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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethylene glycol

RTECS #

KW2975000

CAS #

107-21-1; 71767-64-1

Updated

December 2013

Molecular Weight

62.08

Molecular Formula

C2H6O2

Synonyms

1,2-Dihydroxyethane
1,2-Ethandiol
1,2-Ethanediol
Athylenglykol (German)
Dowtherm SR 1
Ethane-1,2-diol
Ethylene alcohol
Ethylene dihydrate
Ethylene glycol (ACGIH)
Ethylene glycol, aerosol
Glycol alcohol
Lutrol-9
M.E.G.
Macrogol 400 BPC
Monoethylene glycol
NCI-C00920
Norkool
Tescol
Ucar 17

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,205,1986
eye /rabbit 100 mg/1H mildNTIS** LMF-69
eye /rabbit 0.012 ppm/3DTXAPA9 16,646,1970
eye /rabbit 1440 mg/6H moderateBUYRAI 31,25,1977
eye /rat 0.012%/3DTXAPA9 16,646,1970
skin /rabbit 555 mg open irritation test mildUCDS** 7/21/1965

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat1200 mg/kgTGANAK 19,436,1985
DNA Damageovary/hamster50 gm/L/2H (+enzymatic activation step)FCTOD7 48,1905,2010
DNA inhibitionlymphocyte/human320 mmol/LPNASA6 79,1171,1982
micronucleus testovary/hamster50 gm/L/3H (+enzymatic activation step)FCTOD7 48,1905,2010
mutation in mammalian somatic cellslymphocyte/mouse100 mmol/LPAACA3 21,74,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 2500 mg/m3/6H (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
FAATDF 24,57,1995
inhalation/mouse 1000 mg/m3/6H (6-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
FAATDF 24,57,1995
inhalation/mouse 1000 mg/m3/6H (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Sex ratio
FAATDF 24,57,1995
inhalation/mouse 2100 mg/m3/6H (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
FAATDF 27,49,1995
inhalation/mouse 2100 mg/m3/6H (6-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 27,49,1995
oral/rabbit 28 gm/kg (6-19D pregnant)Reproductive: Other effects on femaleNTIS** PB91-211219
oral/mouse 88720 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
EVHPAZ 57,141,1984
oral/mouse 7500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 81,113,1985
oral/mouse 7500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 29(2),52A,1984
oral/mouse 84 gm/kg (1-21D preg/21D after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
TOXID9 4,136,1984
oral/mouse 88720 mg/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
EVHPAZ 57,141,1984
oral/mouse 15 gm/kg (6-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Other measures of fertility
NTIS** PB85-105385
oral/rat 50 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
TXAPA9 81,113,1985
oral/rat 8580 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
CHYCDW 20,289,1986
oral/rat 12500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 29(2),52A,1984
oral/rat 25 gm/kg (6-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** PB85-104594
oral/rat 51948 mg/kg (13W male)Reproductive: Paternal effects: Testes, epididymis, sperm ductWDZAEK 8,12,1994
oral/mouse 413 gm/kg (15W male/15W pre-3W after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 81,100,1985
oral/mouse 413 gm/kg (15W male/15W pre-3W after birth)Reproductive: Effects on newborn: Delayed effectsTXAPA9 81,100,1985
oral/mouse 1.7 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB84241108
oral/mouse 1.7 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Central nervous systemNTIS** #PB84241108
oral/mouse 1.7 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary systemNTIS** #PB84241108
oral/mouse 7.5 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** #PB85-105385
oral/mouse 7.5 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
NTIS** #PB85-105385
oral/mouse 29.75 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB84241108
oral/mouse 59.5 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility
NTIS** #PB84241108
oral/mouse 98 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)NTIS** #PB86177383
oral/mouse 294 gm/kg (15W prior to copulation)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB86177383
oral/mouse 15 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** #PB85-105385
oral/mouse 15 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathNTIS** #PB85-105385
oral/rat 18.8 gm/kg (6-20D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB88-204326/AS
oral/mouse 850 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB86177383
oral/mouse 850 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital systemNTIS** #PB86177383
oral/rat 25000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB95-274528
oral/rabbit 28000 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Stillbirth
NTIS** #PB91-211219
oral/rat 33750 mg/kg (6-20D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB88-204326/AS
oral/rat 33750 mg/kg (6-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** #PB88-204326/AS
unreported route/rat 50000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,140,1994
unreported route/mouse 7500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,140,1994
unreported route/rat 5000 mg/kg (multigenerations)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,140,1994
unreported route/mouse 750 mg/kg (multigenerations)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,140,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
eye/rabbit lowest published toxic dose: 10 pphEye: Conjunctiva irritationVCVGK* -,141,1984
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 1706485 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 712350 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 1447621 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 591179 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Hamster, lung fibroblast Inhibitor Concentration (50 percent kill): 365 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Hamster, lung fibroblast Inhibitor Concentration (10 percent kill): 100 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Human, HeLa cell Inhibitor Concentration (50 percent kill): 415 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Human, HeLa cell Inhibitor Concentration (10 percent kill): 117.5 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Human, liver Inhibitor Concentration (50 percent kill): 138 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Human, liver Inhibitor Concentration (10 percent kill): 70 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 60000 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,367,1992
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 440000 mg/L/1MIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,367,1992
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 290 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 83 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 262 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Rat, liver Inhibitor Concentration (10 percent kill): 83 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 93 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 96 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 35.5 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 169 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 43.7 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 158 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
inhalation/human lowest published toxic concentration: 10000 mg/m3Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
AGGHAR 5,1,1933
inhalation/human lowest published toxic concentration: 22 mg/m3Kidney, Ureter, and Bladder: ProteinuriaIAEHDW 69,255,1997
inhalation/mouse Lethal concentration: >200 mg/m3/2HGTPZAB 25(11),57,1981
inhalation/rabbit lowest published toxic concentration: 12 mg/m3Eye: Conjunctiva irritationVCVGK* -,141,1984
inhalation/rabbit lowest published toxic concentration: 4 mg/m3/2HBehavioral: Alteration of classical conditioningVCVGK* -,139,1984
inhalation/rat lowest published toxic concentration: 0.004 gm/m3/2HBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea
TPKVAL 7,102,1965
inhalation/rat Lethal concentration: >200 mg/m3/4HGTPZAB 25(11),57,1981
intramuscular/rabbit lowest published lethal dose: 5500 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
JPETAB 41,387,1931
intramuscular/rabbit lowest published lethal dose: 5500 mg/kgVCVGK* -,139,1984
intramuscular/rat lowest published lethal dose: 3300 mg/kgVCVGK* -,139,1984
intramuscular/rat lowest published lethal dose: 3300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
JPETAB 41,387,1931
intraperitoneal/monkey lowest published lethal dose: 4000 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)VCVGK* -,140,1984
intraperitoneal/mouse lethal dose (50 percent kill): 1700 mg/kgVCVGK* -,139,1984
intraperitoneal/mouse lethal dose (50 percent kill): 5614 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen
FEPRA7 6,342,1947
intraperitoneal/rabbit lowest published lethal dose: 1000 mg/kgVCVGK* -,139,1984
intraperitoneal/rat lethal dose (50 percent kill): 5010 mg/kgKRKRDT 9,36,1981
intravenous/mouse lethal dose (50 percent kill): 300 mg/kgVCVGK* -,139,1984
intravenous/rabbit lowest published lethal dose: 5 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
JPETAB 41,387,1931
intravenous/rabbit lowest published lethal dose: 5000 mg/kgVCVGK* -,139,1984
intravenous/rat lowest published lethal dose: 2800 mg/kgVCVGK* -,139,1984
intravenous/rat lethal dose (50 percent kill): 3260 mg/kgKRKRDT 9,36,1981
ocular/rabbit lowest published toxic dose: 100 pphEye: Lacrimation

Eye: Conjunctiva irritation
TPKVAL 7,102,1965
oral/cat lethal dose (50 percent kill): 2000 mg/kgVCVGK* -,139,1984
oral/cat lethal dose (50 percent kill): 1650 mg/kgKidney, Ureter, and Bladder: Other changesRMVEAG 154,137,1978
oral/child lowest published toxic dose: 5500 mg/kgBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes
PGMJAO 52,598,1976
oral/Dog lethal dose (50 percent kill): 5500 mg/kgKidney, Ureter, and Bladder: Other changesRMVEAG 154,137,1978
oral/guinea pig lethal dose (50 percent kill): 6610 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/guinea pig lethal dose (50 percent kill): 6600 mg/kgVCVGK* -,139,1984
oral/human lowest published lethal dose: 1.43 mL/kgAPLMAS 129,e81,2005
oral/human lowest published lethal dose: 786 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Gastrointestinal: Hypermotility, diarrhea
EJTXAZ 9,373,1976
oral/human lowest published lethal dose: 398 mg/kgBehavioral: Headache

Gastrointestinal: Nausea or vomiting

Liver: Other changes
SMEZA5 26(2),48,1983
oral/man lowest published toxic dose: 16 gm/kgBehavioral: Coma

Kidney, Ureter, and Bladder: Renal function tests depressed

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
HETOEA 9,317,1990
oral/man lowest published toxic dose: 24 gm/kgBrain and Coverings: Recordings from specific areas of CNS

Eye: Mydriasis (pupilliary dilation)

Lung, Thorax, or Respiration: Other changes
JTCTDW 38,445,2000
oral/man lowest published toxic dose: 15 gm/kgPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Gastrointestinal: Ulceration or bleeding from small intestine

Kidney, Ureter, and Bladder: Renal function tests depressed
AEMED3 20,208,1991
oral/man lowest published toxic dose: 1195 mg/kgPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Kidney, Ureter, and Bladder: Renal function tests depressed
AEMED3 20,208,1991
oral/man lowest published toxic dose: 24 gm/kgBrain and Coverings: Recordings from specific areas of CNS

Brain and Coverings: Other degenerative changes
JTCTDW 38,445,2000
oral/man lowest published toxic dose: 24 gm/kgBrain and Coverings: Other degenerative changes

Behavioral: Ataxia

Behavioral: Coma
JTCTDW 38,445,2000
oral/mouse lethal dose (50 percent kill): 5500 mg/kgGISAAA 32(3),31,1967
oral/rat lowest published toxic dose: 120 mg/kgBlood: Changes in bone marrow not included in aboveVCVGK* -,140,1984
oral/rat lowest published toxic dose: 2 gm/kgKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 46,402,2008
oral/rat lethal dose (50 percent kill): 4700 mg/kgVCVGK* -,139,1984
oral/rat lowest published toxic dose: 1110 mg/kgBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVGK* -,139,1984
oral/rat lowest published toxic dose: 5000 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Tetany

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVGK* -,139,1984
oral/rat lowest published toxic dose: 1000 mg/kgBrain and Coverings: Increased intracranial pressure

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,139,1984
skin/rabbit lethal dose (50 percent kill): 9530 µL/kg34ZIAG -,731,1969
subcutaneous/cat lowest published lethal dose: 2 gm/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Blood: Other changes
AGGHAR 5,1,1933
subcutaneous/cat lowest published lethal dose: 2000 mg/kgVCVGK* -,139,1984
subcutaneous/guinea pig lowest published lethal dose: 5000 mg/kgVCVGK* -,139,1984
subcutaneous/mouse lowest published toxic dose: 5000 mg/kgKidney, Ureter, and Bladder: Renal function tests depressedEKFAE9 55,21,1992
subcutaneous/mouse lowest published lethal dose: 2700 mg/kgBJIMAG 1,207,1944
subcutaneous/mouse lethal dose (50 percent kill): 2700 mg/kgVCVGK* -,139,1984
subcutaneous/rabbit lethal dose (50 percent kill): 19500 mg/kgVCVGK* -,139,1984
subcutaneous/rat lowest published toxic dose: 3000 mg/kgKidney, Ureter, and Bladder: Renal function tests depressedEKFAE9 55,21,1992
subcutaneous/rat lethal dose (50 percent kill): 2800 mg/kgNPIRI* 1,49,1974
unreported route/guinea pig lethal dose (50 percent kill): 11150 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968
unreported route/human lowest published lethal dose: 70 mg/kgCardiac: Change in rate

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes
VCVGK* -,140,1984
unreported route/man lowest published lethal dose: 1637 mg/kg85DCAI 2,73,1970
unreported route/mouse lethal dose (50 percent kill): 8050 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968
unreported route/rabbit lethal dose (50 percent kill): 5017 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968
unreported route/rat lethal dose (50 percent kill): 13 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 500000 mg/m3/6H/5D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: General anesthetic
VCVGK* -,140,1994
inhalation/guinea pig lowest published toxic concentration: 1 mg/m3/122D- intermittentEye: Conjunctiva irritation

Behavioral: Irritability

Lung, Thorax, or Respiration: Cough
VCVGK* -,140,1994
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/7D- intermittentLung, Thorax, or Respiration: Respiratory depressionTPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/45D- intermittentBehavioral: Excitement

Liver: Liver function tests impaired
TPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/76D- intermittentBehavioral: AggressionTPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/106D- intermittentBehavioral: Somnolence (general depressed activity)TPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/122D- intermittentKidney, Ureter, and Bladder: Urine volume increasedTPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/61D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/183D- intermittentBrain and Coverings: Other degenerative changes

Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 1 mg/m3/154D- intermittentVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
VCVGK* -,140,1994
inhalation/human lowest published toxic concentration: 140 mg/m3/30D- intermittentLung, Thorax, or Respiration: CoughVCVGK* -,140,1994
inhalation/mammal (species unspecified) lowest published toxic concentration: 20 mg/m3/5Y- intermittentCardiac: Other changes

Vascular: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,141,1994
inhalation/mammal (species unspecified) lowest published toxic concentration: 256 mg/m3/28D- intermittentLiver: Liver function tests impairedVCVGK* -,140,1994
inhalation/monkey lowest published toxic concentration: 500000 mg/m3/6H/5D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: General anesthetic
VCVGK* -,140,1994
inhalation/mouse lowest published toxic concentration: 1 mg/m3/154D- intermittentVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
VCVGK* -,140,1994
inhalation/mouse lowest published toxic concentration: 10 mg/m3/122D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,140,1994
inhalation/mouse lowest published toxic concentration: 1 mg/m3/122D- intermittentEye: Conjunctiva irritation

Behavioral: Irritability

Lung, Thorax, or Respiration: Cough
VCVGK* -,140,1994
inhalation/mouse lowest published toxic concentration: 0.003 gm/m3/61D- intermittentBehavioral: Aggression

Vascular: Other changes

Lung, Thorax, or Respiration: Respiratory stimulation
TPKVAL 7,102,1965
inhalation/mouse lowest published toxic concentration: 0.003 gm/m3/30D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 7,102,1965
inhalation/mouse lowest published toxic concentration: 0.003 gm/m3/122D- intermittentLung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,102,1965
inhalation/rabbit lowest published toxic concentration: 12 mg/m3/8H/90D- intermittentEye: Corneal damage

Eye: Other eye effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 16,646,1970
inhalation/rat lowest published toxic concentration: 120 mg/m3/8D- intermittentEye: Corneal damageVCVGK* -,140,1994
inhalation/rat lowest published toxic concentration: 198 mg/m3/4H/122D- intermittentCardiac: Other changes

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,140,1994
inhalation/rat lowest published toxic concentration: 8400 µg/m3/24H/12W- continuousBrain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 39(9),106,1974
inhalation/rat lowest published toxic concentration: 12 mg/m3/8H/90D- intermittentEye: Corneal damage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 16,646,1970
inhalation/rat lowest published toxic concentration: 1 mg/m3/122D- intermittentEye: Conjunctiva irritation

Behavioral: Irritability

Lung, Thorax, or Respiration: Cough
VCVGK* -,140,1994
inhalation/rat lowest published toxic concentration: 1 mg/m3/154D- intermittentVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
VCVGK* -,140,1994
inhalation/rat lowest published toxic concentration: 1 mg/m3/32W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/7D- intermittentBehavioral: Excitement

Vascular: Other changes
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/14D- intermittentEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory stimulation
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/61D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/76D- intermittentBehavioral: AggressionTPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/106D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/228D- intermittentBrain and Coverings: Other degenerative changes

Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Emphysema
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/2W- intermittentBehavioral: AggressionTPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/20D- intermittentBehavioral: Somnolence (general depressed activity)TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/4W- intermittentEye: Conjunctiva irritation

Vascular: Other changes
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/153D- intermittentLung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/45D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/61D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in other cell count (unspecified)
TPKVAL 7,102,1965
oral/monkey lowest published toxic dose: 5751 gm/kg/22W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)TXAPA9 15,624,1969
oral/mouse lowest published toxic dose: 88720 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/mouse lowest published toxic dose: 546 gm/kg/13W- continuousLiver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-413,1993
oral/mouse lowest published toxic dose: 1081 gm/kg/2Y- continuousLiver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
NTPTR* NTP-TR-413,1993
oral/mouse lowest published toxic dose: 29.4 gm/kg/7D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 81,100,1985
oral/mouse lowest published toxic dose: 117.6 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 81,100,1985
oral/mouse lowest published toxic dose: 82.3 gm/kg/14W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 81,100,1985
oral/mouse lowest published toxic dose: 15000 mg/kg/10D- continuousSkin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Changes in liver weight
NTIS** #PB85-105385
oral/mouse lowest published toxic dose: 294000 mg/kg/15W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB86177383
oral/rabbit lowest published toxic dose: 28000 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** #PB91-211219
oral/rat lowest published toxic dose: 25000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB95-274528
oral/rat lowest published toxic dose: 10.9 gm/kg/7D- intermittentKidney, Ureter, and Bladder: Proteinuria

Nutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: P
PHMREP 43,89,2001
oral/rat lowest published toxic dose: 18.2 gm/kg/1Y- continuousKidney, Ureter, and Bladder: Other changes in urine compositionTXAPA9 228,165,2008
oral/rat lowest published toxic dose: 109.5 gm/kg/1Y- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Urine volume increased
TXAPA9 228,165,2008
oral/rat lowest published toxic dose: 146 gm/kg/1Y- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 228,165,2008
oral/rat lowest published toxic dose: 42 mg/kg/8W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
TOXID9 -,103,2009
oral/rat lowest published toxic dose: 5.25 gm/kg/1W- continuousKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition
FCTOD7 48,1013,2010
oral/rat lowest published toxic dose: 21 gm/kg/4W- continuousKidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
FCTOD7 48,1013,2010
oral/rat lowest published toxic dose: 33750 mg/kg/15D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Maternal effects: Uterus, cervix, vagina
NTIS** #PB85-105385
oral/rat lowest published toxic dose: 18750 mg/kg/15D- intermittentKidney, Ureter, and Bladder: Other changesNTIS** #PB85-105385
oral/rat lowest published toxic dose: 14 mL/kg/2W- continuousLiver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
JOUOD4 13,13,1991
oral/rat lowest published toxic dose: 438 gm/kg/2Y- continuousBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTXAV 3,229,1965
oral/rat lowest published toxic dose: 85230 mg/kg/90D- continuousKidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: P
DCTODJ 13,43,1990
oral/rat lowest published toxic dose: 12 mL/kg/6D- intermittentNutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: P

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TXAPA9 39,543,1977
oral/rat lowest published toxic dose: 26150 mg/kg/10D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
DCTODJ 13,43,1990
unreported route/rat lowest published toxic dose: 9.1 mg/kg/26W- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVGK* -,141,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 100 mg/m3 (aerosol)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWREPTED 8,99,1994
TOXICOLOGY REVIEWJEMME* 15,653,1997
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWARTODN 78,671,2004
TOXICOLOGY REVIEWAINCM* 7,63,2006
TOXICOLOGY REVIEWENTOX* -,287,2005
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWFSINDR 155,179,2005
TOXICOLOGY REVIEWHUTOX* -,623,1996
TOXICOLOGY REVIEWAIRMJ* 18,114,1999
TOXICOLOGY REVIEWFESTAS 90,911,2008
TOXICOLOGY REVIEWREPTED 34,298,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,308,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 mg/m3 (particulate)DTLWS* 3,19,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3 (aerosol), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 20 ppm (52 mg/m3), short term exposure limit 40 ppm (104 mg/m3) (vapor), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (26 mg/m3);KZW 20 ppm (52 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (52 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 40 ppm (104 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 mg/m3 (aerosol), MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (26 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 52 mg/m3 (20 ppm);short term exposure limit 104 mg/m3 (40 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (50 mg/m3), short term exposure limit 40 ppm (100 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 20 ppm (52 mg/m3), VLE 40 ppm (104 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (26 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 52 mg/m3, short term exposure limit 104 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (26 mg/m3), aerosol, NOV2011
Occupational Exposure Limit-KOREAceiling concentration 50 ppm (125 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (125 mg/m3) (vapor), 2004
Occupational Exposure Limit-MEXICOpeak 100 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 50 ppm (127 mg/m3) (vapour and mist), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (63 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 39 ppm (100 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 15 mg/m3, MAC(short term exposure limit) 50 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (25 mg/m3);short term exposure limit 20 ppm (50 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (26 mg/m3), KZG-week 20 ppm (52 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3 (drops), 2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 52 mg/m3 (fume), 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3 (particulate), skin, OCT2007
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 20 ppm (52 mg/m3);short term exposure limit 40 ppm (104 mg/m3) (vapor), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 32385; Number of Industries 340; Total Number of Facilities 102395; Number of Occupations 214; Total Number of Employees Exposed 1511087; Total Number of Female Employees Exposed 446607
National Occupational Hazard Survey 1974Hazard Code 32385; Number of Industries 308; Total Number of Facilities 69314; Number of Occupations 174; Total Number of Employees Exposed 743782

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101108/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9100;8EHQ-0892-9252
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse
NIOSH Analytical Method, 1994: Ethylene glycol, 5500
NIOSH Analytical Method, 1996: Glycols, 5523
On EPA IRIS database
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