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Ethanol, 2 - butoxy -

RTECS #: KJ8575000

CAS #: 111-76-2

UPDATE: May 2009 MW: 118.20 MF: C6H14O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 - Butossi - etanolo (Italian)
  2. 2 - Butoxy - 1 - ethanol
  3. 2 - Butoxy - aethanol (German)
  4. 2 - Butoxyethanol
  5. 2 - Butoxyethanol (ACGIH:OSHA)
  6. 3 - Oxa - 1 - heptanol
  7. BUCS
  8. Butoksyetylowy alkohol (Polish)
  9. Butoxyethanol
  10. Butyl cellosolve
  11. Butyl cellosolve (OSHA)
  12. Butyl oxitol
  13. Butylcelosolv (Czech)
  14. Butylglycol (French,German)
  15. Dowanol EB
  1. Ektasolve EB
  2. Ethylene glycol monobutyl ether
  3. Ethylene glycol n - butyl ether
  4. Ethylene glycol, monobutyl ether
  5. Gafcol EB
  6. Glycol butyl ether
  7. Glycol ether EB
  8. Glycol monobutyl ether
  9. Jeffersol EB
  10. Monobutyl ether of ethylene glycol
  11. Monobutyl glycol ether
  12. O - Butyl ethylene glycol
  13. Poly - Solv EB
  14. n - Butoxyethanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe AJOPAA 29,1363,1946
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,629,1986
skin
rabbit 		500 mg open irritation test mild UCDS**


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage unreported route
mouse 		3,150 mg/kg/7 day TOXID9 66,306,2002
unscheduled DNA synthesis unreported route
mouse 		1,575 mg/kg/7 day TOXID9 66,306,2002
mutation in microorganisms Salmonella typhimurium 19 µmol/plate (-enzymatic activation step) MUREAV 341,281,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 ppm/6 hour (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		EVHPAZ 57,47,1984
inhalation
rat 		lowest published toxic concentration: 25 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system EVHPAZ 57,47,1984
inhalation
rat 		lowest published toxic concentration: 12 mg/kg/4 hour (1-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAVUAI 21,30,1989
inhalation
rat 		lowest published toxic concentration: 200 ppm/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** OTS0571237
inhalation
rat 		lowest published toxic concentration: 483 mg/m3 (6 hour/6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		VCVGK* -,167,1994
inhalation
rabbit 		lowest published toxic concentration: 200 ppm/6 hour (6-18 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) 		EVHPAZ 57,47,1984
inhalation
rabbit 		lowest published toxic concentration: 100 ppm/6 hour (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system EVHPAZ 57,47,1984
inhalation
rabbit 		lowest published toxic concentration: 483 mg/m3 (6 hour/6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		VCVGK* -,167,1994
oral
mouse 		lowest published toxic dose: 9,440 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) EVHPAZ 57,141,1984
oral
mouse 		lowest published toxic dose: 7 gm/kg (8-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TCMUD8 7,55,1987
oral
mouse 		lowest published toxic dose: 9,440 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TCMUD8 7,29,1987
oral
mouse 		lowest published toxic dose: 9,440 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) EVHPAZ 57,141,1984
oral
mouse 		lowest published toxic dose: 25.2 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB85226827
oral
mouse 		lowest published toxic dose: 47.25 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) NTIS** #PB85226827
oral
mouse 		lowest published toxic dose: 0.72 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB85226827
oral
mouse 		lowest published toxic dose: 0.72 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system NTIS** #PB85226827
oral
mouse 		lowest published toxic dose: 198.45 gm/kg (21 week prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB85226827
oral
rat 		lowest published toxic dose: 6,279 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTPTR* NIH-93-3349
oral
rat 		lowest published toxic dose: 600 mg/kg (9-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** #PB89-165849


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 250 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-484,2000
inhalation
mouse 		lowest published toxic concentration: 15,600 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB#2000-105865
inhalation
mouse 		lowest published toxic concentration: 15,600 mg/kg/104 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB#2000-105865
inhalation
rat 		lowest published toxic concentration: 125 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors 		NTPTR* NTP-TR-484,2000
inhalation
rat 		lowest published toxic concentration: 3,250 mg/kg/104 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors 		NTIS** PB#2000-105865


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration : >633 ppm/1 hour N/R NTIS** OTS0572613
inhalation
human 		lowest published toxic concentration: 195 ppm/8 hour Gastrointestinal: Nausea or vomiting AMIHAB 14,114,1956
inhalation
human 		lowest published toxic concentration: 100 ppm Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes 		NPIRI* 1,50,1974
inhalation
human 		lowest published toxic concentration: 1,500 mg/m3 Eye: Conjunctiva irritation

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,166,1984
inhalation
mouse 		lethal concentration (50 percent kill): 700 ppm/7 hour Behavioral: Analgesia

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria 		JIHTAB 25,157,1943
inhalation
mouse 		lethal concentration (50 percent kill): 3,380 mg/m3/7 hour Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia 		VCVGK* -,166,1984
inhalation
rat 		lethal concentration (50 percent kill): 450 ppm/4 hour Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 68,405,1983
inhalation
rat 		lethal concentration (50 percent kill): 2,900 mg/m3/7 hour Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia 		VCVGK* -,166,1984
inhalation
rat 		lowest published lethal concentration: 1,800 mg/m3/7 hour Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia 		VCVGK* -,166,1984
intraperitoneal
mammal (species unspecified) 		lowest published toxic dose: 100 mg/kg Endocrine: Change in gonadotropins VCVGK* -,166,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 536 mg/kg N/R SCCUR* -,2,1961
intraperitoneal
rat 		lethal dose (50 percent kill): 220 mg/kg N/R 85GMAT -,67,1982
intraperitoneal
rabbit 		lethal dose (50 percent kill): 220 mg/kg N/R 85GMAT -,67,1982
intravenous
mouse 		lethal dose (50 percent kill): 1,130 mg/kg N/R AMIHAB 14,114,1956
intravenous
rat 		lethal dose (50 percent kill): 307 mg/kg N/R AMIHAB 14,114,1956
intravenous
rabbit 		lethal dose (50 percent kill): 252 mg/kg N/R AMIHAB 14,114,1956
oral
guinea pig 		lethal dose (50 percent kill): 1,200 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIHTAB 23,259,1941
oral
human 		lowest published lethal dose: 143 mg/kg N/R VCVGK* -,166,1984
oral
man 		lowest published toxic dose: 132 mg/kg Behavioral: Sleep

Kidney, Ureter, and Bladder: Hematuria

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis 		JTCTDW 41,57,2003
oral
mouse 		lethal dose (50 percent kill): 1,230 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair 		AMIHAB 14,114,1956
oral
mouse 		lethal dose (50 percent kill): 1,167 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia 		VCVGK* -,166,1984
oral
rat 		lethal dose (50 percent kill): 917 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia 		VCVGK* -,166,1984
oral
rat 		lowest published toxic dose: 500 mg/kg Blood: Other hemolysis with or without anemia TOXID9 44,172,2005
oral
rat 		lowest published lethal dose: 1,500 mg/kg Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance TOXID9 90,61,2006
oral
rat 		lethal dose (50 percent kill): 250 mg/kg N/R ENTOX* -,290,2005
oral
rat 		lethal dose (90 percent kill): 1,500 mg/kg Kidney, Ureter, and Bladder: Hematuria

Blood: Other changes 		TXAPA9 225,102,2007
oral
rabbit 		lethal dose (50 percent kill): 300 mg/kg N/R YKYUA6 32,1241,1981
oral
rabbit 		lethal dose (50 percent kill): 320 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia 		VCVGK* -,166,1984
oral
woman 		lowest published toxic dose: 600 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis 		HUTODJ 7,187,1988
oral
woman 		lowest published toxic dose: 7,813 µL/kg Behavioral: Coma

Vascular: BP lowering not characterized in autonomic section

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis 		HUTODJ 8,243,1989
subcutaneous
mouse 		lowest published lethal dose: 500 mg/kg N/R JPETAB 42,355,1931
skin
guinea pig 		lethal dose (50 percent kill): 230 µL/kg N/R TXAPA9 7,559,1965
skin
rabbit 		lethal dose (50 percent kill): 220 mg/kg N/R DOWCC* MSD-46
skin
rabbit 		lowest published toxic dose: 0.56 mL/kg/1 hour Blood: Other hemolysis with or without anemia

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,167,1984
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,500 mg/kg N/R GISAAA 51(5),61,1986
unreported route
mouse 		lethal dose (50 percent kill): 1,050 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes 		GISAAA 41(11),7,1976
unreported route
rat 		lethal dose (50 percent kill): 917 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes 		GISAAA 41(11),7,1976
unreported route
rat 		lowest published toxic dose: 250 mg/kg Blood: Change in clotting factors TOXID9 44,172,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 415 ppm/7 hour/12 week- intermittent Blood: Microcytosis with or without anemia

Kidney, Ureter, and Bladder: Other changes in urine composition 		JIHTAB 25,409,1943
inhalation
dog 		lowest published toxic concentration: 385 ppm/7 hour/28 day- intermittent Blood: Other changes

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHAB 14,114,1956
inhalation
dog 		lowest published toxic concentration: 2,000 mg/m3/7 hour/12 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		VCVGK* -,167,1994
inhalation
guinea pig 		lowest published toxic concentration: 376 ppm/7 hour/30 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AMIHAB 14,114,1956
inhalation
guinea pig 		lowest published toxic concentration: 2,500 mg/m3/8 hour/12 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,167,1994
inhalation
monkey 		lowest published toxic concentration: 500 mg/m3/7 hour/12 week- intermittent Blood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		VCVGK* -,167,1994
inhalation
mouse 		lowest published toxic concentration: 396 ppm/7 hour/30 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Hematuria

Blood: Other changes 		AMIHAB 14,114,1956
inhalation
mouse 		lowest published toxic concentration: 401 ppm/7 hour/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Hematuria

Blood: Other changes 		AMIHAB 14,114,1956
inhalation
rat 		lowest published toxic concentration: 1,540 mg/m3/7 hour/5 week- intermittent Blood: Changes in erythrocyte (RBC) count JIHTAB 25,374,1943
inhalation
rat 		lowest published toxic concentration: 432 ppm/7 hour/30 day- intermittent Kidney, Ureter, and Bladder: Hematuria

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHAB 14,114,1956
inhalation
rat 		lowest published toxic concentration: 245 ppm/6 hour/9 day- intermittent Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		TXAPA9 68,405,1983
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/24 hour/13 week- continuous Endocrine: Hypoglycemia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 41(11),7,1976
inhalation
rat 		lowest published toxic concentration: 900 mg/m3/4 hour/25 day- intermittent Brain and Coverings: Increased intracranial pressure

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,167,1994
inhalation
rat 		lowest published toxic concentration: 421 mg/m3/13 week- intermittent Blood: Other hemolysis with or without anemia VCVGK* -,167,1994
inhalation
rat 		lowest published toxic concentration: 516 mg/m3/30 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,167,1994
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/90 day- continuous Endocrine: Hypoglycemia

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,167,1994
oral
mouse 		lowest published toxic dose: 5,180 mg/kg/2 week- continuous Endocrine: Changes in thymus weight NTPTR* NIH-93-3349
oral
mouse 		lowest published toxic dose: 9,440 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984
oral
mouse 		lowest published toxic dose: 198.45 gm/kg/21 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB85226827
oral
mouse 		lowest published toxic dose: 37.8 gm/kg/4 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB85226827
oral
mouse 		lowest published toxic dose: 20.16 gm/kg/4 week- continuous Behavioral: Fluid intake NTIS** #PB85226827
oral
mouse 		lowest published toxic dose: 198.45 gm/kg/21 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB85226827
oral
mouse 		lowest published toxic dose: 198.45 gm/kg/21 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB85226827
oral
mouse 		lowest published toxic dose: 5 gm/kg/10 day- intermittent Gastrointestinal: Gastritis TXCYAC 180,257,2002
oral
mouse 		lowest published toxic dose: 2,250 mg/kg/7 day- intermittent Liver: Changes in liver weight

Blood: Other hemolysis with or without anemia

Blood: Changes in spleen 		TOSCF2 70,252,2002
oral
mouse 		lowest published toxic dose: 51,429 mg/kg/90 day- intermittent Liver: Other changes

Blood: Other changes

Nutritional and Gross Metabolic: Conditioned vitamin deficiency 		TOXID9 60,287,2001
oral
mouse 		lowest published toxic dose: 51,429 mg/kg/90 day- intermittent Biochemical: Metabolism (intermediary): Other TOXID9 60,287,2001
oral
rat 		lowest published toxic dose: 139 gm/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AMIHAB 14,114,1956
oral
rat 		lowest published toxic dose: 9,324 mg/m3/21 day- continuous Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 16,830,1991
oral
rat 		lowest published toxic dose: 1,500 mg/kg/12 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Other changes

Blood: Changes in erythrocyte (RBC) count 		TXAPA9 112,198,1992
oral
rat 		lowest published toxic dose: 13,290 mg/kg/6 week- intermittent Liver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		FAATDF 6,349,1986
oral
rat 		lowest published toxic dose: 14,000 mg/kg/4 week- intermittent Endocrine: Changes in thymus weight

Blood: Changes in bone marrow not included in above

Related to Chronic Data: Changes in ovarian weight 		VCVGK* -,166,1994
oral
rat 		lowest published toxic dose: 2,170 mg/kg/4 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count 		VCVGK* -,166,1994
oral
rat 		lowest published toxic dose: 46.5 mg/kg/60 day- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,167,1994
oral
rat 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight 		NTIS** #PB89-165849
oral
rat 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Blood: Normocytic anemia

Blood: Other hemolysis with or without anemia 		NTIS** #PB89-165849
oral
rat 		lowest published toxic dose: 1,000 mg/kg/4 day- intermittent Cardiac: Cardiomyopathy including infarction

Vascular: Thromobosis distant from injection site

Blood: Changes in bone marrow not included in above 		TOXID9 72,30,2003
oral
rat 		lowest published toxic dose: 1,575 mg/kg/7 day- intermittent Liver: Other changes

Blood: Other hemolysis with or without anemia

Blood: Changes in spleen 		TOSCF2 70,252,2002
oral
rat 		lowest published toxic dose: 500 mg/kg/2 day- intermittent Blood: Other changes ARTODN 77,465,2003
oral
rat 		lowest published toxic dose: 500 mg/kg/4 day- intermittent Vascular: Thromobosis distant from injection site

Blood: Other hemolysis with or without anemia 		ETPAEK 58,311,2007
oral
rat 		lowest published toxic dose: 3,500 mg/kg/7 day- intermittent Blood: Other changes TXAPA9 230,338,2008
skin
mouse 		lowest published toxic dose: 6 gm/kg/4 day- intermittent Endocrine: Changes in spleen weight

Blood: Changes in spleen

Immunological Including Allergic: Decreased immune response 		TOXID9 42,209,1998
skin
mouse 		lowest published toxic dose: 6,000 mg/kg/4 day- continuous Endocrine: Changes in spleen weight

Blood: Changes in spleen 		IJTOFN 20,383,2001
skin
mouse 		lowest published toxic dose: 2,000 mg/kg/4 day- continuous Immunological Including Allergic: Decrease in cellular immune response IJTOFN 20,383,2001
skin
rat 		lowest published toxic dose: 17.5 mL/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,167,1994
skin
rabbit 		lowest published toxic dose: 4,500 µL/kg/9 day- intermittent Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		NTIS** OTS0516797
skin
rabbit 		lowest published toxic dose: 6.3 mL/kg/2 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,167,1994
unreported route
rat 		lowest published toxic dose: 750 mg/kg/3 day- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other)

Eye: Changes in circulation 		TOXID9 72,311,2003
unreported route
rat 		lowest published toxic dose: 1,000 mg/kg/4 day- intermittent Blood: Change in clotting factors

Musculoskeletal: Other changes 		TOXID9 44,172,2005
unreported route
rat 		lowest published toxic dose: 500 mg/kg/4 day- intermittent Blood: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 90,341,2006
unreported route
rat 		lowest published toxic dose: 1,000 mg/kg/4 day- intermittent Blood: Other hemolysis with or without anemia

Blood: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 90,341,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 20 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
ENTOX* -,290,2005
TOXICOLOGY REVIEW
ENTOX* -,451,2005
TOXICOLOGY REVIEW
IJTOFN 24,1,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
TOPADD 33,517,2005
TOXICOLOGY REVIEW
JTEHD6 7,385,2004
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
MUREAV 566,49,2004
TOXICOLOGY REVIEW
HUTOX* -,623,1996
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,241,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (240 mg/m3) (skin) DTLVS* 3,29,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (240 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (240 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (240 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (240 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 20 ppm (96.9 mg/m3), short term exposure limit 50 ppm (242 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 20 ppm (98 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 50 ppm (246 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 20 ppm (98 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 98 mg/m3 (20 ppm);
short term exposure limit 246 mg/m3 (skin), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (120 mg/m3), short term exposure limit 75 ppm (350 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (9.8 mg/m3), VLE 30 ppm (147.6 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 98 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 98 mg/m3, short term exposure limit 246 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 25 ppm (120 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 26 ppm (120 mg/m3);
short term exposure limit 75 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 100 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 25 ppm (121 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (240 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 360 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (50 mg/m3);
short term exposure limit 20 ppm (100 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (49 mg/m3);
KZG- week 20 ppm (98 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm;
short term exposure limit 50 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE GLYCOL MONOBUTYL ETHER-air 10 hour time-weighted average 5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 29930;
Number of Industries 398;
Total Number of Facilities 141,929;
Number of Occupations 199;
Total Number of Employees Exposed 1,547,951
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 29930;
Number of Industries 402;
Total Number of Facilities 130,413;
Number of Occupations 239;
Total Number of Employees Exposed 2,139,297;
Total Number of Female Employees Exposed 585,932


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/102527/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in protective coatings and solvents for cleaners and also in chemical synthesis
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols IV, 1403
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenisis Studies (inhalation):some evidence:mouse NTPTR* NTP-TR-484,2000
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse,rat
NTP Toxicity studies, RPT# TOX-26, October 2000
OSHA ANALYTICAL METHOD #83


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
HUTOX*
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used in protective coatings and solvents for cleaners and also in chemical synthesis

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

 Click Here for Additional Information about RTECS

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