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1,4:5,8 - Dimethanonaphthalene, 1,2,3,4,10,10 - hexachloro - 6,7 - epoxy - 1,4,4a,5,6,7,8,8a - octahydro - , endo,endo -

RTECS #: IO1575000

CAS #: 72-20-8


UPDATE: May 2009 MW: 380.90 MF: C12H8Cl6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Compound 269
  2. EN 57
  3. ENT 17,251
  4. Endrex
  5. Endricol
  6. Endrin
  7. Endrin (ACGIH:OSHA)
  8. Endrine (French)
  9. Experimental insecticide 269
  10. Hexachloroepoxyoctahydro - endo,endo - dimethanonaphthalene
  1. Hexadrin
  2. Latka 269 (Czech)
  3. Mendrin
  4. NCI - C00157
  5. OMS 197
  6. Oktanex
  7. RCRA waste number P051
  8. SD 3419
  9. Stardrin
  10. Stardrin 20


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis parenteral
rat
1 mg/kg BECTA6 9,65,1973
sister chromatid exchange multiple
other fish
54 pmol/L MUREAV 118,61,1983
sperm morphology parenteral
rat
10 mg/kg/10 day- continuous APTOA6 31,1,1972


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratesticular
rat
lowest published toxic dose: 10 mg/kg (10 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) APTOA6 31,1,1972
oral
hamster
lowest published toxic dose: 15 mg/kg (5-14 day pregnant) Reproductive: Effects on newborn: Behavioral TXCYAC 21,187,1981
oral
hamster
lowest published toxic dose: 5 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 9,11,1974
oral
hamster
lowest published toxic dose: 5 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 9,11,1974
oral
hamster
lowest published toxic dose: 7,500 g/kg (5-14 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) TXAPA9 48,A200,1979
oral
hamster
lowest published toxic dose: 5 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 48,A201,1979
oral
mouse
lowest published toxic dose: 10 mg/kg (8-12 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JTEHD6 10,541,1982
oral
mouse
lowest published toxic dose: 2,500 g/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 9,11,1974
oral
mouse
lowest published toxic dose: 2,320 g/kg (4 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
OYYAA2 6,673,1972
oral
mouse
lowest published toxic dose: 7 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TCMUD8 5,3,1985
oral
mouse
lowest published toxic dose: 16,500 g/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TXCYAC 21,141,1981
oral
rat
lowest published toxic dose: 2,320 g/kg (4 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
OYYAA2 6,673,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
mouse
lethal dose (50 percent kill): 400 g/kg Behavioral: Convulsions or effect on seizure threshold TOLED5 60,289,1992
intraperitoneal
mouse
lethal dose (50 percent kill): 5 mg/kg N/R TOLED5 60,289,1992
intravenous
mouse
lethal dose (50 percent kill): 2,300 g/kg N/R TXAPA9 23,408,1972
intravenous
pigeon
lethal dose (50 percent kill): 1,500 g/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 9,75,1966
oral
wild bird
lethal dose (50 percent kill): 1,780 g/kg N/R ASTTA8 (680),157,1979
oral
cat
lowest published lethal dose: 5 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
JAFCAU 3,842,1955
oral
chicken
lowest published lethal dose: 2 mg/kg Behavioral: Ataxia

Behavioral: Irritability
CNVJA9 11,74,1970
oral
duck
lethal dose (50 percent kill): 5,330 g/kg N/R TXAPA9 22,556,1972
oral
guinea pig
lethal dose (50 percent kill): 16 mg/kg N/R PCOC** -,475,1966
oral
hamster
lethal dose (50 percent kill): 10 mg/kg N/R TJADAB 9,11,1974
oral
man
lowest published lethal dose: 171 mg/kg Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Thrombocytopenia
HUTODJ 4,241,1985
oral
monkey
lethal dose (50 percent kill): 3 mg/kg N/R PCOC** -,475,1966
oral
mouse
lowest published toxic dose: 137 g/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 175,73,2002
oral
mouse
lethal dose (50 percent kill): 1,370 g/kg N/R ENTOX* -,176,2005
oral
pigeon
lethal dose (50 percent kill): 5,600 g/kg N/R TXAPA9 21,315,1972
oral
quail
lethal dose (50 percent kill): 4,210 g/kg N/R ASTTA8 (680),157,1979
oral
rat
lethal dose (50 percent kill): 3 mg/kg N/R WRPCA2 9,119,1970
oral
rabbit
lethal dose (50 percent kill): 7 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
JAFCAU 3,842,1955
oral
woman
lowest published lethal dose: 234 mg/kg Behavioral: Headache

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature increase
NEZAAQ 22,254,1967
skin
cat
lowest published lethal dose: 75 mg/kg Behavioral: Food intake (animal)

Behavioral: Withdrawal

Gastrointestinal: Nausea or vomiting
CVETAA 2,71,1958
skin
rat
lethal dose (50 percent kill): 12 mg/kg N/R SPEADM 78-1,13,1978
skin
rabbit
lethal dose (50 percent kill): 60 mg/kg N/R SPEADM 78-1,13,1978
unreported route
rat
lethal dose (50 percent kill): 17 mg/kg N/R 30ZDA9 -,64,1971
unreported route
rabbit
lethal dose (50 percent kill): 7 mg/kg N/R 30ZDA9 -,64,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 360 ppb/7 hour/22 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JAFCAU 3,842,1955
inhalation
rabbit
lowest published toxic concentration: 360 ppb/7 hour/24 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JAFCAU 3,842,1955
oral
dog
lowest published toxic dose: 12,150 g/kg/81 week- intermittent Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight
JAFCAU 3,842,1955
oral
rat
lowest published toxic dose: 1,975 mg/kg/79 day- intermittent Eye: Hemorrhage

Behavioral: Excitement

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 14,556,1969
oral
rat
lowest published toxic dose: 219 mg/kg/2 year- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Other changes
JAFCAU 3,842,1955
oral
rat
lowest published toxic dose: 6,720 mg/kg/16 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAFCAU 4,696,1956
oral
rabbit
lowest published toxic dose: 50 mg/kg/72 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JAFCAU 3,842,1955
skin
rabbit
lowest published toxic dose: 1,400 mg/kg/14 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JAFCAU 3,842,1955


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 5,157,1974
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 5,157,1974
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
TOLED5 127,101,2002
TOXICOLOGY REVIEW
BECTA6 15,283,1976
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
BNYMAM 54,413,1978
TOXICOLOGY REVIEW
CTOXAO 13,231,1978
TOXICOLOGY REVIEW
26UZAB 6,149,1968/1970
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,176,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,180,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 (skin) DTLVS* 3,98,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3,KZG- week 0.8 mg/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ENDRIN-air 10 hour time-weighted average 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used as an insecticide, avicide, and rodenticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Endrin, 5519
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-12,1979


REFERENCES:

CODEN
REFERENCE

26UZAB "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CNVJA9 Canadian Veterinary Journal. (339 Booth St., Ottawa, ON K1R 6J3, Canada) V.1- 1960-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
CVETAA Communicationes Veterinariae. (Bogor, Indonesia) V.1-9, 1957-65. Discontinued.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as an insecticide, avicide, and rodenticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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