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Ethylene glycol, dinitrate

RTECS #: KW5600000

CAS #: 628-96-6


UPDATE: May 2009 MW: 152.08 MF: C2H4N2O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Dinitroglicol (Italian)
  2. Dinitroglycol
  3. EGDN
  4. Ethanediol dinitrate
  5. Ethylene dinitrate
  6. Ethylene glycol dinitrate (ACGIH:OSHA)
  7. Ethylene nitrate
  1. Ethylenglykoldinitrat (Czech)
  2. Glycol (dinitrate de) (French)
  3. Glycol dinitrate
  4. Glycoldinitraat (Dutch)
  5. Glykoldinitrat (German)
  6. Nitroglycol
  7. Nitroglykol (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 540 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes
STGNBT -,96,1999
oral
rat
lethal dose (50 percent kill): 460 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes
STGNBT -,96,1999
subcutaneous
cat
lowest published lethal dose: 75 mg/kg Blood: Normocytic anemia AEPPAE 200,271,1942
subcutaneous
rabbit
lowest published lethal dose: 300 mg/kg Vascular: Other changes

Blood: Normocytic anemia
AEPPAE 200,271,1942
skin
rat
lethal dose (50 percent kill): 3,800 mg/kg N/R STGNBT -,96,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 10 mg/m3/17 week- intermittent Cardiac: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Pigmented or nucleated red blood cells
STGNBT -,96,1999
oral
rat
lowest published toxic dose: 3,067 mg/kg/20 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
STGNBT -,96,1999
subcutaneous
rat
lowest published toxic dose: 1 gm/kg/10 day- intermittent Behavioral: Tolerance

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
PHTOEH 61,172,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
NTIS** AD778-725
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.2 ppm (1 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.2 ppm (1 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.2 ppm (1 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.2 ppm (1 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.31 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.31 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.02 ppm (0.12 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.6 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.17 ppm (1 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.32 mg/m3 (0.05 mL/m3), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 ppm (0.31 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.05 ppm (0.3 mg/m3), skin, 2006
Occupational Exposure Limit - KOREA time-weighted average 0.5 ppm (1.2 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.05 ppm (0.3 mg/m3);
short term exposure limit 0.1 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.3 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 ppm (0.31 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.03 ppm (0.18 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 ppm (1.2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 0.3 mg/m3, short term exposure limit 0.4 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.03 ppm (0.2 mg/m3);
short term exposure limit 0.1 ppm (0.6 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.3 mg/m3),KZG- week 0.05 ppm (0.3 mg/m3), Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.2 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.2 ppm (1 mg/m3), Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE GLYCOL DINITRATE-air short term exposure limit 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethylene glycol dinitrate, 2507
OSHA ANALYTICAL METHOD #43


REFERENCES:

CODEN
REFERENCE

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999

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