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Ethane, 1,1,2,2 - tetrachloro -

RTECS #: KI8575000

CAS #: 79-34-5


UPDATE: May 2009 MW: 167.84 MF: C2H2Cl4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1,2,2 - Czterochloroetan (Polish)
  2. 1,1,2,2 - Tetrachloorethaan (Dutch)
  3. 1,1,2,2 - Tetrachloraethan (German)
  4. 1,1,2,2 - Tetrachlorethane (French)
  5. 1,1,2,2 - Tetrachloroethane
  6. 1,1,2,2 - Tetrachloroethane (ACGIH:OSHA)
  7. 1,1,2,2 - Tetracloroetano (Italian)
  8. 1,1 - Dichloro - 2,2 - dichloroethane
  9. Acetylene tetrachloride
  10. Bonoform
  1. Cellon
  2. NCI - C03554
  3. RCRA waste number U209
  4. TCE
  5. Tetrachlorethane
  6. Tetrachloroethane
  7. Tetrachlorure d'acetylene (French)
  8. Westron
  9. s - Tetrachloroethane
  10. sym - Tetrachloroethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition human HeLa cell 6 mmol/L CRNGDP 13,2389,1992
DNA repair Escherichia coli 15,866 g/plate CNREA8 34,2576,1974
mutation in microorganisms Salmonella typhimurium 10 g/plate (+/-enzymatic activation step) TECSDY 15,101,1987
other mutation test systems Escherichia coli 14,768 mol/L EMMUEG 19,98,1992
other mutation test systems oral
mouse
200 mg/kg MUREAV 343,157,1995
sister chromatid exchange hamster ovary 56 mg/L EMMUEG 10(Suppl 10),1,1987
sex chromosome loss and nondisjunction Aspergillus nidulans 200 ppm MUREAV 201,401,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 55 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-27,1978
oral
mouse
toxic dose : 110 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-27,1978
oral
rat
lowest published toxic dose: 42 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-27,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 19 gm/m3/45 minute Eye: Lacrimation

Behavioral: General anesthetic

Gastrointestinal: Changes in structure or function of salivary glands
AHBAAM 116,131,1936
inhalation
cat
lowest published toxic concentration: 5,700 mg/m3/5 hour Behavioral: General anesthetic VCVGH* -,386,1990
inhalation
human
lowest published toxic concentration: 1,000 mg/m3/30 minute Behavioral: Somnolence (general depressed activity)

Behavioral: Hallucinations, distorted perceptions
AHBAAM 116,131,1936
inhalation
human
lowest published toxic concentration: 1,000 mg/kg/30 minute Behavioral: Somnolence (general depressed activity)

Behavioral: Headache
VCVGH* -,386,1990
inhalation
mouse
lowest published toxic concentration: 8,500 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,307,1990
inhalation
mouse
lowest published lethal concentration: 40,000 mg/m3/2 hour N/R VCVGH* -,386,1990
inhalation
mouse
lethal concentration (50 percent kill): 4,500 mg/m3/2 hour N/R VCVGH* -,386,1990
inhalation
rat
lowest published lethal concentration: 1,000 ppm/4 hour N/R JIHTAB 31,343,1949
inhalation
rat
lowest published toxic concentration: 130 mg/m3 Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Necrotic changes
TPKVAL 15,76,1979
inhalation
rat
lowest published toxic concentration: 50 mg/m3/4 hour Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Necrotic changes
TPKVAL 15,76,1979
intraperitoneal
guinea pig
lowest published lethal dose: 500 mg/kg Liver: Fatty liver degeneration AIHAAP 35,21,1974
intraperitoneal
mouse
lethal dose (50 percent kill): 821 mg/kg N/R SAIGBL 8,371,1966
intravenous
dog
lowest published lethal dose: 50 mg/kg N/R QJPPAL 7,205,1934
oral
dog
lowest published lethal dose: 300 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Behavioral: Sleep

Liver: Fatty liver degeneration
AJHYA2 16,325,1932
oral
human
lowest published toxic dose: 30 mg/kg Behavioral: General anesthetic PCOC** -,1110,1966
oral
rat
lethal dose (50 percent kill): 200 mg/kg N/R INHEAO 32,145,1994
subcutaneous
mouse
lethal dose (50 percent kill): 1,108 mg/kg Behavioral: Sleep

Behavioral: Ataxia
JPETAB 123,224,1958
subcutaneous
rabbit
lowest published lethal dose: 500 mg/kg N/R QJPPAL 7,205,1934


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 50 mg/m3/4 hour/6 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GTPZAB 21(2),30,1977
inhalation
rat
lowest published toxic concentration: 130 mg/m3/4 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 15,76,1979
inhalation
rat
lowest published toxic concentration: 130 mg/m3/8 day- intermittent Endocrine: Changes in spleen weight TPKVAL 15,76,1979
inhalation
rat
lowest published toxic concentration: 50 mg/m3/4 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Kidney, Ureter, and Bladder: Changes in kidney weight
TPKVAL 15,76,1979
intraperitoneal
mouse
lowest published toxic dose: 16 gm/kg/40 day- intermittent Behavioral: Sleep

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
SAIGBL 8,371,1966
oral
rat
lowest published toxic dose: 9,480 mg/kg/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NCITR* NCI-TR-27,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 20,477,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,817,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,354,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,817,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,817,1999
TOXICOLOGY REVIEW
AIHAAP 40(3),A46,1979
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 628,67,2007
TOXICOLOGY REVIEW
ENTOX* -,148,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HETOEA 25,413,2006
TOXICOLOGY REVIEW
HUTOX* -,577,1996
TOXICOLOGY REVIEW
MUREAV 672,10,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (35 mg/m3) (skin) DTLVS* 3,249,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (35 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (35 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (35 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (35 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (6.9 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (7 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (7 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (7 mg/m3), short term exposure limit 3 ppm (21 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (7 mg/m3), VLE 5 ppm (35 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 7 mg/m3 (1 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 7 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 1 ppm (6.9 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 1 ppm (7 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (35 mg/m3);
short term exposure limit 10 ppm (70 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 7 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (6.9 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (7 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (35 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 35 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (7 mg/m3),KZG- week 2 ppm (14 mg/m3), Skin, dayEC2006
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (35 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,2,2-TETRACHLOROETHANE-air Carcinogen;
10 hour time-weighted average 1 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71460;
Number of Industries 8;
Total Number of Facilities 244;
Number of Occupations 15;
Total Number of Employees Exposed 7,044
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71460;
Number of Industries 2;
Total Number of Facilities 501;
Number of Occupations 10;
Total Number of Employees Exposed 4,145;
Total Number of Female Employees Exposed 926


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121099/AS)
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis; S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in the TRICHLOROETHYLENE production from ACETYLENE and as a solvent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NIOSH Analytical Method, 1994: 1,1,2,2-Tetrachloroethane, 1019
NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse NCITR* NCI-TR-27,1978
NCI Carcinogenesis Bioassay (gavage);equivocal evidence:rat NCITR* NCI-TR-27,1978
NTP Toxicity studies, RPT# TOX-45, October 2000
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE

AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For publisher information, see AJEPAS.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as an intermediate in the TRICHLOROETHYLENE production from ACETYLENE and as a solvent

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Human Data

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