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Ethane, hexachloro -

RTECS #: KI4025000

CAS #: 67-72-1


UPDATE: May 2009 MW: 236.72 MF: C2Cl6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,1,1,2,2,2 - Hexachloroethane
  2. Avlothane
  3. Carbon hexachloride
  4. Distokal
  5. Distopan
  6. Distopin
  7. Egitol
  8. Ethane hexachloride
  9. Ethylene hexachloride
  10. Falkitol
  11. Fasciolin
  1. Hexachlor - aethan (German)
  2. Hexachlorethane
  3. Hexachloroethane
  4. Hexachloroethane (ACGIH:OSHA)
  5. Hexachloroethylene
  6. Mottenhexe
  7. NCI - C04604
  8. Perchloroethane
  9. Phenohep
  10. RCRA waste number U131


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
other mutation test systems oral
mouse
1 gm/kg MUREAV 343,157,1995
sister chromatid exchange hamster ovary 330 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 5,500 mg/kg (6-16 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility
AIHAAP 40,187,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 230 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-68,1978
oral
mouse
toxic dose : 460 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-68,1978
oral
rat
lowest published toxic dose: 10,300 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-361,1989
oral
rat
lowest published toxic dose: 10,300 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB90-170895/AS
oral
rat
lowest published toxic dose: 5,150 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors
NTIS** PB90-170895/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 5,900 ppm/8 hour Behavioral: Muscle weakness AIHAAP 40,187,1979
intraperitoneal
mouse
lethal dose (50 percent kill): 4.5 mg/kg N/R VCVGH* -,392,1990
intraperitoneal
rat
lowest published lethal dose: 2,900 mg/kg N/R AIHAAP 40,187,1979
intravenous
dog
lowest published lethal dose: 325 mg/kg N/R QJPPAL 7,205,1934
oral
guinea pig
lethal dose (50 percent kill): 4,970 mg/kg N/R AIHAAP 40,187,1979
oral
rat
lethal dose (50 percent kill): 4,460 mg/kg N/R AIHAAP 40,187,1979
oral
rabbit
lethal dose : >1 gm/kg N/R AIHAAP 40,187,1979
subcutaneous
rabbit
lowest published lethal dose: 4 gm/kg N/R QJPPAL 7,205,1934
skin
rabbit
lethal dose (50 percent kill): 32 gm/kg N/R AIHAAP 40,187,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 260 ppm/6 hour/6 week- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 40,187,1979
inhalation
rat
lowest published toxic concentration: 260 ppm/6 hour/6 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight

Related to Chronic Data: Changes in testicular weight
AIHAAP 40,187,1979
oral
rat
lowest published toxic dose: 6,944 mg/kg/16 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
DCTODJ 8,155,1985
oral
rat
lowest published toxic dose: 9 gm/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-361,1989
oral
rat
lowest published toxic dose: 48,750 mg/kg/13 week- intermittent Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NTP-TR-361,1989
oral
rabbit
lowest published toxic dose: 12 gm/kg/12 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 40,187,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 20,467,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 73,295,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 20,467,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,295,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 73,295,1999
TOXICOLOGY REVIEW
AIHAAP 40(3),A46,1979
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
TXCYAC 196,1,2004
TOXICOLOGY REVIEW
MUREAV 627,59,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
TOPADD 33,517,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (10 mg/m3) (skin) DTLVS* 3,124,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (10 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (10 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (10 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (10 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (9.7 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (9.8 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (10 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (10 mg/m3), short term exposure limit 3 ppm (30 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm, VLE 10 ppm, FEB2006
Occupational Exposure Limit - GERMANY MAK 9.8 mg/m3 (1 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 1 ppm (10 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 ppm (10 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (9.7 mg/m3), skin, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (10 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, MAC(short term exposure limit) 30 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (10 mg/m3),KZG- week 2 ppm (20 mg/m3), Skin,DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXACHLOROETHANE-air Carcinogen;
8 hour time-weighted average 1 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 17385;
Number of Industries 5;
Total Number of Facilities 219;
Number of Occupations 9;
Total Number of Employees Exposed 1,488
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 17385;
Number of Industries 12;
Total Number of Facilities 170;
Number of Occupations 23;
Total Number of Employees Exposed 8,516;
Total Number of Female Employees Exposed 576


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101041/AS)
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a constituent of candles and grenades for smoke generation and as moth repellant
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE FEREAC 47,27009,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Studies (gavage);clear evidence:rat
NTP Carcinogenesis Studies (gavage);clear evidence:rat NTPTR* NTP-TR-361,1989
NCI Carcinogenesis Bioassay (gavage);no evidence:rat NCITR* NCI-TR-68,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Toxicity studies, RPT# TOX-45, October 2000


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB.
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a constituent of candles and grenades for smoke generation and as moth repellant

NIOSH PROFILE (HEXACHLOROETHANE), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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