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Ethanol, 2 - (dibutylamino) -

RTECS #: KK3850000

CAS #: 102-81-8


UPDATE: May 2009 MW: 173.34 MF: C10H23NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Di - n - butylaminoethanol
  2. 2 - Dibutylaminoethanol
  3. 2 - N - Dibutylaminoethanol
  4. 2 - N - Dibutylaminoethanol (ACGIH)
  5. BU2AE
  1. DBAE
  2. N,N - Dibutylethanolamine
  3. N,N - Dibutyl - N - (2 - hydroxyethyl) amine
  4. beta - n - Dibutylaminoethyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg open irritation test severe UCDS** 11/29/1963
skin
rabbit
5 mg/24 hour severe 85JCAE -,695,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mammal (species unspecified)
lethal dose (50 percent kill): 120 mg/kg Cardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 8,344,1966
intraperitoneal
mouse
lethal dose (50 percent kill): 52 mg/kg N/R RCRVAB 38,975,1969
intraperitoneal
rat
lethal dose (50 percent kill): 144 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 12,486,1968
oral
rat
lethal dose (50 percent kill): 1,070 mg/kg N/R AMIHBC 10,61,1954
skin
rabbit
lethal dose (50 percent kill): 1,680 ÁL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 70 ppm/6 hour/5 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 30,46,1969
oral
rat
lowest published toxic dose: 7 gm/kg/5 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight AIHAAP 30,46,1969


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (14 mg/m3) (skin) DTLVS* 3,74,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (14 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (3.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (3.5 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 2 ppm (14 mg/m3), short term exposure limit 4 ppm (28 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (14 mg/m3), Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 2 ppm (14 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 ppm (3.5 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3.5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 ppm (14 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (14 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (14 mg/m3), Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-N-DIBUTYLAMINOETHANOL-air 10 hour time-weighted average 2 ppm (Sk) NIOSH* DHHS #95-121,1995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in industry as emulsifying, curing and flotation agent
NIOSH Analytical Method, 1994: Aminoethanol compounds I, 2007


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RCRVAB Russian Chemical Reviws (English Translation). Translation of USKHAB. (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.29- 1960-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in industry as emulsifying, curing and flotation agent

RTECS Compound Description:
   Primary Irritant

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