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Cyclohexane, 1,2,3,4,5,6 - hexachloro - , gamma - isomer

RTECS #: GV4900000

CAS #: 58-89-9


UPDATE: May 2009 MW: 290.82 MF: C6H6Cl6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2,3,4,5,6 - Hexachlorocyclohexane
  2. 1,2,3,4,5,6 - Hexachlorocyclohexane, alpha isomer
  3. 1,2,3,4,5,6 - Hexachlorocyclohexane, gamma - isomer
  4. 1 - alpha,2 - alpha,3 - beta,4 - alpha,5 - alpha,6 - beta - Hexachlorocyclohexane
  5. Aalindan
  6. Aficide
  7. Agrocide
  8. Agrocide 2
  9. Agrocide III
  10. Agrocide 7
  11. Agrocide 6G
  12. Agrocide WP
  13. Agronexit
  14. Ameisenmittel merck
  15. Ameisentod
  16. Aparasin
  17. Aphtiria
  18. Aplidal
  19. Arbitex
  20. BBH
  21. BHC
  22. Ben - Hex
  23. Benhexol
  24. Bentox 10
  25. Benzene hexachloride
  26. Bexol
  27. Celanex
  28. Chloresene
  29. Codechine
  30. Detmol - extrakt
  31. Detox 25
  32. Devoran
  33. Dol Granule
  34. Drilltox - Spezial Aglukon
  35. ENT 7,796
  36. Entomoxan
  37. Fenoform forte
  38. Forst - Nexen
  39. Gallogama
  40. Gamacarbatox
  41. Gamacid
  42. Gamaphex
  43. Gamene
  44. Gamiso
  45. Gamma - mean 400
  46. Gammalin
  47. Gammalin 20
  48. Gammaterr
  49. Geobilan
  50. Geolin G 3
  51. Gexane
  52. HCC
  53. HCCH
  54. HCH
  55. HEXA
  56. HGI
  57. Heclotox
  58. Hexachloran
  59. Hexachlorane
  60. Hexachlorocyclohexane
  61. Hexachlorocyclohexane, gamma - isomer
  62. Hexaverm
  63. Hexicide
  64. Hexyclan
  65. Hilbeech
  1. Hortex
  2. Hungaria L7
  3. Inexit
  4. Isotox
  5. Jacutin
  6. Kokotine
  7. Kwell
  8. Lacco HI lin
  9. Lasochron
  10. Lendine
  11. Lentox
  12. Lidenal
  13. Lindafor
  14. Lindagam
  15. Lindagrain
  16. Lindagranox
  17. Lindane
  18. Lindane (ACGIH:OSHA)
  19. Lindapoudre
  20. Lindatox
  21. Lindex
  22. Lindosep
  23. Lintox
  24. Linvur
  25. Lorexane
  26. Mglawik L
  27. Milbol 49
  28. Mszycol
  29. NCI - C00204
  30. Neo - Scabicidol
  31. Nexen FB
  32. Nexit
  33. Nexit - stark
  34. Nexol - E
  35. Nicochloran
  36. Novigam
  37. Omnitox
  38. Ovadziak
  39. Owadziak
  40. PLK
  41. Pedraczak
  42. Pflanzol
  43. Quellada
  44. RCRA waste number U129
  45. Sang gamma
  46. Silvanol
  47. Spritz - Rapidin
  48. Spritzlindane
  49. Spruehpflanzol
  50. Streunex
  51. TAP 85
  52. Tri - 6
  53. Verindal Ultra
  54. Viton
  55. gamma - 1,2,3,4,5,6 - Hexachlorocyclohexane
  56. gamma - Benzene hexachloride
  57. gamma - Benzohexachloride
  58. gamma - BHC
  59. gamma - HCH
  60. gamma - Hexachlorane
  61. gamma - Hexachlorobenzene
  62. gamma - Hexachloran
  63. gamma - Hexachlorocyclohexane
  64. gamma - Lindane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis intraperitoneal
chicken
50 mg/kg MUREAV 272,175,1992
cytogenetic analysis oral
chicken
100 mg/kg MUREAV 272,175,1992
cytogenetic analysis hamster fibroblast 63 mg/L/48 hour MUREAV 48,337,1977
cytogenetic analysis human lymphocyte 5 mg/L BIHAA2 38(Pt1),344,1971
cytogenetic analysis intraperitoneal
mouse
5 mg/kg SOGEBZ 2,80,1966
cytogenetic analysis oral
mouse
12,600 g/kg/7 day- continuous FCTOD7 33,309,1995
dominant lethal test oral
Drosophila melanogaster
22 g/L FCTOD7 33,309,1995
dominant lethal test oral
mouse
6,720 mg/kg MUREAV 101,315,1982
DNA damage human other cell types 500 mol/L EMMUEG 24,23,1994
DNA damage human fibroblast 6 mmol/L/1 hour TOLED5 147,35,2004
DNA damage oral
mouse
200 mg/kg/8 day- intermittent REPTED 17,25,2003
DNA damage rat other cell types 500 nmol/tube FCTOD7 31,271,1993
DNA damage rat liver 30 mol/L SinJF# 26OCT1982
DNA damage oral
rat
60 mg/kg FCTOD7 31,271,1993
DNA inhibition human lymphocyte 500 mg/L ARTODN 45,101,1980
DNA inhibition rat other cell types 1 gm/L ARTODN 45,101,1980
unscheduled DNA synthesis other fish liver 45 mol/L HKXUDL 4,368,1984
unscheduled DNA synthesis rat liver 100 pmol/L CRNGDP 5,1547,1984
micronucleus test intraperitoneal
chicken
50 mg/kg MUREAV 272,175,1992
micronucleus test oral
chicken
50 mg/kg MUREAV 272,175,1992
micronucleus test intraperitoneal
mouse
100 mg/kg GISAAA 49(5),82,1984
mutation in mammalian somatic cells hamster lung 200 mg/L GISAAA 49(5),82,1984
other mutation test systems human fibroblast 100 mg/kg GTPZAB 17(3),32,1973
other mutation test systems human lymphocyte 5 mg/L BIHAA2 38(Pt1),344,1971
phage inhibition capacity Escherichia coli 1,070 mol/L MUREAV 182,193,1987
specific locus test oral
Drosophila melanogaster
6 g/L FCTOD7 33,309,1995
sperm morphology parenteral
rat
10 mg/kg/10 day- continuous APTOA6 31,1,1972


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratesticular
rat
lowest published toxic dose: 10 mg/kg (10 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct APTOA6 31,1,1972
oral
dog
lowest published toxic dose: 473 mg/kg (1-63 day pregnant) Reproductive: Effects on newborn: Stillbirth 32OAAP -,253,1973
oral
hamster
lowest published toxic dose: 20 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BVIPA7 21,85,1977
oral
man
lowest published toxic dose: 124 mg/kg (multigeneration) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Delayed effects
JRPFA4 113,95,1998
oral
mouse
lowest published toxic dose: 2,730 mg/kg (13 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FCTXAV 19,131,1981
oral
mouse
lowest published toxic dose: 43,300 g/kg (1-4 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) TXCYAC 59,171,1989
oral
mouse
lowest published toxic dose: 44 mg/kg (6-12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXCYAC 59,171,1989
oral
mouse
lowest published toxic dose: 22,500 g/kg (14-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXCYAC 59,171,1989
oral
mouse
lowest published toxic dose: 120 mg/kg (9-16 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Germ cell effects (in offspring)
REPTED 17,25,2003
oral
mouse
lowest published toxic dose: 120 mg/kg (9-16 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 17,25,2003
oral
mouse
lowest published toxic dose: 200 mg/kg (9-16 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) REPTED 17,25,2003
oral
mouse
lowest published toxic dose: 120 mg/kg (9-16 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 17,475,2003
oral
rat
lowest published toxic dose: 30 mg/kg (15 day pregnant) Reproductive: Effects on newborn: Delayed effects BECTA6 59,360,1997
oral
rat
lowest published toxic dose: 200 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXCYAC 9,239,1978
oral
rat
lowest published toxic dose: 100 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BVIPA7 21,85,1977
oral
rat
lowest published toxic dose: 6,100 g/kg (18 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders GISAAA 36(5),19,1971
oral
rat
lowest published toxic dose: 12,500 g/kg (16 day pregnant) Reproductive: Effects on embryo or fetus: Maternal- fetal exchange BECTA6 47,508,1991
oral
rat
lowest published toxic dose: 6 mg/kg (9-14 day after birth) Reproductive: Effects on newborn: Delayed effects HETOEA 16,146,1997
oral
rat
lowest published toxic dose: 5 mg/kg (1-10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death VCVGH* -,541,1990
oral
rat
lowest published toxic dose: 2.125 mg/kg (5-21 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
TXAPA9 225,278,2007
oral
rat
lowest published toxic dose: 3 mg/kg (5-21 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TXAPA9 231,10,2008
oral
rabbit
lowest published toxic dose: 260 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXCYAC 9,239,1978
oral
rabbit
lowest published toxic dose: 40 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BVIPA7 21,85,1977
oral
rabbit
lowest published toxic dose: 60 mg/kg (9 day pregnant) Reproductive: Effects on newborn: Physical BVIPA7 21,85,1977
oral
woman
lowest published toxic dose: 5 mL/kg (18 week pregnant) Reproductive: Effects on embryo or fetus: Fetal death JRPMAP 37,992,1993
unreported route
rat
lowest published toxic dose: 25 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders TOLED5 48,21,1989
unreported route
rat
lowest published toxic dose: 33 mg/kg (1 day prior to copulation) Reproductive: Other effects on female TOLED5 48,21,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 14 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
CRNGDP 8,1889,1987
oral
mouse
toxic dose : 25 gm/kg/73 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
FCTXAV 11,433,1973
oral
mouse
lowest published toxic dose: 36,960 mg/kg/110 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
ENVRAL 19,460,1979
oral
mouse
lowest published toxic dose: 5,376 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
ENVRAL 19,460,1979
oral
mouse
lowest published toxic dose: 10,752 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
ENVRAL 19,460,1979
oral
mouse
lowest published toxic dose: 13,204 mg/kg/26 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
ENVRAL 19,460,1979
oral
rat
lowest published toxic dose: 3,780 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumor types after systemic administration not seen spontaneously
ENVRAL 19,460,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
mouse
lethal dose (50 percent kill): 60 mg/kg Behavioral: Convulsions or effect on seizure threshold TOLED5 60,289,1992
inhalation
mouse
lowest published lethal concentration: 120 mg/m3/6 hour Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count
GTPZAB 8(10),55,1964
intraperitoneal
chicken
lowest published toxic dose: 50 mg/kg Liver: Other changes HBPTO* 1,879,2001
intraperitoneal
hamster
lethal dose (50 percent kill): 640 mg/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse
lethal dose (50 percent kill): 125 mg/kg N/R SOGEBZ 2,80,1966
intraperitoneal
rat
lethal dose (50 percent kill): 35 mg/kg N/R AEPPAE 212,463,1951
intraperitoneal
rat
lowest published toxic dose: 58.16 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other
GEPHDP 18,165,1987
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 148,21,2004
intraperitoneal
rat
lowest published toxic dose: 4 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Convulsions or effect on seizure threshold
JPHPH* 58,641,2007
intraperitoneal
rat
lowest published toxic dose: 8 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 46,1739,2008
intravenous
dog
lowest published lethal dose: 7,500 g/kg N/R TIEUA7 5,61,1950
intravenous
rat
lowest published toxic dose: 80 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BCPCA6 67,2141,2004
intravenous
rabbit
lowest published lethal dose: 4,500 g/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
JPETAB 92,140,1948
oral
domestic bird
lowest published lethal dose: 400 mg/kg N/R CNVJA9 23,267,1982
oral
cat
lethal dose (50 percent kill): 25 mg/kg N/R VCVGH* -,537,1990
oral
cat
lowest published lethal dose: 5 mg/kg N/R VCVGH* -,537,1990
oral
child
lowest published toxic dose: 180 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
CMEP** -,1,1956
oral
child
lowest published toxic dose: 111 mg/kg Behavioral: Convulsions or effect on seizure threshold AEHLAU 25,374,1972
oral
duck
lowest published lethal dose: 2 gm/kg N/R CNVJA9 23,267,1982
oral
dog
lethal dose (50 percent kill): 40 mg/kg N/R SPEADM 78-1,11,1978
oral
dog
lowest published lethal dose: 5 mg/kg N/R VCVGH* -,537,1990
oral
guinea pig
lethal dose (50 percent kill): 127 mg/kg N/R FEPRA7 6,386,1947
oral
hamster
lethal dose (50 percent kill): 360 mg/kg N/R EJTXAZ 7,159,1974
oral
human
lowest published lethal dose: 840 mg/kg N/R YAKUD5 34,1232,1992
oral
mouse
lethal dose (50 percent kill): 44 mg/kg N/R JEENAI 65,632,1972
oral
mouse
lethal dose (50 percent kill): 85.8 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases TXCYAC 61,41,1990
oral
mouse
lowest published lethal dose: 15 mg/kg N/R VCVGH* -,537,1990
oral
rat
lethal dose (50 percent kill): 76 mg/kg N/R SPEADM 78-1,11,1978
oral
rat
lowest published toxic dose: 30 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TJADAB 51,22A,1995
oral
rat
lowest published lethal dose: 15 mg/kg N/R VCVGH* -,537,1990
oral
rat
lowest published toxic dose: 5 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 243,116,2008
oral
rat
lowest published toxic dose: 10 mg/kg Liver: Other changes JTSCDR 32,261,2007
oral
rat
lowest published toxic dose: 5 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TXCYAC 244,190,2008
oral
rat
lowest published toxic dose: 30 mg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 231,10,2008
oral
rabbit
lethal dose (50 percent kill): 60 mg/kg N/R JHEMA2 22,115,1978
skin
man
lowest published toxic dose: 20 mg/kg/6 week- intermittent Eye: Visual field changes

Cardiac: Other changes
AJDCAI 141,125,1987
skin
rat
lethal dose (50 percent kill): 414 mg/kg N/R GISAAA 55(7),87,1990
skin
rat
lowest published lethal dose: 500 mg/kg N/R VCVGH* -,537,1990
skin
rabbit
lethal dose (50 percent kill): 50 mg/kg Behavioral: Excitement

Behavioral: Convulsions or effect on seizure threshold
AFDOAQ 16,3,1952
skin
rabbit
lethal dose (50 percent kill): 500 mg/kg N/R FEREAC 64,46191,1999
skin
rabbit
lowest published lethal dose: 200 mg/kg N/R VCVGH* -,537,1990
skin
woman
lowest published toxic dose: 19 mg/kg/1 hour- intermittent Behavioral: Hallucinations, distorted perceptions

Behavioral: Excitement

Skin: After systemic exposure: Dermatitis, other
AEMED3 24,972,1994
unreported route
cat
lowest published lethal dose: 50 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands
PHTXA6 22,273,1959
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 300 mg/kg N/R GTPZAB 17(3),32,1973
unreported route
rat
lethal dose (50 percent kill): 125 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 28(8),29,1963
unreported route
rat
lowest published toxic dose: 20 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
HBPTO* 1,879,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 2 mg/m3/4 hour/9 week- intermittent Immunological Including Allergic: Decreased immune response

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 28(8),29,1963
inhalation
mouse
lowest published toxic concentration: 1 mg/m3/80 day- intermittent Blood: Changes in bone marrow not included in above GTPZAB 8(10),55,1964
inhalation
rat
lowest published toxic concentration: 1,700 g/m3/17 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 43(3),41,1978
intraperitoneal
rat
lowest published toxic dose: 40 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
BECTA6 38,154,1987
intraperitoneal
rat
lowest published toxic dose: 105 mg/kg/7 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TXAPA9 19,234,1971
intraperitoneal
rat
lowest published toxic dose: 60 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 193,66,2003
intraperitoneal
rat
lowest published toxic dose: 6 mg/kg/2 week- intermittent Behavioral: Change in psychophysiological tests TXCYAC 217,147,2006
oral
duck
lowest published toxic dose: 480 mg/kg/8 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
IJEBA6 29,94,1991
oral
dog
lowest published toxic dose: 383.1 mg/kg/613 day- continuous Behavioral: Convulsions or effect on seizure threshold

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ENVRAL 19,460,1979
oral
dog
lowest published toxic dose: 465 mg/kg/93 day- continuous Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ENVRAL 19,460,1979
oral
dog
lowest published toxic dose: 875 mg/kg/50 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Liver: Other changes
ENVRAL 19,460,1979
oral
dog
lowest published toxic dose: 1,120 mg/kg/32 week- continuous Cardiac: EKG changes not diagnostic of above

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ENVRAL 19,460,1979
oral
dog
lowest published toxic dose: 170 mg/kg/17 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field ENVRAL 19,460,1979
oral
dog
lowest published toxic dose: 480 mg/kg/48 day- continuous Behavioral: Convulsions or effect on seizure threshold

Behavioral: Tremor

Liver: Fatty liver degeneration
ENVRAL 19,460,1979
oral
guinea pig
lowest published toxic dose: 142 mg/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
BCTKAG 7,37,1974
oral
mouse
lowest published toxic dose: 1,954 mg/kg/2 week- intermittent Endocrine: Other changes

Endocrine: Changes in adrenal weight

Biochemical: Metabolism (intermediary): Other
TXCYAC 66,75,1991
oral
mouse
lowest published toxic dose: 1,298 mg/kg/4 week- intermittent Endocrine: Other changes

Endocrine: Changes in adrenal weight

Biochemical: Metabolism (intermediary): Other
TXCYAC 66,75,1991
oral
mouse
lowest published toxic dose: 10,483 mg/kg/78 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight
JTEHD6 20,411,1987
oral
mouse
lowest published toxic dose: 7,280 mg/kg/8 week- intermittent Endocrine: Other changes

Endocrine: Changes in adrenal weight

Biochemical: Metabolism (intermediary): Other
TXCYAC 66,75,1991
oral
mouse
lowest published toxic dose: 302 mg/kg/12 week- continuous Liver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response
IJEBA6 34,1109,1996
oral
mouse
lowest published toxic dose: 42.98 mg/kg/2 week- intermittent Endocrine: Other changes

Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXCYAC 66,75,1991
oral
mouse
lowest published toxic dose: 28.56 mg/kg/4 week- intermittent Endocrine: Other changes

Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXCYAC 66,75,1991
oral
mouse
lowest published toxic dose: 42.84 mg/kg/6 week- intermittent Endocrine: Other changes

Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXCYAC 66,75,1991
oral
mouse
lowest published toxic dose: 160.16 mg/kg/8 week- intermittent Endocrine: Other changes

Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXCYAC 66,75,1991
oral
mouse
lowest published toxic dose: 13,104 mg/kg/26 week- continuous Liver: Other changes

Liver: Tumors

Liver: Changes in liver weight
CMSHAF 1,279,1972
oral
mouse
lowest published toxic dose: 6,048 mg/kg/12 week- continuous Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CMSHAF 1,153,1972
oral
mouse
lowest published toxic dose: 2,856 mg/kg/17 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field ENVRAL 19,460,1979
oral
mouse
lowest published toxic dose: 5,376 mg/kg/80 week- continuous Behavioral: Aggression

Skin and Appendages: Other: Hair

Reproductive: Paternal effects: Testes, epididymis, sperm duct
ENVRAL 19,460,1979
oral
mouse
lowest published toxic dose: 5,376 mg/kg/80 week- continuous Behavioral: Excitement

Skin and Appendages: Other: Hair
ENVRAL 19,460,1979
oral
mouse
lowest published toxic dose: 13,104 mg/kg/26 week- continuous Liver: Changes in liver weight ENVRAL 19,460,1979
oral
mouse
lowest published toxic dose: 840 mg/kg/80 week- continuous Blood: Leukemia ENVRAL 19,460,1979
oral
mouse
lowest published toxic dose: 23.24 mg/kg/4 week- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Metabolism (intermediary): Other
TXCYAC 61,41,1990
oral
mouse
lowest published toxic dose: 40.88 mg/kg/2 week- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Metabolism (intermediary): Other
TXCYAC 61,41,1990
oral
mouse
lowest published toxic dose: 52.5 mg/kg/6 week- intermittent Biochemical: Metabolism (intermediary): Other TXCYAC 61,41,1990
oral
mouse
lowest published toxic dose: 30 mg/kg/2 day- continuous Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 17,475,2003
oral
rat
lowest published toxic dose: 101 mg/kg/8 week- continuous Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
IJEBA6 35,1132,1997
oral
rat
lowest published toxic dose: 70 mg/kg/7 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 49,389,1988
oral
rat
lowest published toxic dose: 364 mg/kg/13 week- intermittent Blood: Normocytic anemia

Blood: Pigmented or nucleated red blood cells

Blood: Changes in other cell count (unspecified)
GISAAA 41(10),14,1976
oral
rat
lowest published toxic dose: 185 mg/kg/22 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
BECTA6 51,795,1993
oral
rat
lowest published toxic dose: 672 mg/kg/2 week- continuous Liver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
BECTA6 41,531,1988
oral
rat
lowest published toxic dose: 36 mg/kg/30 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 56,137,1991
oral
rat
lowest published toxic dose: 126 mg/kg/6 week- intermittent Cardiac: EKG changes not diagnostic of above

Vascular: BP elevation not characterized in autonomic section

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JJATDK 15,245,1995
oral
rat
lowest published toxic dose: 30 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TJADAB 51,22A,1995
oral
rat
lowest published toxic dose: 7,929.6 mg/kg/80 week- continuous Kidney, Ureter, and Bladder: Other changes

Skin: After systemic exposure: Dermatitis, other

Reproductive: Paternal effects: Testes, epididymis, sperm duct
ENVRAL 19,460,1979
oral
rat
lowest published toxic dose: 3,780 mg/kg/80 week- continuous Kidney, Ureter, and Bladder: Other changes

Skin: After systemic exposure: Dermatitis, other
ENVRAL 19,460,1979
oral
rat
lowest published toxic dose: 10,080 mg/kg/24 week- continuous Liver: Changes in liver weight ENVRAL 19,460,1979
oral
rat
lowest published toxic dose: 11,116 mg/kg/40 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field ENVRAL 19,460,1979
oral
rat
lowest published toxic dose: 4,494 mg/kg/107 week- continuous Liver: Changes in liver weight ENVRAL 19,460,1979
oral
rat
lowest published toxic dose: 150 mg/kg/30 day- intermittent Endocrine: Effect on menstrual cycle TXAPA9 99,384,1989
oral
rat
lowest published toxic dose: 520 mg/kg/104 day- intermittent Related to Chronic Data: Changes in uterine weight TXAPA9 99,384,1989
oral
rat
lowest published toxic dose: 1,040 mg/kg/104 day- intermittent Endocrine: Changes in pituitary weight

Endocrine: Estrogenic
TXAPA9 99,384,1989
oral
rat
lowest published toxic dose: 400 mg/kg/20 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 99,384,1989
oral
rat
lowest published toxic dose: 200 mg/kg/104 day- intermittent Related to Chronic Data: Changes in ovarian weight

Endocrine: Change in LH

Endocrine: Change in gonadotropins
TXAPA9 99,384,1989
oral
rat
lowest published toxic dose: 25 mg/kg/5 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) FCTOD7 41,1077,2003
oral
rat
lowest published toxic dose: 75 mg/kg/5 day- intermittent Liver: Changes in liver weight FCTOD7 41,1077,2003
oral
rat
lowest published toxic dose: 375 mg/kg/15 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
FCTOD7 41,1077,2003
oral
rat
lowest published toxic dose: 45 mg/kg/45 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
ETOPFR 22,90,2006
oral
rat
lowest published toxic dose: 630 mg/kg/6 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Metabolism (intermediary): Other
TXCYAC 239,116,2007
oral
rat
lowest published toxic dose: 45 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
JPHSC* 101,250,2006
oral
rat
lowest published toxic dose: 280 mg/kg/28 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTSCDR 32,261,2007
oral
rat
lowest published toxic dose: 70 mg/kg/7 day- intermittent Liver: Other changes

Liver: Changes in liver weight
JTSCDR 32,261,2007
oral
rabbit
lowest published toxic dose: 364 mg/kg/13 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Increased immune response
GISAAA 45(1),72,1980
oral
rabbit
lowest published toxic dose: 118 mg/kg/28 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
BECTA6 54,258,1995
skin
pig
lowest published toxic dose: 7,500 mg/kg/15 day- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 10,55,1978
unreported route
rat
lowest published toxic dose: 280 mg/kg/7 day- continuous Endocrine: Effect on menstrual cycle

Related to Chronic Data: Changes in uterine weight
HBPTO* 1,734,2001
unreported route
rat
lowest published toxic dose: 70 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
HBPTO* 1,879,2001
unreported route
rabbit
lowest published toxic dose: 105 mg/kg/5 week- intermittent Immunological Including Allergic: Decrease in humoral immune response HBPTO* 1,771,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMSUDL 7,220,1987
TOXICOLOGY REVIEW
TOLED5 127,101,2002
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
PMDCAY 10,85,1974
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
ARDEAC 113,353,1977
TOXICOLOGY REVIEW
CTOXAO 13,231,1978
TOXICOLOGY REVIEW
GISAAA 42(9),66,1977
TOXICOLOGY REVIEW
CNDQA8 14,49,1979
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
REPTED 19,209,2004
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
MUREAV 586,138,2005
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
MUTAEX 20,389,2005
TOXICOLOGY REVIEW
CLBIAS 39,762,2006
TOXICOLOGY REVIEW
CLBIAS 39,762,2006
TOXICOLOGY REVIEW
ENTOX* -,253,2005
TOXICOLOGY REVIEW
ENTOX* -,515,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUTAEX 20,389,2005
TOXICOLOGY REVIEW
ENTOX* -,4,2005
TOXICOLOGY REVIEW
TOXIA6 49,413,2007
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
FEREAC 72,32570,2007
TOXICOLOGY REVIEW
FEREAC 72,53449,2007
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
FEREAC 72,32570,2007
TOXICOLOGY REVIEW
FEREAC 72,53449,2007
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
REPTED 26,1,2008
TOXICOLOGY REVIEW
JTPAE7 19,111,2006
TOXICOLOGY REVIEW
REPTED 25,316,2007
TOXICOLOGY REVIEW
ITODC* -,355,2004
TOXICOLOGY REVIEW
MUREAV 543,251,2003
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,124,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg/m3 (skin) DTLVS* 3,146,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.008 ppm (0.1 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 mg/m3, Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.5 mg/m3, short term exposure limit 2 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.5 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg/m3;
short term exposure limit 1.5 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4 g/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LINDANE-air 8 hour time-weighted average 0.5 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 09318;
Number of Industries 5;
Total Number of Facilities 424;
Number of Occupations 6;
Total Number of Employees Exposed 689
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 09318;
Number of Industries 6;
Total Number of Facilities 2,617;
Number of Occupations 11;
Total Number of Employees Exposed 15,036;
Total Number of Female Employees Exposed 5,153


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166662)
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Host-mediated assay; D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an insecticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Lindane, 5502
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-14,1977
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

32OAAP "Pesticide and the Environment: a Continuing Controversy, Selected Papers Presented and Papers Reviewed at the 8th Inter-American Conference on Toxicology and Occupational Medicine, Miami, FL, 1973," Deichmann, W.B., ed., New York, Stratton Intercontinental Medical Book Corp., 1973
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74.
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIHAA2 Bibliotheca Haematologica (Basel). (S. Karger AG, Postfach, CH-4009 Basel, Switzerland) No.1- 1955-
BVIPA7 Bulletin of the Veterinary Institute in Pulawy. (Instytut Weterynaryjny, Aleja Partyzantow 55, Pulawy, Poland) V.1- 1957-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CLBIAS Clinical Biochemistry (Ottawa). (Laureen Dodge, Bus. Off., Ottawa, Ont., Canada) V.1- 1967-
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CNVJA9 Canadian Veterinary Journal. (339 Booth St., Ottawa, ON K1R 6J3, Canada) V.1- 1960-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HKXUDL Huanjing Kexue Xuebao. Environmental Sciences Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981-
HTOPA*
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
ITODC*
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology. (Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1- 1957-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPHPH*
JPHSC*
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued.
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TIEUA7 Tieraerztliche Umschau. (Terra-Verlag, Heizmann, Postfach 1222, 7750 Konstanze, Fed. Rep. Ger.) V.1- 1946-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as an insecticide

FDA-proprietary drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 8007-42-9
ALT CAS #: 55963-79-6
Click Here for Additional Information about RTECS

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