: 1,000 ppm Behavioral: General anesthetic VCVGH* -,457,1990
inhalation
human
lowest published toxic concentration: 500 mg/m3/1 minute Eye: Conjunctiva irritation VCVGH* -,457,1990
inhalation
human
lowest published toxic concentration: 650 mg/m3/7 hour Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Behavioral: Headache
VCVGH* -,457,1990
inhalation
human
lowest published toxic concentration: 1,500 mg/m3/20 minute Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)
VCVGH* -,458,1990
inhalation
human
lowest published toxic concentration: 1,900 mg/m3/2 hour Eye: Conjunctiva irritation

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting
VCVGH* -,458,1990
inhalation
human
lowest published toxic concentration: 2,700 mg/m3/3 hour Behavioral: Somnolence (general depressed activity)

Liver: Other changes
VCVGH* -,458,1990
inhalation
human
lowest published toxic concentration: 3,500 mg/m3/10 minute Lung, Thorax, or Respiration: Cough VCVGH* -,458,1990
inhalation
human
lowest published toxic concentration: 6,400 mg/m3 Eye: Conjunctiva irritation

Gastrointestinal: Changes in structure or function of salivary glands
VCVGH* -,458,1990
inhalation
human
lowest published toxic concentration: 13,500 mg/m3/5 minute Gastrointestinal: Changes in structure or function of salivary glands VCVGH* -,458,1990
inhalation
human
lowest published toxic concentration: 200 ppm Eye: Conjunctiva irritation VCVGH* -,458,1990
inhalation
human
lowest published toxic concentration: 6,000 ppm/1 minute Behavioral: Coma

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Hepatitis (hepatocellular necrosis), diffuse
VCVGH* -,458,1990
inhalation
man
lowest published toxic concentration: 600 ppm/10 minute Eye: Conjunctiva irritation

Behavioral: General anesthetic
AMIHBC 5,566,1952
inhalation
mouse
lethal concentration (50 percent kill): 5,200 ppm/4 hour N/R APTOA6 9,303,1953
inhalation
mouse
lowest published toxic concentration: 20,000 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,456,1990
inhalation
mouse
lowest published lethal concentration: 40,000 mg/m3/2 hour N/R VCVGH* -,456,1990
inhalation
mouse
lethal concentration (50 percent kill): 35,000 mg/m3/4 hour N/R VCVGH* -,456,1990
inhalation
mouse
lethal concentration (50 percent kill): 20,200 mg/m3/6 hour N/R VCVGH* -,456,1990
inhalation
mouse
lowest published toxic concentration: 1,340 mg/m3/4 hour Liver: Fatty liver degeneration VCVGH* -,457,1990
inhalation
mouse
lowest published toxic concentration: 3,390 mg/m3/4 hour Liver: Other changes VCVGH* -,457,1990
inhalation
mouse
lethal concentration (50 percent kill): 2,978 ppm/6 hour N/R ENTOX* -,150,2005
inhalation
rat
lethal concentration (50 percent kill): 34,200 mg/m3/8 hour N/R AIHAAP 20,364,1959
inhalation
rat
lowest published lethal concentration: 40,800 mg/m3/1 minute Behavioral: General anesthetic VCVGH* -,456,1990
inhalation
rat
lowest published lethal concentration: 40,800 mg/m3/5 hour N/R VCVGH* -,456,1990
inhalation
rat
lethal concentration (50 percent kill): 4,100 ppm/6 hour N/R ENTOX* -,150,2005
intraperitoneal
dog
lethal dose (50 percent kill): 2,100 mg/kg Liver: Liver function tests impaired TXAPA9 10,119,1967
intraperitoneal
mouse
lethal dose : >500 mg/kg N/R CBCCT* 4,378,1952
intraperitoneal
rat
lethal dose (50 percent kill): 4,678 mg/kg N/R ENVRAL 40,411,1986
intratracheal
rat
lowest published lethal dose: 450 mg/kg N/R NTIS** OTS0520615
intravenous
dog
lowest published lethal dose: 85 mg/kg N/R QJPPAL 7,205,1934
oral
cat
lowest published lethal dose: 4 gm/kg Behavioral: Sleep

Behavioral: Somnolence (general depressed activity)
AJHYA2 9,430,1929
oral
child
lowest published toxic dose: 545 mg/kg Behavioral: Coma JTCTDW 23,103,1985
oral
dog
lowest published lethal dose: 4 gm/kg Behavioral: Sleep

Behavioral: Somnolence (general depressed activity)
AJHYA2 9,430,1929
oral
dog
lowest published toxic dose: 306 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGH* -,457,1990
oral
mouse
lethal dose (50 percent kill): 8,100 mg/kg Behavioral: General anesthetic NTIS** PB257-185
oral
mouse
lethal dose (50 percent kill): 6,400 mg/kg N/R VCVGH* -,457,1990
oral
mouse
lowest published toxic dose: 150 mg/kg Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 232,1,2007
oral
mouse
lowest published toxic dose: 500 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration
TXCYAC 232,1,2007
oral
rat
lethal dose (50 percent kill): 2,629 mg/kg N/R AIHAAP 20,364,1959
oral
rat
lowest published toxic dose: 50 mg/kg Behavioral: Anticonvulsant TXCYAC 170,201,2002
oral
rabbit
lowest published lethal dose: 5 gm/kg Behavioral: Sleep

Behavioral: Somnolence (general depressed activity)
AJHYA2 9,430,1929
subcutaneous
mouse
lethal dose (50 percent kill): 65 gm/kg Behavioral: Sleep

Behavioral: Ataxia
JPETAB 123,224,1958
subcutaneous
rabbit
lowest published lethal dose: 2,200 mg/kg N/R QJPPAL 7,205,1934
skin
rabbit
lethal dose : >3,228 mg/kg N/R NTIS** AD-A180-198
unreported route
human
lowest published lethal dose: 0.7 mL/kg N/R VCVGH* -,457,1990
unreported route
rat
lethal dose (50 percent kill): 4,000 mg/kg N/R VCVGH* -,457,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 200 ppm/7 hour/32 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHBC 5,566,1952
inhalation
guinea pig
lowest published toxic concentration: 680 mg/m3/200 day- continuous Liver: Changes in liver weight VCVGH* -,460,1990
inhalation
gerbil
lowest published toxic concentration: 120 ppm/24 hour/1 year- continuous Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 22,343,1984
inhalation
mouse
lowest published toxic concentration: 200 ppm/4 hour/8 week- intermittent Liver: Fatty liver degeneration APTOA6 22,379,1965
inhalation
mouse
lowest published toxic concentration: 1,750 ppm/6 hour/14 day- intermittent Liver: Fatty liver degeneration NTPTR* NTP-TR-311,1986
inhalation
mouse
lowest published toxic concentration: 1,600 ppm/6 hour/13 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-311,1986
inhalation
rat
lowest published toxic concentration: 1,750 ppm/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-311,1986
inhalation
rat
lowest published toxic concentration: 19,300 mg/m3/24 hour/94 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 42(8),50,1977
inhalation
rat
lowest published toxic concentration: 200 ppm/4 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOLED5 54,207,1990
inhalation
rat
lowest published toxic concentration: 7,000 ppm/8 hour/50 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Blood: Changes in spleen
JIHTAB 19,323,1937
inhalation
rat
lowest published toxic concentration: 1,500 mg/m3/8 hour/28 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
VCVGH* -,459,1990
inhalation
rat
lowest published toxic concentration: 10,900 mg/m3/2 week- continuous Gastrointestinal: Changes in structure or function of salivary glands

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
VCVGH* -,459,1990
inhalation
rat
lowest published toxic concentration: 320 ppm/30 day- intermittent Brain and Coverings: Other degenerative changes

Brain and Coverings: Changes in brain weight

Biochemical: Metabolism (intermediary): Lipids including transport
SWEHDO 14,91,1988
inhalation
rat
lowest published toxic concentration: 1,700 ppm/10 day- intermittent Reproductive: Effects on fertility: Other measures of fertility REPTED 17,273,2003
inhalation
rat
lowest published toxic concentration: 600 ppm/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 77,405,2006
inhalation
rabbit
lowest published toxic concentration: 2,500 ppm/7 hour/39 day- intermittent Behavioral: Somnolence (general depressed activity) AMIHBC 5,566,1952
intramuscular
gerbil
lowest published toxic dose: 320 ppm/90 day- continuous Brain and Coverings: Other degenerative changes

Brain and Coverings: Changes in brain weight

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 60,397,1987
intramuscular
gerbil
lowest published toxic dose: 120 ppm/1 year- continuous Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 22,343,1984
intramuscular
rat
lowest published toxic dose: 320 ppm/90 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 52,279,1990
intramuscular
rat
lowest published toxic dose: 320 ppm/30 day- continuous Brain and Coverings: Changes in brain weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Lipids including transport
SWEHDO 14,91,1988
intraperitoneal
rat
lowest published toxic dose: 49,750 Ág/kg/3 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Other changes
TIHEEC 8,191,1992
oral
mouse
lowest published toxic dose: 23,215 mg/kg/8 week- intermittent Immunological Including Allergic: Autoimmune (multiple organ involvement) TOXID9 54,74,2000
oral
mouse
lowest published toxic dose: 30,000 mg/kg/30 day- intermittent Behavioral: Tremor

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 232,1,2007
oral
mouse
lowest published toxic dose: 7,000 mg/kg/7 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXCYAC 232,1,2007
oral
mouse
lowest published toxic dose: 1,050 mg/kg/7 day- intermittent Liver: Other changes TXCYAC 232,1,2007
oral
mouse
lowest published toxic dose: 3,500 mg/kg/7 day- intermittent Kidney, Ureter, and Bladder: Other changes TXCYAC 232,1,2007
oral
rat
lowest published toxic dose: 14 gm/kg/4 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition ENVRAL 59,427,1992
oral
rat
lowest published toxic dose: 36 gm/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
FAATDF 7,119,1986
oral
rat
lowest published toxic dose: 3 gm/kg/6 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 78,105,1985
oral
rat
lowest published toxic dose: 200 mg/kg/40 day- intermittent Behavioral: Anticonvulsant

Behavioral: Analgesia
TXCYAC 170,201,2002
oral
rat
lowest published toxic dose: 2,000 mg/kg/40 day- intermittent Behavioral: Anticonvulsant

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 170,201,2002
oral
rat
lowest published toxic dose: 7,000 mg/kg/7 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) CALEDQ 106,235,1996
oral
rat
lowest published toxic dose: 12.6 gm/kg/2 week- continuous Reproductive: Effects on fertility: Other measures of fertility REPTED 17,273,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm;short term exposure limit 100 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMSUDL 7,355,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 63,159,1995
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 63,159,1995
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,355,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,355,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 63,159,1995
TOXICOLOGY REVIEW
CMSHAF 6,517,1977
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
TOLED5 134,17,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
CRTXB2 33,137,2003
TOXICOLOGY REVIEW
TXCYAC 196,1,2004
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
MUREAV 627,59,2007
TOXICOLOGY REVIEW
ENTOX* -,150,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,269,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (670 mg/m3) DTLVS* 3,201,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm;
ceiling concentration 200;
peak concentration 300/5 minute/3 hour
CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (670 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (670 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (670 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 5 ppm (35 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (340 mg/m3), short term exposure limit 150 ppm (1020 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (172 mg/m3), short term exposure limit 100 ppm(695 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (70 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (335 mg/m3), short term exposure limit 75 ppm (520 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (335 mg/m3), continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 50 mg/m3, short term exposure limit 50 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit Pending, skin, 2B carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 50 ppm (335 mg/m3), short term exposure limit 200 ppm (1340 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (670 mg/m3);
short term exposure limit 200 ppm (1340 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 240 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (335 mg/m3), short term exposure limit 150 ppm (1005 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (130 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (670 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 60 mg/m3, MAC(short term exposure limit) 480 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (70 mg/m3);
short term exposure limit 25 ppm (170 mg/m3), Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (345 mg/m3),KZG- week 100 ppm (690 mg/m3), Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 100 ppm, short term exposure limit 200 ppm, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (345 mg/m3);
short term exposure limit 100 ppm, 2005
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRACHLOROETHYLENE-air Carcinogen lowest feasible conc. NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 54790;
Number of Industries 288;
Total Number of Facilities 52,013;
Number of Occupations 155;
Total Number of Employees Exposed 549,154
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 54790;
Number of Industries 268;
Total Number of Facilities 49,025;
Number of Occupations 151;
Total Number of Employees Exposed 688,110;
Total Number of Female Employees Exposed 177,342


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101181/AS)
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in textile industry and as a chemical intermediate or a heat-exchange fluid
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-1292-8618;8EHQ-0393-8618
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0294-8618;8EHQ-0393-8762
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 20, 1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NTP Carcinogenesis Studies (inhalation);clear evidence:mouse,rat NTPTR* NTP-TR-311,1986
NCI Carcinogenesis Bioassay (gavage);inadequate studies:rat NCITR* NCI-TR-13,1977
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #1001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For publisher information, see AJEPAS.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BDERB*
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher information, see ICDBEO.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in textile industry and as a chemical intermediate or a heat-exchange fluid

NIOSH PROFILE (SOLDER, MANUFACTURE AND USE), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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