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Registry of Toxic Effects of Chemical Substances (RTECS)

1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-, endo,exo-

RTECS #

IO2100000

CAS #

309-00-2; 34487-55-3

Updated

September 201

Molecular Weight

364.90

Molecular Formula

C12H8Cl6

Synonyms

1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-1,4,5,8-dimethanonaphthalene
1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-1,4-endo-exo-5,8-dimethanonaphthalene
1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-exo-1,4-endo-5,8-dimethanonaphthalene
Aldrex
Aldrex 30
Aldrex 30 E.C.
Aldrin
Aldrin (ACGIH:OSHA)
Aldrine (French)
Aldrite
Aldrosol
Altox
Compound 118
ENT 15,949
Hexachlorohexahydro-endo-exo-dimethanonaphthalene
HHDN
Kortofin
Latka 118 (Czech)
NCI-C00044
Octalene
RCRA waste number P004
SD 2794
Seedrin
Tatuzinho

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human19125 µg/LMUREAV 31,103,1975
Cytogenetic Analysisleukocyte/human19125 µg/LPHTHDT 6,147,1979
Cytogenetic Analysisintraperitoneal/rat9560 µg/kgPHTHDT 6,147,1979
Cytogenetic Analysisintraperitoneal/mouse9560 µg/kgPHTHDT 6,147,1979
Cytogenetic Analysisoral/mouse13 mg/kgIMSCE2 14,1125,1986
DNA Damageliver/rat300 µmol/LSinJF# 26OCT1982
DNA inhibitionother cell types/rat100 mg/LARTODN 45,101,1980
DNA inhibitionlymphocyte/human100 mg/LARTODN 45,101,1980
micronucleus testintraperitoneal/other fish3000 ppmNULSAK 28,176,1985
mutation in microorganisms/Saccharomyes cerevisiae5 ppm (-enzymatic activation step)RSTUDV 6,161,1976
other mutation test systemsoral/mouse10 mg/kgMUREAV 343,157,1995
Unscheduled DNA Synthesisfibroblast/human1 µmol/LMUREAV 42,161,1977
Unscheduled DNA Synthesisoral/mouse11 µmol/kgCRNGDP 8,1433,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 1950 µg/kg (13D male)Reproductive: Other effects on male

Endocrine: Androgenic
ANDRDQ 20,472,1988
intraperitoneal/rat 3900 µg/kg (26D male)Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsANDRDQ 20,472,1988
oral/mouse 25 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 9,11,1974
oral/Dog 73 mg/kg (44W prior to copulation/1-8W pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)JAVMA4 123,28,1953
oral/hamster 50 mg/kg (7D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 9,11,1974
oral/hamster 50 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TJADAB 9,11,1974
subcutaneous/rat 10 mg/kg (2D prior to copulation)Reproductive: Maternal effects: Uterus, cervix, vaginaENVRAL 16,131,1978
subcutaneous/rat 22 mg/kg (1-22D pregnant)Reproductive: Effects on newborn: BehavioralBJMRDK 22,979,1989
subcutaneous/rat 21 mg/kg (21D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
BJMRDK 22,979,1989

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 270 mg/kg/80W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-21,1978
oral/mouse toxic dose: 540 mg/kg/80W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-21,1978
oral/rat toxic dose: 188 mg/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Multiple effects

Lung, Thorax, or Respiration: Other changes
TXAPA9 11,88,1967
oral/rat lowest published toxic dose: 200 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
FCTXAV 2,551,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 33 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 61 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 14 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 55 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 2,1,1988
inhalation/cat lethal concentration (50 percent kill): 20 mg/m3VCVGH* -,567,1990
inhalation/mouse lethal concentration (50 percent kill): 3 mg/m3VCVGH* -,567,1990
inhalation/rat lethal concentration (50 percent kill): 90 mg/m3VCVGH* -,567,1990
inhalation/rat Lowest published lethal concentration: 5800 µg/m3/4H85GMAT -,73,1982
intracerebral/mouse lethal dose (50 percent kill): 4 mg/kgBehavioral: Convulsions or effect on seizure thresholdTOLED5 60,289,1992
intraperitoneal/Dog lethal dose (50 percent kill): 1999 mg/kgLiver: Liver function tests impairedTXAPA9 10,119,1967
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kgSOGEBZ 2,80,1966
intraperitoneal/rat lethal dose (50 percent kill): 150 mg/kgTXAPA9 11,302,1967
intravenous/mouse lethal dose (50 percent kill): 21 mg/kg32ZDAL -,52,1970
oral/cat lowest published lethal dose: 15 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes
CVETAA 2,71,1958
oral/chicken lethal dose (50 percent kill): 10 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Change in motor activity (specific assay)
JEENAI 45,121,1952
oral/child lowest published lethal dose: 1250 µg/kg34ZIAG -,82,1969
oral/Dog lethal dose (50 percent kill): 65 mg/kgPCOC** -,7,1966
oral/duck lethal dose (50 percent kill): 520 mg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 33 mg/kgPCOC** -,7,1966
oral/hamster lethal dose (50 percent kill): 100 mg/kgTJADAB 9,11,1974
oral/human lowest published toxic dose: 14 mg/kgBehavioral: Tremor

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
34ZIAG -,82,1969
oral/mouse lethal dose (50 percent kill): 18 mg/kgVCVGH* -,567,1990
oral/pigeon lethal dose (50 percent kill): 56200 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 42100 µg/kgASTTA8 (680),157,1979
oral/rabbit lethal dose (50 percent kill): 50 mg/kgPCOC** -,7,1966
oral/rat lethal dose (50 percent kill): 38 mg/kgHBPTO* 2,1136,2001
oral/wild bird lethal dose (50 percent kill): 7200 µg/kgTXAPA9 21,315,1972
skin/cat lowest published lethal dose: 75 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes
CVETAA 2,71,1958
skin/cat lethal dose (50 percent kill): 75 mg/kgVCVGH* -,567,1990
skin/rabbit lethal dose (50 percent kill): 15 mg/kgOlfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
JEENAI 46,702,1953
skin/rabbit lethal dose (50 percent kill): 84 mg/kgVCVGH* -,567,1990
skin/rat lethal dose (50 percent kill): 98 mg/kgTXAPA9 14,515,1969
subcutaneous/rabbit lowest published lethal dose: 100 mg/kg85GMAT -,73,1982
subcutaneous/rat lethal dose (50 percent kill): 62 mg/kg85GMAT -,73,1982
unreported route/Dog lowest published lethal dose: 95 mg/kgAMIHBC 3,64,1951
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 40 mg/kg30ZDA9 -,62,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 290 mg/kg/58D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterasesAMIHBC 9,306,1954
intraperitoneal/rat lowest published toxic dose: 1950 µg/kg/13D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
ENVPAF 51,87,1988
intraperitoneal/rat lowest published toxic dose: 3900 µg/kg/26D- intermittentRelated to Chronic Data: Changes in testicular weightENVPAF 51,87,1988
intraperitoneal/rat lowest published toxic dose: 1950 mg/kg/13D- intermittentEndocrine: Change in LH

Endocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
JOENAK 119,75,1988
intraperitoneal/rat lowest published toxic dose: 3900 mg/kg/26D- intermittentEndocrine: Change in gonadotropinsJOENAK 119,75,1988
oral/cat lowest published toxic dose: 91500 µg/kg/61D- intermittentPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CVETAA 2,71,1958
oral/Dog lowest published toxic dose: 81120 µg/kg/68W- intermittentLiver: Changes in liver weightJAFCAU 3,402,1955
oral/mouse lowest published toxic dose: 66 mg/kg/3D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Liver: Changes in liver weight
TXCYAC 249,176,2008
oral/rat lowest published toxic dose: 9100 µg/kg/26W- intermittentEndocrine: Other changes

Blood: Other changes
GISAAA 31(4),13,1966
oral/rat lowest published toxic dose: 109 mg/kg/2Y- continuousLiver: Changes in liver weightJAFCAU 3,402,1955
oral/rat lowest published toxic dose: 348 mg/kg/58D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterasesAMIHBC 9,306,1954

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMSUDL 7,88,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 5,25,1974
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,88,1987
TOXICOLOGY REVIEWTOLED5 127,101,2002
TOXICOLOGY REVIEWRREVAH 48,141,1973
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWBNYMAM 54,413,1978
TOXICOLOGY REVIEW85CVA2 5,250,1970
TOXICOLOGY REVIEWCTOXAO 13,231,1978
TOXICOLOGY REVIEWEESADV 1,89,1977
TOXICOLOGY REVIEWTXAPA9 10,613,1967
TOXICOLOGY REVIEWNTIS** PB82-219007
TOXICOLOGY REVIEWEVHPAZ 109(Suppl 1),113,2001
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEW26UZAB 6,149,1968/1970
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,66,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWENTOX* -,334,2005
TOXICOLOGY REVIEWHETOEA 25,413,2006
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWTPHSDY 29,322,2008
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUREAV 674,36,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,83,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.25 mg/m3 (skin)DTLVS* 3,7,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.25 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.25 mg/m3;KZW 2.5 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.25 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.25 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.25 mg/m3, short term exposure limit 0.75 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.25 mg/m3, Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.25 mg/m3, inhal, skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.25 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.25 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.25 mg/m3;short term exposure limit 0.75 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.25 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.25 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.25 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.01 mg/m3, short term exposure limit 0.03 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.25 mg/m3, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.25 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.25 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.25 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.25 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.25 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.25 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.25 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.25 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALDRIN-air10H Carcinogen time-weighted average 0.25 mg/m3 (Sk) (0.15 mg/m3 LOQ)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 04260; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 2; Total Number of Employees Exposed 42; Total Number of Female Employees Exposed 7
National Occupational Hazard Survey 1974Hazard Code 04260; Number of Industries 1; Total Number of Facilities 43; Number of Occupations 8; Total Number of Employees Exposed 605

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182368/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouseNCITR* NCI-TR-21,1978
NCI Carcinogenesis Bioassay (feed);equivocal evidence:ratNCITR* NCI-TR-21,1978
NIOSH Analytical Method, 1994: Aldrin, 5502
On EPA IRIS database
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