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Cyclohexane

RTECS #: GU6300000

CAS #: 110-82-7


UPDATE: May 2009 MW: 84.18 MF: C6H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Benzene, hexahydro -
  2. Cicloesano (Italian)
  3. Cyclohexaan (Dutch)
  4. Cyclohexan (German)
  5. Cyclohexane (ACGIH:OSHA)
  1. Cykloheksan (Polish)
  2. Hexahydrobenzene
  3. Hexamethylene
  4. Hexanaphthene
  5. RCRA waste number U056


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
1,548 mg/2 day- intermittent N/R JIHTAB 25,199,1943


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct Escherichia coli 10 Ámol/L MUREAV 89,95,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 62,500 mg/m3/15 minute Behavioral: Convulsions or effect on seizure threshold

Vascular: BP lowering not characterized in autonomic section
VCVGH* -,82,1990
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 70 gm/m3 N/R GTPZAB 32(10),25,1988
inhalation
mouse
lowest published lethal concentration: 70 gm/m3/2 hour N/R 85GMAT -,41,1982
inhalation
mouse
lethal concentration (50 percent kill): 70,000 mg/m3/2 hour N/R VCVGH* -,82,1990
inhalation
rabbit
lowest published lethal concentration: 89,600 mg/m3/1 hour Behavioral: General anesthetic

Behavioral: Tremor

Behavioral: Muscle contraction or spasticity
JIHTAB 25,323,1943
inhalation
rabbit
lowest published lethal concentration: 89,500 mg/m3/1 hour Behavioral: General anesthetic VCVGH* -,82,1990
oral
mouse
lethal dose (50 percent kill): 813 mg/kg N/R ENTOX* -,705,2005
oral
rat
lethal dose (50 percent kill): 12,705 mg/kg N/R ENTOX* -,705,2005
oral
rabbit
lowest published lethal dose: 5,500 mg/kg Gastrointestinal: Hypermotility, diarrhea JIHTAB 25,199,1943
oral
rabbit
lethal dose (50 percent kill): 5.5 mg/kg N/R ENTOX* -,705,2005
skin
rabbit
lethal dose : >180 gm/kg N/R JIHTAB 25,199,1943


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 2,000 ppm/90 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)
TOXID9 42,255,1998
inhalation
rat
lowest published toxic concentration: 300 ppm/6 hour/2 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 7,17,1980
inhalation
rat
lowest published toxic concentration: 2,000 ppm/13 week- intermittent Behavioral: Somnolence (general depressed activity) TOXID9 42,35,1998
inhalation
rabbit
lowest published toxic concentration: 7,444 ppm/6 hour/2 week- intermittent Autonomic Nervous System: Other (direct) parasympathomimetic

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 25,323,1943
inhalation
rabbit
lowest published toxic concentration: 9,220 ppm/6 hour/5 week- intermittent Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Tremor

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 25,323,1943
intraperitoneal
rat
lowest published toxic dose: 15 gm/kg/2 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOLED5 45,271,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,705,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 300 ppm (1050 mg/m3) DTLVS* 3,65,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 300 ppm (1050 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 300 ppm (1050 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 300 ppm (1050 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 300 ppm (1050 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (350 mg/m3), short term exposure limit 300 ppm (1050 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (700 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (172 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 700 mg/m3 (200 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 300 ppm (1050 mg/m3), short term exposure limit 375 ppm (1315 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 300 ppm (1050 mg/m3), VLE 375 ppm (1300 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 700 mg/m3 (200 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 700 mg/m3, short term exposure limit 2800 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 150 ppm (520 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 300 ppm (1050 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 300 ppm (1050 mg/m3);
short term exposure limit 375 ppm (1300 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 875 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 100 ppm (350 mg/m3);
short term exposure limit 300 ppm (1500 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 150 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 1000 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 80 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 300 ppm (1000 mg/m3);
short term exposure limit 370 ppm (1300 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (700 mg/m3);
KZG- week 800 ppm (2800 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 300 ppm (1050 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (350 mg/m3);
short term exposure limit 300 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXANE-air 10 hour time-weighted average 300 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 21190;
Number of Industries 117;
Total Number of Facilities 14,841;
Number of Occupations 74;
Total Number of Employees Exposed 125,761
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 21190;
Number of Industries 37;
Total Number of Facilities 2,260;
Number of Occupations 54;
Total Number of Employees Exposed 55,077;
Total Number of Female Employees Exposed 14,873


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a solvent

Top 50 chemical production: 2.21 billions lbs in 1992, 2.31 billions in 1991

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Primary Irritant

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