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Ethane, 2 - bromo - 2 - chloro - 1,1,1 - trifluoro -

RTECS #: KH6550000

CAS #: 151-67-7


UPDATE: May 2009 MW: 197.39 MF: C2HBrClF3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,1,1 - Trifluoro - 2 - bromo - 2 - chloroethane
  2. 1,1,1 - Trifluoro - 2 - chloro - 2 - bromoethane
  3. 1 - Bromo - 1 - chloro - 2,2,2 - trifluoroethane
  4. 2,2,2 - Trifluoro - 1 - chloro - 1 - bromoethane
  5. 2 - Bromo - 2 - chloro - 1,1,1 - trifluoroethane
  6. Bromochlorotrifluoroethane
  7. Chalothane
  8. Ethane, 1 - bromo - 1 - chloro - 2,2,2 - trifluoro -
  9. Fluorotane
  1. Fluothane
  2. Ftorotan (Russian)
  3. Halotan
  4. Halothane
  5. Halothane (ACGIH)
  6. Halsan
  7. Narcotane
  8. Narcotann NE - spofa (Russian)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg severe FEPRA7 35,729,1976


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis parenteral
chicken
10 mg ENVRAL 12,366,1976
cytogenetic analysis hamster lung 1 pph/48 hour- continuous NSMZDZ 7,19,1979
cytogenetic analysis human lymphocyte 1 pph/48 hour- continuous NSMZDZ 7,19,1979
cytogenetic analysis mouse fibroblast 1,000 ppm ENVRAL 12,366,1976
DNA inhibition inhalation
mouse
8,000 ppm/24 hour- continuous CNREA8 36,3156,1976
unscheduled DNA synthesis inhalation
rat
1,000 ppm/2 hour- continuous ANESAV 30,401,1969
unscheduled DNA synthesis oral
rat
10 gm/kg JTEHD6 10,327,1982
micronucleus test oral
rat
4 mmol/kg MUREAV 413,1,1998
other mutation test systems inhalation
grasshopper
46 pph/16 hour MUREAV 113,467,1983
other mutation test systems hamster fibroblast 1 pph ANESAV 43,21,1975
other mutation test systems inhalation
mouse
1 pph/1 hour BCPCA6 27,2187,1978
other mutation test systems non-mammalian species other cell types 1 mmol/L ECREAL 141,492,1982
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster
1 pph/1 hour ANESAV 62,305,1985
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
3,450 ppm/24 hour- continuous MUREAV 91,225,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 3,000 ppm/4 hour (9 week prior to copulation/1-21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility
ANESAV 48,167,1978
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/4 hour (9 week prior to copulation/1-21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) ANESAV 48,167,1978
inhalation
mouse
lowest published toxic concentration: 1 pph/3 hour (13 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
TJADAB 4,242,1971
inhalation
mouse
lowest published toxic concentration: 3,000 ppm/4 hour (9 week prior to copulation/1-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system ANESAV 51,532,1979
inhalation
mouse
lowest published toxic concentration: 14,000 ppm/1 hour (8-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) DABBBA 31,3599,1970
inhalation
mouse
lowest published toxic concentration: 15,000 ppm/40 minute (3 week prior to copulation) Reproductive: Other effects on female

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Other postnatal measures or effects
REPTED 13,361,1999
inhalation
rat
lowest published toxic concentration: 100 ppm/8 hour (2-22 day pregnant/30 day after birth) Reproductive: Effects on newborn: Behavioral BBREDI 36,147,1990
inhalation
rat
lowest published toxic concentration: 8,000 ppm/12 hour (9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
ANESAV 29,1167,1968
inhalation
rat
lowest published toxic concentration: 1,600 ppm/8 hour (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ANESAV 48,11,1978
inhalation
rat
lowest published toxic concentration: 10 ppm/8 hour (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Central nervous system
ENVRAL 11,40,1976
inhalation
rat
lowest published toxic concentration: 8,000 ppm/6 hour (7-9 day pregnant) Reproductive: Effects on fertility: Abortion AAREAV 32,41,1975
inhalation
rat
lowest published toxic concentration: 10 ppm/8 hour (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Urogenital system
ENVRAL 10,174,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
child
lowest published toxic concentration: 0.9 pph Cardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Metabolism (intermediary): Other
AANEAB 45,639,2001
inhalation
human
lowest published lethal concentration: 7,000 ppm/3 hour Liver: Hepatitis (hepatocellular necrosis), diffuse

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature increase
ANESAV 24,29,1963
inhalation
mouse
lethal concentration (50 percent kill): 98 gm/m3/2 hour Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TLSMA6 111,10,1975
inhalation
mouse
lethal concentration (50 percent kill): 93,600 mg/m3/2 hour N/R VCVGH* -,644,1990
inhalation
mouse
lethal concentration (50 percent kill): 340,575 mg/m3/10 minute N/R VCVGH* -,644,1990
inhalation
mouse
lethal concentration (50 percent kill): 270,662 mg/m3/30 minute N/R VCVGH* -,644,1990
inhalation
mouse
lethal concentration (50 percent kill): 197,421 mg/m3/60 minute N/R VCVGH* -,644,1990
inhalation
mouse
lowest published toxic concentration: 1.21 pph/20 minute Behavioral: Analgesia JPETAB 317,615,2006
inhalation
mouse
lowest published toxic concentration: 2,960.85 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOXID9 -,174,2008
inhalation
rat
lethal concentration (50 percent kill): 29,000 ppm N/R FATOAO 25,143,1962
inhalation
rat
lowest published toxic concentration: 1.5 pph Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FATOAO 55,33,1992
inhalation
rat
lethal concentration (50 percent kill): 120,000 mg/m3/4 hour N/R VCVGH* -,644,1990
inhalation
rat
lowest published toxic concentration: 1.5 pph/30 minute Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other
AANEAB 46,378,2002
inhalation
rat
lowest published toxic concentration: 10 ppm/2 hour Liver: Multiple effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other
TOXID9 227,53,2006
intraperitoneal
guinea pig
lowest published toxic dose: 1.97 gm/kg Liver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
CRTOEC 14,362,2001
intraperitoneal
guinea pig
lowest published toxic dose: 1,974 mg/kg Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 144,35,2003
intraperitoneal
guinea pig
lowest published toxic dose: 1,974 mg/kg Liver: Liver function tests impaired

Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 1,87,2001
intraperitoneal
mouse
lowest published toxic dose: 1,870 mg/kg Liver: Fatty liver degeneration VCVGH* -,644,1990
intraperitoneal
rat
lowest published toxic dose: 1,974 mg/kg Liver: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 60,227,2001
intravenous
man
lowest published lethal dose: 129 mg/kg Behavioral: General anesthetic

Cardiac: Change in rate

Lung, Thorax, or Respiration: Cyanosis
LANCAO 1,340,1982
oral
guinea pig
lethal dose (50 percent kill): 6 gm/kg Behavioral: Excitement

Behavioral: Antipsychotic
GTPZAB 24(3),36,1980
oral
guinea pig
lethal dose (50 percent kill): 6,000 mg/kg N/R VCVGH* -,644,1990
oral
rat
lethal dose (50 percent kill): 5,680 mg/kg Behavioral: Excitement

Behavioral: Antipsychotic
GTPZAB 24(3),36,1980
oral
rat
lethal dose (50 percent kill): 5,680 mg/kg N/R VCVGH* -,644,1990
unreported route
woman
lowest published lethal dose: 0.4 mL/kg Vascular: Regional or general arteriolar or venous dilation

Blood: Hemorrhage
JFSCAS 45,923,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 1 pph/4 hour/80 day- intermittent Liver: Other changes

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXAPA9 143,245,1997
inhalation
guinea pig
lowest published toxic concentration: 50 ppm/24 hour/5 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ANESAV 42,408,1975
inhalation
guinea pig
lowest published toxic concentration: 10,000 ppm/1 hour/7 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Conditioned vitamin deficiency

Biochemical: Effect on specific coenzyme: Other coenzymes
JJATDK 9,9,1989
inhalation
mouse
lowest published toxic concentration: 300 ppm/24 hour/5 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ANESAV 42,408,1975
inhalation
rat
lowest published toxic concentration: 50 ppm/24 hour/4 week- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration

Liver: Changes in liver weight
PHTOEH 62,74,1988
inhalation
rat
lowest published toxic concentration: 10,000 ppm/1 hour/7 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Conditioned vitamin deficiency
JJATDK 9,9,1989
inhalation
rat
lowest published toxic concentration: 300 ppm/24 hour/5 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ANESAV 42,408,1975
inhalation
rat
lowest published toxic concentration: 2,500 ppm/8 hour/8 week- intermittent Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Urine volume increased

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
EXNEAC 76,168,1982
inhalation
rat
lowest published toxic concentration: 5,126 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GTPZAB 24(3),36,1980
inhalation
rat
lowest published toxic concentration: 500 ppm/6 hour/9 day- intermittent Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
DTESD7 11,407,1983
inhalation
rat
lowest published toxic concentration: 200 mg/m3/16 week- continuous Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) VCVGH* -,645,1990
inhalation
rat
lowest published toxic concentration: 15 ppm/4 hour/9 week- intermittent Liver: Liver function tests impaired

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 144,105,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMSUDL 7,93,1987
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
INTEAG 15,7,1974
TOXICOLOGY REVIEW
ARMCAH 25,411,1974
TOXICOLOGY REVIEW
CJSUAX 15,217,1972
TOXICOLOGY REVIEW
AASXAP 49,1,1971
TOXICOLOGY REVIEW
AACRAT 57,328,1978
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TPHSDY 23,374,2002
TOXICOLOGY REVIEW
TPHSDY 23,519,2002
TOXICOLOGY REVIEW
CRTXB2 33,105,2003
TOXICOLOGY REVIEW
TPHSDY 23,552,2002
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
TPHSDY 24,648,2003
TOXICOLOGY REVIEW
AINCM* 7,63,2006
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,125,2005
TOXICOLOGY REVIEW
EJPHAZ 549,1,2006
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (4.1 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (410 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (40 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (8 mg/m3), short term exposure limit 3 ppm (24 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 41 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 40 mg/m3, short term exposure limit 160 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 40 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 ppm, JAN2002
Occupational Exposure Limit - POLAND time-weighted average 40 mg/m3, short term exposure limit 100 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 20 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 5 ppm (40 mg/m3);
short term exposure limit 10 ppm (80 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (40 mg/m3);
KZG- week 40 ppm (320 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (82 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HALOTHANE-air ceiling concentration 2 ppm/60 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82943;
Number of Industries 2;
Total Number of Facilities 806;
Number of Occupations 8;
Total Number of Employees Exposed 9,490
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82943;
Number of Industries 3;
Total Number of Facilities 4,118;
Number of Occupations 15;
Total Number of Employees Exposed 94,682;
Total Number of Female Employees Exposed 76,108


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #29


REFERENCES:

CODEN
REFERENCE

AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957-
AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81.
AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959-
AINCM* Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
ARMCAH Annual Review of Medicine. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1950-
BBREDI Behavioural Brain Research. (Elsevier Science Publishers B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1980-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CJSUAX Canadian Journal of Surgery. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1957-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier Science, New York, NY) V.1-15, 1977-87. Discontinued
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EXNEAC Experimental Neurology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTOX*
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960-
JFSCAS Journal of Forensic Sciences. (American Soc. for Testing and Materials, 1916 Race St., Philadelphia, PA 19103) V.1- 1956-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NSMZDZ Nippon Shika Masui Gakkai Zasshi. Journal of Japanese Dental Anesthesia Society. (Nippon Shika Masui Gakkai, c/o Koko Hoken Kyokai, 1-44-2, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1973-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

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