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Ethylene, bromo -

RTECS #: KU8400000

CAS #: 593-60-2


UPDATE: May 2009 MW: 106.96 MF: C2H3Br


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bromoethene
  2. Bromoethene (9CI)
  3. Bromoethylene
  4. Bromure de vinyle (French)
  5. Ethene, bromo -
  6. NCI - C50373
  1. Vinile (bromuro di) (Italian)
  2. Vinyl bromide
  3. Vinyl bromide (ACGIH)
  4. Vinylbromid (German)
  5. Vinyle (bromure de) (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage oral
mouse
2 gm/kg MUREAV 419,13,1998
mutation in microorganisms Salmonella typhimurium 2 pph/16 hour (+/-enzymatic activation step) ARTODN 41,249,1979
morphological transform inhalation
rat
2,000 ppm/14 week- intermittent ARTODN 47,71,1981
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster
14,500 ppm CRNGDP 17,1083,1996
specific locus test inhalation
Drosophila melanogaster
54,000 ppm CRNGDP 17,1083,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 10 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors
TXAPA9 64,367,1982
inhalation
rat
toxic concentration (other than lowest) : 10 ppm Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease
CHWKA9 123(24),25,1978
inhalation
rat
toxic concentration (other than lowest) : 52 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors
TXAPA9 64,367,1982


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 50,000 ppm/7 hour N/R 85INA8 6,1690,1991
inhalation
rat
lowest published toxic concentration: 109,000 mg/m3/7 hour Behavioral: General anesthetic VCVGH* -,599,1990
inhalation
rat
lowest published lethal concentration: 219,000 mg/m3/7 hour N/R VCVGH* -,599,1990
oral
rat
lethal dose (50 percent kill): 500 mg/kg N/R DOWCC* -,12,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 10,000 ppm/7 hour/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 31,1,1970
inhalation
rat
lowest published toxic concentration: 250 ppm/6 hour/26 week- intermittent Cardiac: Changes in heart weight

Liver: Changes in liver weight
AIHAAP 31,1,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 39,133,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,923,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,133,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,923,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 71,923,1999
TOXICOLOGY REVIEW
VHTODE 22,31,1980
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
ENTOX* -,435,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 250 ppm (1100 mg/m3) DTLWS* 3,31,1972
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (22 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (22 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (20 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY ceiling concentration 22 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (20 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.012 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (22 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (22 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL BROMIDE-air Carcinogen lowest feasible concentration NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84575;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84575;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 1,822;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a comonomer with ACRYLONITRILE and other vinyl monomers in modacrylic fibers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 28, 1978
NIOSH Analytical Method, 1994: Vinyl bromide, 1009
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #08


REFERENCES:

CODEN
REFERENCE

85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CHWKA9 Chemical Week. (McGraw-Hill, Inc., 1221 Ave. of the Americas, New York, NY 10020) V.68- 1951-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as a comonomer with ACRYLONITRILE and other vinyl monomers in modacrylic fibers

RTECS Compound Description:
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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