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Diethylamine

RTECS #: HZ8750000

CAS #: 109-89-7


UPDATE: May 2009 MW: 73.16 MF: C4H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. DEN
  2. Diaethylamin (German)
  3. Diethamine
  4. Diethylamine (ACGIH:OSHA)
  1. Dietilamina (Italian)
  2. Dwuetyloamina (Polish)
  3. Ethanamine, N - ethyl -
  4. N,N - Diethylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg open irritation test mild UCDS** 5/21/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms other microorganisms 50 ÁL/plate (-enzymatic activation step) EJMBA2 16,133,1981
mutation in microorganisms other microorganisms 400 ÁL/plate (-enzymatic activation step) EJMBA2 15,113,1980
mutation in microorganisms other microorganisms 200 ÁL/plate (-enzymatic activation step) EJMBA2 15,113,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 5,000 mg/m3 N/R TPKVAL 14,80,1975
inhalation
mouse
lowest published lethal concentration: 3 gm/m3/2 hour Brain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration
GISAAA 20(4),28,1955
inhalation
mouse
lowest published toxic concentration: 0.25 gm/m3 Behavioral: Alteration of classical conditioning TPKVAL 7,56,1965
inhalation
mouse
lethal concentration (50 percent kill): 5 gm/m3 N/R TPKVAL 7,56,1965
inhalation
mouse
lowest published lethal concentration: 3 gm/m3 Eye: Conjunctiva irritation TPKVAL 7,56,1965
inhalation
rat
lethal concentration (50 percent kill): 4,000 ppm/4 hour N/R ENTOX* -,34,2005
inhalation
rat
lowest published toxic concentration: 0.3 gm/m3 N/R TPKVAL 7,56,1965
inhalation
rabbit
lowest published lethal concentration: 20 gm/m3 Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Emphysema

Liver: Fatty liver degeneration
12OVAW -,176,1960
intraperitoneal
mouse
lethal dose (50 percent kill): 585 mg/kg N/R YKKZAJ 97,1117,1977
intraperitoneal
rat
lowest published lethal dose: 50 mg/kg N/R FATOAO 31,238,1968
oral
mouse
lethal dose (50 percent kill): 500 mg/kg Behavioral: Sleep

Behavioral: Somnolence (general depressed activity)
BBIADT 44,795,1985
oral
rat
lethal dose (50 percent kill): 540 mg/kg N/R ENTOX* -,34,2005
skin
rabbit
lethal dose (50 percent kill): 820 ÁL/kg N/R AMIHBC 4,119,1951
skin
rabbit
lethal dose (50 percent kill): 580 mg/kg N/R ENTOX* -,34,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 250 ppm/6 hour/24 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 6,559,1986
inhalation
rat
lowest published toxic concentration: 4 mg/m3/24 hour/93 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(1),28,1968
oral
rat
lowest published toxic dose: 4,994 mg/kg/11 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain GISAAA 30(9),28,1965


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm;short term exposure limit 15 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CHREAY 9,389,1931
TOXICOLOGY REVIEW
ENTOX* -,34,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (75 mg/m3) DTLVS* 3,84,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (75 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (75 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (75 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (75 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (30 mg/m3), short term exposure limit 25 ppm (75 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (15 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 10 ppm (30 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (15 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 15 mg/m3 (5 ppm);
short term exposure limit 30 mg/m3 (10 mL/m3), FEB 2006
Occupational Exposure Limit - FINLAND short term exposure limit 10 ppm (30 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 10 ppm (30 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 15 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 30 mg/m3, short term exposure limit 30 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (30 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (30 mg/m3), short term exposure limit 25 ppm (75 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (30 mg/m3);
short term exposure limit 25 ppm (75 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 15 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (30 mg/m3);
short term exposure limit 25 ppm (75 mg/m3), skin,JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (75 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 30 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (30 mg/m3);
short term exposure limit 15 ppm (45 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (15 mg/m3),KZG- week 10 ppm (30 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (75 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (30 mg/m3);
short term exposure limit 25 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHYLAMINE-air 10 hour time-weighted average 10 ppm;
short term exposure limit 25 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24680;
Number of Industries 20;
Total Number of Facilities 2,138;
Number of Occupations 28;
Total Number of Employees Exposed 34,647
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24680;
Number of Industries 22;
Total Number of Facilities 1,387;
Number of Occupations 24;
Total Number of Employees Exposed 28,361;
Total Number of Female Employees Exposed 6,878


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aliphatic, 2010
NTP Carcinogenesis studies; selected, October 2000
OSHA ANALYTICAL METHOD #41


REFERENCES:

CODEN
REFERENCE

12OVAW "Voprosy Promyshlennoi Toksikologii," Pravdin, N.S., ed., Akademiya Meditsinskikh Nauk-SSSR, Moscos, Russia, 1960
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.42- 1983-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJMBA2 Egyptian Journal of Microbiology. (National Information and Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt) V.7- 1972-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

NIOSH PROFILE (AMINES, SECONDARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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