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| UPDATE: May 2009 | MW: 84.18 | MF: C6H12 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
skin | rabbit
1,548 mg/2 day- intermittent
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N/R
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JIHTAB 25,199,1943
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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DNA adduct
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Escherichia coli
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10 µmol/L
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MUREAV 89,95,1981
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
inhalation | cat
lowest published toxic concentration: 62,500 mg/m3/15 minute
|
Behavioral: Convulsions or effect on seizure threshold | Vascular: BP lowering not characterized in autonomic section
VCVGH* -,82,1990
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inhalation | mammal (species unspecified)
lethal concentration (50 percent kill): 70 gm/m3
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N/R
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GTPZAB 32(10),25,1988
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inhalation | mouse
lowest published lethal concentration: 70 gm/m3/2 hour
|
N/R
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85GMAT -,41,1982
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inhalation | mouse
lethal concentration (50 percent kill): 70,000 mg/m3/2 hour
|
N/R
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VCVGH* -,82,1990
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inhalation | rabbit
lowest published lethal concentration: 89,600 mg/m3/1 hour
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Behavioral: General anesthetic | Behavioral: Tremor Behavioral: Muscle contraction or spasticity
JIHTAB 25,323,1943
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inhalation | rabbit
lowest published lethal concentration: 89,500 mg/m3/1 hour
|
Behavioral: General anesthetic
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VCVGH* -,82,1990
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oral | mouse
lethal dose (50 percent kill): 813 mg/kg
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N/R
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ENTOX* -,705,2005
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oral | rat
lethal dose (50 percent kill): 12,705 mg/kg
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N/R
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ENTOX* -,705,2005
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oral | rabbit
lowest published lethal dose: 5,500 mg/kg
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Gastrointestinal: Hypermotility, diarrhea
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JIHTAB 25,199,1943
|
oral | rabbit
lethal dose (50 percent kill): 5.5 mg/kg
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N/R
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ENTOX* -,705,2005
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skin | rabbit
lethal dose : >180 gm/kg
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N/R
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JIHTAB 25,199,1943
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
inhalation | mouse
lowest published toxic concentration: 2,000 ppm/90 day- intermittent
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Behavioral: Somnolence (general depressed activity) | Behavioral: Change in motor activity (specific assay)
TOXID9 42,255,1998
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inhalation | rat
lowest published toxic concentration: 300 ppm/6 hour/2 week- intermittent
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Brain and Coverings: Other degenerative changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOLED5 7,17,1980
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inhalation | rat
lowest published toxic concentration: 2,000 ppm/13 week- intermittent
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Behavioral: Somnolence (general depressed activity)
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TOXID9 42,35,1998
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inhalation | rabbit
lowest published toxic concentration: 7,444 ppm/6 hour/2 week- intermittent
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Autonomic Nervous System: Other (direct) parasympathomimetic | Gastrointestinal: Hypermotility, diarrhea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 25,323,1943
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inhalation | rabbit
lowest published toxic concentration: 9,220 ppm/6 hour/5 week- intermittent
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Autonomic Nervous System: Other (direct) parasympathomimetic | Behavioral: Tremor Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 25,323,1943
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intraperitoneal | rat
lowest published toxic dose: 15 gm/kg/2 week- intermittent
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Kidney, Ureter, and Bladder: Other changes in urine composition
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TOLED5 45,271,1989
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REVIEWS:
ORGANIZATION
|
STANDARD
|
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 100 ppm
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DTLVS* TLV/BEI,2007
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TOXICOLOGY REVIEW
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ENTOX* -,705,2005
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air
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time-weighted average 300 ppm (1050 mg/m3)
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DTLVS* 3,65,1971
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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8 hour time-weighted average 300 ppm (1050 mg/m3)
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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8 hour time-weighted average 300 ppm (1050 mg/m3)
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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8 hour time-weighted average 300 ppm (1050 mg/m3)
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
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8 hour time-weighted average 300 ppm (1050 mg/m3)
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CFRGBR 41,50-204.50,1994
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 100 ppm (350 mg/m3), short term exposure limit 300 ppm (1050 mg/m3), JUL2008
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Occupational Exposure Limit - BELGIUM
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time-weighted average 200 ppm (700 mg/m3), MAR2002
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Occupational Exposure Limit - DENMARK
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time-weighted average 50 ppm (172 mg/m3), OCT 2002
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Occupational Exposure Limit - EC
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time-weighted average 700 mg/m3 (200 ppm), FEB 2006
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Occupational Exposure Limit - FINLAND
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time-weighted average 300 ppm (1050 mg/m3), short term exposure limit 375 ppm (1315 mg/m3), JAN1999
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Occupational Exposure Limit - FRANCE
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VME 300 ppm (1050 mg/m3), VLE 375 ppm (1300 mg/m3), FEB2006
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Occupational Exposure Limit - GERMANY
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MAK 700 mg/m3 (200 mL/m3), 2005
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Occupational Exposure Limit - HUNGARY
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time-weighted average 700 mg/m3, short term exposure limit 2800 mg/m3, Skin, SEP2000
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Occupational Exposure Limit - JAPAN
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Occupational Exposure Limit 150 ppm (520 mg/m3), APR2007
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Occupational Exposure Limit - KOREA
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time-weighted average 300 ppm (1050 mg/m3), 2006
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Occupational Exposure Limit - MEXICO
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time-weighted average 300 ppm (1050 mg/m3); | short term exposure limit 375 ppm (1300 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 875 mg/m3, 2003
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Occupational Exposure Limit - NEW ZEALAND
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time-weighted average 100 ppm (350 mg/m3); | short term exposure limit 300 ppm (1500 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY
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time-weighted average 150 ppm (525 mg/m3), JAN1999
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Occupational Exposure Limit - POLAND
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MAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 1000 mg/m3, JAN1999
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Occupational Exposure Limit - RUSSIA
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short term exposure limit 80 mg/m3, JUN2003
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Occupational Exposure Limit - SWEDEN
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time-weighted average 300 ppm (1000 mg/m3); | short term exposure limit 370 ppm (1300 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND
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MAK- week 200 ppm (700 mg/m3); | KZG- week 800 ppm (2800 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY
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time-weighted average 300 ppm (1050 mg/m3), JAN1993
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 100 ppm (350 mg/m3); | short term exposure limit 300 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | time-weighted average 100 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
time-weighted average 100 ppm | ||||||||||||||||||||||||
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
|
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXANE-air
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10 hour time-weighted average 300 ppm
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NIOSH* DHHS #92-100,1992
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 21190; | Number of Industries 117; Total Number of Facilities 14,841; Number of Occupations 74; Total Number of Employees Exposed 125,761
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 21190 |
Number of Industries 37; Total Number of Facilities 2,260; Number of Occupations 54; Total Number of Employees Exposed 55,077; Total Number of Female Employees Exposed 14,873 | ||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
|
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; Histidine reversion-Ames test
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EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as a solvent
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EPA TSCA Section 8(d) unpublished health/safety studies
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
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REFERENCES:
CODEN
|
|
REFERENCE
85GMAT
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"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F.,
et al., Moscow, Centre of International Projects, GKNT, 1982
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CFRGBR
|
Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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ENTOX*
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Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
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GTPZAB
|
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see
MTPEEI
|
JIHTAB
|
Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For
publisher information, see AEHLAU.
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NIOSH*
|
National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
|
TOXID9
|
Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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VCVGH*
|
"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances:
Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
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