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Dipropylene glycol, monomethyl ether

RTECS #: JM1575000

CAS #: 34590-94-8


UPDATE: May 2009 MW: 148.23 MF: C7H16O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,4 - Dimethyl - 3,6 - dioxa - 1 - heptanol
  2. 1 - (1 - Methyl - 2 - methoxyethoxy) - 2 - propanol
  3. 1 - (2 - Methoxyisopropoxy) - 2 - propanol
  4. Arcosolv
  5. Dipropylene glycol methyl ether
  6. Dipropylene glycol methyl ether (ACGIH:OSHA)
  1. Dowanol DPM
  2. Dowanol - 50B
  3. Kino - red
  4. Methyl dipropanol
  5. Oxybispropanol methyl ether
  6. Ucar solvent 2LM


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
8 mg mild JTOTDO 2,229,1983/1984
eye
rabbit
500 mg/24 hour mild 85JCAE -,633,1986
skin
rabbit
500 mg open irritation test mild UCDS** 11/15/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 3,000 mg/m3 Behavioral: General anesthetic VCVGK* -,175,1984
oral
dog
lethal dose (50 percent kill): 7,500 mg/kg Lung, Thorax, or Respiration: Other changes JPETAB 102,79,1951
oral
rat
lethal dose (50 percent kill): 5,400 ÁL/kg N/R AMIHBC 9,509,1954
oral
rat
lethal dose (50 percent kill): 5.5 mL/kg N/R VCVGK* -,175,1984
skin
rabbit
lethal dose (50 percent kill): 10 mL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 2,000 mg/m3/7 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,175,1994
inhalation
monkey
lowest published toxic concentration: 2,000 mg/m3/7 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,175,1994
inhalation
rat
lowest published toxic concentration: 2,000 mg/m3/7 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,175,1994
inhalation
rabbit
lowest published toxic concentration: 2,000 mg/m3/7 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,175,1994
skin
rabbit
lowest published toxic dose: 650 mL/kg/13 week- intermittent Behavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 9,509,1954


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm;short term exposure limit 150 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,451,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (600 mg/m3) (skin) DTLVS* 3,96,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (600 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (600 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (600 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (600 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (308 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (308 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (300 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 50 ppm (308 mg/m3) (skin), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (600 mg/m3), short term exposure limit 150 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (308 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 310 mg/m3 (50 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 308 mg/m3, short term exposure limit 308 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 100 ppm (600 mg/m3), short term exposure limit 150 ppm (900 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (60 mg/m3);
short term exposure limit 150 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 300 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 100 ppm (606 mg/m3);
short term exposure limit 150 ppm (909 mg/m3), skin, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (600 mg/m3), Skin, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (300 mg/m3);
short term exposure limit 75 ppm (450 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (300 mg/m3),KZG- week 50 ppm (300 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 300 ppm (600 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (308 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm;
short term exposure limit 150 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm;
short term exposure limit 150 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 100 ppm (Sk);
short term exposure limit 150 ppm (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84537;
Number of Industries 66;
Total Number of Facilities 5,594;
Number of Occupations 55;
Total Number of Employees Exposed 52,536
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84537;
Number of Industries 123;
Total Number of Facilities 15,846;
Number of Occupations 89;
Total Number of Employees Exposed 210,740;
Total Number of Female Employees Exposed 21,792


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in antifreeze formulations, cosmetics, cleaning compounds, heat transfer fluids
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #101


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in antifreeze formulations, cosmetics, cleaning compounds, heat transfer fluids

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Human Data
   Primary Irritant

ALT CAS #: 12002-25-4
ALT CAS #: 12002-35-6
ALT CAS #: 83730-60-3
ALT CAS #: 104512-57-4
ALT CAS #: 112388-78-0
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