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Dibenzo - p - dioxin, 2,3,7,8 - tetrachloro -

RTECS #: HP3500000

CAS #: 1746-01-6


UPDATE: May 2009 MW: 321.96 MF: C12H4Cl4O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2,3,7,8 - Czterochlorodwubenzo - p - dwuoksyny (Polish)
  2. 2,3,7,8 - TCDD
  3. 2,3,7,8 - Tetrachlorodibenzo (b,e) (1,4) dioxan
  4. 2,3,7,8 - Tetrachlorodibenzo - 1,4 - dioxin
  5. 2,3,7,8 - Tetrachlorodibenzo - p - dioxin
  6. 2,3,7,8 - Tetrachlorodibenzo - p - dioxin (TCDD)
  7. Dibenzo (b,e) (1,4) dioxin, 2,3,7,8 - tetrachloro -
  8. Dioksyny (Polish)
  1. Dioxin
  2. Dioxin (herbicide contaminant)
  3. Dioxine
  4. NCI - C03714
  5. TCDBD
  6. TCDD
  7. Tetradioxin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
2 mg moderate EVHPAZ 5,87,1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
mouse
100 g/kg TXAPA9 29,229,1974
cytogenetic analysis intraperitoneal
mouse
10 g/kg PSSID2 5,419,1982
cytogenetic analysis mouse lung 10 g/kg TOVEFN (5),2,1998
cytogenetic analysis oral
rat
100 g/kg MUREAV 47,141,1978
cytogenetic analysis intraperitoneal
rat
10 mg/kg MUREAV 47,141,1978
cytogenetic analysis rat lung 104 g/kg/13 week- intermittent TOVEFN (5),2,1998
DNA adduct intraperitoneal
rat
40 g/kg/4 week- intermittent CMSHAF 25,975,1992
DNA adduct oral
rat
0.21 mg/kg/30 week- intermittent CRTOEC 14,849,2001
DNA damage hamster ovary 0.5 nmol/L MUREAV 563,71,2004
DNA damage human mammary gland 1 nmol/L/5 hour TOLED5 172,146,2007
DNA damage mouse other cell types 10 nmol/L/24 hour TOLED5 145,55,2003
DNA damage oral
mouse
100 g/kg BPBLEO 29,2284,2006
DNA damage oral
rat
100 g/kg CALEDQ 39,281,1988
DNA damage unreported route
rat
100 g/kg CALEDQ 29,281,1988
DNA damage oral
rat
450 ng/kg/30 week- intermittent JJTHEC 65,825,2002
DNA inhibition human other cell types 10 nmol/L TXAPA9 77,434,1985
DNA inhibition intraperitoneal
mouse
400 g/kg MUREAV 46,305,1977
DNA inhibition intraperitoneal
rat
10 g/kg CBINA8 8,31,1974
DNA inhibition oral
rat
200 g/kg CBINA8 8,31,1974
unscheduled DNA synthesis human other cell types 100 pmol/L CRNGDP 11,1335,1990
unscheduled DNA synthesis oral
mouse
800 pmol/kg CRNGDP 8,1433,1987
unscheduled DNA synthesis intravenous
rat
4 g/kg BCPCA6 31,2459,1982
unscheduled DNA synthesis oral
rat
5 g/kg TXCYAC 28,133,1983
host-mediated assay mouse
Saccharomyes cerevisiae
25 g/kg CMSHAF 12,549,1983
mutation in microorganisms Escherichia coli 2 mg/L (-enzymatic activation step) AMBOCX 1,1,1972
mutation in microorganisms Salmonella typhimurium 2 mg/L (+enzymatic activation step) AMBOCX 1,32,1972
mutation in microorganisms Saccharomyes cerevisiae 10 mg/L (-enzymatic activation step) CMSHAF 12,549,1983
mutation in microorganisms Saccharomyes cerevisiae 2 mg/L (+enzymatic activation step) PSSID2 5,429,1982
gene conversion and mitotic recombination hamster ovary 0.5 nmol/L/24 hour TOXID9 72,369,2003
gene conversion and mitotic recombination Saccharomyes cerevisiae 10 mg/L CMSHAF 12,549,1983
mutation in mammalian somatic cells mouse lymphocyte 50 mg/L ENMUDM 4,391,1982
morphological transform mouse fibroblast 200 nmol/L ENMUDM 6,461,1984
morphological transform mouse fibroblast 10 nmol/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
other mutation test systems mouse other cell types 1 nmol/L JBCHA3 259,12357,1984
other mutation test systems oral
mouse
50 g/kg TXCYAC 56,239,1989
other mutation test systems rat liver 1 nmol/L/48 hour MUREAV 615,87,2007
phage inhibition capacity Escherichia coli 500 g/L AMBOCX 1,1,1972


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 25 g/kg (7-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TXCYAC 20,299,1981
intraperitoneal
mouse
lowest published toxic dose: 20 g/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) ATSUDG 8,43,1985
intraperitoneal
mouse
lowest published toxic dose: 30 g/kg (14 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) TOXID9 72(Suppl 1),231,2003
intraperitoneal
mouse
lowest published toxic dose: 10 g/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Other neonatal measures or effects
TOXID9 78,98,2004
intraperitoneal
mouse
lowest published toxic dose: 30 g/kg (13 day pregnant) Reproductive: Other effects to embryo or fetus TOSCF2 94,163,2006
intraperitoneal
mouse
lowest published toxic dose: 30 g/kg (16 day pregnant) Reproductive: Other effects to embryo or fetus TOSCF2 94,163,2006
intraperitoneal
rat
lowest published toxic dose: 6 g/kg (17 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic BCPCA6 26,1383,1977
intraperitoneal
rat
lowest published toxic dose: 50 g/kg (1 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects TXAPA9 173,38,2001
oral
hamster
lowest published toxic dose: 18 g/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death CMSHAF 20,1117,1990
oral
hamster
lowest published toxic dose: 2 g/kg (11 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
TOSCF2 51,259,1999
oral
hamster
lowest published toxic dose: 1 g/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 131,108,1995
oral
hamster
lowest published toxic dose: 2 g/kg (11 day pregnant) Reproductive: Effects on newborn: Physical TOSCF2 51,259,1999
oral
mammal (species unspecified)
lowest published toxic dose: 19 g/kg (132 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) VHTODE 43,134,2001
oral
mammal (species unspecified)
lowest published toxic dose: 2.4 g/kg (132 day prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) VHTODE 43,134,2001
oral
mammal (species unspecified)
lowest published toxic dose: 699.6 ng/kg (132 day prior to copulation) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) VHTODE 43,134,2001
oral
monkey
lowest published toxic dose: 92 ng/kg (46 week prior to copulation-17 week after birth) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
NETEEC 11,13,1989
oral
monkey
lowest published toxic dose: 107 mg/kg (4 year male) Reproductive: Effects on newborn: Behavioral CMSHAF 20,1103,1990
oral
monkey
lowest published toxic dose: 123 ng/kg (30 week prior to copulation-17 week after birth) Reproductive: Effects on newborn: Behavioral TOXID9 3,68,1983
oral
monkey
lowest published toxic dose: 163 ng/kg (182 week prior to copulation) Reproductive: Effects on newborn: Behavioral NETEEC 14,433,1992
oral
monkey
lowest published toxic dose: 2 g/kg (12 day pregnant) Reproductive: Effects on fertility: Abortion BESCE5 13,26,2000
oral
monkey
lowest published toxic dose: 0.535 g/kg (30 week prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion
ANYAA9 -,419,1979
oral
monkey
lowest published toxic dose: 4 g/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BDERB* 71,37,2004
oral
monkey
lowest published toxic dose: 4 g/kg (20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BDERB* 71,37,2004
oral
mouse
lowest published toxic dose: 1 g/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system EVHPAZ 5,81,1973
oral
mouse
lowest published toxic dose: 9 g/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TXAPA9 98,487,1989
oral
mouse
lowest published toxic dose: 13,500 mg/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TJADAB 44,385,1991
oral
mouse
lowest published toxic dose: 235 g/kg (28 day prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system DCTODJ 2,77,1979
oral
mouse
lowest published toxic dose: 20 g/kg (14 day pregnant/3 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
IJIMDS 2,301,1980
oral
mouse
lowest published toxic dose: 12 g/kg (10-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 33,29,1986
oral
mouse
lowest published toxic dose: 10 g/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system MOPMA3 35,18,1989
oral
mouse
lowest published toxic dose: 12 g/kg (10-13 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TOXID9 13,103,1993
oral
mouse
lowest published toxic dose: 240 g/kg (1 day after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) ARTODN 69,87,1994
oral
mouse
lowest published toxic dose: 320 g/kg (1 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) ARTODN 69,87,1994
oral
mouse
lowest published toxic dose: 480 g/kg (1 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system ARTODN 69,87,1994
oral
mouse
lowest published toxic dose: 3 g/kg (8 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
TOSCF2 52,45,1999
oral
mouse
lowest published toxic dose: 15 g/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
CMSHAF 25,103,1992
oral
mouse
lowest published toxic dose: 50 g/kg (105 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Other reproductive system tumors
EVHPAZ 105,750,1997
oral
mouse
lowest published toxic dose: 5 g/kg (9 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
ARTODN 67,591,1993
oral
mouse
lowest published toxic dose: 40 g/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) TCMUD8 20,73,2000
oral
mouse
lowest published toxic dose: 5 g/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 72(Suppl 1),365,2003
oral
mouse
lowest published toxic dose: 10 g/kg (17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),366,2003
oral
mouse
lowest published toxic dose: 6 g/kg (14 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TOXID9 72(Suppl 1),231,2003
oral
mouse
lowest published toxic dose: 0.2 g/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
TOSCF2 71,84,2003
oral
mouse
lowest published toxic dose: 5 g/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Skin and skin appendages
TOSCF2 68,465,2002
oral
mouse
lowest published toxic dose: 5 g/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other postnatal measures or effects
TOSCF2 68,479,2002
oral
mouse
lowest published toxic dose: 5 g/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Urogenital system
TOSCF2 76,171,2003
oral
mouse
lowest published toxic dose: 5 g/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Urogenital system
TOSCF2 71,84,2003
oral
mouse
lowest published toxic dose: 5 g/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 197,211,2004
oral
mouse
lowest published toxic dose: 24 g/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TOXID9 44,251,2005
oral
mouse
lowest published toxic dose: 4.4 g/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
TOLED5 150,285,2004
oral
mouse
lowest published toxic dose: 30 g/kg (14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 44,418,2005
oral
mouse
lowest published toxic dose: 5 g/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 78,189,2004
oral
mouse
lowest published toxic dose: 5 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 78,189,2004
oral
mouse
lowest published toxic dose: 5 g/kg (16 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 78,189,2004
oral
mouse
lowest published toxic dose: 5 g/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOXID9 78,248,2004
oral
mouse
lowest published toxic dose: 5 g/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 60,273,2001
oral
mouse
lowest published toxic dose: 400 ng/kg (1-8 day pregnant) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
REPTED 21,301,2006
oral
mouse
lowest published toxic dose: 150 ng/kg (1-3 day pregnant) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
REPTED 21,301,2006
oral
mouse
lowest published toxic dose: 250 ng/kg (4-8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) REPTED 21,301,2006
oral
mouse
lowest published toxic dose: 1 g/kg (13 day pregnant) Reproductive: Effects on newborn: Physical TXCYAC 242,52,2007
oral
mouse
lowest published toxic dose: 180 g/kg (8-9 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TSPLS* -,218,2003
oral
mouse
lowest published toxic dose: 24 g/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TERAD* -,247,2004
oral
mouse
lowest published toxic dose: 3 g/kg (12 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TOXID9 -,140,2008
oral
mouse
lowest published toxic dose: 3 g/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Delayed effects
TOXID9 -,140,2008
oral
mouse
lowest published toxic dose: 6 g/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Delayed effects
TOXID9 -,140,2008
oral
mouse
lowest published toxic dose: 10 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system REPTED 23,326,2007
oral
mouse
lowest published toxic dose: 10 g/kg (multigeneration) Reproductive: Specific developmental abnormalities: Endocrine system REPTED 23,326,2007
oral
mouse
lowest published toxic dose: 0.1 g/kg (13 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects
TOXID9 -,164,2008
oral
mouse
lowest published toxic dose: 40 g/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Delayed effects
TOXID9 12,437,2008
oral
mouse
lowest published toxic dose: 10 g/kg (1 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities
TOXID9 12,416,2008
oral
mouse
lowest published toxic dose: 10 g/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Other postnatal measures or effects
TOXID9 12,437,2008
oral
rat
lowest published toxic dose: 1,500 ng/kg (1-3 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 25(1),21A,1982
oral
rat
lowest published toxic dose: 1,250 ng/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
FCTXAV 9,405,1971
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other neonatal measures or effects
TXAPA9 150,254,1998
oral
rat
lowest published toxic dose: 1,270 ng/kg (multigenerations) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 50,241,1979
oral
rat
lowest published toxic dose: 1 g/kg (15 day after birth) Reproductive: Effects on newborn: Physical TXAPA9 140,146,1996
oral
rat
lowest published toxic dose: 20 g/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina TXCYAC 21,77,1981
oral
rat
lowest published toxic dose: 12 g/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 55,326,1997
oral
rat
lowest published toxic dose: 1 g/kg (8 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 133,285,1995
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 133,285,1995
oral
rat
lowest published toxic dose: 0.5 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 146,11,1997
oral
rat
lowest published toxic dose: 56 mg/kg (10-16 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system
TOLED5 78,253,1995
oral
rat
lowest published toxic dose: 0.7 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral
TOXID9 14,197,1994
oral
rat
lowest published toxic dose: 0.64 g/kg (15 day pregnant) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 10,313,1990
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 127,241,1994
oral
rat
lowest published toxic dose: 0.7 g/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 127,250,1994
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
BIREBV 55,62,1996
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 140,146,1996
oral
rat
lowest published toxic dose: 1 g/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 15,292,1995
oral
rat
lowest published toxic dose: 1 g/kg (18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 15,292,1995
oral
rat
lowest published toxic dose: 1 g/kg (8 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
TOSCF2 52,45,1999
oral
rat
lowest published toxic dose: 800 ng/kg (15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Other effects to embryo or fetus

Reproductive: Effects on newborn: Biochemical and metabolic
ETOPFR 11,1,2002
oral
rat
lowest published toxic dose: 0.3 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TXAPA9 174,216,2001
oral
rat
lowest published toxic dose: 1.4 g/kg (10-15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
NETEEC 22,511,2001
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TXAPA9 134,241,1995
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
TXAPA9 134,241,1995
oral
rat
lowest published toxic dose: 0.35 g/kg (16 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system CMSHAF 18,955,1989
oral
rat
lowest published toxic dose: 0.125 g/kg (16 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system CMSHAF 18,955,1989
oral
rat
lowest published toxic dose: 13 g/kg (7-19 day pregnant) Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Other developmental abnormalities
BCPCA6 32,991,1983
oral
rat
lowest published toxic dose: 12 g/kg (4-15 day pregnant) Reproductive: Specific developmental abnormalities: Gastrointestinal system BCPCA6 32,991,1983
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
BIRSB5 62,184,2000
oral
rat
lowest published toxic dose: 0.18 g/kg (15 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
NETEEC 24,209,2002
oral
rat
lowest published toxic dose: 45 ng/kg (45 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
JJATDK 22,345,2002
oral
rat
lowest published toxic dose: 700 ng/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Other developmental abnormalities
TOXID9 72,125,2003
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Biochemical and metabolic
EVHPAZ 110(Suppl 3),369,2002
oral
rat
lowest published toxic dose: 20 ng/kg (8 day pregnant) Endocrine: Differential effect of sex or castration on observed toxicity

Reproductive: Effects on newborn: Behavioral
EVHPAZ 110,247,2002
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Specific developmental abnormalities: Endocrine system
BIREBV 66,1621,2002
oral
rat
lowest published toxic dose: 20 ng/kg (18 day pregnant) Reproductive: Effects on newborn: Behavioral EVHPAZ 109,621,2001
oral
rat
lowest published toxic dose: 1 g/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Stillbirth
TXAPA9 184,57,2002
oral
rat
lowest published toxic dose: 800 ng/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NRTXDN 24,207,2003
oral
rat
lowest published toxic dose: 0.7 g/kg (10-16 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
NETEEC 25,459,2003
oral
rat
lowest published toxic dose: 3 g/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXCYAC 197,57,2004
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Delayed effects
TOXID9 44,138,2005
oral
rat
lowest published toxic dose: 10 gm/kg (1 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 44,439,2005
oral
rat
lowest published toxic dose: 20 ng/kg (8 day pregnant) Reproductive: Other developmental abnormalities TOXID9 66,168,2002
oral
rat
lowest published toxic dose: 180 ng/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 66,168,2002
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 66,170,2002
oral
rat
lowest published toxic dose: 100 ng/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
TOXID9 78,381,2004
oral
rat
lowest published toxic dose: 180 ng/kg (18 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects TOXID9 1,114,2001
oral
rat
lowest published toxic dose: 1 g/kg (11 day pregnant) Reproductive: Other developmental abnormalities TOXID9 66,333,2002
oral
rat
lowest published toxic dose: 1 g/kg (1 day after birth) Reproductive: Other developmental abnormalities TOXID9 66,333,2002
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,273,2001
oral
rat
lowest published toxic dose: 12.5 ng/kg (15 day pregnant) Reproductive: Effects on newborn: Sex ratio TOXID9 60,274,2001
oral
rat
lowest published toxic dose: 200 ng/kg (15 day pregnant) Reproductive: Effects on newborn: Physical TOXID9 60,274,2001
oral
rat
lowest published toxic dose: 800 ng/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,274,2001
oral
rat
lowest published toxic dose: 0.7 g/kg (14 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 60,274,2001
oral
rat
lowest published toxic dose: 800 ng/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 60,332,2001
oral
rat
lowest published toxic dose: 60 ng/kg (8 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects TOXID9 60,444,2001
oral
rat
lowest published toxic dose: 200 ng/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic
TXAPA9 205,98,2005
oral
rat
lowest published toxic dose: 800 ng/kg (15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic
TXAPA9 205,98,2005
oral
rat
lowest published toxic dose: 0.1 mg/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 227,117,2006
oral
rat
lowest published toxic dose: 0.1 mg/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 227,117,2006
oral
rat
lowest published toxic dose: 0.1 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 227,117,2006
oral
rat
lowest published toxic dose: 1.6 g/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TXAPA9 212,224,2006
oral
rat
lowest published toxic dose: 0.2 g/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) TXAPA9 212,224,2006
oral
rat
lowest published toxic dose: 800 ng/kg (15 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Sex ratio

Reproductive: Effects on newborn: Physical
TXAPA9 205,98,2005
oral
rat
lowest published toxic dose: 200 ng/kg (15 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TXAPA9 205,98,2005
oral
rat
lowest published toxic dose: 6 g/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TXAPA9 224,29,2007
oral
rat
lowest published toxic dose: 1.5 g/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TXAPA9 224,29,2007
oral
rat
lowest published toxic dose: 3 g/kg (10 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 224,29,2007
oral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TOSCF2 91,568,2006
oral
rat
lowest published toxic dose: 0.3 g/kg (15 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects TOSCF2 91,568,2006
oral
rat
lowest published toxic dose: 700 ng/kg (15 day pregnant) Reproductive: Effects on newborn: Behavioral NRTXDN 27,1032,2006
oral
rat
lowest published toxic dose: 100 ng/kg (15 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic NRTXDN 27,1032,2006
oral
rat
lowest published toxic dose: 6,678 ng/kg (12 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXCYAC 240,170,2007
oral
rat
lowest published toxic dose: 6,678 ng/kg (12 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Behavioral TXCYAC 240,170,2007
oral
rat
lowest published toxic dose: 352.8 ng/kg (12 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Other postnatal measures or effects TXCYAC 240,170,2007
oral
rat
lowest published toxic dose: 1.1 g/kg (9-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Physical
TOLED5 173,41,2007
oral
rat
lowest published toxic dose: 1 g/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system REPTED 22,521,2006
oral
rat
lowest published toxic dose: 1.6 ng/kg (15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
TOXID9 -,228,2008
oral
rat
lowest published toxic dose: 1.5 g/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TOXID9 -,161,2008
oral
rabbit
lowest published toxic dose: 2,500 ng/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Urogenital system
ENVRAL 27,74,1982
oral
rabbit
lowest published toxic dose: 10 g/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Abortion
ENVRAL 27,74,1982
oral
rabbit
lowest published toxic dose: 1 g/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ENVRAL 27,74,1982
parenteral
rat
lowest published toxic dose: 1 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 14,197,1994
subcutaneous
monkey
lowest published toxic dose: 405 ng/kg (20-165 day pregnant/90 day after birth) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
REPTED 20,21,2005
subcutaneous
monkey
lowest published toxic dose: 34.5 ng/kg (20 day pregnant-90 day after birth) Reproductive: Effects on newborn: Behavioral TOLED5 160,233,2006
subcutaneous
mouse
lowest published toxic dose: 250 g/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
BECTA6 16,674,1976
subcutaneous
mouse
lowest published toxic dose: 250 g/kg (7-16 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death
BECTA6 16,674,1976
subcutaneous
mouse
lowest published toxic dose: 100 g/kg (2 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TCMUD8 4,427,1984
subcutaneous
mouse
lowest published toxic dose: 30 g/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) MOPMA3 17,86,1980
subcutaneous
mouse
lowest published toxic dose: 100 g/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TCMUD8 4,427,1984
subcutaneous
mouse
lowest published toxic dose: 90 g/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TJADAB 21,62A,1980
subcutaneous
mouse
lowest published toxic dose: 90 g/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TJADAB 21,62A,1980
subcutaneous
mouse
lowest published toxic dose: 90 g/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TJADAB 21,62A,1980
subcutaneous
rat
lowest published toxic dose: 5 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 20,396,1971
subcutaneous
rat
lowest published toxic dose: 2,200 ng/kg (19 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) CMSHAF 25,1227,1992
subcutaneous
rat
lowest published toxic dose: 0.5 g/kg (7-20 day pregnant/9-16 day after birth) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Biochemical and metabolic
BCPCA6 62,617,2001
subcutaneous
rat
lowest published toxic dose: 185 ng/kg (2 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Germ cell effects (in offspring) TXAPA9 150,383,1998
subcutaneous
rat
lowest published toxic dose: 2,700 ng/kg (2 week prior to copulation-3 week after birth) Reproductive: Specific developmental abnormalities: Endocrine system TXAPA9 150,383,1998
subcutaneous
rat
lowest published toxic dose: 3 g/kg (19 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TJADAB 40,292,1989
subcutaneous
rat
lowest published toxic dose: 0.5 g/kg (7-20 day pregnant/2 day after birth) Reproductive: Specific developmental abnormalities: Hepatobiliary system BCPCA6 59,1147,2000
unreported route
mouse
lowest published toxic dose: 12 g/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system CMSHAF 25,115,1992
unreported route
mouse
lowest published toxic dose: 5 g/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72,113,2003
unreported route
mouse
lowest published toxic dose: 1.5 g/kg (0-14 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TOXID9 72,121,2003
unreported route
mouse
lowest published toxic dose: 5.5 g/kg (0-14 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) TOXID9 72,121,2003
unreported route
mouse
lowest published toxic dose: 3 g/kg (17 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system TOXID9 44,172,2005
unreported route
mouse
lowest published toxic dose: 10 g/kg (14-16 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 44,181,2005
unreported route
mouse
lowest published toxic dose: 24 g/kg (12 day pregnant) Reproductive: Other effects to embryo or fetus TOXID9 44,138,2005
unreported route
mouse
lowest published toxic dose: 1 g/kg (12 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 44,145,2005
unreported route
mouse
lowest published toxic dose: 5 g/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,112,2005
unreported route
mouse
lowest published toxic dose: 5 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,112,2005
unreported route
mouse
lowest published toxic dose: 5 g/kg (16 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,112,2005
unreported route
mouse
lowest published toxic dose: 5 g/kg (17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,113,2005
unreported route
mouse
lowest published toxic dose: 5 g/kg (13 day pregnant) Reproductive: Other developmental abnormalities TOXID9 66,132,2002
unreported route
mouse
lowest published toxic dose: 1 g/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 66,168,2002
unreported route
mouse
lowest published toxic dose: 30 g/kg (14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
TOXID9 66,169,2002
unreported route
mouse
lowest published toxic dose: 15 g/kg (1 day prior to copulation/7-14 day pregnant) Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Reproductive: Other effects on female

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TOXID9 78,218,2004
unreported route
mouse
lowest published toxic dose: 5 g/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 66,300,2002
unreported route
mouse
lowest published toxic dose: 24 g/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 60,181,2001
unreported route
mouse
lowest published toxic dose: 5 g/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 60,333,2001
unreported route
mouse
lowest published toxic dose: 135 g/kg (16 day pregnant-21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 60,333,2001
unreported route
mouse
lowest published toxic dose: 150 g/kg (13 day pregnant-21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 60,333,2001
unreported route
mouse
lowest published toxic dose: 200 g/kg (13 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,440,2001
unreported route
mouse
lowest published toxic dose: 3 g/kg (14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TERST* -,290,2005
unreported route
rat
lowest published toxic dose: 1,500 mg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ATSUDG 11,344,1987
unreported route
rat
lowest published toxic dose: 0.7 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 14,382,1994
unreported route
rat
lowest published toxic dose: 0.8 g/kg (15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) HBPTO* 1,741,2001
unreported route
rat
lowest published toxic dose: 0.2 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system HBPTO* 1,741,2001
unreported route
rat
lowest published toxic dose: 0.5 g/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Physical
HBPTO* 1,741,2001
unreported route
rat
lowest published toxic dose: 1,000 ng/kg (15 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Physical
TOXID9 44,139,2005
unreported route
rat
lowest published toxic dose: 1,000 ng/kg (15 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects TOXID9 44,139,2005
unreported route
rat
lowest published toxic dose: 4 g/kg (15 day pregnant/3 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 66,132,2002
unreported route
rat
lowest published toxic dose: 3 g/kg (14 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,24,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 1.61 g/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Facilitates action of known carcinogens
TXAPA9 179,21,2002
oral
mouse
lowest published toxic dose: 52 g/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
NTPTR* NTP-TR-209,1982
oral
mouse
toxic dose : 1 g/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
NTPTR* NTP-TR-209,1982
oral
mouse
toxic dose : 36 g/kg/52 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NATUAS 278,548,1979
oral
mouse
lowest published toxic dose: 0.52 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-163445
oral
mouse
lowest published toxic dose: 0.208 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
NTIS** PB82-163445
oral
rat
lowest published toxic dose: 52 g/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
NTPTR* NTP-TR-209,1982
oral
rat
toxic dose : 328 g/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
PESTC* 5,12,1977
oral
rat
toxic dose : 137 g/kg/65 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
FEPRA7 36,396,1977
oral
rat
toxic dose : 73 g/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
ANYAA9 320,397,1979
oral
rat
toxic dose : 1 g/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
NTPTR* NTP-TR-209,1982
oral
rat
lowest published toxic dose: 164 g/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
CMSHAF 6,625,1977
oral
rat
toxic dose : 190 g/kg/95 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
CMSHAF 6,537,1977
oral
rat
toxic dose : 27 g/kg/65 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
FEPRA7 36,396,1977
oral
rat
lowest published toxic dose: 0.52 mg/kg/104 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors
NTIS** PB82-163445
oral
rat
lowest published toxic dose: 0.52 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-163445
oral
rat
lowest published toxic dose: 73,000 ng/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Angiosarcoma
TOPADD 33,165,2005
oral
rat
lowest published toxic dose: 73,000 ng/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
TOPADD 33,165,2005
oral
rat
lowest published toxic dose: 33,580 ng/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Liver: Angiosarcoma
TOPADD 33,165,2005
skin
mouse
lowest published toxic dose: 62 g/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
NCITR* NCI-TR-201,1982
skin
mouse
toxic dose : 80 g/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
BECTA6 18,552,1977
skin
mouse
lowest published toxic dose: 0.594 mg/kg/99 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
NTIS** PB82-163684
skin
mouse
lowest published toxic dose: 0.1,188 mg/kg/99 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
NTIS** PB82-163684


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
wild bird
lowest published toxic dose: 20 g/kg Endocrine: Evidence of thyroid hyperfunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
ETOCDK 16,985,1997
intraperitoneal
chicken
lowest published lethal dose: 25 g/kg Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Other changes
JTEHD6 35,187,1992
intraperitoneal
chicken
lowest published toxic dose: 10 g/kg N/R TOXID9 60,441,2001
intraperitoneal
chicken
lowest published toxic dose: 10 g/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
TOXID9 60,441,2001
intraperitoneal
guinea pig
lowest published toxic dose: 29.9 ng/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
BCPCA6 36,1535,1988
intraperitoneal
guinea pig
lowest published toxic dose: 1.8 g/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain BCPCA6 36,1535,1988
intraperitoneal
hamster
lethal dose (50 percent kill): >3 mg/kg Endocrine: Changes in thymus weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 55,67,1980
intraperitoneal
hamster
lowest published toxic dose: 1 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) BCPCA6 35,2737,1986
intraperitoneal
hamster
lowest published toxic dose: 10 g/kg Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BCPCA6 35,2737,1986
intraperitoneal
hamster
lowest published toxic dose: 100 g/kg Endocrine: Changes in thymus weight BCPCA6 35,2737,1986
intraperitoneal
hamster
lowest published toxic dose: 500 g/kg Liver: Other changes BCPCA6 35,2737,1986
intraperitoneal
mouse
lethal dose (50 percent kill): 120 g/kg N/R SCAMAC 254,29,1986
intraperitoneal
mouse
lowest published toxic dose: 0.6 g/kg Immunological Including Allergic: Decrease in humoral immune response TXCYAC 92,155,1994
intraperitoneal
mouse
lowest published toxic dose: 10 g/kg Blood: Luekopenia

Blood: Changes in bone marrow not included in above
CMSHAF 43,819,2001
intraperitoneal
mouse
lowest published toxic dose: 9.66 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) MOPMA3 13,924,1977
intraperitoneal
mouse
lowest published toxic dose: 782 ng/kg Immunological Including Allergic: Decrease in humoral immune response

Immunological Including Allergic: Decreased immune response
TXAPA9 94,141,1988
intraperitoneal
mouse
lowest published toxic dose: 1.5 g/kg Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decreased immune response
TXCYAC 80,217,1993
intraperitoneal
mouse
lowest published toxic dose: 0.29 g/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXCYAC 80,217,1993
intraperitoneal
mouse
lowest published toxic dose: 20 g/kg Blood: Changes in bone marrow not included in above

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides
AECTCV 41,232,2001
intraperitoneal
mouse
lowest published toxic dose: 50 g/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 72,66,2003
intraperitoneal
mouse
lowest published toxic dose: 0.1 g/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOXID9 72,66,2003
intraperitoneal
mouse
lowest published toxic dose: 30 g/kg Endocrine: Other changes

Blood: Changes in bone marrow not included in above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
CMSHAF 25,103,1992
intraperitoneal
mouse
lowest published toxic dose: 11.19 g/kg Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 63,97,1990
intraperitoneal
mouse
lowest published toxic dose: 30 g/kg Endocrine: Changes in thymus weight

Blood: Changes in bone marrow not included in above
TOSCF2 69,117,2002
intraperitoneal
mouse
lowest published toxic dose: 15 g/kg Blood: Methemoglobinemia- Carboxhemoglobinemia TXAPA9 181,32,2002
intraperitoneal
mouse
lowest published toxic dose: 115 g/kg Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 172,125,2002
intraperitoneal
mouse
lowest published toxic dose: 0.1 g/kg Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 178,241,2002
intraperitoneal
mouse
lowest published toxic dose: 5 g/kg Liver: Fatty liver degeneration TOXID9 72(Suppl 1),336,2003
intraperitoneal
mouse
lowest published toxic dose: 5 g/kg Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOSCF2 66,62,2002
intraperitoneal
mouse
lowest published toxic dose: 0.1 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TOSCF2 69,109,2002
intraperitoneal
mouse
lowest published toxic dose: 1 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport
TOSCF2 69,109,2002
intraperitoneal
mouse
lowest published toxic dose: 10 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOSCF2 69,109,2002
intraperitoneal
mouse
lowest published toxic dose: 30 g/kg Endocrine: Changes in thymus weight

Blood: Changes in bone marrow not included in above

Immunological Including Allergic: Decreased immune response
TOLED5 129,1,2002
intraperitoneal
mouse
lowest published toxic dose: 1 g/kg Blood: Changes in bone marrow not included in above

Immunological Including Allergic: Decreased immune response
TXAPA9 197,185,2004
intraperitoneal
mouse
lowest published toxic dose: 100 ng/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,18,2004
intraperitoneal
mouse
lowest published toxic dose: 200 g/kg Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
TOXID9 66,21,2002
intraperitoneal
mouse
lowest published toxic dose: 10 g/kg Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
ARTODN 78,290,2004
intraperitoneal
mouse
lowest published toxic dose: 10 g/kg Immunological Including Allergic: Decrease in cellular immune response ARTODN 76,570,2002
intraperitoneal
mouse
lowest published toxic dose: 30 g/kg Endocrine: Other changes

Endocrine: Changes in thymus weight
TOXID9 1,68,2001
intraperitoneal
mouse
lowest published toxic dose: 5 g/kg Endocrine: Changes in thymus weight TOXID9 66,334,2002
intraperitoneal
mouse
lowest published toxic dose: 10 g/kg Related to Chronic Data: Changes in uterine weight TOXID9 60,249,2001
intraperitoneal
mouse
lowest published toxic dose: 5 g/kg Reproductive: Maternal effects: Uterus, cervix, vagina TOXID9 60,249,2001
intraperitoneal
mouse
lowest published toxic dose: 2.5 g/kg Lung, Thorax, or Respiration: Other changes

Blood: Changes in spleen

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 157,89,2005
intraperitoneal
mouse
lowest published toxic dose: 50 g/kg Immunological Including Allergic: Decreased immune response TOVEFN (2),20,1998
intraperitoneal
mouse
lowest published toxic dose: 150 g/kg Brain and Coverings: Other degenerative changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes
JTPAE7 18,41,2005
intraperitoneal
rat
lethal dose (50 percent kill): 24,600 ng/kg N/R TXAPA9 45,513,1978
intraperitoneal
rat
lowest published toxic dose: 1 g/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 150,427,1998
intraperitoneal
rat
lowest published toxic dose: 10 g/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 150,427,1998
intraperitoneal
rat
lowest published toxic dose: 12.5 g/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 89,49,1994
intraperitoneal
rat
lowest published toxic dose: 82.4 g/kg Endocrine: Estrogenic

Endocrine: Other changes
CMSHAF 19,785,1989
intraperitoneal
rat
lowest published lethal dose: 100 g/kg Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHD6 16,481,1985
intraperitoneal
rat
lowest published toxic dose: 9.66 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) MOPMA3 13,924,1977
intraperitoneal
rat
lowest published toxic dose: 1 g/kg Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 44,297,1987
intraperitoneal
rat
lowest published lethal dose: 25 g/kg Endocrine: Other changes TXCYAC 44,297,1987
intraperitoneal
rat
lowest published toxic dose: 125 g/kg Behavioral: Food intake (animal)

Endocrine: Hypoglycemia
TXCYAC 44,297,1987
intraperitoneal
rat
lowest published toxic dose: 10.3 g/kg Liver: Other changes

Endocrine: Estrogenic
TXAPA9 95,435,1988
intraperitoneal
rat
lowest published toxic dose: 20 g/kg Endocrine: Estrogenic TXAPA9 92,368,1988
intraperitoneal
rat
lowest published toxic dose: 10 g/kg Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 29,61,1983
intraperitoneal
rat
lowest published toxic dose: 5 g/kg Endocrine: Changes in spleen weight

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
ATXKA8 53,177,1983
intraperitoneal
rat
lowest published toxic dose: 5 g/kg Liver: Other changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
ARTODN 53,177,1983
intraperitoneal
rat
lowest published toxic dose: 5 g/kg Endocrine: Other changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
ARTODN 53,177,1983
intraperitoneal
rat
lowest published toxic dose: 125 g/kg Behavioral: Food intake (animal)

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 62,146,1988
intraperitoneal
rat
lowest published toxic dose: 10 g/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
LPDSAP 23,904,1988
intraperitoneal
rat
lowest published toxic dose: 1 g/kg Liver: Changes in liver weight

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
LPDSAP 23,904,1988
intraperitoneal
rat
lowest published toxic dose: 10 g/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
JPETAB 248,62,1989
intraperitoneal
rat
lowest published toxic dose: 5 g/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
ARTODN 53,177,1983
intraperitoneal
rat
lethal dose (50 percent kill): 60 g/kg Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
BBRCA9 125,996,1984
intraperitoneal
rat
lowest published toxic dose: 2.5 g/kg Endocrine: Changes in thymus weight BBRCA9 160,1003,1989
intraperitoneal
rat
lowest published toxic dose: 25 g/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain BBRCA9 160,1003,1989
intraperitoneal
rat
lowest published toxic dose: 50 g/kg Endocrine: Change in gonadotropins

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TXAPA9 94,496,1988
intraperitoneal
rat
lowest published toxic dose: 12.5 g/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 76,103,1992
intraperitoneal
rat
lowest published toxic dose: 25 g/kg Endocrine: Androgenic

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 76,103,1992
intraperitoneal
rat
lowest published toxic dose: 50 g/kg Related to Chronic Data: Changes in testicular weight TXCYAC 76,103,1992
intraperitoneal
rat
lowest published toxic dose: 25 g/kg Behavioral: Food intake (animal)

Endocrine: Adrenal cortex hyperplasia

Endocrine: Changes in thymus weight
TXCYAC 53,19,1988
intraperitoneal
rat
lowest published lethal dose: 125 g/kg N/R TXCYAC 53,19,1988
intraperitoneal
rat
lowest published toxic dose: 19.31 g/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other
CJPPA3 63,1537,1985
intraperitoneal
rat
lowest published toxic dose: 20 g/kg Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
BCPCA6 39,485,1990
intraperitoneal
rat
lowest published toxic dose: 80 g/kg Related to Chronic Data: Changes in uterine weight BCPCA6 39,485,1990
intraperitoneal
rat
lowest published toxic dose: 100 g/kg Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 37,51,1985
intraperitoneal
rat
lethal dose (25 percent kill): 1,000 g/kg N/R TOXID9 66,334,2002
intraperitoneal
rabbit
lethal dose (50 percent kill): 252 g/kg N/R SCAMAC 254,29,1986
oral
chicken
lowest published lethal dose: 25 g/kg Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTXAV 11,585,1973
oral
dog
lethal dose (50 percent kill): 1 g/kg N/R ENTOX* -,70,2005
oral
frog
lethal dose (50 percent kill): 1 mg/kg N/R SCAMAC 254,29,1986
oral
guinea pig
lethal dose (50 percent kill): 500 ng/kg N/R EVSRBT 2,708,1973
oral
hamster
lethal dose (50 percent kill): 1,157 g/kg Gastrointestinal: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 55,67,1980
oral
hamster
lethal dose (50 percent kill): 1,157 g/kg N/R ENTOX* -,70,2005
oral
mammal (species unspecified)
lethal dose (50 percent kill): 4,200 ng/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
AECTCV 17,33,1988
oral
monkey
lethal dose (50 percent kill): 2 g/kg N/R EXPEAM 38,879,1982
oral
monkey
lowest published toxic dose: 0.4 mg/kg Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
REPTED 15,377,2001
oral
mouse
lethal dose (50 percent kill): 114 g/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes
TXAPA9 29,229,1974
oral
mouse
lowest published toxic dose: 10 g/kg Behavioral: Change in motor activity (specific assay) TOSCF2 56,114,2000
oral
mouse
lowest published toxic dose: 50 g/kg Endocrine: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other
NRTXDN 23,783,2002
oral
mouse
lowest published toxic dose: 400 g/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 190,120,2003
oral
mouse
lowest published toxic dose: 4,000 g/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 190,120,2003
oral
mouse
lowest published toxic dose: 50 g/kg Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 192,262,2003
oral
mouse
lowest published toxic dose: 10 g/kg Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 192,275,2003
oral
mouse
lowest published toxic dose: 0.3 g/kg Immunological Including Allergic: Decrease in cellular immune response TOXID9 72(Suppl 1),403,2003
oral
mouse
lowest published toxic dose: 0.3 g/kg Liver: Changes in liver weight TOXID9 72(Suppl 1),403,2003
oral
mouse
lowest published toxic dose: 5 g/kg Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 172,49,2002
oral
mouse
lowest published toxic dose: 20 g/kg Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 172,49,2002
oral
mouse
lowest published toxic dose: 156 g/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition
TOXID9 72(Suppl 1),363,2003
oral
mouse
lowest published toxic dose: 0.1 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 72(Suppl 1),364,2003
oral
mouse
lowest published toxic dose: 5 g/kg Liver: Other changes

Blood: Other changes
TOXID9 72(Suppl 1),364,2003
oral
mouse
lowest published toxic dose: 12.5 g/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 175,73,2002
oral
mouse
lowest published toxic dose: 5 g/kg Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 188,15,2003
oral
mouse
lowest published toxic dose: 20 g/kg Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
TOSCF2 66,117,2002
oral
mouse
lowest published toxic dose: 3 g/kg Liver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response
TXCYAC 197,15,2004
oral
mouse
lowest published toxic dose: 10 g/kg Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
TXCYAC 197,15,2004
oral
mouse
lowest published toxic dose: 0.3 g/kg Immunological Including Allergic: Decrease in humoral immune response TXCYAC 197,15,2004
oral
mouse
lowest published toxic dose: 10 g/kg Immunological Including Allergic: Decrease in humoral immune response

Endocrine: Changes in thymus weight
TXCYAC 197,15,2004
oral
mouse
lowest published toxic dose: 1 g/kg Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,222,2005
oral
mouse
lowest published toxic dose: 30 g/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,279,2005
oral
mouse
lowest published toxic dose: 75 mg/kg Liver: Liver function tests impaired

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments

Biochemical: Metabolism (intermediary): Other
TOXID9 44,389,2005
oral
mouse
lowest published toxic dose: 75 mg/kg Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Changes in: Fe

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
TOXID9 44,389,2005
oral
mouse
lowest published toxic dose: 20 g/kg Blood: Changes in spleen

Immunological Including Allergic: Decrease in humoral immune response
TOXID9 66,178,2002
oral
mouse
lowest published toxic dose: 20 g/kg Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
TOXID9 60,25,2001
oral
mouse
lowest published toxic dose: 100 g/kg Gastrointestinal: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 205,89,2005
oral
mouse
lowest published toxic dose: 100 g/kg Liver: Changes in liver weight

Endocrine: Changes in thymus weight
BPBLEO 27,1397,2004
oral
mouse
lowest published toxic dose: 10 g/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
TXCYAC 224,191,2006
oral
mouse
lowest published toxic dose: 100 g/kg Gastrointestinal: Other changes

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 205,89,2005
oral
mouse
lethal dose (50 percent kill): 114 g/kg N/R ENTOX* -,70,2005
oral
mouse
lowest published lethal dose: 100 g/kg Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BPBLEO 29,2284,2006
oral
mouse
lowest published toxic dose: 10 g/kg Biochemical: Metabolism (intermediary): Other proteins REPTED 23,326,2007
oral
mouse
lowest published toxic dose: 30 g/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 -,174,2008
oral
rat
lowest published toxic dose: 50 g/kg Endocrine: Adrenal cortex hypoplasia

Endocrine: Other changes
NETEEC 15,365,1993
oral
rat
lowest published toxic dose: 90 g/kg Endocrine: Changes in spleen weight TXCYAC 106,221,1996
oral
rat
lowest published toxic dose: 10 g/kg Immunological Including Allergic: Increase in humoral response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 106,221,1996
oral
rat
lowest published toxic dose: 1 g/kg Endocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 106,221,1996
oral
rat
lowest published toxic dose: 5 g/kg Endocrine: Changes in thymus weight TXAPA9 128,97,1994
oral
rat
lowest published toxic dose: 0.3 g/kg Endocrine: Change in LH

Endocrine: Change in gonadotropins
TXAPA9 142,264,1997
oral
rat
lowest published toxic dose: 1 g/kg Liver: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Metabolism (intermediary): Other proteins
LIFSAK 69,1291,2001
oral
rat
lowest published toxic dose: 2 g/kg Nutritional and Gross Metabolic: Changes in: Fe LIFSAK 69,1291,2001
oral
rat
lowest published toxic dose: 4 g/kg Nutritional and Gross Metabolic: Changes in: Other metals LIFSAK 69,1291,2001
oral
rat
lowest published toxic dose: 1 g/kg Vascular: BP elevation not characterized in autonomic section

Cardiac: Pulse rate decreased with fall in BP

Nutritional and Gross Metabolic: Body temperature decrease
TXCYAC 145,227,2000
oral
rat
lowest published toxic dose: 50 g/kg Endocrine: Change in LH

Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BIREBV 45,143,1991
oral
rat
lowest published toxic dose: 100 g/kg Endocrine: Androgenic TXAPA9 105,78,1990
oral
rat
lowest published toxic dose: 6.25 g/kg Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Respiratory depression

Endocrine: Other changes
TXAPA9 84,45,1986
oral
rat
lowest published toxic dose: 12.5 g/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 84,45,1986
oral
rat
lowest published toxic dose: 25 g/kg Endocrine: Other changes BCPCA6 33,2531,1984
oral
rat
lowest published toxic dose: 10 g/kg Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
JPETAB 215,601,1980
oral
rat
lowest published toxic dose: 12.5 mg/kg Endocrine: Androgenic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Other
BCPCA6 36,727,1987
oral
rat
lowest published toxic dose: 25 g/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
BCPCA6 31,3663,1982
oral
rat
lowest published toxic dose: 50 g/kg Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Other
BCPCA6 35,4359,1986
oral
rat
lowest published toxic dose: 100 g/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TXAPA9 106,112,1990
oral
rat
lowest published toxic dose: 0.1 mg/kg Reproductive: Maternal effects: Oogenesis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight
TXAPA9 133,321,1995
oral
rat
lowest published toxic dose: 10 g/kg Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 78,219,1995
oral
rat
lowest published toxic dose: 50 g/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
CRTOEC 13,1051,2000
oral
rat
lowest published toxic dose: 2.5 g/kg Skin and Appendages: Other: Breast

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
EVHPAZ 109,739,2001
oral
rat
lowest published toxic dose: 0.14 g/kg Liver: Other changes TXAPA9 187,128,2003
oral
rat
lowest published toxic dose: 0.83 g/kg Liver: Other changes

Endocrine: Changes in thymus weight
TXAPA9 187,128,2003
oral
rat
lowest published toxic dose: 5.5 g/kg Liver: Other changes

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 187,128,2003
oral
rat
lowest published toxic dose: 0.77 g/kg Endocrine: Evidence of thyroid hypofunction TXAPA9 181,38,2002
oral
rat
lowest published toxic dose: 2.3 g/kg Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thymus weight
TXAPA9 181,38,2002
oral
rat
lowest published toxic dose: 6.3 g/kg Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 181,38,2002
oral
rat
lowest published toxic dose: 4 g/kg Liver: Other changes

Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 171,73,2002
oral
rat
lowest published toxic dose: 50 g/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 72(Suppl 1),361,2003
oral
rat
lowest published toxic dose: 300 g/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes
TOSCF2 71,112,2003
oral
rat
lowest published toxic dose: 10 g/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
CBINA8 145,1,2003
oral
rat
lowest published toxic dose: 1 g/kg Kidney, Ureter, and Bladder: Other changes CBINA8 145,1,2003
oral
rat
lowest published toxic dose: 0.1 g/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Other
CBINA8 145,1,2003
oral
rat
lowest published toxic dose: 50 g/kg Behavioral: Food intake (animal) TXAPA9 197,214,2004
oral
rat
lowest published toxic dose: 1 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases TOLED5 147,133,2004
oral
rat
lowest published toxic dose: 5 g/kg Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 147,133,2004
oral
rat
lowest published lethal dose: 60 g/kg Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 147,133,2004
oral
rat
lowest published toxic dose: 10 g/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 197,354,2004
oral
rat
lowest published toxic dose: 5 g/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,19,2004
oral
rat
lowest published toxic dose: 5 g/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,418,2005
oral
rat
lowest published toxic dose: 12.5 ng/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 66,169,2002
oral
rat
lowest published toxic dose: 30 g/kg Endocrine: Androgenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 66,170,2002
oral
rat
lowest published toxic dose: 300 g/kg Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight
TOXID9 66,170,2002
oral
rat
lowest published toxic dose: 10 g/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 66,170,2002
oral
rat
lowest published toxic dose: 1 g/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 60,236,2001
oral
rat
lowest published toxic dose: 25 g/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other
TOXID9 60,138,2001
oral
rat
lowest published toxic dose: 7.5 g/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 60,252,2001
oral
rat
lowest published toxic dose: 32 g/kg Endocrine: Change in LH

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,376,2002
oral
rat
lowest published toxic dose: 40 g/kg Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 207,1,2005
oral
rat
lowest published toxic dose: 32 g/kg Behavioral: Convulsions or effect on seizure threshold TOXID9 60,444,2001
oral
rat
lowest published toxic dose: 0.1 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) TOXID9 227,117,2006
oral
rat
lowest published toxic dose: 0.8 g/kg Liver: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TXAPA9 212,224,2006
oral
rat
lowest published toxic dose: 40 g/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 207,1,2005
oral
rat
lowest published toxic dose: 0.4 g/kg Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 207,1,2005
oral
rat
lethal dose (50 percent kill): 20 g/kg N/R ENTOX* -,70,2005
oral
rat
lowest published toxic dose: 2,000 g/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Liver: Other changes
TXCYAC 235,39,2007
oral
rat
lowest published lethal dose: 10,000 g/kg N/R TXCYAC 235,39,2007
oral
rat
lowest published toxic dose: 4 g/kg Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 81,261,2007
oral
rat
lowest published toxic dose: 16 g/kg Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
ARTODN 81,261,2007
oral
rat
lowest published toxic dose: 10 g/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 -,174,2008
oral
rabbit
lethal dose (50 percent kill): 115 g/kg N/R TXAPA9 35,553,1976
parenteral
chicken
lowest published toxic dose: 50 g/kg Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 60,440,2001
parenteral
mouse
lowest published toxic dose: 0.1 g/kg Liver: Other changes

Endocrine: Other changes

Blood: Changes in spleen
TOXID9 66,334,2002
parenteral
mouse
lowest published toxic dose: 0.1 g/kg Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Metabolism (intermediary): Other
TOXID9 60,201,2001
parenteral
mouse
lowest published toxic dose: 50 g/kg Endocrine: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 60,269,2001
subcutaneous
monkey
lowest published toxic dose: 1 ng/kg Cardiac: Cardiomyopathy including infarction

Biochemical: Metabolism (intermediary): Other proteins
ARTODN 76,360,2002
subcutaneous
mouse
lowest published toxic dose: 27.5 g/kg Endocrine: Change in LH

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 194,239,2004
subcutaneous
mouse
lowest published toxic dose: 10 g/kg Cardiac: Other changes

Biochemical: Metabolism (intermediary): Other proteins
NSAPCC 369(Suppl 1),R118,2004
subcutaneous
rat
lowest published toxic dose: 20 g/kg Liver: Changes in liver weight TXAPA9 133,313,1995
subcutaneous
rat
lowest published toxic dose: 40 g/kg Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 133,313,1995
subcutaneous
rat
lowest published toxic dose: 2,500 ng/kg Endocrine: Other changes JDPHDH 15,337,1991
subcutaneous
rat
lowest published toxic dose: 2,500 ng/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JDPHDH 15,337,1991
skin
human
lowest published toxic dose: 107 g/kg Skin: After topical application: Dermatitis, allergic SCAMAC 254,29,1986
skin
monkey
lowest published toxic dose: 10 ng/kg Blood: Other changes

Blood: Changes in leukocyte (WBC) count
TAEHC* VI:205,1,1998
skin
mouse
lowest published lethal dose: 80 g/kg Gastrointestinal: Other changes RCOCB8 20,101,1978
skin
rabbit
lethal dose (50 percent kill): 275 g/kg N/R EVHPAZ 5,87,1973
unreported route
human
lowest published toxic dose: 25 g/kg Gastrointestinal: Nausea or vomiting

Blood: Normocytic anemia

Skin: After systemic exposure: Dermatitis, other
EVHPAZ 109,865,2001
unreported route
human
lowest published toxic dose: 6 g/kg Gastrointestinal: Nausea or vomiting

Skin: After systemic exposure: Dermatitis, other

Biochemical: Metabolism (intermediary): Lipids including transport
EVHPAZ 109,865,2001
unreported route
mouse
lowest published lethal dose: 200 g/kg Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ANYAA9 320,204,1979
unreported route
mouse
lowest published toxic dose: 0.32 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 72,109,2003
unreported route
mouse
lowest published toxic dose: 8 g/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,109,2003
unreported route
mouse
lowest published toxic dose: 10 g/kg Immunological Including Allergic: Decrease in cellular immune response TOXID9 78,19,2004
unreported route
mouse
lowest published toxic dose: 15 g/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,247,2004
unreported route
mouse
lowest published toxic dose: 24 g/kg Liver: Changes in liver weight TOXID9 60,181,2001
unreported route
mouse
lowest published toxic dose: 25 g/kg Behavioral: Anticonvulsant TOXID9 60,442,2001
unreported route
rat
lowest published lethal dose: 19 g/kg N/R TXAPA9 187,128,2003
unreported route
rat
lowest published toxic dose: 100 g/kg Liver: Other changes TXAPA9 197,215,2004
unreported route
rat
lowest published toxic dose: 50 g/kg Brain and Coverings: Other degenerative changes

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,418,2005
unreported route
rat
lowest published lethal dose: 50 g/kg Behavioral: Food intake (animal)

Biochemical: Metabolism (intermediary): Other
TOXID9 44,418,2005
unreported route
rat
lowest published toxic dose: 32 g/kg Endocrine: Change in LH

Endocrine: Change in gonadotropins

Reproductive: Maternal effects: Ovaries, fallopian tubes
TOXID9 60,273,2001
unreported route
rat
lowest published toxic dose: 32 g/kg Reproductive: Maternal effects: Menstrual cycle changes or disorders TOXID9 60,273,2001
unreported route
rat
lethal dose (50 percent kill): 10 g/kg N/R TOXID9 60,331,2001
unreported route
rat
lowest published toxic dose: 10 mg/kg Behavioral: Convulsions or effect on seizure threshold TOXID9 60,444,2001
unreported route
rat
lowest published lethal dose: 90 mg/kg Behavioral: Convulsions or effect on seizure threshold TOXID9 60,444,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 9,260 ng/kg/4 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count
TOLED5 60,247,1992
intraperitoneal
mouse
lowest published toxic dose: 180 g/kg/6 week- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
CMSHAF 14,949,1985
intraperitoneal
mouse
lowest published toxic dose: 120 g/kg/12 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Changes in other cell count (unspecified)
CMSHAF 19,927,1989
intraperitoneal
mouse
lowest published toxic dose: 32 g/kg/7 day- intermittent Related to Chronic Data: Changes in uterine weight ARTODN 78,309,2004
intraperitoneal
mouse
lowest published toxic dose: 32 g/kg/7 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases ARTODN 78,309,2004
intraperitoneal
mouse
lowest published toxic dose: 32 g/kg/7 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Related to Chronic Data: Changes in uterine weight
ARTODN 78,309,2004
intraperitoneal
mouse
lowest published toxic dose: 45 g/kg/3 day- intermittent Liver: Other changes TOXID9 66,334,2002
intraperitoneal
mouse
lowest published toxic dose: 400 g/kg/8 week- intermittent Related to Chronic Data: Changes in uterine weight TXAPA9 226,107,2008
intraperitoneal
mouse
lowest published toxic dose: 4 g/kg/8 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 226,107,2008
intraperitoneal
mouse
lowest published toxic dose: 40 g/kg/8 week- intermittent Endocrine: Changes in thymus weight TXAPA9 226,107,2008
intraperitoneal
mouse
lowest published toxic dose: 80 g/kg/16 week- intermittent Related to Chronic Data: Changes in uterine weight TXAPA9 226,107,2008
intraperitoneal
mouse
lowest published toxic dose: 300 g/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
JCINAO 113,137,2004
intraperitoneal
rat
lowest published toxic dose: 240 ng/kg/8 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXCYAC 171,117,2002
intraperitoneal
rat
lowest published toxic dose: 40 g/kg/4 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
FCTOD7 45,2237,2007
oral
guinea pig
lowest published toxic dose: 441 ng/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 6,454,1986
oral
guinea pig
lowest published toxic dose: 1,600 ng/kg/8 week- intermittent Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EVHPAZ 5,101,1973
oral
guinea pig
lowest published toxic dose: 5 g/kg/5 week- intermittent Endocrine: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVHPAZ 5,125,1973
oral
hamster
lowest published toxic dose: 600 g/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
BECTA6 31,649,1983
oral
mammal (species unspecified)
lowest published toxic dose: 1.68 g/kg/14 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 43,22,2001
oral
mammal (species unspecified)
lowest published toxic dose: 3.36 g/kg/28 day- continuous Musculoskeletal: Changes in teeth and supporting structures

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VHTODE 43,22,2001
oral
mammal (species unspecified)
lowest published toxic dose: 3.92 g/kg/4 week- continuous Behavioral: Somnolence (general depressed activity) VHTODE 43,134,2001
oral
mammal (species unspecified)
lowest published toxic dose: 4.76 g/kg/34 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VHTODE 43,134,2001
oral
mammal (species unspecified)
lowest published toxic dose: 18.48 g/kg/132 day- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VHTODE 43,134,2001
oral
mammal (species unspecified)
lowest published toxic dose: 211.2 ng/kg/132 day- continuous Blood: Other changes

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Nutritional and Gross Metabolic: Changes in: Fe
VHTODE 43,134,2001
oral
monkey
lowest published toxic dose: 10 g/kg/12 day- continuous Gastrointestinal: Ulceration or bleeding from stomach

Nutritional and Gross Metabolic: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BECTA6 18,108,1977
oral
monkey
lowest published toxic dose: 2.143 g/kg/120 day- intermittent Immunological Including Allergic: Decreased immune response TOSCF2 56,374,2000
oral
monkey
lowest published toxic dose: 170.4 g/kg/240 day- intermittent Reproductive: Other effects on female TOSCF2 56,374,2000
oral
monkey
lowest published toxic dose: 5.35 g/kg/30 week- continuous Endocrine: Estrogenic

Endocrine: Other changes
ANYAA9 -,419,1979
oral
monkey
lowest published toxic dose: 0.535 g/kg/30 week- continuous Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Maternal effects: Parturition
ANYAA9 -,419,1979
oral
mouse
lowest published toxic dose: 588 g/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
TXAPA9 112,128,1992
oral
mouse
lowest published toxic dose: 20 g/kg/4 week- intermittent Endocrine: Other changes

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in cellular immune response
EVHPAZ 5,149,1973
oral
mouse
lowest published toxic dose: 520 g/kg/13 week- intermittent Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-209,1982
oral
mouse
lowest published toxic dose: 336 g/kg/8 week- continuous Blood: Other changes

Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Decrease in humoral immune response
JEPTDQ 4(2-3),401,1980
oral
mouse
lowest published toxic dose: 150 g/kg/6 week- intermittent Liver: Fatty liver degeneration

Endocrine: Changes in thymus weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXAPA9 29,229,1974
oral
mouse
lowest published toxic dose: 97.5 ng/kg/13 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
TXAPA9 124,82,1994
oral
mouse
lowest published toxic dose: 12 g/kg/4 day- intermittent Liver: Changes in liver weight TJADAB 33,29,1986
oral
mouse
lowest published toxic dose: 50 g/kg/15 week- intermittent Liver: Changes in liver weight

Tumorigenic: Increased incidence of tumors in susceptible strains

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
EVHPAZ 105,750,1997
oral
mouse
lowest published toxic dose: 4,050 ng/kg/9 week- intermittent Vascular: BP elevation not characterized in autonomic section TOXID9 44,173,2005
oral
mouse
lowest published toxic dose: 475 g/kg/178 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 66,168,2002
oral
mouse
lowest published toxic dose: 81,900 mg/kg/26 week- continuous Skin and Appendages: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,367,2004
oral
mouse
lowest published toxic dose: 6 ng/kg/3 day- intermittent Endocrine: Estrogenic REPTED 21,301,2006
oral
mouse
lowest published toxic dose: 500 ng/kg/5 day- intermittent Related to Chronic Data: Changes in uterine weight REPTED 21,301,2006
oral
mouse
lowest published toxic dose: 45 g/kg/3 day- intermittent Immunological Including Allergic: Decrease in cellular immune response TIHEEC 17,192,2001
oral
mouse
lowest published toxic dose: 20 g/kg/2 day- intermittent Biochemical: Metabolism (intermediary): Other proteins REPTED 23,326,2007
oral
mouse
lowest published toxic dose: 1,350 ng/kg/60 day- intermittent Cardiac: Other changes

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Other changes
TOXID9 12,454,2008
oral
mouse
lowest published toxic dose: 900 mg/kg/18 day- intermittent Liver: Changes in liver weight

Liver: Other changes
TXAPA9 229,10,2008
oral
rat
lowest published toxic dose: 30 g/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in platelet count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
EVHPAZ 5,111,1973
oral
rat
lowest published toxic dose: 6,500 ng/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Pigmented or nucleated red blood cells
TXAPA9 35,553,1976
oral
rat
lowest published toxic dose: 7,300 mg/kg/2 year- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition
TXAPA9 46(2),279,1978
oral
rat
lowest published toxic dose: 16 g/kg/16 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
BCPCA6 31,1607,1982
oral
rat
lowest published toxic dose: 120 g/kg/3 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Changes in: Fe

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
BECTA6 45,436,1990
oral
rat
lowest published toxic dose: 450 ng/kg/45 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TXAPA9 57,156,1981
oral
rat
lowest published toxic dose: 140 g/kg/14 day- intermittent Blood: Change in clotting factors

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count
EVHPAZ 5,119,1973
oral
rat
lowest published toxic dose: 3 g/kg/80 day- continuous Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
EJPHAZ 293,429,1995
oral
rat
lowest published toxic dose: 2.9 g/kg/30 day- continuous Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
EJPHAZ 293,429,1995
oral
rat
lowest published toxic dose: 70 g/kg/13 week- intermittent Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CMSHAF 29,2381,1994
oral
rat
lowest published toxic dose: 41.9 g/kg/13 week- intermittent Blood: Changes in platelet count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 146,217,1997
oral
rat
lowest published toxic dose: 7,000 ng/kg/28 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
CMSHAF 43,807,2001
oral
rat
lowest published toxic dose: 28,000 ng/kg/28 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Changes in liver weight

Blood: Microcytosis with or without anemia
CMSHAF 43,807,2001
oral
rat
lowest published toxic dose: 22.75 g/kg/91 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CMSHAF 25,2023,1992
oral
rat
lowest published toxic dose: 2.275 g/kg/91 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) CMSHAF 25,2023,1992
oral
rat
lowest published toxic dose: 10 g/kg/7 day- intermittent Skin and Appendages: Other: Breast

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight
EVHPAZ 103,708,1995
oral
rat
lowest published toxic dose: 2.9 g/kg/30 day- continuous Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in cellular immune response
EPEPEG 293,429,1995
oral
rat
lowest published toxic dose: 3 g/kg/180 day- continuous Immunological Including Allergic: Decrease in cellular immune response EPEPEG 293,429,1995
oral
rat
lowest published toxic dose: 13 g/kg/13 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other
BCPCA6 32,991,1983
oral
rat
lowest published toxic dose: 7 g/kg/4 week- continuous Endocrine: Evidence of thyroid hypofunction CMSHAF 25,1239,1992
oral
rat
lowest published toxic dose: 0.7 g/kg/4 week- continuous Biochemical: Metabolism (intermediary): Other CMSHAF 25,1239,1992
oral
rat
lowest published toxic dose: 2.275 g/kg/13 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Conditioned vitamin deficiency
CMSHAF 25,1239,1992
oral
rat
lowest published toxic dose: 105 g/kg/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 43,22,2001
oral
rat
lowest published toxic dose: 45 ng/kg/45 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
JJATDK 22,345,2002
oral
rat
lowest published toxic dose: 72.8 g/kg/2 year- intermittent Cardiac: Cardiomyopathy including infarction

Vascular: Structural changes in vessels

Liver: Other changes
TOXID9 72,30,2003
oral
rat
lowest published toxic dose: 900 ng/kg/90 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Brain and Coverings: Other degenerative changes
TOXID9 72,77,2003
oral
rat
lowest published toxic dose: 45 ng/kg/45 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Related to Chronic Data: Changes in testicular weight
JAPTO* 22,345,2002
oral
rat
lowest published toxic dose: 45 ng/kg/45 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Related to Chronic Data: Changes in prostate weight
JAPTO* 22,345,2002
oral
rat
lowest published toxic dose: 450 ng/kg/30 week- intermittent Brain and Coverings: Other degenerative changes JJTHEC 65,825,2002
oral
rat
lowest published toxic dose: 3,300 ng/kg/30 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JJTHEC 65,825,2002
oral
rat
lowest published toxic dose: 3,500 ng/kg/5 week- intermittent Liver: Fatty liver degeneration

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 191,12,2003
oral
rat
lowest published toxic dose: 45 ng/kg/45 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport

Related to Chronic Data: Changes in testicular weight
TXCYAC 171,127,2002
oral
rat
lowest published toxic dose: 3,000 ng/kg/60 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
TOXID9 72,362,2003
oral
rat
lowest published toxic dose: 0.7 g/kg/28 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 178,45,2002
oral
rat
lowest published toxic dose: 275 ng/kg/64 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 72,361,2003
oral
rat
lowest published toxic dose: 15.5 g/kg/31 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Multiple effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 78,19,2004
oral
rat
lowest published toxic dose: 52 g/kg/2 year- intermittent Lung, Thorax, or Respiration: Tumors

Liver: Tumors

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 78,19,2004
oral
rat
lowest published toxic dose: 3.5 g/kg/5 week- intermittent Lung, Thorax, or Respiration: Other changes TOXID9 66,9,2002
oral
rat
lowest published toxic dose: 9,800 ng/kg/14 week- continuous Gastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Metabolism (intermediary): Other
TOXID9 44,372,2005
oral
rat
lowest published toxic dose: 1,980 ng/kg/90 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TOXID9 44,416,2005
oral
rat
lowest published toxic dose: 2,156 ng/kg/14 week- intermittent Endocrine: Other changes TOXID9 44,416,2005
oral
rat
lowest published toxic dose: 4,900 ng/kg/14 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 44,416,2005
oral
rat
lowest published toxic dose: 98 ng/kg/14 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 44,416,2005
oral
rat
lowest published toxic dose: 40 g/kg/4 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 77,280,2003
oral
rat
lowest published toxic dose: 45 ng/kg/45 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 76,113,2002
oral
rat
lowest published toxic dose: 10.5 g/kg/15 week- intermittent Liver: Other changes TOXID9 66,157,2002
oral
rat
lowest published toxic dose: 3,000 ng/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes
TOXID9 66,168,2002
oral
rat
lowest published toxic dose: 37.5 ng/kg/8 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 66,169,2002
oral
rat
lowest published toxic dose: 273 ng/kg/13 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Lung, Thorax, or Respiration: Other changes
TOXID9 66,170,2002
oral
rat
lowest published toxic dose: 1,000 ng/kg/12 day- intermittent Liver: Other changes

Endocrine: Changes in thymus weight
TOXID9 78,245,2004
oral
rat
lowest published toxic dose: 9 g/kg/3 day- intermittent Liver: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,246,2004
oral
rat
lowest published toxic dose: 4,140 ng/kg/90 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 78,247,2004
oral
rat
lowest published toxic dose: 273 ng/kg/13 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 60,235,2001
oral
rat
lowest published toxic dose: 110 ng/kg/22 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 60,331,2001
oral
rat
lowest published toxic dose: 0.2 g/kg/14 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOVEFN (6),34,2003
oral
rat
: 23,920 ng/kg/104 week- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Reproductive: Tumorigenic effects: Uterine tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-521
oral
rat
: 23,920 ng/kg/104 week- intermittent Endocrine: Other changes NTPTR* NTP-TR-521
oral
rat
: 1,100 ng/kg/10 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-521
oral
rat
: 6,500 ng/kg/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-521
oral
rat
: 1,540 ng/kg/14 week- intermittent Liver: Other changes

Endocrine: Evidence of thyroid hypofunction
NTPTR* NTP-TR-521
oral
rat
: 3,220 ng/kg/14 week- intermittent Endocrine: Evidence of thyroid hyperfunction

Endocrine: Evidence of thyroid hyperfunction

Endocrine: Changes in thyroid weight
NTPTR* NTP-TR-521
oral
rat
: 2,650 ng/kg/53 week- intermittent Endocrine: Evidence of thyroid hyperfunction NTPTR* NTP-TR-521
oral
rat
: 1,550 ng/kg/31 week- intermittent Liver: Other changes NTPTR* NTP-TR-521
oral
rat
: 700 ng/kg/14 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Multiple effects

Liver: Changes in liver weight
NTPTR* NTP-TR-521
oral
rat
: 700 ng/kg/14 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight NTPTR* NTP-TR-521
oral
rat
: 11,440 ng/kg/104 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Change in gall bladder structure or function

Liver: Angiosarcoma
NTPTR* NTP-TR-521
oral
rat
: 11,440 ng/kg/104 week- intermittent Liver: Other changes

Endocrine: Changes in thymus weight

Reproductive: Other effects on female
NTPTR* NTP-TR-521
oral
rat
: 15,000 ng/kg/30 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Angiosarcoma
NTPTR* NTP-TR-521
oral
rat
: 15,000 ng/kg/30 week- intermittent Gastrointestinal: Tumors

Endocrine: Adrenal cortex hypoplasia

Reproductive: Tumorigenic effects: Uterine tumors
NTPTR* NTP-TR-521
oral
rat
: 15,000 ng/kg/30 week- intermittent Kidney, Ureter, and Bladder: Interstitial nephritis NTPTR* NTP-TR-521
oral
rat
: 5,200 ng/kg/104 week- intermittent Liver: Fatty liver degeneration

Liver: Multiple effects

Endocrine: Adrenal cortex hyperplasia
NTPTR* NTP-TR-521
oral
rat
: 5,200 ng/kg/104 week- intermittent Cardiac: Cardiomyopathy including infarction

Blood: Eosinophilia
NTPTR* NTP-TR-521
oral
rat
: 465 ng/kg/31 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight NTPTR* NTP-TR-521
oral
rat
: 52,000 ng/kg/104 week- intermittent Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Tumors
NTPTR* NTP-TR-521
oral
rat
: 52,000 ng/kg/104 week- intermittent Vascular: Other changes

Gastrointestinal: Other changes
NTPTR* NTP-TR-521
oral
rat
: 1,560 ng/kg/104 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi NTPTR* NTP-TR-521
oral
rat
: 15,500 ng/kg/31 week- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas NTPTR* NTP-TR-521
oral
rat
lowest published toxic dose: 52 g/kg/2 year- intermittent Endocrine: Other changes TOPADD 32,41,2004
oral
rat
lowest published toxic dose: 651 ng/kg/31 week- intermittent Liver: Other changes TOPADD 33,165,2005
oral
rat
lowest published toxic dose: 2,156 ng/kg/14 week- intermittent Liver: Other changes TOPADD 33,165,2005
oral
rat
lowest published toxic dose: 2,190 ng/kg/2 year- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Other changes
TOPADD 33,165,2005
oral
rat
lowest published toxic dose: 37,100 ng/kg/53 week- intermittent Liver: Fatty liver degeneration

Liver: Change in gall bladder structure or function

Liver: Other changes
TOPADD 33,165,2005
oral
rat
lowest published toxic dose: 21,700 ng/kg/31 week- intermittent Liver: Fatty liver degeneration

Liver: Other changes
TOPADD 33,165,2005
oral
rat
lowest published toxic dose: 4,140 ng/kg/90 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
JTEHF8 69,381,2006
oral
rat
lowest published toxic dose: 0.9 mg/kg/3 day- intermittent Liver: Other changes

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 -,167,2008
oral
rabbit
lowest published toxic dose: 80 g/kg/8 week- intermittent Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0544117
subcutaneous
rat
lowest published toxic dose: 3,500 ng/kg/5 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Tumorigenic: Cells (cultured) transformed
CRNGDP 15,1143,1994
subcutaneous
rat
lowest published toxic dose: 6,300 ng/kg/9 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases CRNGDP 15,1143,1994
subcutaneous
rat
lowest published toxic dose: 17 g/kg/19 week- intermittent Musculoskeletal: Changes in teeth and supporting structures TOSCF2 69,482,2002
subcutaneous
rat
lowest published toxic dose: 170 g/kg/19 week- intermittent Vascular: Structural changes in vessels

Musculoskeletal: Changes in teeth and supporting structures
TOSCF2 69,482,2002
subcutaneous
rat
lowest published toxic dose: 140 ng/kg/20 week- intermittent Liver: Other changes TXAPA9 197,212,2004
skin
mouse
lowest published toxic dose: 97 g/kg/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NCITR* NCI-TR-201-82
skin
mouse
lowest published toxic dose: 8 mg/kg/20 week- intermittent Liver: Changes in liver weight

Skin: After systemic exposure: Dermatitis, other

Tumorigenic: Facilitates action of known carcinogens
TXAPA9 102,362,1990
skin
mouse
lowest published toxic dose: 200 g/kg/20 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Changes in liver weight

Liver: Fatty liver degeneration
FCTOD7 42,1217,2004
skin
mouse
lowest published toxic dose: 200 ng/kg/1 week- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FCTOD7 42,1217,2004
skin
mouse
lowest published toxic dose: 300 ng/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) FCTOD7 42,1217,2004
skin
mouse
lowest published toxic dose: 15 g/kg/3 day- intermittent Biochemical: Metabolism (intermediary): Lipids including transport FCTOD7 42,1217,2004
skin
mouse
lowest published toxic dose: 910 mg/kg/26 week- continuous Skin and Appendages: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,367,2004
unreported route
mouse
lowest published toxic dose: 5.5 g/kg/14 day- intermittent Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) TOXID9 72,121,2003
unreported route
mouse
lowest published toxic dose: 15 g/kg/14 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)
TOXID9 72,230,2003
unreported route
mouse
lowest published toxic dose: 45 g/kg/3 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on mitochondrial function

Biochemical: Metabolism (intermediary): Other
TOXID9 60,269,2001
unreported route
rat
lowest published toxic dose: 9,100 ng/kg/13 week- intermittent Liver: Other changes TOXID9 72,264,2003
unreported route
rat
lowest published toxic dose: 9.8 g/kg/14 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,19,2004
unreported route
rat
lowest published toxic dose: 102.4 g/kg/32 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 44,416,2005
unreported route
rat
lowest published toxic dose: 0.2 g/kg/16 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 44,416,2005
unreported route
rat
lowest published toxic dose: 51.2 g/kg/16 day- intermittent Endocrine: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,416,2005
unreported route
rat
lowest published toxic dose: 0.75 g/kg/3 day- intermittent Liver: Other changes

Endocrine: Other changes
TOXID9 66,62,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 69,33,1997
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 15,41,1977
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMSUDL 7,350,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 69,33,1997
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 69,33,1997
TOXICOLOGY REVIEW
RREVAH 59,1,1975
TOXICOLOGY REVIEW
ARPAAQ 94,125,1972
TOXICOLOGY REVIEW
CHRYAQ 47(2),15,1974
TOXICOLOGY REVIEW
TXCYAC 3,187,1975
TOXICOLOGY REVIEW
RPZHAW 26,623,1975
TOXICOLOGY REVIEW
BIOGAL 40(2),44,1974
TOXICOLOGY REVIEW
STEVA8 2,305,1974
TOXICOLOGY REVIEW
EVHPAZ 15,121,1976
TOXICOLOGY REVIEW
FCTXAV 17,95,1979
TOXICOLOGY REVIEW
PHTHDT 7,513,1979
TOXICOLOGY REVIEW
MUREAV 47,141,1978
TOXICOLOGY REVIEW
ARTODN 40,161,1978
TOXICOLOGY REVIEW
EVSRBT 2,708,1973
TOXICOLOGY REVIEW
NTIS** PB82-922905
TOXICOLOGY REVIEW
MEPAAX 29,59,1978
TOXICOLOGY REVIEW
VHTODE 22,31,1980
TOXICOLOGY REVIEW
MGLFDB -,123,1978
TOXICOLOGY REVIEW
FCTOD7 25,257,1987
TOXICOLOGY REVIEW
ARPTDI 22,517,1982
TOXICOLOGY REVIEW
ARPTDI 43,309,2003
TOXICOLOGY REVIEW
TOLED5 134,3,2002
TOXICOLOGY REVIEW
TOLED5 138,9,2003
TOXICOLOGY REVIEW
REPTED 20,441,2005
TOXICOLOGY REVIEW
TOLED5 140-141,3,2003
TOXICOLOGY REVIEW
MUREAV 561,147,2004
TOXICOLOGY REVIEW
MUTAEX 15,431,2000
TOXICOLOGY REVIEW
TXAPA9 197,49,2004
TOXICOLOGY REVIEW
TXAPA9 198,111,2004
TOXICOLOGY REVIEW
TPHSDY 24,508,2003
TOXICOLOGY REVIEW
CRTXB2 32,311,2002
TOXICOLOGY REVIEW
ARTODN 44,211,1980
TOXICOLOGY REVIEW
EJIME* 12,406,2001
TOXICOLOGY REVIEW
REPTED 22,164,2006
TOXICOLOGY REVIEW
DMTRAR 13,387,1982
TOXICOLOGY REVIEW
MUREAV 613,17,2006
TOXICOLOGY REVIEW
NETOX* 26,531,2005
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
ENTOX* -,70,2005
TOXICOLOGY REVIEW
ENTOX* -,334,2005
TOXICOLOGY REVIEW
ENTOX* -,136,2005
TOXICOLOGY REVIEW
TIHEEC 16,305,2000
TOXICOLOGY REVIEW
TIHEEC 16,305,2000
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
HETOEA 25,413,2006
TOXICOLOGY REVIEW
HETOEA 25,413,2006
TOXICOLOGY REVIEW
MUREAV 658,124,2008
TOXICOLOGY REVIEW
JTEHD6 6,115,2003
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
JTEHD6 9,1,2006
TOXICOLOGY REVIEW
REPTED 23,337,2007
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
JTPAE7 17,137,2004
TOXICOLOGY REVIEW
JTPAE7 19,111,2006
TOXICOLOGY REVIEW
JTPAE7 19,111,2006
TOXICOLOGY REVIEW
REPTED 23,133,2007
TOXICOLOGY REVIEW
ITODC* -,327,2004
TOXICOLOGY REVIEW
HUTOX* -,551,1996
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 picograms/m3, Skin, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TCDD-air Carcinogen lowest feasible concentration NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7301;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 14;
Total Number of Female Employees Exposed 5


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/89/214522/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 40, 1984
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NCI Carcinogenesis Bioassay (dermal);clear evidence:mouse NCITR* NCI-TR-201,1982
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
NTP Carcinogenesis studies; on test (two year studies), October 2000
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE

AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AMBOCX Ambio. A Journal of the Human Environment. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS.
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BDERB*
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BESCE5 Biomedical and Environmental Sciences. (Academic Press, 525 B St., Suite 1900, San Diego, CA 92101) V.1- 1988-
BIOGAL Biologico. (Instituto Biologica, Av. Cons. Rodriques Alves, 1252, CEP 04014, Sao Paulo, Brazil) V.1- 1935-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BIRSB5 Biology of Reproduction, Supplement. (Champaign, IL) No.1-4, 1969-71(?). Discontinued. For publisher information, see BIREBV.
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CHRYAQ Chemistry. (Washington, DC) V.18-52, 1944-79.
CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DMTRAR Drug Metabolism Reviews. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1972-
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
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RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

ALT CAS #: 56795-67-6
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