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Dimethylamine

RTECS #: IP8750000

CAS #: 124-40-3


UPDATE: May 2009 MW: 45.10 MF: C2H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Dimethylamine (ACGIH:OSHA)
  2. Methanamine, N - methyl - (9CI)
  1. N - Methylmethanamine
  2. RCRA waste number U092


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 mg/5 minute N/R BJIMAG 23,153,1966


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 10 mmol/L MOTOEX 1,217,1987
cytogenetic analysis inhalation
rat
50 µg/m3 GISAAA 36(11),9,1971
sister chromatid exchange hamster ovary 500 µmol/L MOTOEX 1,217,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 0.2 gm/m3 N/R TPKVAL 7,56,1965
inhalation
human
lowest published toxic concentration: 0.5 gm/m3 Eye: Conjunctiva irritation TPKVAL 7,56,1965
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 3,700 mg/m3 N/R TPKVAL 14,80,1975
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 0.7 gm/m3 Behavioral: Alteration of classical conditioning TPKVAL 7,56,1965
inhalation
mammal (species unspecified)
lethal concentration : 2.4 gm/m3 Eye: Conjunctiva irritation TPKVAL 7,56,1965
inhalation
mammal (species unspecified)
lowest published toxic concentration: 0.5 gm/m3 Eye: Conjunctiva irritation

Behavioral: Convulsions or effect on seizure threshold

Vascular: Other changes
TPKVAL 7,56,1965
inhalation
mouse
lethal concentration (50 percent kill): 4,725 ppm/2 hour N/R AIHAAP 43,411,1982
inhalation
mouse
lethal concentration : 0.3 gm/m3/2 hour Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory obstruction
TPKVAL 1,41,1961
inhalation
mouse
lethal concentration (50 percent kill): 0.7 gm/m3/2 hour Behavioral: Alteration of classical conditioning TPKVAL 1,41,1961
inhalation
mouse
lethal concentration : 0.35 gm/m3/2 hour Behavioral: Alteration of classical conditioning TPKVAL 1,41,1961
inhalation
mouse
lowest published toxic concentration: 0.5 gm/m3/2 hour Behavioral: Somnolence (general depressed activity)

Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Respiratory stimulation
TPKVAL 1,41,1961
inhalation
mouse
lowest published toxic concentration: 0.5 gm/m3/2 hour Behavioral: Alteration of classical conditioning TPKVAL 7,56,1965
inhalation
rat
lethal concentration (50 percent kill): 4,540 ppm/6 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 43,411,1982
inhalation
rat
lethal concentration (50 percent kill): 3 gm/m3/2 hour Eye: Conjunctiva irritation

Eye: Corneal damage

Skin: After systemic exposure: Dermatitis, other
TPKVAL 1,41,1961
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/2 hour Liver: Fatty liver degeneration

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TPKVAL 1,41,1961
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/2 hour N/R TPKVAL 7,56,1965
intraperitoneal
mouse
lethal dose (50 percent kill): 736 mg/kg N/R YKKZAJ 97,1117,1977
intravenous
rabbit
lowest published lethal dose: 4 gm/kg N/R 85KYAH 11,509,1989
ocular
mammal (species unspecified)
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 7,56,1965
ocular
rabbit
lowest published toxic dose: 3 pph Eye: Lacrimation

Eye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 1,41,1961
oral
guinea pig
lethal dose (50 percent kill): 240 mg/kg Behavioral: Excitement

Behavioral: Muscle weakness

Gastrointestinal: Ulceration or bleeding from stomach
HYSAAV 32(6),329,1967
oral
mouse
lethal dose (50 percent kill): 316 mg/kg Behavioral: Excitement

Behavioral: Muscle weakness

Gastrointestinal: Ulceration or bleeding from stomach
HYSAAV 32(6),329,1967
oral
mouse
lowest published lethal dose: 600 mg/kg N/R MUREAV 539,65,2003
oral
rat
lethal dose (50 percent kill): 698 mg/kg Behavioral: Excitement

Behavioral: Muscle weakness

Gastrointestinal: Ulceration or bleeding from stomach
HYSAAV 32(6),329,1967
oral
rabbit
lethal dose (50 percent kill): 240 mg/kg Behavioral: Excitement

Behavioral: Muscle weakness

Gastrointestinal: Ulceration or bleeding from stomach
HYSAAV 32(6),329,1967
skin
mammal (species unspecified)
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 7,56,1965
skin
mouse
lowest published toxic dose: 6 pph/2 hour Skin: After topical application: Corrosive TPKVAL 1,41,1961
skin
rabbit
lowest published toxic dose: 6 pph Skin: After topical application: Primary irritation TPKVAL 1,41,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 0.5 gm/m3/213 day- intermittent Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 7,56,1965
inhalation
mouse
lowest published toxic dose: 175 ppm/6 hour/1 year- intermittent Olfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 5,341,1985
inhalation
mouse
lowest published toxic concentration: 175 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 3,24,1983
inhalation
rat
lowest published toxic concentration: 175 ppm/6 hour/1 year- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
FAATDF 5,341,1985
inhalation
rat
lowest published toxic concentration: 175 ppm/6 hour/9 day- intermittent Olfaction: Other olfaction effects TXAPA9 90,359,1987
inhalation
rat
lowest published toxic concentration: 175 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 3,24,1983
inhalation
rat
lowest published toxic concentration: 0.3 gm/m3/10 day- intermittent Behavioral: Alteration of classical conditioning TPKVAL 1,41,1961
inhalation
rat
lowest published toxic concentration: 0.3 gm/m3/213 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 1,41,1961
inhalation
rat
lowest published toxic concentration: 0.3 gm/m3/122 day- intermittent Blood: Other changes TPKVAL 1,41,1961
inhalation
rat
lowest published toxic concentration: 0.3 gm/m3/61 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 1,41,1961
oral
guinea pig
lowest published toxic dose: 850 mg/kg/35 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Other changes
GISAAA 32(6),12,1967
oral
rat
lowest published toxic dose: 85 mg/kg/35 week- intermittent Behavioral: Alteration of classical conditioning

Liver: Changes in liver weight

Immunological Including Allergic: Decrease in cellular immune response
GISAAA 32(6),12,1967
oral
rat
lowest published toxic dose: 37,128 gm/kg/39 week- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOLED5 17,125,1983
skin
rabbit
lowest published toxic dose: 3 pph/5 day- intermittent Skin: After topical application: Primary irritation TPKVAL 1,41,1961


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm;short term exposure limit 15 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CHREAY 9,389,1931


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (18 mg/m3) DTLVS* 3,88,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (18 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (18 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (18 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (18 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (3.8 mg/m3), short term exposure limit 6 ppm (11 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (3.8 mg/m3), short term exposure limit 5 ppm (9.4 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (3.7 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 2 ppm (3.8 mg/m3);
short term exposure limit 5 ppm (9.4 mg/m3), FEB 2006
Occupational Exposure Limit - FINLAND short term exposure limit 10 ppm (18 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (1.9 mg/m3), VLE 2 ppm (3.8 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 3.7 mg/m3 (2 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 3.8 mg/m3, short term exposure limit 9.4 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (18 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (18 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (18 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1.8 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (18 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (18 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 9 mg/m3, MAC(short term exposure limit) 18 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 2 ppm (3.5 mg/m3);
short term exposure limit 5 ppm (9 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (4 mg/m3),KZG- week 4 ppm (8 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (3.8 mg/m3);
short term exposure limit 6 ppm (11 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLAMINE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26130;
Number of Industries 13;
Total Number of Facilities 291;
Number of Occupations 16;
Total Number of Employees Exposed 3,174
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1555;
Number of Industries 1;
Total Number of Facilities 32;
Number of Occupations 1;
Total Number of Employees Exposed 65;
Total Number of Female Employees Exposed 65
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 26130;
Number of Industries 22;
Total Number of Facilities 1,406;
Number of Occupations 42;
Total Number of Employees Exposed 28,879;
Total Number of Female Employees Exposed 2,001


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aliphatic, 2010
OSHA ANALYTICAL METHOD #34


REFERENCES:

CODEN
REFERENCE

85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MOTOEX Molecular Toxicology. (Taylor & Francis, Inc., 242 Cherry St., Philadelphia, PA USA 19106) V.1- 1987-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

NIOSH PROFILE (AMINES, SECONDARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

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